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Items: 36


Hepatic thrombopoietin gene silencing reduces platelet count and breast cancer progression in transgenic MMTV-PyMT mice.

Shirai T, Revenko AS, Tibbitts J, Ngo ATP, Mitrugno A, Healy LD, Johnson J, Tucker EI, Hinds MT, Coussens LM, McCarty OJT, Monia BP, Gruber A.

Blood Adv. 2019 Oct 22;3(20):3080-3091. doi: 10.1182/bloodadvances.2019000250.


Inhibition of contact-mediated activation of factor XI protects baboons against S aureus-induced organ damage and death.

Silasi R, Keshari RS, Lupu C, Van Rensburg WJ, Chaaban H, Regmi G, Shamanaev A, Shatzel JJ, Puy C, Lorentz CU, Tucker EI, Gailani D, Gruber A, McCarty OJT, Lupu F.

Blood Adv. 2019 Feb 26;3(4):658-669. doi: 10.1182/bloodadvances.2018029983.


Contact Activation Inhibitor and Factor XI Antibody, AB023, Produces Safe, Dose-Dependent Anticoagulation in a Phase 1 First-In-Human Trial.

Lorentz CU, Verbout NG, Wallisch M, Hagen MW, Shatzel JJ, Olson SR, Puy C, Hinds MT, McCarty OJT, Gailani D, Gruber A, Tucker EI.

Arterioscler Thromb Vasc Biol. 2019 Apr;39(4):799-809. doi: 10.1161/ATVBAHA.118.312328.


Factor XII Activation Promotes Platelet Consumption in the Presence of Bacterial-Type Long-Chain Polyphosphate In Vitro and In Vivo.

Zilberman-Rudenko J, Reitsma SE, Puy C, Rigg RA, Smith SA, Tucker EI, Silasi R, Merkulova A, McCrae KR, Maas C, Urbanus RT, Gailani D, Morrissey JH, Gruber A, Lupu F, Schmaier AH, McCarty OJT.

Arterioscler Thromb Vasc Biol. 2018 Aug;38(8):1748-1760. doi: 10.1161/ATVBAHA.118.311193.


Factor XI contributes to myocardial ischemia-reperfusion injury in mice.

Lorentz CU, Verbout NG, Cao Z, Liu L, Hinds MT, McCarty OJT, Ivanov I, Tucker EI, Gailani D, Gruber A.

Blood Adv. 2018 Jan 23;2(2):85-88. doi: 10.1182/bloodadvances.2017004879. No abstract available.


Removal of the C-Terminal Domains of ADAMTS13 by Activated Coagulation Factor XI induces Platelet Adhesion on Endothelial Cells under Flow Conditions.

Garland KS, Reitsma SE, Shirai T, Zilberman-Rudenko J, Tucker EI, Gailani D, Gruber A, McCarty OJT, Puy C.

Front Med (Lausanne). 2017 Dec 20;4:232. doi: 10.3389/fmed.2017.00232. eCollection 2017.


Biorheology of platelet activation in the bloodstream distal to thrombus formation.

Zilberman-Rudenko J, Itakura A, Maddala J, Baker-Groberg SM, Vetter R, Tucker EI, Gruber A, Gerdes C, McCarty OJ.

Cell Mol Bioeng. 2016 Dec;9(4):496-508. doi: 10.1007/s12195-016-0448-5. Epub 2016 May 26.


Differential Roles for the Coagulation Factors XI and XII in Regulating the Physical Biology of Fibrin.

Sylman JL, Daalkhaijav U, Zhang Y, Gray EM, Farhang PA, Chu TT, Zilberman-Rudenko J, Puy C, Tucker EI, Smith SA, Morrissey JH, Walker TW, Nan XL, Gruber A, McCarty OJT.

Ann Biomed Eng. 2017 May;45(5):1328-1340. doi: 10.1007/s10439-016-1771-7. Epub 2016 Dec 8.


Platelet-Derived Short-Chain Polyphosphates Enhance the Inactivation of Tissue Factor Pathway Inhibitor by Activated Coagulation Factor XI.

Puy C, Tucker EI, Ivanov IS, Gailani D, Smith SA, Morrissey JH, Gruber A, McCarty OJ.

PLoS One. 2016 Oct 20;11(10):e0165172. doi: 10.1371/journal.pone.0165172. eCollection 2016.


Factor XI Deficiency Alters the Cytokine Response and Activation of Contact Proteases during Polymicrobial Sepsis in Mice.

Bane CE Jr, Ivanov I, Matafonov A, Boyd KL, Cheng Q, Sherwood ER, Tucker EI, Smiley ST, McCarty OJ, Gruber A, Gailani D.

PLoS One. 2016 Apr 5;11(4):e0152968. doi: 10.1371/journal.pone.0152968. eCollection 2016.


Coagulation Factor XI Promotes Distal Platelet Activation and Single Platelet Consumption in the Bloodstream Under Shear Flow.

