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Items: 1 to 50 of 103

1.

Helper-Dependent Adenovirus Transduces the Human and Rat Retina but Elicits an Inflammatory Reaction When Delivered Subretinally in Rats.

Han IC, Burnight ER, Ulferts MJ, Worthington KS, Russell SR, Sohn EH, Mullins RF, Stone EM, Tucker BA, Wiley LA.

Hum Gene Ther. 2019 Nov;30(11):1371-1384. doi: 10.1089/hum.2019.159. Epub 2019 Sep 26.

PMID:
31456426
2.

Development of High-Resolution Three-Dimensional-Printed Extracellular Matrix Scaffolds and Their Compatibility with Pluripotent Stem Cells and Early Retinal Cells.

Shrestha A, Allen BN, Wiley LA, Tucker BA, Worthington KS.

J Ocul Pharmacol Ther. 2019 Aug 16. doi: 10.1089/jop.2018.0146. [Epub ahead of print]

PMID:
31414943
3.

Development of a Molecularly Stable Gene Therapy Vector for the Treatment of RPGR-Associated X-Linked Retinitis Pigmentosa.

Giacalone JC, Andorf JL, Zhang Q, Burnight ER, Ochoa D, Reutzel AJ, Collins MM, Sheffield VC, Mullins RF, Han IC, Stone EM, Tucker BA.

Hum Gene Ther. 2019 Aug;30(8):967-974. doi: 10.1089/hum.2018.244.

PMID:
31106594
4.

Molecular characterization of foveal versus peripheral human retina by single-cell RNA sequencing.

Voigt AP, Whitmore SS, Flamme-Wiese MJ, Riker MJ, Wiley LA, Tucker BA, Stone EM, Mullins RF, Scheetz TE.

Exp Eye Res. 2019 Jul;184:234-242. doi: 10.1016/j.exer.2019.05.001. Epub 2019 May 8.

5.

Two-photon polymerized poly(caprolactone) retinal cell delivery scaffolds and their systemic and retinal biocompatibility.

Thompson JR, Worthington KS, Green BJ, Mullin NK, Jiao C, Kaalberg EE, Wiley LA, Han IC, Russell SR, Sohn EH, Guymon CA, Mullins RF, Stone EM, Tucker BA.

Acta Biomater. 2019 Aug;94:204-218. doi: 10.1016/j.actbio.2019.04.057. Epub 2019 May 3.

PMID:
31055121
6.

Choriocapillaris Degeneration in Geographic Atrophy.

Sohn EH, Flamme-Wiese MJ, Whitmore SS, Workalemahu G, Marneros AG, Boese EA, Kwon YH, Wang K, Abramoff MD, Tucker BA, Stone EM, Mullins RF.

Am J Pathol. 2019 Jul;189(7):1473-1480. doi: 10.1016/j.ajpath.2019.04.005. Epub 2019 Apr 30.

PMID:
31051169
7.

Wide-Field Swept-Source OCT and Angiography in X-Linked Retinoschisis.

Han IC, Whitmore SS, Critser DB, Lee SY, DeLuca AP, Daggett HT, Affatigato LM, Mullins RF, Tucker BA, Drack AV, Stone EM.

Ophthalmol Retina. 2019 Feb;3(2):178-185. doi: 10.1016/j.oret.2018.09.006. Epub 2018 Sep 19.

PMID:
31014769
8.

Optimizing Donor Cellular Dissociation and Subretinal Injection Parameters for Stem Cell-Based Treatments.

Scruggs BA, Jiao C, Cranston CM, Kaalberg E, Wang K, Russell SR, Wiley LA, Mullins RF, Stone EM, Tucker BA, Sohn EH.

Stem Cells Transl Med. 2019 Aug;8(8):797-809. doi: 10.1002/sctm.18-0210. Epub 2019 Apr 19.

9.

Correction of NR2E3 Associated Enhanced S-cone Syndrome Patient-specific iPSCs using CRISPR-Cas9.

Bohrer LR, Wiley LA, Burnight ER, Cooke JA, Giacalone JC, Anfinson KR, Andorf JL, Mullins RF, Stone EM, Tucker BA.

Genes (Basel). 2019 Apr 5;10(4). pii: E278. doi: 10.3390/genes10040278.

10.

PyMINEr Finds Gene and Autocrine-Paracrine Networks from Human Islet scRNA-Seq.

