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Items: 1 to 50 of 120

1.

Phosphorylation of the phosphatase PTPROt at Tyr399 is a molecular switch that controls osteoclast activity and bone mass in vivo.

Roth L, Wakim J, Wasserman E, Shalev M, Arman E, Stein M, Brumfeld V, Sagum CA, Bedford MT, Tuckermann J, Elson A.

Sci Signal. 2019 Jan 8;12(563). pii: eaau0240. doi: 10.1126/scisignal.aau0240.

PMID:
30622194
2.

Insulin signaling and reduced glucocorticoid receptor activity attenuate postprandial gene expression in liver.

Kalvisa A, Siersbæk MS, Præstholm SM, Christensen LJL, Nielsen R, Stohr O, Vettorazzi S, Tuckermann J, White M, Mandrup S, Grøntved L.

PLoS Biol. 2018 Dec 10;16(12):e2006249. doi: 10.1371/journal.pbio.2006249. eCollection 2018 Dec.

3.

Cell-based RNAi screening and high-content analysis in primary calvarian osteoblasts applied to identification of osteoblast differentiation regulators.

Ahmad M, Kroll T, Jakob J, Rauch A, Ploubidou A, Tuckermann J.

Sci Rep. 2018 Sep 19;8(1):14045. doi: 10.1038/s41598-018-32364-8.

4.

Thy-1 (CD90) promotes bone formation and protects against obesity.

Picke AK, Campbell GM, Blüher M, Krügel U, Schmidt FN, Tsourdi E, Winzer M, Rauner M, Vukicevic V, Busse B, Salbach-Hirsch J, Tuckermann JP, Simon JC, Anderegg U, Hofbauer LC, Saalbach A.

Sci Transl Med. 2018 Aug 8;10(453). pii: eaao6806. doi: 10.1126/scitranslmed.aao6806.

PMID:
30089635
5.

New horizons for osteoanabolic treatment?

Ignatius A, Tuckermann J.

Nat Rev Endocrinol. 2018 Sep;14(9):508-509. doi: 10.1038/s41574-018-0069-2. No abstract available.

PMID:
30050157
6.

Correction: Increased survival and cell cycle progression pathways are required for EWS/FLI1-induced malignant transformation.

Javaheri T, Kazemi Z, Jan Pencik, Pham HTT, Kauer M, Noorizadeh R, Sax B, Nivarthi H, Schlederer M, Maurer B, Hofbauer M, Aryee DNT, Wiedner M, Tomazou EM, Logan M, Hartmann C, Tuckermann JP, Kenner L, Mikula M, Dolznig H, Üren A, Richter GH, Grebien F, Kovar H, Moriggl R.

Cell Death Dis. 2018 Jul 23;9(8):800. doi: 10.1038/s41419-018-0773-9.

7.

Glucocorticoid receptor in stromal cells is essential for glucocorticoid-mediated suppression of inflammation in arthritis.

Koenen M, Culemann S, Vettorazzi S, Caratti G, Frappart L, Baum W, Krönke G, Baschant U, Tuckermann JP.

Ann Rheum Dis. 2018 Nov;77(11):1610-1618. doi: 10.1136/annrheumdis-2017-212762. Epub 2018 Jul 11.

8.

NR4A1 Regulates Motility of Osteoclast Precursors and Serves as Target for the Modulation of Systemic Bone Turnover.

Scholtysek C, Ipseiz N, Böhm C, Krishnacoumar B, Stenzel M, Czerwinski T, Palumbo-Zerr K, Rothe T, Weidner D, Klej A, Stoll C, Distler J, Tuckermann J, Herrmann M, Fabry B, Goldmann WH, Schett G, Krönke G.

J Bone Miner Res. 2018 Nov;33(11):2035-2047. doi: 10.1002/jbmr.3533. Epub 2018 Jul 24.

PMID:
29949664
9.

Liver Cancer Initiation Requires p53 Inhibition by CD44-Enhanced Growth Factor Signaling.

Dhar D, Antonucci L, Nakagawa H, Kim JY, Glitzner E, Caruso S, Shalapour S, Yang L, Valasek MA, Lee S, Minnich K, Seki E, Tuckermann J, Sibilia M, Zucman-Rossi J, Karin M.