Zilberman-Rudenko J, Itakura A, Wiesenekker CP, Vetter R, Maas C, Gailani D, Tucker EI, Gruber A, Gerdes C, McCarty OJ.

Arterioscler Thromb Vasc Biol. 2016 Mar;36(3):510-7. doi: 10.1161/ATVBAHA.115.307034. Epub 2016 Jan 14.


Activated factor XI increases the procoagulant activity of the extrinsic pathway by inactivating tissue factor pathway inhibitor.

Puy C, Tucker EI, Matafonov A, Cheng Q, Zientek KD, Gailani D, Gruber A, McCarty OJ.

Blood. 2015 Feb 26;125(9):1488-96. doi: 10.1182/blood-2014-10-604587. Epub 2015 Jan 13.


WEDGE: an anticoagulant thrombin mutant produced by autoactivation.

Wood DC, Pelc LA, Pozzi N, Wallisch M, Verbout NG, Tucker EI, Gruber A, Di Cera E.

J Thromb Haemost. 2015 Jan;13(1):111-4. doi: 10.1111/jth.12774. Epub 2014 Nov 29.


Thrombin mutant W215A/E217A treatment improves neurological outcome and attenuates central nervous system damage in experimental autoimmune encephalomyelitis.

Verbout NG, Yu X, Healy LD, Phillips KG, Tucker EI, Gruber A, McCarty OJ, Offner H.

Metab Brain Dis. 2015 Feb;30(1):57-65. doi: 10.1007/s11011-014-9558-8. Epub 2014 May 9.


Factor XII inhibition reduces thrombus formation in a primate thrombosis model.

Matafonov A, Leung PY, Gailani AE, Grach SL, Puy C, Cheng Q, Sun MF, McCarty OJ, Tucker EI, Kataoka H, Renné T, Morrissey JH, Gruber A, Gailani D.

Blood. 2014 Mar 13;123(11):1739-46. doi: 10.1182/blood-2013-04-499111. Epub 2014 Jan 9.


Evidence for factor IX-independent roles for factor XIa in blood coagulation.

Matafonov A, Cheng Q, Geng Y, Verhamme IM, Umunakwe O, Tucker EI, Sun MF, Serebrov V, Gruber A, Gailani D.

J Thromb Haemost. 2013 Dec;11(12):2118-27. doi: 10.1111/jth.12435.


Factor XII promotes blood coagulation independent of factor XI in the presence of long-chain polyphosphates.

Puy C, Tucker EI, Wong ZC, Gailani D, Smith SA, Choi SH, Morrissey JH, Gruber A, McCarty OJ.

J Thromb Haemost. 2013 Jul;11(7):1341-52. doi: 10.1111/jth.12295.


Inhibition of Factor XII-Mediated Activation of Factor XI Provides Protection Against Experimental Acute Ischemic Stroke in Mice.

Leung PY, Hurst S, Berny-Lang MA, Verbout NG, Gailani D, Tucker EI, Wang RK, McCarty OJ, Gruber A.

Transl Stroke Res. 2012 Sep;3(3):381-9. doi: 10.1007/s12975-012-0186-5.


Antithrombotic effect of antisense factor XI oligonucleotide treatment in primates.

Crosby JR, Marzec U, Revenko AS, Zhao C, Gao D, Matafonov A, Gailani D, MacLeod AR, Tucker EI, Gruber A, Hanson SR, Monia BP.

Arterioscler Thromb Vasc Biol. 2013 Jul;33(7):1670-8. doi: 10.1161/ATVBAHA.113.301282. Epub 2013 Apr 4. Erratum in: Arterioscler Thromb Vasc Biol. 2013 Aug;33(8):e127. Arterioscler Thromb Vasc Biol. 2013 Oct;33(10):e130.


Red blood cell-derived microparticles isolated from blood units initiate and propagate thrombin generation.

Rubin O, Delobel J, Prudent M, Lion N, Kohl K, Tucker EI, Tissot JD, Angelillo-Scherrer A.

Transfusion. 2013 Aug;53(8):1744-54. doi: 10.1111/trf.12008. Epub 2012 Dec 11.


Inhibition of factor XI activation attenuates inflammation and coagulopathy while improving the survival of mouse polymicrobial sepsis.

Tucker EI, Verbout NG, Leung PY, Hurst S, McCarty OJ, Gailani D, Gruber A.

Blood. 2012 May 17;119(20):4762-8. doi: 10.1182/blood-2011-10-386185. Epub 2012 Mar 22.


Size matters.

Gruber A, Tucker EI.

Blood. 2011 Dec 15;118(25):6481-2. doi: 10.1182/blood-2011-10-382622.


Factor XI-deficient mice display reduced inflammation, coagulopathy, and bacterial growth during listeriosis.

Luo D, Szaba FM, Kummer LW, Johnson LL, Tucker EI, Gruber A, Gailani D, Smiley ST.

