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Items: 1 to 50 of 221

1.

Factor VIII: the protein, cloning its gene, synthetic factor and now - 35 years later - gene therapy; what happened in between?

Ling G, Tuddenham EGD.

Br J Haematol. 2020 Jan 3. doi: 10.1111/bjh.16311. [Epub ahead of print] Review.

PMID:
31900934
2.

Interaction Between the a3 Region of Factor VIII and the TIL'E' Domains of the von Willebrand Factor.

Dagil L, Troelsen KS, Bolt G, Thim L, Wu B, Zhao X, Tuddenham EGD, Nielsen TE, Tanner DA, Faber JH, Breinholt J, Rasmussen JE, Hansen DF.

Biophys J. 2019 Aug 6;117(3):479-489. doi: 10.1016/j.bpj.2019.07.007. Epub 2019 Jul 11.

3.

Recent advances in developing specific therapies for haemophilia.

Ling G, Nathwani AC, Tuddenham EGD.

Br J Haematol. 2018 Apr;181(2):161-172. doi: 10.1111/bjh.15084. Epub 2018 Jan 23. Review.

PMID:
29359795
4.

Gene Therapy for Hemophilia.

Nathwani AC, Davidoff AM, Tuddenham EGD.

Hematol Oncol Clin North Am. 2017 Oct;31(5):853-868. doi: 10.1016/j.hoc.2017.06.011. Review.

PMID:
28895852
5.

Advances in Gene Therapy for Hemophilia.

Nathwani AC, Davidoff AM, Tuddenham EGD.

Hum Gene Ther. 2017 Nov;28(11):1004-1012. doi: 10.1089/hum.2017.167. Review.

PMID:
28835123
6.

Platelets are a safe way to deliver factor VIII. After 13 years of preclinical research it is now time for a clinical trial.

Tuddenham EG.

J Thromb Haemost. 2017 Jan;15(1):96-97. doi: 10.1111/jth.13545. Epub 2016 Nov 19. No abstract available.

7.

Long-term safety and efficacy of factor IX gene therapy in hemophilia B.

Nathwani AC, Reiss UM, Tuddenham EG, Rosales C, Chowdary P, McIntosh J, Della Peruta M, Lheriteau E, Patel N, Raj D, Riddell A, Pie J, Rangarajan S, Bevan D, Recht M, Shen YM, Halka KG, Basner-Tschakarjan E, Mingozzi F, High KA, Allay J, Kay MA, Ng CY, Zhou J, Cancio M, Morton CL, Gray JT, Srivastava D, Nienhuis AW, Davidoff AM.

N Engl J Med. 2014 Nov 20;371(21):1994-2004. doi: 10.1056/NEJMoa1407309.

8.

Thrombin generation assay identifies individual variability in responses to low molecular weight heparin in pregnancy: implications for anticoagulant monitoring.

Chowdary P, Adamidou D, Riddell A, Aghighi S, Griffioen A, Priest P, Moghadam L, Kelaher N, Huq FY, Kadir RA, Tuddenham EG, Gatt A.

Br J Haematol. 2015 Mar;168(5):719-27. doi: 10.1111/bjh.13193. Epub 2014 Oct 29.

PMID:
25351814
9.

Solution structure of the major factor VIII binding region on von Willebrand factor.

Shiltagh N, Kirkpatrick J, Cabrita LD, McKinnon TA, Thalassinos K, Tuddenham EG, Hansen DF.

Blood. 2014 Jun 26;123(26):4143-51. doi: 10.1182/blood-2013-07-517086. Epub 2014 Apr 3.

10.

An interactive mutation database for human coagulation factor IX provides novel insights into the phenotypes and genetics of hemophilia B.

Rallapalli PM, Kemball-Cook G, Tuddenham EG, Gomez K, Perkins SJ.

J Thromb Haemost. 2013 Jul;11(7):1329-40. doi: 10.1111/jth.12276.

11.

Therapeutic levels of FVIII following a single peripheral vein administration of rAAV vector encoding a novel human factor VIII variant.

McIntosh J, Lenting PJ, Rosales C, Lee D, Rabbanian S, Raj D, Patel N, Tuddenham EG, Christophe OD, McVey JH, Waddington S, Nienhuis AW, Gray JT, Fagone P, Mingozzi F, Zhou SZ, High KA, Cancio M, Ng CY, Zhou J, Morton CL, Davidoff AM, Nathwani AC.

Blood. 2013 Apr 25;121(17):3335-44. doi: 10.1182/blood-2012-10-462200. Epub 2013 Feb 20.

12.

"Magic" mushrooms don't cause renal failure.

Tuddenham EG.

BMJ. 2012 Oct 17;345:e6893. doi: 10.1136/bmj.e6893. No abstract available.

PMID:
23077354
13.