Cancer Cell. 2018 Jun 11;33(6):1061-1077.e6. doi: 10.1016/j.ccell.2018.05.003.

PMID:
29894692
10.

Glucocorticoids suppress Wnt16 expression in osteoblasts in vitro and in vivo.

Hildebrandt S, Baschant U, Thiele S, Tuckermann J, Hofbauer LC, Rauner M.

Sci Rep. 2018 Jun 7;8(1):8711. doi: 10.1038/s41598-018-26300-z.

11.

Glucocorticoid receptor dimers control intestinal STAT1 and TNF-induced inflammation in mice.

Ballegeer M, Van Looveren K, Timmermans S, Eggermont M, Vandevyver S, Thery F, Dendoncker K, Souffriau J, Vandewalle J, Van Wyngene L, De Rycke R, Takahashi N, Vandenabeele P, Tuckermann J, Reichardt HM, Impens F, Beyaert R, De Bosscher K, Vandenbroucke RE, Libert C.

J Clin Invest. 2018 Aug 1;128(8):3265-3279. doi: 10.1172/JCI96636. Epub 2018 Jun 25.

12.

Reduced expression of C/EBPβ-LIP extends health and lifespan in mice.

Müller C, Zidek LM, Ackermann T, de Jong T, Liu P, Kliche V, Zaini MA, Kortman G, Harkema L, Verbeek DS, Tuckermann JP, von Maltzahn J, de Bruin A, Guryev V, Wang ZQ, Calkhoven CF.

Elife. 2018 Jun 4;7. pii: e34985. doi: 10.7554/eLife.34985.

13.

[Osteoimmunology-IMMUNOBONE : Regulation of bone by inflammation].

Rauner M, Buttgereit F, Distler J, Garbe AI, Herrmann M, Hofbauer L, Hoffmann M, Jessberger R, Kornak U, Krönke G, Mundlos S, Spies C, Tuckermann J, Zwerina J.

Z Rheumatol. 2018 May;77(Suppl 1):12-15. doi: 10.1007/s00393-018-0455-0. Review. German. No abstract available.

PMID:
29691689
14.

[Mutual influence of immune system and bones].

Kamradt T, Amling M, Dankbar B, Dudeck A, Gunzer M, Ignatius A, Krönke G, Kubatzky K, Pap T, Prinz I, Schett G, Schinke T, Tuckermann J, Waisman A.

Z Rheumatol. 2018 May;77(Suppl 1):8-11. doi: 10.1007/s00393-018-0454-1. Review. German. No abstract available.

PMID:
29675686
15.

The glucocorticoid receptor in recipient cells keeps cytokine secretion in acute graft-versus-host disease at bay.

Baake T, Jörß K, Suennemann J, Roßmann L, Bohnenberger H, Tuckermann JP, Reichardt HM, Fischer HJ, Reichardt SD.

Oncotarget. 2018 Mar 2;9(21):15437-15450. doi: 10.18632/oncotarget.24602. eCollection 2018 Mar 20.

16.

Molecular mechanisms of glucocorticoids on skeleton and bone regeneration after fracture.

Hachemi Y, Rapp AE, Picke AK, Weidinger G, Ignatius A, Tuckermann J.

J Mol Endocrinol. 2018 Jul;61(1):R75-R90. doi: 10.1530/JME-18-0024. Epub 2018 Mar 27. Review.

17.

Lrp1 in osteoblasts controls osteoclast activity and protects against osteoporosis by limiting PDGF-RANKL signaling.

Bartelt A, Behler-Janbeck F, Beil FT, Koehne T, Müller B, Schmidt T, Heine M, Ochs L, Yilmaz T, Dietrich M, Tuckermann JP, Amling M, Herz J, Schinke T, Heeren J, Niemeier A.

Bone Res. 2018 Feb 26;6:4. doi: 10.1038/s41413-017-0006-3. eCollection 2018.

18.

EGFR controls bone development by negatively regulating mTOR-signaling during osteoblast differentiation.

