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Items: 1 to 50 of 58

1.

Thy-1 (CD90) promotes bone formation and protects against obesity.

Picke AK, Campbell GM, Blüher M, Krügel U, Schmidt FN, Tsourdi E, Winzer M, Rauner M, Vukicevic V, Busse B, Salbach-Hirsch J, Tuckermann JP, Simon JC, Anderegg U, Hofbauer LC, Saalbach A.

Sci Transl Med. 2018 Aug 8;10(453). pii: eaao6806. doi: 10.1126/scitranslmed.aao6806.

PMID:
30089635
2.

Correction: Increased survival and cell cycle progression pathways are required for EWS/FLI1-induced malignant transformation.

Javaheri T, Kazemi Z, Jan Pencik, Pham HTT, Kauer M, Noorizadeh R, Sax B, Nivarthi H, Schlederer M, Maurer B, Hofbauer M, Aryee DNT, Wiedner M, Tomazou EM, Logan M, Hartmann C, Tuckermann JP, Kenner L, Mikula M, Dolznig H, Üren A, Richter GH, Grebien F, Kovar H, Moriggl R.

Cell Death Dis. 2018 Jul 23;9(8):800. doi: 10.1038/s41419-018-0773-9.

3.

Glucocorticoid receptor in stromal cells is essential for glucocorticoid-mediated suppression of inflammation in arthritis.

Koenen M, Culemann S, Vettorazzi S, Caratti G, Frappart L, Baum W, Krönke G, Baschant U, Tuckermann JP.

Ann Rheum Dis. 2018 Jul 11. pii: annrheumdis-2017-212762. doi: 10.1136/annrheumdis-2017-212762. [Epub ahead of print]

4.

Reduced expression of C/EBPβ-LIP extends health and lifespan in mice.

Müller C, Zidek LM, Ackermann T, de Jong T, Liu P, Kliche V, Zaini MA, Kortman G, Harkema L, Verbeek DS, Tuckermann JP, von Maltzahn J, de Bruin A, Guryev V, Wang ZQ, Calkhoven CF.

Elife. 2018 Jun 4;7. pii: e34985. doi: 10.7554/eLife.34985.

5.

The glucocorticoid receptor in recipient cells keeps cytokine secretion in acute graft-versus-host disease at bay.

Baake T, Jörß K, Suennemann J, Roßmann L, Bohnenberger H, Tuckermann JP, Reichardt HM, Fischer HJ, Reichardt SD.

Oncotarget. 2018 Mar 2;9(21):15437-15450. doi: 10.18632/oncotarget.24602. eCollection 2018 Mar 20.

6.

Lrp1 in osteoblasts controls osteoclast activity and protects against osteoporosis by limiting PDGF-RANKL signaling.

Bartelt A, Behler-Janbeck F, Beil FT, Koehne T, Müller B, Schmidt T, Heine M, Ochs L, Yilmaz T, Dietrich M, Tuckermann JP, Amling M, Herz J, Schinke T, Heeren J, Niemeier A.

Bone Res. 2018 Feb 26;6:4. doi: 10.1038/s41413-017-0006-3. eCollection 2018.

7.

Erratum. Adipocyte Glucocorticoid Receptor Deficiency Attenuates Aging- and HFD-Induced Obesity and Impairs the Feeding-Fasting Transition. Diabetes 2017;66:272-286.

Mueller KM, Hartmann K, Kaltenecker D, Vettorazzi S, Bauer M, Mauser L, Amann S, Jall S, Fischer K, Esterbauer H, Müller TD, Tschöp MH, Magnes C, Haybaeck J, Scherer T, Bordag N, Tuckermann JP, Moriggl R.

Diabetes. 2018 Feb;67(2):343-344. doi: 10.2337/db18-er02a. Epub 2017 Nov 16. No abstract available.

8.

The glucocorticoid receptor in monocyte-derived macrophages is critical for cardiac infarct repair and remodeling.