Journal rubric. Haemophilic pseudotumour of the carotid artery.

Malam Y, Tsui J, Sheikh SE, Tuddenham EG, Baker DM.

Vasc Med. 2012 Jun;17(3):193-4. doi: 10.1177/1358863X11429998. Epub 2012 Jan 13. No abstract available.

PMID:
22246584
14.

Adenovirus-associated virus vector-mediated gene transfer in hemophilia B.

Nathwani AC, Tuddenham EG, Rangarajan S, Rosales C, McIntosh J, Linch DC, Chowdary P, Riddell A, Pie AJ, Harrington C, O'Beirne J, Smith K, Pasi J, Glader B, Rustagi P, Ng CY, Kay MA, Zhou J, Spence Y, Morton CL, Allay J, Coleman J, Sleep S, Cunningham JM, Srivastava D, Basner-Tschakarjan E, Mingozzi F, High KA, Gray JT, Reiss UM, Nienhuis AW, Davidoff AM.

N Engl J Med. 2011 Dec 22;365(25):2357-65. doi: 10.1056/NEJMoa1108046. Epub 2011 Dec 10.

15.

AAV-mediated gene transfer in the perinatal period results in expression of FVII at levels that protect against fatal spontaneous hemorrhage.

Binny C, McIntosh J, Della Peruta M, Kymalainen H, Tuddenham EG, Buckley SM, Waddington SN, McVey JH, Spence Y, Morton CL, Thrasher AJ, Gray JT, Castellino FJ, Tarantal AF, Davidoff AM, Nathwani AC.

Blood. 2012 Jan 26;119(4):957-66. doi: 10.1182/blood-2011-09-377630. Epub 2011 Dec 1.

16.

Human congenital diseases with mixed modes of inheritance have a shortage of recessive disease. A demographic scenario?

Mitchison NA, Bhattacharya S, Tuddenham EG.

Ann Hum Genet. 2011 Nov;75(6):688-93. doi: 10.1111/j.1469-1809.2011.00679.x. Epub 2011 Sep 22.

17.

Noninvasive prenatal diagnosis of hemophilia by microfluidics digital PCR analysis of maternal plasma DNA.

Tsui NB, Kadir RA, Chan KC, Chi C, Mellars G, Tuddenham EG, Leung TY, Lau TK, Chiu RW, Lo YM.

Blood. 2011 Mar 31;117(13):3684-91. doi: 10.1182/blood-2010-10-310789. Epub 2011 Jan 24. Erratum in: Blood. 2012 May 10;119(19):4577.

PMID:
21263151
18.

Codon optimization of human factor VIII cDNAs leads to high-level expression.

Ward NJ, Buckley SM, Waddington SN, Vandendriessche T, Chuah MK, Nathwani AC, McIntosh J, Tuddenham EG, Kinnon C, Thrasher AJ, McVey JH.

Blood. 2011 Jan 20;117(3):798-807. doi: 10.1182/blood-2010-05-282707. Epub 2010 Nov 1.

PMID:
21041718
19.

Enhanced thrombin generation in patients with cirrhosis-induced coagulopathy.

Gatt A, Riddell A, Calvaruso V, Tuddenham EG, Makris M, Burroughs AK.

J Thromb Haemost. 2010 Sep;8(9):1994-2000. doi: 10.1111/j.1538-7836.2010.03937.x.

20.

Menorrhagia in adolescents with inherited bleeding disorders.

Chi C, Pollard D, Tuddenham EG, Kadir RA.

J Pediatr Adolesc Gynecol. 2010 Aug;23(4):215-22. doi: 10.1016/j.jpag.2009.11.008. Epub 2010 May 14.

PMID:
20471874
21.

Bernard Soulier syndrome in pregnancy: a systematic review.

Peitsidis P, Datta T, Pafilis I, Otomewo O, Tuddenham EG, Kadir RA.

Haemophilia. 2010 Jul 1;16(4):584-91. doi: 10.1111/j.1365-2516.2009.02137.x. Epub 2010 Jan 12. Review.

PMID:
20070385
22.

Structural analysis of eight novel and 112 previously reported missense mutations in the interactive FXI mutation database reveals new insight on FXI deficiency.

Saunders RE, Shiltagh N, Gomez K, Mellars G, Cooper C, Perry DJ, Tuddenham EG, Perkins SJ.

Thromb Haemost. 2009 Aug;102(2):287-301. doi: 10.1160/TH09-01-0044.

PMID:
19652879
23.

Optimizing warfarin reversal--an ex vivo study.

Gatt A, Riddell A, van Veen JJ, Kitchen S, Tuddenham EG, Makris M.

J Thromb Haemost. 2009 Jul;7(7):1123-7. doi: 10.1111/j.1538-7836.2009.03435.x.

24.

