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Pulmonary Arteries and Microcirculation in COPD With Pulmonary Hypertension: Bystander or Culprit?

Tuder RM, Cool CD.

Chest. 2019 Jul;156(1):4-6. doi: 10.1016/j.chest.2019.04.100. No abstract available.


IL-6Ra in Smooth Muscle Cells Protects against Schistosoma- and Hypoxia-induced Pulmonary Hypertension.

Mickael C, Kumar R, Hernandez-Saavedra D, Kassa B, Sanders L, Koyanagi D, Gu S, Lee MH, Tuder RM, Graham BB.

Am J Respir Cell Mol Biol. 2019 Jul;61(1):123-126. doi: 10.1165/rcmb.2018-0277LE. No abstract available.


Bringing Light to Chronic Obstructive Pulmonary Disease Pathogenesis and Resilience.

Tuder RM.

Ann Am Thorac Soc. 2018 Dec;15(Supplement_4):S227-S233. doi: 10.1513/AnnalsATS.201808-583MG.


A Review of Neuropathological Features of Familial and Adult Hemophagocytic Lymphohistiocytosis.

Klein C, Kleinschmidt-DeMasters BK, Liang X, Stence N, Tuder RM, Moore BE.

J Neuropathol Exp Neurol. 2019 Mar 1;78(3):197-208. doi: 10.1093/jnen/nlz001.


Pseudomonas aeruginosa stimulates nuclear sphingosine-1-phosphate generation and epigenetic regulation of lung inflammatory injury.

Ebenezer DL, Berdyshev EV, Bronova IA, Liu Y, Tiruppathi C, Komarova Y, Benevolenskaya EV, Suryadevara V, Ha AW, Harijith A, Tuder RM, Natarajan V, Fu P.

Thorax. 2019 Jun;74(6):579-591. doi: 10.1136/thoraxjnl-2018-212378. Epub 2019 Feb 5.


Systems Analysis of the Human Pulmonary Arterial Hypertension Lung Transcriptome.

Stearman RS, Bui QM, Speyer G, Handen A, Cornelius AR, Graham BB, Kim S, Mickler EA, Tuder RM, Chan SY, Geraci MW.

Am J Respir Cell Mol Biol. 2019 Jun;60(6):637-649. doi: 10.1165/rcmb.2018-0368OC.


Paclitaxel blocks Th2-mediated TGF-β activation in Schistosoma mansoni-induced pulmonary hypertension.

Kassa B, Mickael C, Kumar R, Sanders L, Koyanagi D, Hernandez-Saavedra D, Tuder RM, Graham BB.

Pulm Circ. 2019 Jan-Mar;9(1):2045894018820813. doi: 10.1177/2045894018820813. Epub 2018 Dec 4.


S100A8 Protects Human Primary Alveolar Type II Cells against Injury and Emphysema.

Lin CR, Bahmed K, Criner GJ, Marchetti N, Tuder RM, Kelsen S, Bolla S, Mandapati C, Kosmider B.

Am J Respir Cell Mol Biol. 2019 Mar;60(3):299-307. doi: 10.1165/rcmb.2018-0144OC.


Cardiopulmonary remodeling in fattened beef cattle: a naturally occurring large animal model of obesity-associated pulmonary hypertension with left heart disease.

Krafsur GM, Neary JM, Garry F, Holt T, Gould DH, Mason GL, Thomas MG, Enns RM, Tuder RM, Heaton MP, Brown RD, Stenmark KR.

Pulm Circ. 2019 Jan-Mar;9(1):2045894018796804. doi: 10.1177/2045894018796804. Epub 2018 Aug 20.


Assessment of Right Ventricular Function in the Research Setting: Knowledge Gaps and Pathways Forward. An Official American Thoracic Society Research Statement.

Lahm T, Douglas IS, Archer SL, Bogaard HJ, Chesler NC, Haddad F, Hemnes AR, Kawut SM, Kline JA, Kolb TM, Mathai SC, Mercier O, Michelakis ED, Naeije R, Tuder RM, Ventetuolo CE, Vieillard-Baron A, Voelkel NF, Vonk-Noordegraaf A, Hassoun PM; American Thoracic Society Assembly on Pulmonary Circulation.