Galuppo P, Vettorazzi S, Hövelmann J, Scholz CJ, Tuckermann JP, Bauersachs J, Fraccarollo D.

FASEB J. 2017 Nov;31(11):5122-5132. doi: 10.1096/fj.201700317R. Epub 2017 Aug 2.

9.

Airway Epithelial Cells Are Crucial Targets of Glucocorticoids in a Mouse Model of Allergic Asthma.

Klaßen C, Karabinskaya A, Dejager L, Vettorazzi S, Van Moorleghem J, Lühder F, Meijsing SH, Tuckermann JP, Bohnenberger H, Libert C, Reichardt HM.

J Immunol. 2017 Jul 1;199(1):48-61. doi: 10.4049/jimmunol.1601691. Epub 2017 May 17.

10.

Loss of menin in osteoblast lineage affects osteocyte-osteoclast crosstalk causing osteoporosis.

Liu P, Lee S, Knoll J, Rauch A, Ostermay S, Luther J, Malkusch N, Lerner UH, Zaiss MM, Neven M, Wittig R, Rauner M, David JP, Bertolino P, Zhang CX, Tuckermann JP.

Cell Death Differ. 2017 Apr;24(4):672-682. doi: 10.1038/cdd.2016.165. Epub 2017 Jan 20.

11.

GR-independent down-modulation on GM-CSF bone marrow-derived dendritic cells by the selective glucocorticoid receptor modulator Compound A.

Barcala Tabarrozzi AE, Andreone L, Deckers J, Castro CN, Gimeno ML, Ariolfo L, Berguer PM, Antunica-Noguerol M, Liberman AC, Vettorazzi S, Tuckermann JP, De Bosscher K, Perone MJ.

Sci Rep. 2016 Nov 18;6:36646. doi: 10.1038/srep36646.

12.

Increased survival and cell cycle progression pathways are required for EWS/FLI1-induced malignant transformation.

Javaheri T, Kazemi Z, Pencik J, Pham HT, Kauer M, Noorizadeh R, Sax B, Nivarthi H, Schlederer M, Maurer B, Hofbauer M, Aryee DN, Wiedner M, Tomazou EM, Logan M, Hartmann C, Tuckermann JP, Kenner L, Mikula M, Dolznig H, Üren A, Richter GH, Grebien F, Kovar H, Moriggl R.

Cell Death Dis. 2016 Oct 13;7(10):e2419. doi: 10.1038/cddis.2016.268. Erratum in: Cell Death Dis. 2018 Jul 23;9(8):800.

13.

Adipocyte Glucocorticoid Receptor Deficiency Attenuates Aging- and HFD-Induced Obesity and Impairs the Feeding-Fasting Transition.

Mueller KM, Hartmann K, Kaltenecker D, Vettorazzi S, Bauer M, Mauser L, Amann S, Jall S, Fischer K, Esterbauer H, Müller TD, Tschöp MH, Magnes C, Haybaeck J, Scherer T, Bordag N, Tuckermann JP, Moriggl R.

Diabetes. 2017 Feb;66(2):272-286. doi: 10.2337/db16-0381. Epub 2016 Sep 20. Erratum in: Diabetes. 2017 Nov 16;:.

14.

Dicer ablation in osteoblasts by Runx2 driven cre-loxP recombination affects bone integrity, but not glucocorticoid-induced suppression of bone formation.

Liu P, Baumgart M, Groth M, Wittmann J, Jäck HM, Platzer M, Tuckermann JP, Baschant U.

Sci Rep. 2016 Aug 24;6:32112. doi: 10.1038/srep32112.

15.

Molecular Actions of Glucocorticoids in Cartilage and Bone During Health, Disease, and Steroid Therapy.

Hartmann K, Koenen M, Schauer S, Wittig-Blaich S, Ahmad M, Baschant U, Tuckermann JP.