Alpha1-antitrypsin Pittsburgh in a family with bleeding tendency.

Hua B, Fan L, Liang Y, Zhao Y, Tuddenham EG.

Haematologica. 2009 Jun;94(6):881-4. doi: 10.3324/haematol.2008.004739.

25.

Consensus protocol for the use of recombinant activated factor VII [eptacog alfa (activated); NovoSeven] in elective orthopaedic surgery in haemophilic patients with inhibitors.

Giangrande PL, Wilde JT, Madan B, Ludlam CA, Tuddenham EG, Goddard NJ, Dolan G, Ingerslev J.

Haemophilia. 2009 Mar;15(2):501-8. doi: 10.1111/j.1365-2516.2008.01952.x. Epub 2009 Feb 1.

PMID:
19187194
26.

Killing 2 birds with 1 stone.

Tuddenham EG.

Blood. 2008 Oct 1;112(7):2595. doi: 10.1182/blood-2008-07-163030. No abstract available.

PMID:
18809765
27.

Consideration of platelet function disorders in patients with reduced VWF levels.

Millar CM, Riddell AF, Tuddenham EG.

Haemophilia. 2008 Sep;14(5):1131-2. doi: 10.1111/j.1365-2516.2008.01818.x. Epub 2008 Jul 28. No abstract available.

PMID:
18665850
28.

Autosomal dominant erythrocytosis and pulmonary arterial hypertension associated with an activating HIF2 alpha mutation.

Gale DP, Harten SK, Reid CD, Tuddenham EG, Maxwell PH.

Blood. 2008 Aug 1;112(3):919-21. doi: 10.1182/blood-2008-04-153718. No abstract available.

PMID:
18650473
29.

Genetic aspects and research development in haemostasis.

Tuddenham EG, Ingerslev J, Sørensen LN, Christiansen K, Mariani G, Peyvandi F, Waddington SN, Buckley SM, Kochanek S, Chuah MK, Vandendriessche T, Berntorp E.

Haemophilia. 2008 Jul;14 Suppl 3:113-8. doi: 10.1111/j.1365-2516.2008.01740.x. Review. No abstract available.

PMID:
18510530
30.

Therapeutic shoulder arthroscopy in patients with clotting disorders.

Thomas JM, Tuddenham EG, Ahrens PM.

Haemophilia. 2008 Jul;14(4):859-61. doi: 10.1111/j.1365-2516.2008.01683.x. Epub 2008 Apr 10. No abstract available.

PMID:
18422609
31.

Genotype-phenotype correlation in combined deficiency of factor V and factor VIII.

Zhang B, Spreafico M, Zheng C, Yang A, Platzer P, Callaghan MU, Avci Z, Ozbek N, Mahlangu J, Haw T, Kaufman RJ, Marchant K, Tuddenham EG, Seligsohn U, Peyvandi F, Ginsburg D.

Blood. 2008 Jun 15;111(12):5592-600. doi: 10.1182/blood-2007-10-113951. Epub 2008 Apr 7.

32.

Safe and efficient transduction of the liver after peripheral vein infusion of self-complementary AAV vector results in stable therapeutic expression of human FIX in nonhuman primates.

Nathwani AC, Gray JT, McIntosh J, Ng CY, Zhou J, Spence Y, Cochrane M, Gray E, Tuddenham EG, Davidoff AM.

Blood. 2007 Feb 15;109(4):1414-21. Epub 2006 Nov 7.

33.

Identification of factor IX mutations in Iranian haemophilia B patients by SSCP and sequencing.

Karimipoor M, Zeinali S, Nafissi N, Tuddenham EG, Lak M, Safaee R.

Thromb Res. 2007;120(1):135-9. Epub 2006 Oct 2.

PMID:
17014892
34.

Postinjury vascular intimal hyperplasia in mice is completely inhibited by CD34+ bone marrow-derived progenitor cells expressing membrane-tethered anticoagulant fusion proteins.

Chen D, Weber M, Shiels PG, Dong R, Webster Z, McVey JH, Kemball-Cook G, Tuddenham EG, Lechler RI, Dorling A.

J Thromb Haemost. 2006 Oct;4(10):2191-8. Epub 2006 Jun 27.

35.

Detection of functional differences between different platelet membrane glycoprotein Ibalpha variable number tandem repeat and Kozak genotypes as shown by the PFA-100 system.

Douglas H, Davies GJ, Michaelides K, Gorog DA, Timlin H, Ahmed N, Tuddenham EG.

Heart. 2006 May;92(5):676-8. No abstract available.

36.

Ways to bypass a blocked tenase complex.

Tuddenham EG.

Thromb Haemost. 2006 Jan;95(1):1-2. No abstract available.

PMID:
16543953
37.

Live birth following the first mutation specific pre-implantation genetic diagnosis for haemophilia A.