Linder M, Hecking M, Glitzner E, Zwerina K, Holcmann M, Bakiri L, Ruocco MG, Tuckermann J, Schett G, Wagner EF, Sibilia M.

Cell Death Differ. 2018 Jun;25(6):1094-1106. doi: 10.1038/s41418-017-0054-7. Epub 2018 Feb 14.

19.

Estrogen receptor α- (ERα), but not ERβ-signaling, is crucially involved in mechanostimulation of bone fracture healing by whole-body vibration.

Haffner-Luntzer M, Kovtun A, Lackner I, Mödinger Y, Hacker S, Liedert A, Tuckermann J, Ignatius A.

Bone. 2018 May;110:11-20. doi: 10.1016/j.bone.2018.01.017. Epub 2018 Feb 3.

PMID:
29367057
20.

Induced global deletion of glucocorticoid receptor impairs fracture healing.

Rapp AE, Hachemi Y, Kemmler J, Koenen M, Tuckermann J, Ignatius A.

FASEB J. 2018 Apr;32(4):2235-2245. doi: 10.1096/fj.201700459RR. Epub 2018 Jan 5.

21.

Erratum. Adipocyte Glucocorticoid Receptor Deficiency Attenuates Aging- and HFD-Induced Obesity and Impairs the Feeding-Fasting Transition. Diabetes 2017;66:272-286.

Mueller KM, Hartmann K, Kaltenecker D, Vettorazzi S, Bauer M, Mauser L, Amann S, Jall S, Fischer K, Esterbauer H, Müller TD, Tschöp MH, Magnes C, Haybaeck J, Scherer T, Bordag N, Tuckermann JP, Moriggl R.

Diabetes. 2018 Feb;67(2):343-344. doi: 10.2337/db18-er02a. Epub 2017 Nov 16. No abstract available.

22.

Deletion of Menin in craniofacial osteogenic cells in mice elicits development of mandibular ossifying fibroma.

Lee S, Liu P, Teinturier R, Jakob J, Tschaffon M, Tasdogan A, Wittig R, Hoeller S, Baumhoer D, Frappart L, Vettorazzi S, Bertolino P, Zhang C, Tuckermann J.

Oncogene. 2018 Feb 1;37(5):616-626. doi: 10.1038/onc.2017.364. Epub 2017 Oct 9.

PMID:
28991228
23.

Molecular Integration of Incretin and Glucocorticoid Action Reverses Immunometabolic Dysfunction and Obesity.

Quarta C, Clemmensen C, Zhu Z, Yang B, Joseph SS, Lutter D, Yi CX, Graf E, García-Cáceres C, Legutko B, Fischer K, Brommage R, Zizzari P, Franklin BS, Krueger M, Koch M, Vettorazzi S, Li P, Hofmann SM, Bakhti M, Bastidas-Ponce A, Lickert H, Strom TM, Gailus-Durner V, Bechmann I, Perez-Tilve D, Tuckermann J, Hrabě de Angelis M, Sandoval D, Cota D, Latz E, Seeley RJ, Müller TD, DiMarchi RD, Finan B, Tschöp MH.

Cell Metab. 2017 Oct 3;26(4):620-632.e6. doi: 10.1016/j.cmet.2017.08.023. Epub 2017 Sep 21.

24.

Endogenous glucocorticoid signaling in chondrocytes attenuates joint inflammation and damage.

Tu J, Stoner S, Fromm PD, Wang T, Chen D, Tuckermann J, Cooper MS, Seibel MJ, Zhou H.

FASEB J. 2018 Jan;32(1):478-487. doi: 10.1096/fj.201700659R. Epub 2017 Sep 19.

PMID:
28928247
25.

The glucocorticoid receptor in monocyte-derived macrophages is critical for cardiac infarct repair and remodeling.

Galuppo P, Vettorazzi S, Hövelmann J, Scholz CJ, Tuckermann JP, Bauersachs J, Fraccarollo D.

FASEB J. 2017 Nov;31(11):5122-5132. doi: 10.1096/fj.201700317R. Epub 2017 Aug 2.

26.

Airway Epithelial Cells Are Crucial Targets of Glucocorticoids in a Mouse Model of Allergic Asthma.

