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Differential role of LXRα and LXRβ in the regulation of UDP-glucuronosyltransferase 1A1 in humanized UGT1 mice.

Hansmann E, Mennillo E, Yoda E, Verreault M, Barbier O, Chen SJ, Tukey RH.

Drug Metab Dispos. 2020 Jan 24. pii: dmd.119.090068. doi: 10.1124/dmd.119.090068. [Epub ahead of print]


NRF2-Independent Regulation of Intestinal Constitutive Androstane Receptor by the Pro-Oxidants Cadmium and Isothiocyanate in hUGT1 Mice.

Paszek M, Tukey RH.

Drug Metab Dispos. 2020 Jan;48(1):25-30. doi: 10.1124/dmd.119.089508. Epub 2019 Nov 8.


Humanized UGT1 Mice, Regulation of UGT1A1, and the Role of the Intestinal Tract in Neonatal Hyperbilirubinemia and Breast Milk-Induced Jaundice.

Chen S, Tukey RH.

Drug Metab Dispos. 2018 Nov;46(11):1745-1755. doi: 10.1124/dmd.118.083212. Epub 2018 Aug 9.


Severe Neonatal Hyperbilirubinemia in Crigler-Najjar Syndrome Model Mice Can Be Reversed With Zinc Protoporphyrin.

Fujiwara R, Mitsugi R, Uemura A, Itoh T, Tukey RH.

Hepatol Commun. 2017 Oct;1(8):792-802. doi: 10.1002/hep4.1082. Epub 2017 Aug 10.


Species differences in drug glucuronidation: Humanized UDP-glucuronosyltransferase 1 mice and their application for predicting drug glucuronidation and drug-induced toxicity in humans.

Fujiwara R, Yoda E, Tukey RH.

Drug Metab Pharmacokinet. 2018 Feb;33(1):9-16. doi: 10.1016/j.dmpk.2017.10.002. Epub 2017 Oct 7. Review.


Crypt Organoid Culture as an in Vitro Model in Drug Metabolism and Cytotoxicity Studies.

Lu W, Rettenmeier E, Paszek M, Yueh MF, Tukey RH, Trottier J, Barbier O, Chen S.

Drug Metab Dispos. 2017 Jul;45(7):748-754. doi: 10.1124/dmd.117.075945. Epub 2017 May 3.


Isothiocyanates induce UGT1A1 in humanized UGT1 mice in a CAR dependent fashion that is highly dependent upon oxidative stress.

Yoda E, Paszek M, Konopnicki C, Fujiwara R, Chen S, Tukey RH.

Sci Rep. 2017 Apr 19;7:46489. doi: 10.1038/srep46489.


Developmental, Genetic, Dietary, and Xenobiotic Influences on Neonatal Hyperbilirubinemia.

Yueh MF, Chen S, Nguyen N, Tukey RH.

Mol Pharmacol. 2017 May;91(5):545-553. doi: 10.1124/mol.116.107524. Epub 2017 Mar 10. Review.


Intestinal NCoR1, a regulator of epithelial cell maturation, controls neonatal hyperbilirubinemia.

Chen S, Lu W, Yueh MF, Rettenmeier E, Liu M, Paszek M, Auwerx J, Yu RT, Evans RM, Wang K, Karin M, Tukey RH.

Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):E1432-E1440. doi: 10.1073/pnas.1700232114. Epub 2017 Feb 6. Erratum in: Proc Natl Acad Sci U S A. 2017 May 16;114(20):E4115. Paszek, Miles [added].


Prediction of drug-induced liver injury using keratinocytes.

Hirashima R, Itoh T, Tukey RH, Fujiwara R.

J Appl Toxicol. 2017 Jul;37(7):863-872. doi: 10.1002/jat.3435. Epub 2017 Jan 31.


Mice with hyperbilirubinemia due to Gilbert's syndrome polymorphism are resistant to hepatic steatosis by decreased serine 73 phosphorylation of PPARα.

Hinds TD Jr, Hosick PA, Chen S, Tukey RH, Hankins MW, Nestor-Kalinoski A, Stec DE.

Am J Physiol Endocrinol Metab. 2017 Apr 1;312(4):E244-E252. doi: 10.1152/ajpendo.00396.2016. Epub 2017 Jan 17.


Induction of the UDP-Glucuronosyltransferase 1A1 during the Perinatal Period Can Cause Neurodevelopmental Toxicity.