Infect Immun. 2012 Jan;80(1):91-9. doi: 10.1128/IAI.05568-11. Epub 2011 Oct 17.


Activated factor XI inhibits chemotaxis of polymorphonuclear leukocytes.

Itakura A, Verbout NG, Phillips KG, Insall RH, Gailani D, Tucker EI, Gruber A, McCarty OJ.

J Leukoc Biol. 2011 Nov;90(5):923-7. doi: 10.1189/jlb.0411182. Epub 2011 Aug 1.


Thrombin mutant W215A/E217A treatment improves neurological outcome and reduces cerebral infarct size in a mouse model of ischemic stroke.

Berny-Lang MA, Hurst S, Tucker EI, Pelc LA, Wang RK, Hurn PD, Di Cera E, McCarty OJ, Gruber A.

Stroke. 2011 Jun;42(6):1736-41. doi: 10.1161/STROKEAHA.110.603811. Epub 2011 Apr 21.


Laminin promotes coagulation and thrombus formation in a factor XII-dependent manner.

White-Adams TC, Berny MA, Patel IA, Tucker EI, Gailani D, Gruber A, McCarty OJ.

J Thromb Haemost. 2010 Jun;8(6):1295-301. doi: 10.1111/j.1538-7836.2010.03850.x.


Evidence against a protein in plasma that is a product of a factor XI mRNA splice variant missing exons 6 and 7.

Gailani D, Sun MF, Cheng Q, Matafonov A, Tucker EI, Gruber A, Emsley J.

Blood. 2010 Aug 19;116(7):1185-6; author reply 1186-7. doi: 10.1182/blood-2010-01-265702. No abstract available.


A role for factor XIIa-mediated factor XI activation in thrombus formation in vivo.

Cheng Q, Tucker EI, Pine MS, Sisler I, Matafonov A, Sun MF, White-Adams TC, Smith SA, Hanson SR, McCarty OJ, Renné T, Gruber A, Gailani D.

Blood. 2010 Nov 11;116(19):3981-9. doi: 10.1182/blood-2010-02-270918. Epub 2010 Jul 15.


Safety and antithrombotic efficacy of moderate platelet count reduction by thrombopoietin inhibition in primates.

Tucker EI, Marzec UM, Berny MA, Hurst S, Bunting S, McCarty OJ, Gruber A, Hanson SR.

Sci Transl Med. 2010 Jun 23;2(37):37ra45. doi: 10.1126/scitranslmed.3000697.


Identification of coagulation factor XI as a ligand for platelet apolipoprotein E receptor 2 (ApoER2).

White-Adams TC, Berny MA, Tucker EI, Gertz JM, Gailani D, Urbanus RT, de Groot PG, Gruber A, McCarty OJ.

Arterioscler Thromb Vasc Biol. 2009 Oct;29(10):1602-7. doi: 10.1161/ATVBAHA.109.187393. Epub 2009 Aug 6.


Factor XI contributes to thrombin generation in the absence of factor XII.

Kravtsov DV, Matafonov A, Tucker EI, Sun MF, Walsh PN, Gruber A, Gailani D.

Blood. 2009 Jul 9;114(2):452-8. doi: 10.1182/blood-2009-02-203604. Epub 2009 Apr 7.


Prevention of vascular graft occlusion and thrombus-associated thrombin generation by inhibition of factor XI.

Tucker EI, Marzec UM, White TC, Hurst S, Rugonyi S, McCarty OJ, Gailani D, Gruber A, Hanson SR.

Blood. 2009 Jan 22;113(4):936-44. doi: 10.1182/blood-2008-06-163675. Epub 2008 Oct 22.


Survival advantage of coagulation factor XI-deficient mice during peritoneal sepsis.

Tucker EI, Gailani D, Hurst S, Cheng Q, Hanson SR, Gruber A.

J Infect Dis. 2008 Jul 15;198(2):271-4. doi: 10.1086/589514.


Protein C supports platelet binding and activation under flow: role of glycoprotein Ib and apolipoprotein E receptor 2.

White TC, Berny MA, Tucker EI, Urbanus RT, de Groot PG, Fernández JA, Griffin JH, Gruber A, McCarty OJ.

J Thromb Haemost. 2008 Jun;6(6):995-1002. doi: 10.1111/j.1538-7836.2008.02979.x.


Thrombin mutant W215A/E217A acts as a platelet GPIb antagonist.

Berny MA, White TC, Tucker EI, Bush-Pelc LA, Di Cera E, Gruber A, McCarty OJ.

Arterioscler Thromb Vasc Biol. 2008 Feb;28(2):329-34. Epub 2007 Oct 25.


Relative antithrombotic and antihemostatic effects of protein C activator versus low-molecular-weight heparin in primates.

Gruber A, Marzec UM, Bush L, Di Cera E, Fernández JA, Berny MA, Tucker EI, McCarty OJ, Griffin JH, Hanson SR.

Blood. 2007 May 1;109(9):3733-40. Epub 2007 Jan 16.

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