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Items: 27

1.

Larotrectinib in adult patients with solid tumours: a multi-centre, open-label, phase I dose-escalation study.

Hong DS, Bauer TM, Lee JJ, Dowlati A, Brose MS, Farago AF, Taylor M, Shaw AT, Montez S, Meric-Bernstam F, Smith S, Tuch BB, Ebata K, Cruickshank S, Cox MC, Burris HA, Doebele RC.

Ann Oncol. 2019 Feb 1;30(2):325-331. doi: 10.1093/annonc/mdy539.

2.

Oncogenic TRK fusions are amenable to inhibition in hematologic malignancies.

Taylor J, Pavlick D, Yoshimi A, Marcelus C, Chung SS, Hechtman JF, Benayed R, Cocco E, Durham BH, Bitner L, Inoue D, Chung YR, Mullaney K, Watts JM, Diamond EL, Albacker LA, Mughal TI, Ebata K, Tuch BB, Ku N, Scaltriti M, Roshal M, Arcila M, Ali S, Hyman DM, Park JH, Abdel-Wahab O.

J Clin Invest. 2018 Aug 31;128(9):3819-3825. doi: 10.1172/JCI120787. Epub 2018 Aug 6.

3.

Selective RET kinase inhibition for patients with RET-altered cancers.

Subbiah V, Velcheti V, Tuch BB, Ebata K, Busaidy NL, Cabanillas ME, Wirth LJ, Stock S, Smith S, Lauriault V, Corsi-Travali S, Henry D, Burkard M, Hamor R, Bouhana K, Winski S, Wallace RD, Hartley D, Rhodes S, Reddy M, Brandhuber BJ, Andrews S, Rothenberg SM, Drilon A.

Ann Oncol. 2018 Aug 1;29(8):1869-1876. doi: 10.1093/annonc/mdy137.

4.

ETV6-NTRK3 induces aggressive acute lymphoblastic leukemia highly sensitive to selective TRK inhibition.

Roberts KG, Janke LJ, Zhao Y, Seth A, Ma J, Finkelstein D, Smith S, Ebata K, Tuch BB, Hunger SP, Mullighan CG.

Blood. 2018 Aug 23;132(8):861-865. doi: 10.1182/blood-2018-05-849554. Epub 2018 Jun 7. No abstract available.

PMID:
29880614
5.

Larotrectinib for paediatric solid tumours harbouring NTRK gene fusions: phase 1 results from a multicentre, open-label, phase 1/2 study.

Laetsch TW, DuBois SG, Mascarenhas L, Turpin B, Federman N, Albert CM, Nagasubramanian R, Davis JL, Rudzinski E, Feraco AM, Tuch BB, Ebata KT, Reynolds M, Smith S, Cruickshank S, Cox MC, Pappo AS, Hawkins DS.

Lancet Oncol. 2018 May;19(5):705-714. doi: 10.1016/S1470-2045(18)30119-0. Epub 2018 Mar 29. Erratum in: Lancet Oncol. 2018 May;19(5):e229.

6.

Efficacy of Larotrectinib in TRK Fusion-Positive Cancers in Adults and Children.

Drilon A, Laetsch TW, Kummar S, DuBois SG, Lassen UN, Demetri GD, Nathenson M, Doebele RC, Farago AF, Pappo AS, Turpin B, Dowlati A, Brose MS, Mascarenhas L, Federman N, Berlin J, El-Deiry WS, Baik C, Deeken J, Boni V, Nagasubramanian R, Taylor M, Rudzinski ER, Meric-Bernstam F, Sohal DPS, Ma PC, Raez LE, Hechtman JF, Benayed R, Ladanyi M, Tuch BB, Ebata K, Cruickshank S, Ku NC, Cox MC, Hawkins DS, Hong DS, Hyman DM.

N Engl J Med. 2018 Feb 22;378(8):731-739. doi: 10.1056/NEJMoa1714448.

7.

A Next-Generation TRK Kinase Inhibitor Overcomes Acquired Resistance to Prior TRK Kinase Inhibition in Patients with TRK Fusion-Positive Solid Tumors.