Am J Respir Crit Care Med. 2018 Aug 15;198(4):e15-e43. doi: 10.1164/rccm.201806-1160ST.


Lung Histological Methods.

Gandjeva A, Tuder RM.

Methods Mol Biol. 2018;1809:315-329. doi: 10.1007/978-1-4939-8570-8_20.


Vascular Adaptation of the Right Ventricle in Experimental Pulmonary Hypertension.

Graham BB, Kumar R, Mickael C, Kassa B, Koyanagi D, Sanders L, Zhang L, Perez M, Hernandez-Saavedra D, Valencia C, Dixon K, Harral J, Loomis Z, Irwin D, Nemkov T, D'Alessandro A, Stenmark KR, Tuder RM.

Am J Respir Cell Mol Biol. 2018 Oct;59(4):479-489. doi: 10.1165/rcmb.2018-0095OC.


Protein Tyrosine Phosphatase-N13 Promotes Myofibroblast Resistance to Apoptosis in Idiopathic Pulmonary Fibrosis.

Bamberg A, Redente EF, Groshong SD, Tuder RM, Cool CD, Keith RC, Edelman BL, Black BP, Cosgrove GP, Wynes MW, Curran-Everett D, De Langhe S, Ortiz LA, Thorburn A, Riches DWH.

Am J Respir Crit Care Med. 2018 Oct 1;198(7):914-927. doi: 10.1164/rccm.201707-1497OC.


Peroxisome Proliferator-activated Receptor γ and Mitochondria: Drivers or Passengers on the Road to Pulmonary Hypertension?

Stenmark KR, Tuder RM.

Am J Respir Cell Mol Biol. 2018 May;58(5):555-557. doi: 10.1165/rcmb.2017-0318ED. No abstract available.


Epithelial Heparan Sulfate Contributes to Alveolar Barrier Function and Is Shed during Lung Injury.

Haeger SM, Liu X, Han X, McNeil JB, Oshima K, McMurtry SA, Yang Y, Ouyang Y, Zhang F, Nozik-Grayck E, Zemans RL, Tuder RM, Bastarache JA, Linhardt RJ, Schmidt EP.

Am J Respir Cell Mol Biol. 2018 Sep;59(3):363-374. doi: 10.1165/rcmb.2017-0428OC.


Flow Cytometry Underestimates and Planimetry Overestimates Alveolar Epithelial Type 2 Cell Expansion after Lung Injury.

Jansing NL, Patel N, McClendon J, Redente EF, Henson PM, Tuder RM, Hyde DM, Nyengaard JR, Zemans RL.

Am J Respir Crit Care Med. 2018 Aug 1;198(3):390-392. doi: 10.1164/rccm.201709-1838LE. No abstract available.


Advanced Microengineered Lung Models for Translational Drug Discovery.

Niemeyer BF, Zhao P, Tuder RM, Benam KH.

SLAS Discov. 2018 Sep;23(8):777-789. doi: 10.1177/2472555218760217. Epub 2018 Feb 15.


Dynamic and diverse changes in the functional properties of vascular smooth muscle cells in pulmonary hypertension.

Stenmark KR, Frid MG, Graham BB, Tuder RM.

Cardiovasc Res. 2018 Mar 15;114(4):551-564. doi: 10.1093/cvr/cvy004.


Hypoxia-Inducible Factor 1α Signaling Promotes Repair of the Alveolar Epithelium after Acute Lung Injury.

McClendon J, Jansing NL, Redente EF, Gandjeva A, Ito Y, Colgan SP, Ahmad A, Riches DWH, Chapman HA, Mason RJ, Tuder RM, Zemans RL.

Am J Pathol. 2017 Aug;187(8):1772-1786. doi: 10.1016/j.ajpath.2017.04.012. Epub 2017 Jun 12.


Unbiased Quantitation of Alveolar Type II to Alveolar Type I Cell Transdifferentiation during Repair after Lung Injury in Mice.

Jansing NL, McClendon J, Henson PM, Tuder RM, Hyde DM, Zemans RL.

Am J Respir Cell Mol Biol. 2017 Nov;57(5):519-526. doi: 10.1165/rcmb.2017-0037MA.


TGF-β activation by bone marrow-derived thrombospondin-1 causes Schistosoma- and hypoxia-induced pulmonary hypertension.