Tyler SR, Rotti PG, Sun X, Yi Y, Xie W, Winter MC, Flamme-Wiese MJ, Tucker BA, Mullins RF, Norris AW, Engelhardt JF.

Cell Rep. 2019 Feb 12;26(7):1951-1964.e8. doi: 10.1016/j.celrep.2019.01.063.

11.

Disruption of RPGR protein interaction network is the common feature of RPGR missense variations that cause XLRP.

Zhang Q, Giacalone JC, Searby C, Stone EM, Tucker BA, Sheffield VC.

Proc Natl Acad Sci U S A. 2019 Jan 22;116(4):1353-1360. doi: 10.1073/pnas.1817639116. Epub 2019 Jan 8.

12.

Generation of an immortalized human choroid endothelial cell line (iChEC-1) using an endothelial cell specific promoter.

Giacalone JC, Miller MJ, Workalemahu G, Reutzel AJ, Ochoa D, Whitmore SS, Stone EM, Tucker BA, Mullins RF.

Microvasc Res. 2019 May;123:50-57. doi: 10.1016/j.mvr.2018.12.002. Epub 2018 Dec 18.

PMID:
30571950
13.

Correlation of Optical Coherence Tomography and Retinal Histology in Normal and Pro23His Retinal Degeneration Pig.

Cheng J, Sohn EH, Jiao C, Adler KL, Kaalberg EE, Russell SR, Mullins RF, Stone EM, Tucker BA, Han IC.

Transl Vis Sci Technol. 2018 Nov 30;7(6):18. doi: 10.1167/tvst.7.6.18. eCollection 2018 Nov.

14.

Two-Photon Polymerization as a Tool for Studying 3D Printed Topography-Induced Stem Cell Fate.

Worthington KS, Do AV, Smith R, Tucker BA, Salem AK.

Macromol Biosci. 2019 Feb;19(2):e1800370. doi: 10.1002/mabi.201800370. Epub 2018 Nov 14.

PMID:
30430755
15.

Controlled drug delivery from 3D printed two-photon polymerized poly(ethylene glycol) dimethacrylate devices.

Do AV, Worthington KS, Tucker BA, Salem AK.

Int J Pharm. 2018 Dec 1;552(1-2):217-224. doi: 10.1016/j.ijpharm.2018.09.065. Epub 2018 Sep 27.

PMID:
30268853
16.

Imidazole Compounds for Protecting Choroidal Endothelial Cells from Complement Injury.

Zeng S, Wen KK, Workalemahu G, Sohn EH, Wu M, Chirco KR, Flamme-Wiese MJ, Liu X, Stone EM, Tucker BA, Mullins RF.

Sci Rep. 2018 Sep 6;8(1):13387. doi: 10.1038/s41598-018-31846-z.

17.

Effect of Molecular Weight and Functionality on Acrylated Poly(caprolactone) for Stereolithography and Biomedical Applications.

Green BJ, Worthington KS, Thompson JR, Bunn SJ, Rethwisch M, Kaalberg EE, Jiao C, Wiley LA, Mullins RF, Stone EM, Sohn EH, Tucker BA, Guymon CA.

Biomacromolecules. 2018 Sep 10;19(9):3682-3692. doi: 10.1021/acs.biomac.8b00784. Epub 2018 Aug 9.

PMID:
30044915
18.

Stability of the Na+ Form of the Human Telomeric G-Quadruplex: Role of Adenines in Stabilizing G-Quadruplex Structure.

Tucker BA, Hudson JS, Ding L, Lewis E, Sheardy RD, Kharlampieva E, Graves D.

ACS Omega. 2018 Jan 31;3(1):844-855. doi: 10.1021/acsomega.7b01649. Epub 2018 Jan 24.

19.

Evaluation of serum and ocular levels of membrane attack complex and C-reactive protein in CFH-genotyped human donors.

Chirco KR, Flamme-Wiese MJ, Wiley JS, Potempa LA, Stone EM, Tucker BA, Mullins RF.

Eye (Lond). 2018 Nov;32(11):1740-1742. doi: 10.1038/s41433-018-0170-8. Epub 2018 Jul 16.

20.

Feeder-free differentiation of cells exhibiting characteristics of corneal endothelium from human induced pluripotent stem cells.

Wagoner MD, Bohrer LR, Aldrich BT, Greiner MA, Mullins RF, Worthington KS, Tucker BA, Wiley LA.