Drilon A, Nagasubramanian R, Blake JF, Ku N, Tuch BB, Ebata K, Smith S, Lauriault V, Kolakowski GR, Brandhuber BJ, Larsen PD, Bouhana KS, Winski SL, Hamor R, Wu WI, Parker A, Morales TH, Sullivan FX, DeWolf WE, Wollenberg LA, Gordon PR, Douglas-Lindsay DN, Scaltriti M, Benayed R, Raj S, Hanusch B, Schram AM, Jonsson P, Berger MF, Hechtman JF, Taylor BS, Andrews S, Rothenberg SM, Hyman DM.

Cancer Discov. 2017 Sep;7(9):963-972. doi: 10.1158/2159-8290.CD-17-0507. Epub 2017 Jun 3.

8.

An Oncogenic NTRK Fusion in a Patient with Soft-Tissue Sarcoma with Response to the Tropomyosin-Related Kinase Inhibitor LOXO-101.

Doebele RC, Davis LE, Vaishnavi A, Le AT, Estrada-Bernal A, Keysar S, Jimeno A, Varella-Garcia M, Aisner DL, Li Y, Stephens PJ, Morosini D, Tuch BB, Fernandes M, Nanda N, Low JA.

Cancer Discov. 2015 Oct;5(10):1049-57. doi: 10.1158/2159-8290.CD-15-0443. Epub 2015 Jul 27.

9.

Intersecting transcription networks constrain gene regulatory evolution.

Sorrells TR, Booth LN, Tuch BB, Johnson AD.

Nature. 2015 Jul 16;523(7560):361-5. doi: 10.1038/nature14613. Epub 2015 Jul 8.

10.

Nucleosome regulatory dynamics in response to TGFβ.

Enroth S, Andersson R, Bysani M, Wallerman O, Termén S, Tuch BB, De La Vega FM, Heldin CH, Moustakas A, Komorowski J, Wadelius C.

Nucleic Acids Res. 2014 Jun;42(11):6921-34. doi: 10.1093/nar/gku326. Epub 2014 Apr 25.

11.

A recently evolved transcriptional network controls biofilm development in Candida albicans.

Nobile CJ, Fox EP, Nett JE, Sorrells TR, Mitrovich QM, Hernday AD, Tuch BB, Andes DR, Johnson AD.

Cell. 2012 Jan 20;148(1-2):126-38. doi: 10.1016/j.cell.2011.10.048.

12.

An iron homeostasis regulatory circuit with reciprocal roles in Candida albicans commensalism and pathogenesis.

Chen C, Pande K, French SD, Tuch BB, Noble SM.

Cell Host Microbe. 2011 Aug 18;10(2):118-35. doi: 10.1016/j.chom.2011.07.005.

13.

Deterministic and stochastic allele specific gene expression in single mouse blastomeres.

Tang F, Barbacioru C, Nordman E, Bao S, Lee C, Wang X, Tuch BB, Heard E, Lao K, Surani MA.

PLoS One. 2011;6(6):e21208. doi: 10.1371/journal.pone.0021208. Epub 2011 Jun 23.

14.

Extensive DNA-binding specificity divergence of a conserved transcription regulator.

Baker CR, Tuch BB, Johnson AD.

Proc Natl Acad Sci U S A. 2011 May 3;108(18):7493-8. doi: 10.1073/pnas.1019177108. Epub 2011 Apr 15.

15.

The developmental transcriptome of Drosophila melanogaster.

Graveley BR, Brooks AN, Carlson JW, Duff MO, Landolin JM, Yang L, Artieri CG, van Baren MJ, Boley N, Booth BW, Brown JB, Cherbas L, Davis CA, Dobin A, Li R, Lin W, Malone JH, Mattiuzzo NR, Miller D, Sturgill D, Tuch BB, Zaleski C, Zhang D, Blanchette M, Dudoit S, Eads B, Green RE, Hammonds A, Jiang L, Kapranov P, Langton L, Perrimon N, Sandler JE, Wan KH, Willingham A, Zhang Y, Zou Y, Andrews J, Bickel PJ, Brenner SE, Brent MR, Cherbas P, Gingeras TR, Hoskins RA, Kaufman TC, Oliver B, Celniker SE.