Physiol Rev. 2016 Apr;96(2):409-47. doi: 10.1152/physrev.00011.2015. Review.

16.

Decreased expression of the glucocorticoid receptor-GILZ pathway in Kupffer cells promotes liver inflammation in obese mice.

Robert O, Boujedidi H, Bigorgne A, Ferrere G, Voican CS, Vettorazzi S, Tuckermann JP, Bouchet-Delbos L, Tran T, Hemon P, Puchois V, Dagher I, Douard R, Gaudin F, Gary-Gouy H, Capel F, Durand-Gasselin I, Prévot S, Rousset S, Naveau S, Godot V, Emilie D, Lombès M, Perlemuter G, Cassard AM.

J Hepatol. 2016 Apr;64(4):916-24. doi: 10.1016/j.jhep.2015.11.023. Epub 2015 Nov 27.

PMID:
26639395
17.

Glucocorticoids limit acute lung inflammation in concert with inflammatory stimuli by induction of SphK1.

Vettorazzi S, Bode C, Dejager L, Frappart L, Shelest E, Klaßen C, Tasdogan A, Reichardt HM, Libert C, Schneider M, Weih F, Henriette Uhlenhaut N, David JP, Gräler M, Kleiman A, Tuckermann JP.

Nat Commun. 2015 Jul 17;6:7796. doi: 10.1038/ncomms8796.

18.

The glucocorticoid receptor in inflammatory processes: transrepression is not enough.

Hübner S, Dejager L, Libert C, Tuckermann JP.

Biol Chem. 2015 Nov;396(11):1223-31. doi: 10.1515/hsz-2015-0106. Review.

PMID:
25910399
19.

Glucocorticoid receptor regulates accurate chromosome segregation and is associated with malignancy.

Matthews LC, Berry AA, Morgan DJ, Poolman TM, Bauer K, Kramer F, Spiller DG, Richardson RV, Chapman KE, Farrow SN, Norman MR, Williamson AJ, Whetton AD, Taylor SS, Tuckermann JP, White MR, Ray DW.

Proc Natl Acad Sci U S A. 2015 Apr 28;112(17):5479-84. doi: 10.1073/pnas.1411356112. Epub 2015 Apr 6.

20.

ACTH controls thymocyte homeostasis independent of glucocorticoids.

Talaber G, Tuckermann JP, Okret S.

FASEB J. 2015 Jun;29(6):2526-34. doi: 10.1096/fj.14-268508. Epub 2015 Mar 2.

PMID:
25733567
21.

Glucocorticoids attenuate acute graft-versus-host disease by suppressing the cytotoxic capacity of CD8(+) T cells.

Theiss-Suennemann J, Jörß K, Messmann JJ, Reichardt SD, Montes-Cobos E, Lühder F, Tuckermann JP, AWolff H, Dressel R, Gröne HJ, Strauß G, Reichardt HM.

J Pathol. 2015 Mar;235(4):646-55. doi: 10.1002/path.4475. Epub 2015 Jan 7.

PMID:
25358639
22.

Glucocorticoids induce gastroparesis in mice through depletion of l-arginine.

Reichardt SD, Weinhage T, Rotte A, Föller M, Oppermann M, Lühder F, Tuckermann JP, Lang F, van den Brandt J, Reichardt HM.

Endocrinology. 2014 Oct;155(10):3899-908. doi: 10.1210/en.2014-1246. Epub 2014 Jul 24.

PMID:
25057793
23.

Chemokine-mediated redirection of T cells constitutes a critical mechanism of glucocorticoid therapy in autoimmune CNS responses.

Schweingruber N, Fischer HJ, Fischer L, van den Brandt J, Karabinskaya A, Labi V, Villunger A, Kretzschmar B, Huppke P, Simons M, Tuckermann JP, Flügel A, Lühder F, Reichardt HM.

Acta Neuropathol. 2014 May;127(5):713-29. doi: 10.1007/s00401-014-1248-4. Epub 2014 Feb 1.