Biol Open. 2018 May 8;7(5). pii: bio032102. doi: 10.1242/bio.032102.

21.

CRISPR-Cas9 genome engineering: Treating inherited retinal degeneration.

Burnight ER, Giacalone JC, Cooke JA, Thompson JR, Bohrer LR, Chirco KR, Drack AV, Fingert JH, Worthington KS, Wiley LA, Mullins RF, Stone EM, Tucker BA.

Prog Retin Eye Res. 2018 Jul;65:28-49. doi: 10.1016/j.preteyeres.2018.03.003. Epub 2018 Mar 22. Review.

PMID:
29578069
22.

CRISPR-Cas9-Based Genome Editing of Human Induced Pluripotent Stem Cells.

Giacalone JC, Sharma TP, Burnight ER, Fingert JF, Mullins RF, Stone EM, Tucker BA.

Curr Protoc Stem Cell Biol. 2018 Feb 28;44:5B.7.1-5B.7.22. doi: 10.1002/cpsc.46.

23.

CRISPR-Cas9-Mediated Correction of the 1.02 kb Common Deletion in CLN3 in Induced Pluripotent Stem Cells from Patients with Batten Disease.

Burnight ER, Bohrer LR, Giacalone JC, Klaahsen DL, Daggett HT, East JS, Madumba RA, Worthington KS, Mullins RF, Stone EM, Tucker BA, Wiley LA.

CRISPR J. 2018 Feb;1:75-87. doi: 10.1089/crispr.2017.0015.

24.

Assessment of Adeno-Associated Virus Serotype Tropism in Human Retinal Explants.

Wiley LA, Burnight ER, Kaalberg EE, Jiao C, Riker MJ, Halder JA, Luse MA, Han IC, Russell SR, Sohn EH, Stone EM, Tucker BA, Mullins RF.

Hum Gene Ther. 2018 Apr;29(4):424-436. doi: 10.1089/hum.2017.179. Epub 2018 Feb 23.

25.

Evaluation of sFLT1 protein levels in human eyes with the FLT1 rs9943922 polymorphism.

Chirco KR, Lewis CJ, Scheetz TE, Johnston RM, Tucker BA, Stone EM, Fingert JH, Mullins RF.

Ophthalmic Genet. 2018 Jan-Feb;39(1):68-72. doi: 10.1080/13816810.2017.1369550. Epub 2017 Sep 26.

26.

Generation of Xeno-Free, cGMP-Compliant Patient-Specific iPSCs from Skin Biopsy.

Wiley LA, Anfinson KR, Cranston CM, Kaalberg EE, Collins MM, Mullins RF, Stone EM, Tucker BA.

Curr Protoc Stem Cell Biol. 2017 Aug 14;42:4A.12.1-4A.12.14. doi: 10.1002/cpsc.30.

27.

Using CRISPR-Cas9 to Generate Gene-Corrected Autologous iPSCs for the Treatment of Inherited Retinal Degeneration.

Burnight ER, Gupta M, Wiley LA, Anfinson KR, Tran A, Triboulet R, Hoffmann JM, Klaahsen DL, Andorf JL, Jiao C, Sohn EH, Adur MK, Ross JW, Mullins RF, Daley GQ, Schlaeger TM, Stone EM, Tucker BA.

Mol Ther. 2017 Sep 6;25(9):1999-2013. doi: 10.1016/j.ymthe.2017.05.015. Epub 2017 Jun 12.

28.

Clinically Focused Molecular Investigation of 1000 Consecutive Families with Inherited Retinal Disease.

Stone EM, Andorf JL, Whitmore SS, DeLuca AP, Giacalone JC, Streb LM, Braun TA, Mullins RF, Scheetz TE, Sheffield VC, Tucker BA.

Ophthalmology. 2017 Sep;124(9):1314-1331. doi: 10.1016/j.ophtha.2017.04.008. Epub 2017 May 27.

29.

Preparation and evaluation of human choroid extracellular matrix scaffolds for the study of cell replacement strategies.

Chirco KR, Worthington KS, Flamme-Wiese MJ, Riker MJ, Andrade JD, Ueberheide BM, Stone EM, Tucker BA, Mullins RF.

Acta Biomater. 2017 Jul 15;57:293-303. doi: 10.1016/j.actbio.2017.05.011. Epub 2017 May 5.

30.

Connective Tissue Growth Factor Promotes Efficient Generation of Human Induced Pluripotent Stem Cell-Derived Choroidal Endothelium.