Nature. 2011 Mar 24;471(7339):473-9. doi: 10.1038/nature09715. Epub 2010 Dec 22.

16.

Intercalation of a new tier of transcription regulation into an ancient circuit.

Booth LN, Tuch BB, Johnson AD.

Nature. 2010 Dec 16;468(7326):959-63. doi: 10.1038/nature09560.

17.

Evolution of yeast noncoding RNAs reveals an alternative mechanism for widespread intron loss.

Mitrovich QM, Tuch BB, De La Vega FM, Guthrie C, Johnson AD.

Science. 2010 Nov 5;330(6005):838-41. doi: 10.1126/science.1194554.

18.

The transcriptomes of two heritable cell types illuminate the circuit governing their differentiation.

Tuch BB, Mitrovich QM, Homann OR, Hernday AD, Monighetti CK, De La Vega FM, Johnson AD.

PLoS Genet. 2010 Aug 19;6(8):e1001070. doi: 10.1371/journal.pgen.1001070.

19.

Tumor transcriptome sequencing reveals allelic expression imbalances associated with copy number alterations.

Tuch BB, Laborde RR, Xu X, Gu J, Chung CB, Monighetti CK, Stanley SJ, Olsen KD, Kasperbauer JL, Moore EJ, Broomer AJ, Tan R, Brzoska PM, Muller MW, Siddiqui AS, Asmann YW, Sun Y, Kuersten S, Barker MA, De La Vega FM, Smith DI.

PLoS One. 2010 Feb 19;5(2):e9317. doi: 10.1371/journal.pone.0009317.

20.

Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution.

Holt LJ, Tuch BB, Villén J, Johnson AD, Gygi SP, Morgan DO.

Science. 2009 Sep 25;325(5948):1682-6. doi: 10.1126/science.1172867.

21.

mRNA-Seq whole-transcriptome analysis of a single cell.

Tang F, Barbacioru C, Wang Y, Nordman E, Lee C, Xu N, Wang X, Bodeau J, Tuch BB, Siddiqui A, Lao K, Surani MA.

Nat Methods. 2009 May;6(5):377-82. doi: 10.1038/nmeth.1315. Epub 2009 Apr 6.

PMID:
19349980
22.

Measuring the prevalence of regional mutation rates: an analysis of silent substitutions in mammals, fungi, and insects.

Fox AK, Tuch BB, Chuang JH.

BMC Evol Biol. 2008 Jun 27;8:186. doi: 10.1186/1471-2148-8-186.

23.

Evolution of eukaryotic transcription circuits.

Tuch BB, Li H, Johnson AD.

Science. 2008 Mar 28;319(5871):1797-9. doi: 10.1126/science.1152398.

PMID:
18369141
24.

The evolution of combinatorial gene regulation in fungi.

Tuch BB, Galgoczy DJ, Hernday AD, Li H, Johnson AD.

PLoS Biol. 2008 Feb;6(2):e38. doi: 10.1371/journal.pbio.0060038.

25.

Interlocking transcriptional feedback loops control white-opaque switching in Candida albicans.

Zordan RE, Miller MG, Galgoczy DJ, Tuch BB, Johnson AD.

PLoS Biol. 2007 Oct;5(10):e256.

26.

Computational and experimental approaches double the number of known introns in the pathogenic yeast Candida albicans.

Mitrovich QM, Tuch BB, Guthrie C, Johnson AD.

Genome Res. 2007 Apr;17(4):492-502. Epub 2007 Mar 9.

27.

Evolution of alternative transcriptional circuits with identical logic.

Tsong AE, Tuch BB, Li H, Johnson AD.

Nature. 2006 Sep 28;443(7110):415-20.

PMID:
17006507

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