24.

Effects of the selective glucocorticoid receptor modulator compound A on bone metabolism and inflammation in male mice with collagen-induced arthritis.

Rauner M, Thiele S, Sinningen K, Winzer M, Salbach-Hirsch J, Gloe I, Peschke K, Haegeman G, Tuckermann JP, Hofbauer LC.

Endocrinology. 2013 Oct;154(10):3719-28. doi: 10.1210/en.2012-2221. Epub 2013 Jul 24.

PMID:
23885015
25.

PPARβ/δ governs Wnt signaling and bone turnover.

Scholtysek C, Katzenbeisser J, Fu H, Uderhardt S, Ipseiz N, Stoll C, Zaiss MM, Stock M, Donhauser L, Böhm C, Kleyer A, Hess A, Engelke K, David JP, Djouad F, Tuckermann JP, Desvergne B, Schett G, Krönke G.

Nat Med. 2013 May;19(5):608-13. doi: 10.1038/nm.3146. Epub 2013 Mar 31.

PMID:
23542786
26.

The transcription factor early B-cell factor 1 regulates bone formation in an osteoblast-nonautonomous manner.

Zee T, Boller S, Györy I, Makinistoglu MP, Tuckermann JP, Grosschedl R, Karsenty G.

FEBS Lett. 2013 Mar 18;587(6):711-6. doi: 10.1016/j.febslet.2013.01.049. Epub 2013 Feb 5.

27.

Liver X receptors orchestrate osteoblast/osteoclast crosstalk and counteract pathologic bone loss.

Kleyer A, Scholtysek C, Bottesch E, Hillienhof U, Beyer C, Distler JH, Tuckermann JP, Schett G, Krönke G.

J Bone Miner Res. 2012 Dec;27(12):2442-51. doi: 10.1002/jbmr.1702.

28.

Selective glucocorticoid receptor modulation maintains bone mineral density in mice.

Thiele S, Ziegler N, Tsourdi E, De Bosscher K, Tuckermann JP, Hofbauer LC, Rauner M.

J Bone Miner Res. 2012 Nov;27(11):2242-50. doi: 10.1002/jbmr.1688.

29.

Hepatic growth hormone and glucocorticoid receptor signaling in body growth, steatosis and metabolic liver cancer development.

Mueller KM, Themanns M, Friedbichler K, Kornfeld JW, Esterbauer H, Tuckermann JP, Moriggl R.

Mol Cell Endocrinol. 2012 Sep 25;361(1-2):1-11. doi: 10.1016/j.mce.2012.03.026. Epub 2012 Apr 30. Review.

30.

Estradiol increases hematopoietic stem and progenitor cells independent of its actions on bone.

Illing A, Liu P, Ostermay S, Schilling A, de Haan G, Krust A, Amling M, Chambon P, Schinke T, Tuckermann JP.

Haematologica. 2012 Aug;97(8):1131-5. doi: 10.3324/haematol.2011.052456. Epub 2012 Feb 27.

31.

A cell-autonomous role for the glucocorticoid receptor in skeletal muscle atrophy induced by systemic glucocorticoid exposure.

Watson ML, Baehr LM, Reichardt HM, Tuckermann JP, Bodine SC, Furlow JD.

Am J Physiol Endocrinol Metab. 2012 May 1;302(10):E1210-20. doi: 10.1152/ajpendo.00512.2011. Epub 2012 Feb 21.

32.

RSK2 protects mice against TNF-induced bone loss.

Böhm C, Derer A, Axmann R, Hillienhoff U, Zaiss MM, Luther J, Zech C, Stock M, Scholtysek C, Engelke K, Hess A, Tuckermann JP, Schett G, David JP.

J Cell Sci. 2012 May 1;125(Pt 9):2160-71. doi: 10.1242/jcs.096008. Epub 2012 Feb 17.

33.