Michaelides K, Tuddenham EG, Turner C, Lavender B, Lavery SA.

Thromb Haemost. 2006 Feb;95(2):373-9.

PMID:
16493501
38.

Self-complementary adeno-associated virus vectors containing a novel liver-specific human factor IX expression cassette enable highly efficient transduction of murine and nonhuman primate liver.

Nathwani AC, Gray JT, Ng CY, Zhou J, Spence Y, Waddington SN, Tuddenham EG, Kemball-Cook G, McIntosh J, Boon-Spijker M, Mertens K, Davidoff AM.

Blood. 2006 Apr 1;107(7):2653-61. Epub 2005 Dec 1.

39.

Combined deficiency of factor V and factor VIII is due to mutations in either LMAN1 or MCFD2.

Zhang B, McGee B, Yamaoka JS, Guglielmone H, Downes KA, Minoldo S, Jarchum G, Peyvandi F, de Bosch NB, Ruiz-Saez A, Chatelain B, Olpinski M, Bockenstedt P, Sperl W, Kaufman RJ, Nichols WC, Tuddenham EG, Ginsburg D.

Blood. 2006 Mar 1;107(5):1903-7. Epub 2005 Nov 22.

40.

A common ancestral glycoprotein (GP) 9 1828A>G (Asn45Ser) gene mutation occurring in European families from Australia and Northern Europe with Bernard-Soulier Syndrome (BSS).

Liang HP, Morel-Kopp MC, Clemetson JM, Clemetson KJ, Kekomaki R, Kroll H, Michaelides K, Tuddenham EG, Vanhoorelbeke K, Ward CM.

Thromb Haemost. 2005 Sep;94(3):599-605.

PMID:
16268478
41.

Characterisation of blood coagulation factor XI T475I.

McVey JH, Lal K, Imanaka Y, Kemball-Cook G, Bolton-Maggs PH, Tuddenham EG.

Thromb Haemost. 2005 Jun;93(6):1082-8.

PMID:
15968392
42.
43.

A novel missense mutation in ABCA1 results in altered protein trafficking and reduced phosphatidylserine translocation in a patient with Scott syndrome.

Albrecht C, McVey JH, Elliott JI, Sardini A, Kasza I, Mumford AD, Naoumova RP, Tuddenham EG, Szabo K, Higgins CF.

Blood. 2005 Jul 15;106(2):542-9. Epub 2005 Mar 24.

PMID:
15790791
44.

Factor VII and cardiovascular risk.

Tuddenham EG.

Thromb Haemost. 2005 Feb;93(2):189. No abstract available.

PMID:
15711730
45.

Pharmacodynamic resistance to warfarin associated with a Val66Met substitution in vitamin K epoxide reductase complex subunit 1.

Harrington DJ, Underwood S, Morse C, Shearer MJ, Tuddenham EG, Mumford AD.

Thromb Haemost. 2005 Jan;93(1):23-6.

PMID:
15630486
46.

Complete inhibition of acute humoral rejection using regulated expression of membrane-tethered anticoagulants on xenograft endothelium.

Chen D, Weber M, McVey JH, Kemball-Cook G, Tuddenham EG, Lechler RI, Dorling A.

Am J Transplant. 2004 Dec;4(12):1958-63.

47.

Permanent phenotypic correction of hemophilia B in immunocompetent mice by prenatal gene therapy.

Waddington SN, Nivsarkar MS, Mistry AR, Buckley SM, Kemball-Cook G, Mosley KL, Mitrophanous K, Radcliffe P, Holder MV, Brittan M, Georgiadis A, Al-Allaf F, Bigger BW, Gregory LG, Cook HT, Ali RR, Thrasher A, Tuddenham EG, Themis M, Coutelle C.

Blood. 2004 Nov 1;104(9):2714-21. Epub 2004 Jul 1. Erratum in: Blood. 2006 Mar 1;107(5):1750.

PMID:
15231566
48.

Prospects for gene therapy of haemophilia.

Nathwani AC, Davidoff AM, Tuddenham EG.

Haemophilia. 2004 Jul;10(4):309-18. Review.

PMID:
15230943
49.

Two novel mutations in severe factor VII deficiency.

Gomez K, Laffan MA, Kemball-Cook G, Pasi J, Layton M, Singer JD, Tuddenham EG, McVey JH.

Br J Haematol. 2004 Jul;126(1):105-10.

PMID:
15198740
50.

Characterisation of lymphocyte responses to Ca2+ in Scott syndrome.

Elliott JI, Mumford AD, Albrecht C, Collins PW, Giddings JC, Higgins CF, Tuddenham EG, McVey JH.

Thromb Haemost. 2004 Feb;91(2):412-5. Review. No abstract available.

PMID:
14961172

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