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Items: 9


Repurposing of the CDK inhibitor PHA-767491 as a NRF2 inhibitor drug candidate for cancer therapy via redox modulation.

Liu HY, Tuckett AZ, Fennell M, Garippa R, Zakrzewski JL.

Invest New Drugs. 2018 Aug;36(4):590-600. doi: 10.1007/s10637-017-0557-6. Epub 2018 Jan 3.


Intrathymic injection of hematopoietic progenitor cells establishes functional T cell development in a mouse model of severe combined immunodeficiency.

Tuckett AZ, Thornton RH, O'Reilly RJ, van den Brink MRM, Zakrzewski JL.

J Hematol Oncol. 2017 May 16;10(1):109. doi: 10.1186/s13045-017-0478-z.


Donor CD19 CAR T cells exert potent graft-versus-lymphoma activity with diminished graft-versus-host activity.

Ghosh A, Smith M, James SE, Davila ML, Velardi E, Argyropoulos KV, Gunset G, Perna F, Kreines FM, Levy ER, Lieberman S, Jay HV, Tuckett AZ, Zakrzewski JL, Tan L, Young LF, Takvorian K, Dudakov JA, Jenq RR, Hanash AM, Motta AC, Murphy GF, Liu C, Schietinger A, Sadelain M, van den Brink MR.

Nat Med. 2017 Feb;23(2):242-249. doi: 10.1038/nm.4258. Epub 2017 Jan 9.


Characterization of a c-Rel Inhibitor That Mediates Anticancer Properties in Hematologic Malignancies by Blocking NF-κB-Controlled Oxidative Stress Responses.

Shono Y, Tuckett AZ, Liou HC, Doubrovina E, Derenzini E, Ouk S, Tsai JJ, Smith OM, Levy ER, Kreines FM, Ziegler CG, Scallion MI, Doubrovin M, Heller G, Younes A, O'Reilly RJ, van den Brink MR, Zakrzewski JL.

Cancer Res. 2016 Jan 15;76(2):377-89. doi: 10.1158/0008-5472.CAN-14-2814. Epub 2016 Jan 7.


Free-hand ultrasound guidance permits safe and efficient minimally invasive intrathymic injections in both young and aged mice.

Tuckett AZ, Zakrzewski JL, Li D, van den Brink MR, Thornton RH.

Ultrasound Med Biol. 2015 Apr;41(4):1105-11. doi: 10.1016/j.ultrasmedbio.2014.11.011. Epub 2015 Feb 17.


Sex steroid blockade enhances thymopoiesis by modulating Notch signaling.

Velardi E, Tsai JJ, Holland AM, Wertheimer T, Yu VW, Zakrzewski JL, Tuckett AZ, Singer NV, West ML, Smith OM, Young LF, Kreines FM, Levy ER, Boyd RL, Scadden DT, Dudakov JA, van den Brink MR.

J Exp Med. 2014 Nov 17;211(12):2341-9. doi: 10.1084/jem.20131289. Epub 2014 Oct 20.


Image-guided intrathymic injection of multipotent stem cells supports lifelong T-cell immunity and facilitates targeted immunotherapy.

Tuckett AZ, Thornton RH, Shono Y, Smith OM, Levy ER, Kreines FM, van den Brink MR, Zakrzewski JL.

Blood. 2014 May 1;123(18):2797-805. doi: 10.1182/blood-2013-10-535401. Epub 2014 Mar 20.


A small-molecule c-Rel inhibitor reduces alloactivation of T cells without compromising antitumor activity.

Shono Y, Tuckett AZ, Ouk S, Liou HC, Altan-Bonnet G, Tsai JJ, Oyler JE, Smith OM, West ML, Singer NV, Doubrovina E, Pankov D, Undhad CV, Murphy GF, Lezcano C, Liu C, O'Reilly RJ, van den Brink MR, Zakrzewski JL.

Cancer Discov. 2014 May;4(5):578-91. doi: 10.1158/2159-8290.CD-13-0585. Epub 2014 Feb 18.


Transforming lymph nodes into tissue factories.

Zakrzewski JL, Tuckett AZ, van den Brink MR.

Nat Biotechnol. 2012 Oct;30(10):958-9. doi: 10.1038/nbt.2388. No abstract available.


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