Glucocorticoids enhance intestinal glucose uptake via the dimerized glucocorticoid receptor in enterocytes.

Reichardt SD, Föller M, Rexhepaj R, Pathare G, Minnich K, Tuckermann JP, Lang F, Reichardt HM.

Endocrinology. 2012 Apr;153(4):1783-94. doi: 10.1210/en.2011-1747. Epub 2012 Jan 31.

PMID:
22294744
34.

Glucocorticoid therapy of antigen-induced arthritis depends on the dimerized glucocorticoid receptor in T cells.

Baschant U, Frappart L, Rauchhaus U, Bruns L, Reichardt HM, Kamradt T, Bräuer R, Tuckermann JP.

Proc Natl Acad Sci U S A. 2011 Nov 29;108(48):19317-22. doi: 10.1073/pnas.1105857108. Epub 2011 Nov 14.

35.

Glucocorticoid receptor dimerization is required for survival in septic shock via suppression of interleukin-1 in macrophages.

Kleiman A, Hübner S, Rodriguez Parkitna JM, Neumann A, Hofer S, Weigand MA, Bauer M, Schmid W, Schütz G, Libert C, Reichardt HM, Tuckermann JP.

FASEB J. 2012 Feb;26(2):722-9. doi: 10.1096/fj.11-192112. Epub 2011 Oct 31.

PMID:
22042221
36.

Liposomal encapsulation of glucocorticoids alters their mode of action in the treatment of experimental autoimmune encephalomyelitis.

Schweingruber N, Haine A, Tiede K, Karabinskaya A, van den Brandt J, Wüst S, Metselaar JM, Gold R, Tuckermann JP, Reichardt HM, Lühder F.

J Immunol. 2011 Oct 15;187(8):4310-8. doi: 10.4049/jimmunol.1101604. Epub 2011 Sep 14.

37.

Molecular control of systemic bile acid homeostasis by the liver glucocorticoid receptor.

Rose AJ, Berriel Díaz M, Reimann A, Klement J, Walcher T, Krones-Herzig A, Strobel O, Werner J, Peters A, Kleyman A, Tuckermann JP, Vegiopoulos A, Herzig S.

Cell Metab. 2011 Jul 6;14(1):123-30. doi: 10.1016/j.cmet.2011.04.010.

38.

Elevated Fra-1 expression causes severe lipodystrophy.

Luther J, Driessler F, Megges M, Hess A, Herbort B, Mandic V, Zaiss MM, Reichardt A, Zech C, Tuckermann JP, Calkhoven CF, Wagner EF, Schett G, David JP.

J Cell Sci. 2011 May 1;124(Pt 9):1465-76. doi: 10.1242/jcs.079855. Epub 2011 Apr 12.

39.

An anti-inflammatory selective glucocorticoid receptor modulator preserves osteoblast differentiation.

Rauch A, Gossye V, Bracke D, Gevaert E, Jacques P, Van Beneden K, Vandooren B, Rauner M, Hofbauer LC, Haegeman G, Elewaut D, Tuckermann JP, De Bosscher K.

FASEB J. 2011 Apr;25(4):1323-32. doi: 10.1096/fj.10-173393. Epub 2011 Jan 13.

PMID:
21233489
40.

Synergistic activation by p38MAPK and glucocorticoid signaling mediates induction of M2-like tumor-associated macrophages expressing the novel CD20 homolog MS4A8A.

Schmieder A, Schledzewski K, Michel J, Tuckermann JP, Tome L, Sticht C, Gkaniatsou C, Nicolay JP, Demory A, Faulhaber J, Kzhyshkowska J, Géraud C, Goerdt S.

Int J Cancer. 2011 Jul 1;129(1):122-32. doi: 10.1002/ijc.25657. Epub 2010 Nov 28.

41.

Prednisolone-induced differential gene expression in mouse liver carrying wild type or a dimerization-defective glucocorticoid receptor.

