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Items: 1 to 50 of 77


Leveraging insights into cancer metabolism-a symposium report.

Cable J, Finley L, Tu BP, Patti GJ, Oliver TG, Vardhana S, Mana M, Ericksen R, Khare S, DeBerardinis R, Stockwell BR, Edinger A, Haigis M, Kaelin W.

Ann N Y Acad Sci. 2020 Feb;1462(1):5-13. doi: 10.1111/nyas.14274. Epub 2019 Dec 2.


Phylogenetic debugging of a complete human biosynthetic pathway transplanted into yeast.

Agmon N, Temple J, Tang Z, Schraink T, Baron M, Chen J, Mita P, Martin JA, Tu BP, Yanai I, Fenyö D, Boeke JD.

Nucleic Acids Res. 2020 Jan 10;48(1):486-499. doi: 10.1093/nar/gkz1098.


Single-Cell Microscopy Reveals That Levels of Cyclic di-GMP Vary among Bacillus subtilis Subpopulations.

Weiss CA, Hoberg JA, Liu K, Tu BP, Winkler WC.

J Bacteriol. 2019 Jul 24;201(16). pii: e00247-19. doi: 10.1128/JB.00247-19. Print 2019 Aug 15.


Redox State Controls Phase Separation of the Yeast Ataxin-2 Protein via Reversible Oxidation of Its Methionine-Rich Low-Complexity Domain.

Kato M, Yang YS, Sutter BM, Wang Y, McKnight SL, Tu BP.

Cell. 2019 Apr 18;177(3):711-721.e8. doi: 10.1016/j.cell.2019.02.044. Epub 2019 Apr 11.


Yeast Ataxin-2 Forms an Intracellular Condensate Required for the Inhibition of TORC1 Signaling during Respiratory Growth.

Yang YS, Kato M, Wu X, Litsios A, Sutter BM, Wang Y, Hsu CH, Wood NE, Lemoff A, Mirzaei H, Heinemann M, Tu BP.

Cell. 2019 Apr 18;177(3):697-710.e17. doi: 10.1016/j.cell.2019.02.043. Epub 2019 Apr 11.


Cycloheximide can distort measurements of mRNA levels and translation efficiency.

Santos DA, Shi L, Tu BP, Weissman JS.

Nucleic Acids Res. 2019 Jun 4;47(10):4974-4985. doi: 10.1093/nar/gkz205.


Demethylation of the Protein Phosphatase PP2A Promotes Demethylation of Histones to Enable Their Function as a Methyl Group Sink.

Ye C, Sutter BM, Wang Y, Kuang Z, Zhao X, Yu Y, Tu BP.

Mol Cell. 2019 Mar 21;73(6):1115-1126.e6. doi: 10.1016/j.molcel.2019.01.012. Epub 2019 Feb 13.


A Subset of Exoribonucleases Serve as Degradative Enzymes for pGpG in c-di-GMP Signaling.

Orr MW, Weiss CA, Severin GB, Turdiev H, Kim SK, Turdiev A, Liu K, Tu BP, Waters CM, Winkler WC, Lee VT.

J Bacteriol. 2018 Nov 26;200(24). pii: e00300-18. doi: 10.1128/JB.00300-18. Print 2018 Dec 15.


ACSS2 promotes systemic fat storage and utilization through selective regulation of genes involved in lipid metabolism.

Huang Z, Zhang M, Plec AA, Estill SJ, Cai L, Repa JJ, McKnight SL, Tu BP.

Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):E9499-E9506. doi: 10.1073/pnas.1806635115. Epub 2018 Sep 18.


Sink into the Epigenome: Histones as Repositories That Influence Cellular Metabolism.

Ye C, Tu BP.

Trends Endocrinol Metab. 2018 Sep;29(9):626-637. doi: 10.1016/j.tem.2018.06.002. Epub 2018 Jul 11. Review.


Loss of a Negative Regulator of mTORC1 Induces Aerobic Glycolysis and Altered Fiber Composition in Skeletal Muscle.

Dutchak PA, Estill-Terpack SJ, Plec AA, Zhao X, Yang C, Chen J, Ko B, Deberardinis RJ, Yu Y, Tu BP.

Cell Rep. 2018 May 15;23(7):1907-1914. doi: 10.1016/j.celrep.2018.04.058.


Correction to: Eight Kinetically Stable but Thermodynamically Activated Molecules that Power Cell Metabolism.

Walsh CT, Tu BP, Tang Y.