Songstad AE, Worthington KS, Chirco KR, Giacalone JC, Whitmore SS, Anfinson KR, Ochoa D, Cranston CM, Riker MJ, Neiman M, Stone EM, Mullins RF, Tucker BA.

Stem Cells Transl Med. 2017 Jun;6(6):1533-1546. doi: 10.1002/sctm.16-0399. Epub 2017 May 5.

31.

Patient-specific induced pluripotent stem cells to evaluate the pathophysiology of TRNT1-associated Retinitis pigmentosa.

Sharma TP, Wiley LA, Whitmore SS, Anfinson KR, Cranston CM, Oppedal DJ, Daggett HT, Mullins RF, Tucker BA, Stone EM.

Stem Cell Res. 2017 May;21:58-70. doi: 10.1016/j.scr.2017.03.005. Epub 2017 Mar 18.

32.

Restoration of Aqueous Humor Outflow Following Transplantation of iPSC-Derived Trabecular Meshwork Cells in a Transgenic Mouse Model of Glaucoma.

Zhu W, Jain A, Gramlich OW, Tucker BA, Sheffield VC, Kuehn MH.

Invest Ophthalmol Vis Sci. 2017 Apr 1;58(4):2054-2062. doi: 10.1167/iovs.16-20672.

33.

Two-photon polymerization for production of human iPSC-derived retinal cell grafts.

Worthington KS, Wiley LA, Kaalberg EE, Collins MM, Mullins RF, Stone EM, Tucker BA.

Acta Biomater. 2017 Jun;55:385-395. doi: 10.1016/j.actbio.2017.03.039. Epub 2017 Mar 27.

34.

Prevascularized silicon membranes for the enhancement of transport to implanted medical devices.

Worthington KS, Wiley LA, Mullins RF, Tucker BA, Nuxoll E.

J Biomed Mater Res B Appl Biomater. 2016 Nov;104(8):1602-1609. doi: 10.1002/jbm.b.33506. Epub 2015 Aug 28.

35.

Structural and molecular changes in the aging choroid: implications for age-related macular degeneration.

Chirco KR, Sohn EH, Stone EM, Tucker BA, Mullins RF.

Eye (Lond). 2017 Jan;31(1):10-25. doi: 10.1038/eye.2016.216. Epub 2016 Oct 7. Review.

36.

cGMP production of patient-specific iPSCs and photoreceptor precursor cells to treat retinal degenerative blindness.

Wiley LA, Burnight ER, DeLuca AP, Anfinson KR, Cranston CM, Kaalberg EE, Penticoff JA, Affatigato LM, Mullins RF, Stone EM, Tucker BA.

Sci Rep. 2016 Jul 29;6:30742. doi: 10.1038/srep30742.

37.

Using Patient-Specific Induced Pluripotent Stem Cells and Wild-Type Mice to Develop a Gene Augmentation-Based Strategy to Treat CLN3-Associated Retinal Degeneration.

Wiley LA, Burnight ER, Drack AV, Banach BB, Ochoa D, Cranston CM, Madumba RA, East JS, Mullins RF, Stone EM, Tucker BA.

Hum Gene Ther. 2016 Oct;27(10):835-846. doi: 10.1089/hum.2016.049. Epub 2016 Jul 11.

38.

Monomeric C-reactive protein and inflammation in age-related macular degeneration.

Chirco KR, Whitmore SS, Wang K, Potempa LA, Halder JA, Stone EM, Tucker BA, Mullins RF.

J Pathol. 2016 Oct;240(2):173-83. doi: 10.1002/path.4766. Epub 2016 Sep 19.

39.

Using Stem Cells to Rebuild the Outer Neural Retina.

Tucker BA.

Invest Ophthalmol Vis Sci. 2016 Jun 1;57(7):3521. doi: 10.1167/iovs.16-20098. No abstract available.

PMID:
27367587
40.

Transplantation of iPSC-derived TM cells rescues glaucoma phenotypes in vivo.

Zhu W, Gramlich OW, Laboissonniere L, Jain A, Sheffield VC, Trimarchi JM, Tucker BA, Kuehn MH.

Proc Natl Acad Sci U S A. 2016 Jun 21;113(25):E3492-500. doi: 10.1073/pnas.1604153113. Epub 2016 Jun 6.

41.