Frijters R, Fleuren W, Toonen EJ, Tuckermann JP, Reichardt HM, van der Maaden H, van Elsas A, van Lierop MJ, Dokter W, de Vlieg J, Alkema W.

BMC Genomics. 2010 Jun 5;11:359. doi: 10.1186/1471-2164-11-359.

42.

Glucocorticoids suppress bone formation by attenuating osteoblast differentiation via the monomeric glucocorticoid receptor.

Rauch A, Seitz S, Baschant U, Schilling AF, Illing A, Stride B, Kirilov M, Mandic V, Takacz A, Schmidt-Ullrich R, Ostermay S, Schinke T, Spanbroek R, Zaiss MM, Angel PE, Lerner UH, David JP, Reichardt HM, Amling M, Schütz G, Tuckermann JP.

Cell Metab. 2010 Jun 9;11(6):517-31. doi: 10.1016/j.cmet.2010.05.005.

43.

Increased skeletal VEGF enhances beta-catenin activity and results in excessively ossified bones.

Maes C, Goossens S, Bartunkova S, Drogat B, Coenegrachts L, Stockmans I, Moermans K, Nyabi O, Haigh K, Naessens M, Haenebalcke L, Tuckermann JP, Tjwa M, Carmeliet P, Mandic V, David JP, Behrens A, Nagy A, Carmeliet G, Haigh JJ.

EMBO J. 2010 Jan 20;29(2):424-41. doi: 10.1038/emboj.2009.361. Epub 2009 Dec 10.

44.

Therapeutic and adverse effects of a non-steroidal glucocorticoid receptor ligand in a mouse model of multiple sclerosis.

Wüst S, Tischner D, John M, Tuckermann JP, Menzfeld C, Hanisch UK, van den Brandt J, Lühder F, Reichardt HM.

PLoS One. 2009 Dec 7;4(12):e8202. doi: 10.1371/journal.pone.0008202.

45.

Oncostatin M-induced and constitutive activation of the JAK2/STAT5/CIS pathway suppresses CCL1, but not CCL7 and CCL8, chemokine expression.

Hintzen C, Haan C, Tuckermann JP, Heinrich PC, Hermanns HM.

J Immunol. 2008 Nov 15;181(10):7341-9.

46.

Peripheral T cells are the therapeutic targets of glucocorticoids in experimental autoimmune encephalomyelitis.

Wüst S, van den Brandt J, Tischner D, Kleiman A, Tuckermann JP, Gold R, Lühder F, Reichardt HM.

J Immunol. 2008 Jun 15;180(12):8434-43.

47.

JunB is required for IgE-mediated degranulation and cytokine release of mast cells.

Textor B, Licht AH, Tuckermann JP, Jessberger R, Razin E, Angel P, Schorpp-Kistner M, Hartenstein B.

J Immunol. 2007 Nov 15;179(10):6873-80.

48.

Glucocorticoid receptor action in beneficial and side effects of steroid therapy: lessons from conditional knockout mice.

Kleiman A, Tuckermann JP.

Mol Cell Endocrinol. 2007 Sep 15;275(1-2):98-108. Epub 2007 May 18. Review.

PMID:
17587493
49.

Macrophages and neutrophils are the targets for immune suppression by glucocorticoids in contact allergy.

Tuckermann JP, Kleiman A, Moriggl R, Spanbroek R, Neumann A, Illing A, Clausen BE, Stride B, Förster I, Habenicht AJ, Reichardt HM, Tronche F, Schmid W, Schütz G.

J Clin Invest. 2007 May;117(5):1381-90. Epub 2007 Apr 19.

50.

Molecular mechanisms of glucocorticoids in the control of inflammation and lymphocyte apoptosis.

Tuckermann JP, Kleiman A, McPherson KG, Reichardt HM.

Crit Rev Clin Lab Sci. 2005;42(1):71-104. Review.

PMID:
15697171

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