Klaßen C, Karabinskaya A, Dejager L, Vettorazzi S, Van Moorleghem J, Lühder F, Meijsing SH, Tuckermann JP, Bohnenberger H, Libert C, Reichardt HM.

J Immunol. 2017 Jul 1;199(1):48-61. doi: 10.4049/jimmunol.1601691. Epub 2017 May 17.

27.

Loss of menin in osteoblast lineage affects osteocyte-osteoclast crosstalk causing osteoporosis.

Liu P, Lee S, Knoll J, Rauch A, Ostermay S, Luther J, Malkusch N, Lerner UH, Zaiss MM, Neven M, Wittig R, Rauner M, David JP, Bertolino P, Zhang CX, Tuckermann JP.

Cell Death Differ. 2017 Apr;24(4):672-682. doi: 10.1038/cdd.2016.165. Epub 2017 Jan 20.

28.

GR-independent down-modulation on GM-CSF bone marrow-derived dendritic cells by the selective glucocorticoid receptor modulator Compound A.

Barcala Tabarrozzi AE, Andreone L, Deckers J, Castro CN, Gimeno ML, Ariolfo L, Berguer PM, Antunica-Noguerol M, Liberman AC, Vettorazzi S, Tuckermann JP, De Bosscher K, Perone MJ.

Sci Rep. 2016 Nov 18;6:36646. doi: 10.1038/srep36646.

29.

Activation of dimeric glucocorticoid receptors in osteoclast progenitors potentiates RANKL induced mature osteoclast bone resorbing activity.

Conaway HH, Henning P, Lie A, Tuckermann J, Lerner UH.

Bone. 2016 Dec;93:43-54. doi: 10.1016/j.bone.2016.08.024. Epub 2016 Sep 2.

PMID:
27596806
30.

Chemical Hybridization of Glucagon and Thyroid Hormone Optimizes Therapeutic Impact for Metabolic Disease.

Finan B, Clemmensen C, Zhu Z, Stemmer K, Gauthier K, Müller L, De Angelis M, Moreth K, Neff F, Perez-Tilve D, Fischer K, Lutter D, Sánchez-Garrido MA, Liu P, Tuckermann J, Malehmir M, Healy ME, Weber A, Heikenwalder M, Jastroch M, Kleinert M, Jall S, Brandt S, Flamant F, Schramm KW, Biebermann H, Döring Y, Weber C, Habegger KM, Keuper M, Gelfanov V, Liu F, Köhrle J, Rozman J, Fuchs H, Gailus-Durner V, Hrabě de Angelis M, Hofmann SM, Yang B, Tschöp MH, DiMarchi R, Müller TD.

Cell. 2016 Oct 20;167(3):843-857.e14. doi: 10.1016/j.cell.2016.09.014. Epub 2016 Oct 6.

31.

Increased survival and cell cycle progression pathways are required for EWS/FLI1-induced malignant transformation.

Javaheri T, Kazemi Z, Pencik J, Pham HT, Kauer M, Noorizadeh R, Sax B, Nivarthi H, Schlederer M, Maurer B, Hofbauer M, Aryee DN, Wiedner M, Tomazou EM, Logan M, Hartmann C, Tuckermann JP, Kenner L, Mikula M, Dolznig H, Üren A, Richter GH, Grebien F, Kovar H, Moriggl R.

Cell Death Dis. 2016 Oct 13;7(10):e2419. doi: 10.1038/cddis.2016.268. Erratum in: Cell Death Dis. 2018 Jul 23;9(8):800.

32.

Adipocyte Glucocorticoid Receptor Deficiency Attenuates Aging- and HFD-Induced Obesity and Impairs the Feeding-Fasting Transition.

Mueller KM, Hartmann K, Kaltenecker D, Vettorazzi S, Bauer M, Mauser L, Amann S, Jall S, Fischer K, Esterbauer H, Müller TD, Tschöp MH, Magnes C, Haybaeck J, Scherer T, Bordag N, Tuckermann JP, Moriggl R.

Diabetes. 2017 Feb;66(2):272-286. doi: 10.2337/db16-0381. Epub 2016 Sep 20. Erratum in: Diabetes. 2017 Nov 16;:.