Kumar R, Mickael C, Kassa B, Gebreab L, Robinson JC, Koyanagi DE, Sanders L, Barthel L, Meadows C, Fox D, Irwin D, Li M, McKeon BA, Riddle S, Dale Brown R, Morgan LE, Evans CM, Hernandez-Saavedra D, Bandeira A, Maloney JP, Bull TM, Janssen WJ, Stenmark KR, Tuder RM, Graham BB.

Nat Commun. 2017 May 30;8:15494. doi: 10.1038/ncomms15494.


Right Ventricle Vasculature in Human Pulmonary Hypertension Assessed by Stereology.

Graham BB, Koyanagi D, Kandasamy B, Tuder RM.

Am J Respir Crit Care Med. 2017 Oct 15;196(8):1075-1077. doi: 10.1164/rccm.201702-0425LE. No abstract available.


Pulmonary vascular remodeling in pulmonary hypertension.

Tuder RM.

Cell Tissue Res. 2017 Mar;367(3):643-649. doi: 10.1007/s00441-016-2539-y. Epub 2016 Dec 26. Review.


Fatty Acid Metabolism, Bone Morphogenetic Protein Receptor Type 2, and the Right Ventricle.

Graham BB, Robinson JC, Tuder RM.

Am J Respir Crit Care Med. 2016 Sep 15;194(6):655-6. doi: 10.1164/rccm.201603-0592ED. No abstract available.


RTP801 Amplifies Nicotinamide Adenine Dinucleotide Phosphate Oxidase-4-Dependent Oxidative Stress Induced by Cigarette Smoke.

Hernández-Saavedra D, Sanders L, Perez MJ, Kosmider B, Smith LP, Mitchell JD, Yoshida T, Tuder RM.

Am J Respir Cell Mol Biol. 2017 Jan;56(1):62-73. doi: 10.1165/rcmb.2016-0144OC.


Pulmonary Veno-occlusive Disease and Pulmonary Hypertension in Dogs: Striking Similarities to the Human Condition.

Stenmark KR, Krafsur GM, Tuder RM.

Vet Pathol. 2016 Jul;53(4):707-10. doi: 10.1177/0300985816647454. No abstract available.


Increased mitochondrial arginine metabolism supports bioenergetics in asthma.

Xu W, Ghosh S, Comhair SA, Asosingh K, Janocha AJ, Mavrakis DA, Bennett CD, Gruca LL, Graham BB, Queisser KA, Kao CC, Wedes SH, Petrich JM, Tuder RM, Kalhan SC, Erzurum SC.

J Clin Invest. 2016 Jul 1;126(7):2465-81. doi: 10.1172/JCI82925. Epub 2016 May 23.


HIPPO-Integrin-linked Kinase Cross-Talk Controls Self-Sustaining Proliferation and Survival in Pulmonary Hypertension.

Kudryashova TV, Goncharov DA, Pena A, Kelly N, Vanderpool R, Baust J, Kobir A, Shufesky W, Mora AL, Morelli AE, Zhao J, Ihida-Stansbury K, Chang B, DeLisser H, Tuder RM, Kawut SM, Silljé HH, Shapiro S, Zhao Y, Goncharova EA.

Am J Respir Crit Care Med. 2016 Oct 1;194(7):866-877.


DJ-1 Modulates Nuclear Erythroid 2-Related Factor-2-Mediated Protection in Human Primary Alveolar Type II Cells in Smokers.

Bahmed K, Messier EM, Zhou W, Tuder RM, Freed CR, Chu HW, Kelsen SG, Bowler RP, Mason RJ, Kosmider B.

Am J Respir Cell Mol Biol. 2016 Sep;55(3):439-49. doi: 10.1165/rcmb.2015-0304OC.


The Causal Role of IL-4 and IL-13 in Schistosoma mansoni Pulmonary Hypertension.

Kumar R, Mickael C, Chabon J, Gebreab L, Rutebemberwa A, Garcia AR, Koyanagi DE, Sanders L, Gandjeva A, Kearns MT, Barthel L, Janssen WJ, Mauad T, Bandeira A, Schmidt E, Tuder RM, Graham BB.

Am J Respir Crit Care Med. 2015 Oct 15;192(8):998-1008. doi: 10.1164/rccm.201410-1820OC.