Chem Rev. 2018 May 23;118(10):5261-5263. doi: 10.1021/acs.chemrev.8b00181. Epub 2018 Apr 5. No abstract available.


Eight Kinetically Stable but Thermodynamically Activated Molecules that Power Cell Metabolism.

Walsh CT, Tu BP, Tang Y.

Chem Rev. 2018 Feb 28;118(4):1460-1494. doi: 10.1021/acs.chemrev.7b00510. Epub 2017 Dec 22. Review. Erratum in: Chem Rev. 2018 May 23;118(10 ):5261-5263.


GATOR1 regulates nitrogenic cataplerotic reactions of the mitochondrial TCA cycle.

Chen J, Sutter BM, Shi L, Tu BP.

Nat Chem Biol. 2017 Nov;13(11):1179-1186. doi: 10.1038/nchembio.2478. Epub 2017 Sep 18.


The U6 snRNA m6A Methyltransferase METTL16 Regulates SAM Synthetase Intron Retention.

Pendleton KE, Chen B, Liu K, Hunter OV, Xie Y, Tu BP, Conrad NK.

Cell. 2017 May 18;169(5):824-835.e14. doi: 10.1016/j.cell.2017.05.003.


A Metabolic Function for Phospholipid and Histone Methylation.

Ye C, Sutter BM, Wang Y, Kuang Z, Tu BP.

Mol Cell. 2017 Apr 20;66(2):180-193.e8. doi: 10.1016/j.molcel.2017.02.026. Epub 2017 Mar 30.


Low escape-rate genome safeguards with minimal molecular perturbation of Saccharomyces cerevisiae.

Agmon N, Tang Z, Yang K, Sutter B, Ikushima S, Cai Y, Caravelli K, Martin JA, Sun X, Choi WJ, Zhang A, Stracquadanio G, Hao H, Tu BP, Fenyo D, Bader JS, Boeke JD.

Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):E1470-E1479. doi: 10.1073/pnas.1621250114. Epub 2017 Feb 7.


Metabolic influences on RNA biology and translation.

Lee CD, Tu BP.

Crit Rev Biochem Mol Biol. 2017 Apr;52(2):176-184. doi: 10.1080/10409238.2017.1283294. Epub 2017 Feb 2. Review.


Metabolite Regulation of Nuclear Localization of Carbohydrate-response Element-binding Protein (ChREBP): ROLE OF AMP AS AN ALLOSTERIC INHIBITOR.

Sato S, Jung H, Nakagawa T, Pawlosky R, Takeshima T, Lee WR, Sakiyama H, Laxman S, Wynn RM, Tu BP, MacMillan JB, De Brabander JK, Veech RL, Uyeda K.

J Biol Chem. 2016 May 13;291(20):10515-27. doi: 10.1074/jbc.M115.708982. Epub 2016 Mar 16.


Cycling Transcriptional Networks Optimize Energy Utilization on a Genome Scale.

Wang GZ, Hickey SL, Shi L, Huang HC, Nakashe P, Koike N, Tu BP, Takahashi JS, Konopka G.

Cell Rep. 2015 Dec 1;13(9):1868-80. doi: 10.1016/j.celrep.2015.10.043. Epub 2015 Nov 19.


Competitive inhibition can linearize dose-response and generate a linear rectifier.

Savir Y, Tu BP, Springer M.

Cell Syst. 2015 Sep 23;1(3):238-245.


Regulation of Hematopoiesis and Methionine Homeostasis by mTORC1 Inhibitor NPRL2.

Dutchak PA, Laxman S, Estill SJ, Wang C, Wang Y, Wang Y, Bulut GB, Gao J, Huang LJ, Tu BP.

Cell Rep. 2015 Jul 21;12(3):371-9. doi: 10.1016/j.celrep.2015.06.042. Epub 2015 Jul 9.


Dietary control of chromatin.

Huang Z, Cai L, Tu BP.

Curr Opin Cell Biol. 2015 Jun;34:69-74. doi: 10.1016/ Epub 2015 Jun 19. Review.


Glucose-Regulated Phosphorylation of the PUF Protein Puf3 Regulates the Translational Fate of Its Bound mRNAs and Association with RNA Granules.

Lee CD, Tu BP.

Cell Rep. 2015 Jun 16;11(10):1638-50. doi: 10.1016/j.celrep.2015.05.014. Epub 2015 Jun 4.


GMP synthase is essential for viability and infectivity of Trypanosoma brucei despite a redundant purine salvage pathway.