Hirashima R, Michimae H, Takemoto H, Sasaki A, Kobayashi Y, Itoh T, Tukey RH, Fujiwara R.

Mol Pharmacol. 2016 Sep;90(3):265-74. doi: 10.1124/mol.116.104174. Epub 2016 Jul 13.


Cadmium and arsenic override NF-κB developmental regulation of the intestinal UGT1A1 gene and control of hyperbilirubinemia.

Liu M, Chen S, Yueh MF, Fujiwara R, Konopnicki C, Hao H, Tukey RH.

Biochem Pharmacol. 2016 Jun 15;110-111:37-46. doi: 10.1016/j.bcp.2016.04.003. Epub 2016 Apr 6.


Stage-specific regulation of the WNT/β-catenin pathway enhances differentiation of hESCs into hepatocytes.

Touboul T, Chen S, To CC, Mora-Castilla S, Sabatini K, Tukey RH, Laurent LC.

J Hepatol. 2016 Jun;64(6):1315-26. doi: 10.1016/j.jhep.2016.02.028. Epub 2016 Feb 26.


Reduction of p53 by knockdown of the UGT1 locus in colon epithelial cells causes an increase in tumorigenesis.

Liu M, Chen S, Yueh MF, Wang G, Hao H, Tukey RH.

Cell Mol Gastroenterol Hepatol. 2016 Jan;2(1):63-76.e5. Epub 2015 Oct 13.


Triclosan: A Widespread Environmental Toxicant with Many Biological Effects.

Yueh MF, Tukey RH.

Annu Rev Pharmacol Toxicol. 2016;56:251-72. doi: 10.1146/annurev-pharmtox-010715-103417. Review.


Reduced Myelination and Increased Glia Reactivity Resulting from Severe Neonatal Hyperbilirubinemia.

Barateiro A, Chen S, Yueh MF, Fernandes A, Domingues HS, Relvas J, Barbier O, Nguyen N, Tukey RH, Brites D.

Mol Pharmacol. 2016 Jan;89(1):84-93. doi: 10.1124/mol.115.098228. Epub 2015 Oct 19.


Role of extrahepatic UDP-glucuronosyltransferase 1A1: Advances in understanding breast milk-induced neonatal hyperbilirubinemia.

Fujiwara R, Maruo Y, Chen S, Tukey RH.

Toxicol Appl Pharmacol. 2015 Nov 15;289(1):124-32. doi: 10.1016/j.taap.2015.08.018. Epub 2015 Sep 2. Review.


Nicotine regulates the expression of UDP-glucuronosyltransferase (UGT) in humanized UGT1 mouse brain.

Sakamoto M, Itoh T, Tukey RH, Fujiwara R.

Drug Metab Pharmacokinet. 2015 Aug;30(4):269-75. doi: 10.1016/j.dmpk.2015.04.004. Epub 2015 May 7.


The NIEHS Superfund Research Program: 25 Years of Translational Research for Public Health.

Landrigan PJ, Wright RO, Cordero JF, Eaton DL, Goldstein BD, Hennig B, Maier RM, Ozonoff DM, Smith MT, Tukey RH.

Environ Health Perspect. 2015 Oct;123(10):909-18. doi: 10.1289/ehp.1409247. Epub 2015 May 15.


Expression of UDP-Glucuronosyltransferase 1 (UGT1) and Glucuronidation Activity toward Endogenous Substances in Humanized UGT1 Mouse Brain.

Kutsuno Y, Hirashima R, Sakamoto M, Ushikubo H, Michimae H, Itoh T, Tukey RH, Fujiwara R.

Drug Metab Dispos. 2015 Jul;43(7):1071-6. doi: 10.1124/dmd.115.063719. Epub 2015 May 7.


The commonly used antimicrobial additive triclosan is a liver tumor promoter.

Yueh MF, Taniguchi K, Chen S, Evans RM, Hammock BD, Karin M, Tukey RH.

Proc Natl Acad Sci U S A. 2014 Dec 2;111(48):17200-5. doi: 10.1073/pnas.1419119111. Epub 2014 Nov 17.


Glucose induces intestinal human UDP-glucuronosyltransferase (UGT) 1A1 to prevent neonatal hyperbilirubinemia.

Aoshima N, Fujie Y, Itoh T, Tukey RH, Fujiwara R.

Sci Rep. 2014 Sep 11;4:6343. doi: 10.1038/srep06343.