Changes in Aortic Wall Structure, Composition, and Stiffness With Continuous-Flow Left Ventricular Assist Devices: A Pilot Study.

Ambardekar AV, Hunter KS, Babu AN, Tuder RM, Dodson RB, Lindenfeld J.

Circ Heart Fail. 2015 Sep;8(5):944-52. doi: 10.1161/CIRCHEARTFAILURE.114.001955. Epub 2015 Jul 1.


Severe pulmonary hypertension is associated with altered right ventricle metabolic substrate uptake.

Graham BB, Kumar R, Mickael C, Sanders L, Gebreab L, Huber KM, Perez M, Smith-Jones P, Serkova NJ, Tuder RM.

Am J Physiol Lung Cell Mol Physiol. 2015 Sep 1;309(5):L435-40. doi: 10.1152/ajplung.00169.2015. Epub 2015 Jun 26.


Metabolic reprogramming and inflammation act in concert to control vascular remodeling in hypoxic pulmonary hypertension.

Stenmark KR, Tuder RM, El Kasmi KC.

J Appl Physiol (1985). 2015 Nov 15;119(10):1164-72. doi: 10.1152/japplphysiol.00283.2015. Epub 2015 Apr 30. Review.


Telomere dysfunction causes alveolar stem cell failure.

Alder JK, Barkauskas CE, Limjunyawong N, Stanley SE, Kembou F, Tuder RM, Hogan BL, Mitzner W, Armanios M.

Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):5099-104. doi: 10.1073/pnas.1504780112. Epub 2015 Apr 3.


Endothelial chromosome 13 deletion in congenital heart disease-associated pulmonary arterial hypertension dysregulates SMAD9 signaling.

Drake KM, Comhair SA, Erzurum SC, Tuder RM, Aldred MA.

Am J Respir Crit Care Med. 2015 Apr 1;191(7):850-4. doi: 10.1164/rccm.201411-1985LE. No abstract available.


[Relevant issues in the pathology and pathobiology of pulmonary hypertension].

Tuder RM, Archer SL, Dorfmüller P, Erzurum SC, Guignabert C, Michelakis E, Rabinovitch M, Schermuly R, Stenmark KR, Morrell NW.

Turk Kardiyol Dern Ars. 2014 Oct;42 Suppl 1:5-16. Turkish.


Blue journal conference. Aging and susceptibility to lung disease.

Thannickal VJ, Murthy M, Balch WE, Chandel NS, Meiners S, Eickelberg O, Selman M, Pardo A, White ES, Levy BD, Busse PJ, Tuder RM, Antony VB, Sznajder JI, Budinger GR.

Am J Respir Crit Care Med. 2015 Feb 1;191(3):261-9. doi: 10.1164/rccm.201410-1876PP. Review.


Reversal of severe angioproliferative pulmonary arterial hypertension and right ventricular hypertrophy by combined phosphodiesterase-5 and endothelin receptor inhibition.

Cavasin MA, Demos-Davies KM, Schuetze KB, Blakeslee WW, Stratton MS, Tuder RM, McKinsey TA.

J Transl Med. 2014 Nov 26;12:314. doi: 10.1186/s12967-014-0314-y.


Novosphingobium and its potential role in chronic obstructive pulmonary diseases: insights from microbiome studies.

Rutebemberwa A, Stevens MJ, Perez MJ, Smith LP, Sanders L, Cosgrove G, Robertson CE, Tuder RM, Harris JK.

PLoS One. 2014 Oct 23;9(10):e111150. doi: 10.1371/journal.pone.0111150. eCollection 2014.


Kinetics of the angiogenic response in lung endothelium following acute inflammatory injury with bleomycin.

Yunt ZX, Mohning MP, Barthel L, Kearns MT, Tuder RM, Hyde DM, Henson PM, Janssen WJ.

Exp Lung Res. 2014 Oct;40(8):415-25. doi: 10.3109/01902148.2014.938202. Epub 2014 Aug 25.


Rtp801 suppression of epithelial mTORC1 augments endotoxin-induced lung inflammation.

Nadon AM, Perez MJ, Hernandez-Saavedra D, Smith LP, Yang Y, Sanders LA, Gandjeva A, Chabon J, Koyanagi DE, Graham BB, Tuder RM, Schmidt EP.