Li Q, Leija C, Rijo-Ferreira F, Chen J, Cestari I, Stuart K, Tu BP, Phillips MA.

Mol Microbiol. 2015 Sep;97(5):1006-20. doi: 10.1111/mmi.13083. Epub 2015 Jul 4.


Acetyl-CoA and the regulation of metabolism: mechanisms and consequences.

Shi L, Tu BP.

Curr Opin Cell Biol. 2015 Apr;33:125-31. doi: 10.1016/ Epub 2015 Feb 20. Review.


Acetate is a bioenergetic substrate for human glioblastoma and brain metastases.

Mashimo T, Pichumani K, Vemireddy V, Hatanpaa KJ, Singh DK, Sirasanagandla S, Nannepaga S, Piccirillo SG, Kovacs Z, Foong C, Huang Z, Barnett S, Mickey BE, DeBerardinis RJ, Tu BP, Maher EA, Bachoo RM.

Cell. 2014 Dec 18;159(7):1603-14. doi: 10.1016/j.cell.2014.11.025.


Acetate dependence of tumors.

Comerford SA, Huang Z, Du X, Wang Y, Cai L, Witkiewicz AK, Walters H, Tantawy MN, Fu A, Manning HC, Horton JD, Hammer RE, McKnight SL, Tu BP.

Cell. 2014 Dec 18;159(7):1591-602. doi: 10.1016/j.cell.2014.11.020.


Npr2 inhibits TORC1 to prevent inappropriate utilization of glutamine for biosynthesis of nitrogen-containing metabolites.

Laxman S, Sutter BM, Shi L, Tu BP.

Sci Signal. 2014 Dec 16;7(356):ra120. doi: 10.1126/scisignal.2005948.


High-temporal-resolution view of transcription and chromatin states across distinct metabolic states in budding yeast.

Kuang Z, Cai L, Zhang X, Ji H, Tu BP, Boeke JD.

Nat Struct Mol Biol. 2014 Oct;21(10):854-63. doi: 10.1038/nsmb.2881. Epub 2014 Aug 31.


Autophagy is required for G₁/G₀ quiescence in response to nitrogen starvation in Saccharomyces cerevisiae.

An Z, Tassa A, Thomas C, Zhong R, Xiao G, Fotedar R, Tu BP, Klionsky DJ, Levine B.

Autophagy. 2014 Oct 1;10(10):1702-11. doi: 10.4161/auto.32122. Epub 2014 Aug 12.


Protein acetylation as a means to regulate protein function in tune with metabolic state.

Shi L, Tu BP.

Biochem Soc Trans. 2014 Aug;42(4):1037-42. doi: 10.1042/BST20140135. Review.


Concerted effort: oscillations in global gene expression during nematode development.

Laxman S, Tu BP, McKnight SL.

Mol Cell. 2014 Feb 6;53(3):363-4. doi: 10.1016/j.molcel.2014.01.023.


Methionine is a signal of amino acid sufficiency that inhibits autophagy through the methylation of PP2A.

Laxman S, Sutter BM, Tu BP.

Autophagy. 2014 Feb;10(2):386-7. doi: 10.4161/auto.27485. Epub 2013 Dec 18.


Integration of multiple nutrient cues and regulation of lifespan by ribosomal transcription factor Ifh1.

Cai L, McCormick MA, Kennedy BK, Tu BP.

Cell Rep. 2013 Sep 26;4(6):1063-71. doi: 10.1016/j.celrep.2013.08.016. Epub 2013 Sep 12.


Sulfur amino acids regulate translational capacity and metabolic homeostasis through modulation of tRNA thiolation.

Laxman S, Sutter BM, Wu X, Kumar S, Guo X, Trudgian DC, Mirzaei H, Tu BP.

Cell. 2013 Jul 18;154(2):416-29. doi: 10.1016/j.cell.2013.06.043.


Methionine inhibits autophagy and promotes growth by inducing the SAM-responsive methylation of PP2A.

Sutter BM, Wu X, Laxman S, Tu BP.

Cell. 2013 Jul 18;154(2):403-15. doi: 10.1016/j.cell.2013.06.041.


Structure-based design and mechanisms of allosteric inhibitors for mitochondrial branched-chain α-ketoacid dehydrogenase kinase.

Tso SC, Qi X, Gui WJ, Chuang JL, Morlock LK, Wallace AL, Ahmed K, Laxman S, Campeau PM, Lee BH, Hutson SM, Tu BP, Williams NS, Tambar UK, Wynn RM, Chuang DT.

Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9728-33. doi: 10.1073/pnas.1303220110. Epub 2013 May 28.


Product feedback regulation implicated in translational control of the Trypanosoma brucei S-adenosylmethionine decarboxylase regulatory subunit prozyme.

Xiao Y, Nguyen S, Kim SH, Volkov OA, Tu BP, Phillips MA.

Mol Microbiol. 2013 Jun;88(5):846-61. doi: 10.1111/mmi.12226. Epub 2013 May 2.


Acetyl-CoA induces transcription of the key G1 cyclin CLN3 to promote entry into the cell division cycle in Saccharomyces cerevisiae.

Shi L, Tu BP.

Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7318-23. doi: 10.1073/pnas.1302490110. Epub 2013 Apr 15.


Direct regulation of GTP homeostasis by (p)ppGpp: a critical component of viability and stress resistance.

Kriel A, Bittner AN, Kim SH, Liu K, Tehranchi AK, Zou WY, Rendon S, Chen R, Tu BP, Wang JD.

Mol Cell. 2012 Oct 26;48(2):231-41. doi: 10.1016/j.molcel.2012.08.009. Epub 2012 Sep 13.


Gatekeepers of chromatin: Small metabolites elicit big changes in gene expression.

Kaochar S, Tu BP.

Trends Biochem Sci. 2012 Nov;37(11):477-83. doi: 10.1016/j.tibs.2012.07.008. Epub 2012 Sep 1. Review.


Mitochondrial localization of telomeric protein TIN2 links telomere regulation to metabolic control.

Chen LY, Zhang Y, Zhang Q, Li H, Luo Z, Fang H, Kim SH, Qin L, Yotnda P, Xu J, Tu BP, Bai Y, Songyang Z.

Mol Cell. 2012 Sep 28;47(6):839-50. doi: 10.1016/j.molcel.2012.07.002. Epub 2012 Aug 9.


Analysis of tumor metabolism reveals mitochondrial glucose oxidation in genetically diverse human glioblastomas in the mouse brain in vivo.

Marin-Valencia I, Yang C, Mashimo T, Cho S, Baek H, Yang XL, Rajagopalan KN, Maddie M, Vemireddy V, Zhao Z, Cai L, Good L, Tu BP, Hatanpaa KJ, Mickey BE, Matés JM, Pascual JM, Maher EA, Malloy CR, Deberardinis RJ, Bachoo RM.

Cell Metab. 2012 Jun 6;15(6):827-37. doi: 10.1016/j.cmet.2012.05.001. Erratum in: Cell Metab. 2012 Nov 7;16(5):686.


Driving the cell cycle through metabolism.

Cai L, Tu BP.

Annu Rev Cell Dev Biol. 2012;28:59-87. doi: 10.1146/annurev-cellbio-092910-154010. Epub 2012 May 11. Review.


Inhibition of pyrimidine synthesis reverses viral virulence factor-mediated block of mRNA nuclear export.

Zhang L, Das P, Schmolke M, Manicassamy B, Wang Y, Deng X, Cai L, Tu BP, Forst CV, Roth MG, Levy DE, García-Sastre A, de Brabander J, Phillips MA, Fontoura BM.

J Cell Biol. 2012 Feb 6;196(3):315-26. doi: 10.1083/jcb.201107058.


Multiple TORC1-associated proteins regulate nitrogen starvation-dependent cellular differentiation in Saccharomyces cerevisiae.

Laxman S, Tu BP.

PLoS One. 2011;6(10):e26081. doi: 10.1371/journal.pone.0026081. Epub 2011 Oct 17.


Selective regulation of autophagy by the Iml1-Npr2-Npr3 complex in the absence of nitrogen starvation.

Wu X, Tu BP.

Mol Biol Cell. 2011 Nov;22(21):4124-33. doi: 10.1091/mbc.E11-06-0525. Epub 2011 Sep 7.


On acetyl-CoA as a gauge of cellular metabolic state.

Cai L, Tu BP.

Cold Spring Harb Symp Quant Biol. 2011;76:195-202. doi: 10.1101/sqb.2011.76.010769. Epub 2011 Sep 6. Review.


Acetyl-CoA drives the transcriptional growth program in yeast.

Cai L, Tu BP.

Cell Cycle. 2011 Sep 15;10(18):3045-6. Epub 2011 Sep 15. No abstract available.

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