Glucuronidation of drugs and drug-induced toxicity in humanized UDP-glucuronosyltransferase 1 mice.

Kutsuno Y, Itoh T, Tukey RH, Fujiwara R.

Drug Metab Dispos. 2014 Jul;42(7):1146-52. doi: 10.1124/dmd.114.057083. Epub 2014 Apr 24.


Bilirubin uridine diphosphate-glucuronosyltransferase variation is a genetic basis of breast milk jaundice.

Maruo Y, Morioka Y, Fujito H, Nakahara S, Yanagi T, Matsui K, Mori A, Sato H, Tukey RH, Takeuchi Y.

J Pediatr. 2014 Jul;165(1):36-41.e1. doi: 10.1016/j.jpeds.2014.01.060. Epub 2014 Mar 17.


Developmental onset of bilirubin-induced neurotoxicity involves Toll-like receptor 2-dependent signaling in humanized UDP-glucuronosyltransferase1 mice.

Yueh MF, Chen S, Nguyen N, Tukey RH.

J Biol Chem. 2014 Feb 21;289(8):4699-709. doi: 10.1074/jbc.M113.518613. Epub 2014 Jan 8.


Intestinal glucuronidation protects against chemotherapy-induced toxicity by irinotecan (CPT-11).

Chen S, Yueh MF, Bigo C, Barbier O, Wang K, Karin M, Nguyen N, Tukey RH.

Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):19143-8. doi: 10.1073/pnas.1319123110. Epub 2013 Nov 4.


Impact of fatty acids on human UDP-glucuronosyltransferase 1A1 activity and its expression in neonatal hyperbilirubinemia.

Shibuya A, Itoh T, Tukey RH, Fujiwara R.

Sci Rep. 2013 Oct 9;3:2903. doi: 10.1038/srep02903.


Glucuronidation of drugs in humanized UDP-glucuronosyltransferase 1 mice: Similarity with glucuronidation in human liver microsomes.

Kutsuno Y, Sumida K, Itoh T, Tukey RH, Fujiwara R.

Pharmacol Res Perspect. 2013 Oct;1(1):e00002. doi: 10.1002/prp2.2. Epub 2013 Sep 3.


Importance of UDP-glucuronosyltransferase 1A1 expression in skin and its induction by UVB in neonatal hyperbilirubinemia.

Sumida K, Kawana M, Kouno E, Itoh T, Takano S, Narawa T, Tukey RH, Fujiwara R.

Mol Pharmacol. 2013 Nov;84(5):679-86. doi: 10.1124/mol.113.088112. Epub 2013 Aug 15.


Evaluation of UGT protein interactions in human hepatocytes: effect of siRNA down regulation of UGT1A9 and UGT2B7 on propofol glucuronidation in human hepatocytes.

Konopnicki CM, Dickmann LJ, Tracy JM, Tukey RH, Wienkers LC, Foti RS.

Arch Biochem Biophys. 2013 Jul 15;535(2):143-9. doi: 10.1016/ Epub 2013 Apr 4.


Targeting the pregnane X receptor in liver injury.

Li T, Yu RT, Atkins AR, Downes M, Tukey RH, Evans RM.

Expert Opin Ther Targets. 2012 Nov;16(11):1075-83. doi: 10.1517/14728222.2012.715634. Epub 2012 Aug 23. Review.


Triclocarban mediates induction of xenobiotic metabolism through activation of the constitutive androstane receptor and the estrogen receptor alpha.

Yueh MF, Li T, Evans RM, Hammock B, Tukey RH.

PLoS One. 2012;7(6):e37705. doi: 10.1371/journal.pone.0037705. Epub 2012 Jun 15.


Pregnane-x-receptor controls hepatic glucuronidation during pregnancy and neonatal development in humanized UGT1 mice.

Chen S, Yueh MF, Evans RM, Tukey RH.

Hepatology. 2012 Aug;56(2):658-67. doi: 10.1002/hep.25671. Epub 2012 Jun 11.


Reduced expression of UGT1A1 in intestines of humanized UGT1 mice via inactivation of NF-κB leads to hyperbilirubinemia.

Fujiwara R, Chen S, Karin M, Tukey RH.

Gastroenterology. 2012 Jan;142(1):109-118.e2. doi: 10.1053/j.gastro.2011.09.045. Epub 2011 Oct 6.