33.

Dicer ablation in osteoblasts by Runx2 driven cre-loxP recombination affects bone integrity, but not glucocorticoid-induced suppression of bone formation.

Liu P, Baumgart M, Groth M, Wittmann J, Jäck HM, Platzer M, Tuckermann JP, Baschant U.

Sci Rep. 2016 Aug 24;6:32112. doi: 10.1038/srep32112.

34.

High-Content Microscopy Analysis of Subcellular Structures: Assay Development and Application to Focal Adhesion Quantification.

Kroll T, Schmidt D, Schwanitz G, Ahmad M, Hamann J, Schlosser C, Lin YC, Böhm KJ, Tuckermann J, Ploubidou A.

Curr Protoc Cytom. 2016 Jul 1;77:12.43.1-12.43.44. doi: 10.1002/cpcy.7.

PMID:
27367288
35.

Combined experience of six independent laboratories attempting to create an Ewing sarcoma mouse model.

Minas TZ, Surdez D, Javaheri T, Tanaka M, Howarth M, Kang HJ, Han J, Han ZY, Sax B, Kream BE, Hong SH, Çelik H, Tirode F, Tuckermann J, Toretsky JA, Kenner L, Kovar H, Lee S, Sweet-Cordero EA, Nakamura T, Moriggl R, Delattre O, Üren A.

Oncotarget. 2017 May 23;8(21):34141-34163. doi: 10.18632/oncotarget.9388.

36.

Molecular Actions of Glucocorticoids in Cartilage and Bone During Health, Disease, and Steroid Therapy.

Hartmann K, Koenen M, Schauer S, Wittig-Blaich S, Ahmad M, Baschant U, Tuckermann JP.

Physiol Rev. 2016 Apr;96(2):409-47. doi: 10.1152/physrev.00011.2015. Review.

37.

Selepressin in Septic Shock: A Step Toward Decatecholaminization?

Asfar P, Russell JA, Tuckermann J, Radermacher P.

Crit Care Med. 2016 Jan;44(1):234-6. doi: 10.1097/CCM.0000000000001441. No abstract available.

PMID:
26672929
38.

Decreased expression of the glucocorticoid receptor-GILZ pathway in Kupffer cells promotes liver inflammation in obese mice.

Robert O, Boujedidi H, Bigorgne A, Ferrere G, Voican CS, Vettorazzi S, Tuckermann JP, Bouchet-Delbos L, Tran T, Hemon P, Puchois V, Dagher I, Douard R, Gaudin F, Gary-Gouy H, Capel F, Durand-Gasselin I, Prévot S, Rousset S, Naveau S, Godot V, Emilie D, Lombès M, Perlemuter G, Cassard AM.

J Hepatol. 2016 Apr;64(4):916-24. doi: 10.1016/j.jhep.2015.11.023. Epub 2015 Nov 27.

PMID:
26639395
39.

Glucocorticoid-Induced Osteoporosis.

Frenkel B, White W, Tuckermann J.

Adv Exp Med Biol. 2015;872:179-215. doi: 10.1007/978-1-4939-2895-8_8. Review.

40.

Glucocorticoids limit acute lung inflammation in concert with inflammatory stimuli by induction of SphK1.

Vettorazzi S, Bode C, Dejager L, Frappart L, Shelest E, Klaßen C, Tasdogan A, Reichardt HM, Libert C, Schneider M, Weih F, Henriette Uhlenhaut N, David JP, Gräler M, Kleiman A, Tuckermann JP.

Nat Commun. 2015 Jul 17;6:7796. doi: 10.1038/ncomms8796.

41.

Genomic redistribution of GR monomers and dimers mediates transcriptional response to exogenous glucocorticoid in vivo.

Lim HW, Uhlenhaut NH, Rauch A, Weiner J, Hübner S, Hübner N, Won KJ, Lazar MA, Tuckermann J, Steger DJ.

Genome Res. 2015 Jun;25(6):836-44. doi: 10.1101/gr.188581.114. Epub 2015 May 8.

42.

The glucocorticoid receptor in inflammatory processes: transrepression is not enough.