Am J Pathol. 2014 Sep;184(9):2382-9. doi: 10.1016/j.ajpath.2014.06.002. Epub 2014 Jul 9.


Role of vascular endothelial growth factor signaling in Schistosoma-induced experimental pulmonary hypertension.

Chabon JJ, Gebreab L, Kumar R, Debella E, Tanaka T, Koyanagi D, Rodriguez Garcia A, Sanders L, Perez M, Tuder RM, Graham BB.

Pulm Circ. 2014 Jun;4(2):289-99. doi: 10.1086/675992.


The crossroads of iron with hypoxia and cellular metabolism. Implications in the pathobiology of pulmonary hypertension.

Robinson JC, Graham BB, Rouault TC, Tuder RM.

Am J Respir Cell Mol Biol. 2014 Dec;51(6):721-9. doi: 10.1165/rcmb.2014-0021TR. Review.


Adventitial fibroblasts induce a distinct proinflammatory/profibrotic macrophage phenotype in pulmonary hypertension.

El Kasmi KC, Pugliese SC, Riddle SR, Poth JM, Anderson AL, Frid MG, Li M, Pullamsetti SS, Savai R, Nagel MA, Fini MA, Graham BB, Tuder RM, Friedman JE, Eltzschig HK, Sokol RJ, Stenmark KR.

J Immunol. 2014 Jul 15;193(2):597-609. doi: 10.4049/jimmunol.1303048. Epub 2014 Jun 13.


Regulatory T cells modulate granulomatous inflammation in an HLA-DP2 transgenic murine model of beryllium-induced disease.

Mack DG, Falta MT, McKee AS, Martin AK, Simonian PL, Crawford F, Gordon T, Mercer RR, Hoover MD, Marrack P, Kappler JW, Tuder RM, Fontenot AP.

Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):8553-8. doi: 10.1073/pnas.1408048111. Epub 2014 May 27.


How do we measure pathology in PAH (lung and RV) and what does it tell us about the disease.

Tuder RM.

Drug Discov Today. 2014 Aug;19(8):1257-63. doi: 10.1016/j.drudis.2014.05.022. Epub 2014 May 29. Review.


Altered nutrient response of mTORC1 as a result of changes in REDD1 expression: effect of obesity vs. REDD1 deficiency.

Williamson DL, Li Z, Tuder RM, Feinstein E, Kimball SR, Dungan CM.

J Appl Physiol (1985). 2014 Aug 1;117(3):246-56. doi: 10.1152/japplphysiol.01350.2013. Epub 2014 May 29.


Progress in solving the sex hormone paradox in pulmonary hypertension.

Lahm T, Tuder RM, Petrache I.

Am J Physiol Lung Cell Mol Physiol. 2014 Jul 1;307(1):L7-26. doi: 10.1152/ajplung.00337.2013. Epub 2014 May 9. Review.


In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight.

Dahlman JE, Barnes C, Khan O, Thiriot A, Jhunjunwala S, Shaw TE, Xing Y, Sager HB, Sahay G, Speciner L, Bader A, Bogorad RL, Yin H, Racie T, Dong Y, Jiang S, Seedorf D, Dave A, Sandu KS, Webber MJ, Novobrantseva T, Ruda VM, Lytton-Jean AKR, Levins CG, Kalish B, Mudge DK, Perez M, Abezgauz L, Dutta P, Smith L, Charisse K, Kieran MW, Fitzgerald K, Nahrendorf M, Danino D, Tuder RM, von Andrian UH, Akinc A, Schroeder A, Panigrahy D, Kotelianski V, Langer R, Anderson DG.

Nat Nanotechnol. 2014 Aug;9(8):648-655. doi: 10.1038/nnano.2014.84. Epub 2014 May 11.


Functional prostacyclin synthase promoter polymorphisms. Impact in pulmonary arterial hypertension.

Stearman RS, Cornelius AR, Lu X, Conklin DS, Del Rosario MJ, Lowe AM, Elos MT, Fettig LM, Wong RE, Hara N, Cogan JD, Phillips JA 3rd, Taylor MR, Graham BB, Tuder RM, Loyd JE, Geraci MW.

Am J Respir Crit Care Med. 2014 May 1;189(9):1110-20. doi: 10.1164/rccm.201309-1697OC.

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