Genotyping of the UDP-glucuronosyltransferase (UGT) 1A7 gene revisited.

Vogel A, Ockenga J, Tukey RH, Manns MP, Strassburg CP.

Gastroenterology. 2011 May;140(5):1692-3. doi: 10.1053/j.gastro.2011.03.036. Epub 2011 Mar 25. No abstract available.


Inhibition of human UGT2B7 gene expression in transgenic mice by the constitutive androstane receptor.

Yueh MF, Mellon PL, Tukey RH.

Mol Pharmacol. 2011 Jun;79(6):1053-60. doi: 10.1124/mol.110.070649. Epub 2011 Mar 17.


Developmental hyperbilirubinemia and CNS toxicity in mice humanized with the UDP glucuronosyltransferase 1 (UGT1) locus.

Fujiwara R, Nguyen N, Chen S, Tukey RH.

Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):5024-9. doi: 10.1073/pnas.0913290107. Epub 2010 Mar 1.


A humanized UGT1 mouse model expressing the UGT1A1*28 allele for assessing drug clearance by UGT1A1-dependent glucuronidation.

Cai H, Nguyen N, Peterkin V, Yang YS, Hotz K, La Placa DB, Chen S, Tukey RH, Stevens JC.

Drug Metab Dispos. 2010 May;38(5):879-86. doi: 10.1124/dmd.109.030130. Epub 2010 Feb 2.


Studies on induction of lamotrigine metabolism in transgenic UGT1 mice.

Argikar UA, Senekeo-Effenberger K, Larson EE, Tukey RH, Remmel RP.

Xenobiotica. 2009 Nov;39(11):826-35. doi: 10.3109/00498250903188985.


Opposing roles of peroxisome proliferator-activated receptor alpha and growth hormone in the regulation of CYP4A11 expression in a transgenic mouse model.

Savas U, Machemer DE, Hsu MH, Gaynor P, Lasker JM, Tukey RH, Johnson EF.

J Biol Chem. 2009 Jun 12;284(24):16541-52. doi: 10.1074/jbc.M902074200. Epub 2009 Apr 14.


Inactivation by UDP-glucuronosyltransferase enzymes: the end of androgen signaling.

Chouinard S, Yueh MF, Tukey RH, Giton F, Fiet J, Pelletier G, Barbier O, Bélanger A.

J Steroid Biochem Mol Biol. 2008 Apr;109(3-5):247-53. doi: 10.1016/j.jsbmb.2008.03.016. Epub 2008 Mar 13.


Disruption of the ugt1 locus in mice resembles human Crigler-Najjar type I disease.

Nguyen N, Bonzo JA, Chen S, Chouinard S, Kelner MJ, Hardiman G, Bélanger A, Tukey RH.

J Biol Chem. 2008 Mar 21;283(12):7901-11. doi: 10.1074/jbc.M709244200. Epub 2008 Jan 7.


Nrf2-Keap1 signaling pathway regulates human UGT1A1 expression in vitro and in transgenic UGT1 mice.

Yueh MF, Tukey RH.

J Biol Chem. 2007 Mar 23;282(12):8749-58. Epub 2007 Jan 26.


Expression of the human UGT1 locus in transgenic mice by 4-chloro-6-(2,3-xylidino)-2-pyrimidinylthioacetic acid (WY-14643) and implications on drug metabolism through peroxisome proliferator-activated receptor alpha activation.

Senekeo-Effenberger K, Chen S, Brace-Sinnokrak E, Bonzo JA, Yueh MF, Argikar U, Kaeding J, Trottier J, Remmel RP, Ritter JK, Barbier O, Tukey RH.

Drug Metab Dispos. 2007 Mar;35(3):419-27. Epub 2006 Dec 6.


Human CYP1A1GFP expression in transgenic mice serves as a biomarker for environmental toxicant exposure.

Operaña TN, Nguyen N, Chen S, Beaton D, Tukey RH.

Toxicol Sci. 2007 Jan;95(1):98-107. Epub 2006 Oct 25.


The liver X-receptor alpha controls hepatic expression of the human bile acid-glucuronidating UGT1A3 enzyme in human cells and transgenic mice.

Verreault M, Senekeo-Effenberger K, Trottier J, Bonzo JA, Bélanger J, Kaeding J, Staels B, Caron P, Tukey RH, Barbier O.

Hepatology. 2006 Aug;44(2):368-78.


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