A Method for Sectioning and Immunohistochemical Analysis of Stem Cell-Derived 3-D Organoids.

Wiley LA, Beebe DC, Mullins RF, Stone EM, Tucker BA.

Curr Protoc Stem Cell Biol. 2016 May 12;37:1C.19.1-1C.19.11. doi: 10.1002/cpsc.3.

42.

Neuronal Differentiation of Induced Pluripotent Stem Cells on Surfactant Templated Chitosan Hydrogels.

Worthington KS, Green BJ, Rethwisch M, Wiley LA, Tucker BA, Guymon CA, Salem AK.

Biomacromolecules. 2016 May 9;17(5):1684-95. doi: 10.1021/acs.biomac.6b00098. Epub 2016 Apr 4.

PMID:
27008004
43.

Generating iPSC-Derived Choroidal Endothelial Cells to Study Age-Related Macular Degeneration.

Songstad AE, Wiley LA, Duong K, Kaalberg E, Flamme-Wiese MJ, Cranston CM, Riker MJ, Levasseur D, Stone EM, Mullins RF, Tucker BA.

Invest Ophthalmol Vis Sci. 2015 Dec;56(13):8258-67. doi: 10.1167/iovs.15-17073.

44.

Differentiation of Induced Pluripotent Stem Cells to Neural Retinal Precursor Cells on Porous Poly-Lactic-co-Glycolic Acid Scaffolds.

Worthington KS, Wiley LA, Guymon CA, Salem AK, Tucker BA.

J Ocul Pharmacol Ther. 2016 Jun;32(5):310-6. doi: 10.1089/jop.2015.0126. Epub 2015 Dec 21.

45.

Concise Review: Patient-Specific Stem Cells to Interrogate Inherited Eye Disease.

Giacalone JC, Wiley LA, Burnight ER, Songstad AE, Mullins RF, Stone EM, Tucker BA.

Stem Cells Transl Med. 2016 Feb;5(2):132-40. doi: 10.5966/sctm.2015-0206. Epub 2015 Dec 18. Review.

46.

Molecular response of chorioretinal endothelial cells to complement injury: implications for macular degeneration.

Zeng S, Whitmore SS, Sohn EH, Riker MJ, Wiley LA, Scheetz TE, Stone EM, Tucker BA, Mullins RF.

J Pathol. 2016 Feb;238(3):446-56. doi: 10.1002/path.4669. Epub 2015 Dec 24.

47.

North Carolina Macular Dystrophy Is Caused by Dysregulation of the Retinal Transcription Factor PRDM13.

Small KW, DeLuca AP, Whitmore SS, Rosenberg T, Silva-Garcia R, Udar N, Puech B, Garcia CA, Rice TA, Fishman GA, Héon E, Folk JC, Streb LM, Haas CM, Wiley LA, Scheetz TE, Fingert JH, Mullins RF, Tucker BA, Stone EM.

Ophthalmology. 2016 Jan;123(1):9-18. doi: 10.1016/j.ophtha.2015.10.006. Epub 2015 Oct 24.

48.

Hypomorphic mutations in TRNT1 cause retinitis pigmentosa with erythrocytic microcytosis.

DeLuca AP, Whitmore SS, Barnes J, Sharma TP, Westfall TA, Scott CA, Weed MC, Wiley JS, Wiley LA, Johnston RM, Schnieders MJ, Lentz SR, Tucker BA, Mullins RF, Scheetz TE, Stone EM, Slusarski DC.

Hum Mol Genet. 2016 Jan 1;25(1):44-56. doi: 10.1093/hmg/ddv446. Epub 2015 Oct 22.

49.

Selective accumulation of the complement membrane attack complex in aging choriocapillaris.

Chirco KR, Tucker BA, Stone EM, Mullins RF.

Exp Eye Res. 2016 May;146:393-7. doi: 10.1016/j.exer.2015.09.003. Epub 2015 Sep 11.

50.

Using patient-specific induced pluripotent stem cells to interrogate the pathogenicity of a novel retinal pigment epithelium-specific 65 kDa cryptic splice site mutation and confirm eligibility for enrollment into a clinical gene augmentation trial.

Tucker BA, Cranston CM, Anfinson KA, Shrestha S, Streb LM, Leon A, Mullins RF, Stone EM.

Transl Res. 2015 Dec;166(6):740-749.e1. doi: 10.1016/j.trsl.2015.08.007. Epub 2015 Aug 29.

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