Hübner S, Dejager L, Libert C, Tuckermann JP.

Biol Chem. 2015 Nov;396(11):1223-31. doi: 10.1515/hsz-2015-0106. Review.

PMID:
25910399
43.

Glucocorticoid receptor regulates accurate chromosome segregation and is associated with malignancy.

Matthews LC, Berry AA, Morgan DJ, Poolman TM, Bauer K, Kramer F, Spiller DG, Richardson RV, Chapman KE, Farrow SN, Norman MR, Williamson AJ, Whetton AD, Taylor SS, Tuckermann JP, White MR, Ray DW.

Proc Natl Acad Sci U S A. 2015 Apr 28;112(17):5479-84. doi: 10.1073/pnas.1411356112. Epub 2015 Apr 6.

44.

ACTH controls thymocyte homeostasis independent of glucocorticoids.

Talaber G, Tuckermann JP, Okret S.

FASEB J. 2015 Jun;29(6):2526-34. doi: 10.1096/fj.14-268508. Epub 2015 Mar 2.

PMID:
25733567
45.

Mast cell promotion of T cell-driven antigen-induced arthritis despite being dispensable for antibody-induced arthritis in which T cells are bypassed.

Schubert N, Dudeck J, Liu P, Karutz A, Speier S, Maurer M, Tuckermann J, Dudeck A.

Arthritis Rheumatol. 2015 Apr;67(4):903-13. doi: 10.1002/art.38996.

46.

Glucocorticoids attenuate acute graft-versus-host disease by suppressing the cytotoxic capacity of CD8(+) T cells.

Theiss-Suennemann J, Jörß K, Messmann JJ, Reichardt SD, Montes-Cobos E, Lühder F, Tuckermann JP, AWolff H, Dressel R, Gröne HJ, Strauß G, Reichardt HM.

J Pathol. 2015 Mar;235(4):646-55. doi: 10.1002/path.4475. Epub 2015 Jan 7.

PMID:
25358639
47.

Stat5 gene dosage in T cells modulates CD8+ T-cell homeostasis and attenuates contact hypersensitivity response in mice.

Nivarthi H, Prchal-Murphy M, Swoboda A, Hager M, Schlederer M, Kenner L, Tuckermann J, Sexl V, Moriggl R, Ermakova O.

Allergy. 2015 Jan;70(1):67-79. doi: 10.1111/all.12535. Epub 2014 Nov 30.

PMID:
25333229
48.

Osteoblast-derived WNT16 represses osteoclastogenesis and prevents cortical bone fragility fractures.

Movérare-Skrtic S, Henning P, Liu X, Nagano K, Saito H, Börjesson AE, Sjögren K, Windahl SH, Farman H, Kindlund B, Engdahl C, Koskela A, Zhang FP, Eriksson EE, Zaman F, Hammarstedt A, Isaksson H, Bally M, Kassem A, Lindholm C, Sandberg O, Aspenberg P, Sävendahl L, Feng JQ, Tuckermann J, Tuukkanen J, Poutanen M, Baron R, Lerner UH, Gori F, Ohlsson C.

Nat Med. 2014 Nov;20(11):1279-88. doi: 10.1038/nm.3654. Epub 2014 Oct 12.

49.

Disruption of glucocorticoid signaling in chondrocytes delays metaphyseal fracture healing but does not affect normal cartilage and bone development.

Tu J, Henneicke H, Zhang Y, Stoner S, Cheng TL, Schindeler A, Chen D, Tuckermann J, Cooper MS, Seibel MJ, Zhou H.

Bone. 2014 Dec;69:12-22. doi: 10.1016/j.bone.2014.08.016. Epub 2014 Sep 3.

50.

Glucocorticoids induce gastroparesis in mice through depletion of l-arginine.

Reichardt SD, Weinhage T, Rotte A, Föller M, Oppermann M, Lühder F, Tuckermann JP, Lang F, van den Brandt J, Reichardt HM.

Endocrinology. 2014 Oct;155(10):3899-908. doi: 10.1210/en.2014-1246. Epub 2014 Jul 24.

PMID:
25057793

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