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TTC3-Mediated Protein Quality Control, A Potential Mechanism for Cognitive Impairment.
Zhou X, Chen X, Hong T, Zhang M, Cai Y, Cui L. Zhou X, et al. Cell Mol Neurobiol. 2022 Aug;42(6):1659-1669. doi: 10.1007/s10571-021-01060-z. Epub 2021 Feb 27. Cell Mol Neurobiol. 2022. PMID: 33638766 Free PMC article. Review.
The tetrapeptide repeat domain 3 (TTC3) gene falls within Down's syndrome (DS) critical region. Cognitive impairment is a common phenotype of DS and Alzheimer's disease (AD), and overexpression of TTC3 can accelerate cognitive decline, but the specific mechanism is …
The tetrapeptide repeat domain 3 (TTC3) gene falls within Down's syndrome (DS) critical region. Cognitive impairment is a common phen …
Dysregulation of ribosome-associated quality control elicits cognitive disorders via overaccumulation of TTC3.
Endo R, Chen YK, Burke J, Takashima N, Suryawanshi N, Hui KK, Miyazaki T, Tanaka M. Endo R, et al. Proc Natl Acad Sci U S A. 2023 Mar 21;120(12):e2211522120. doi: 10.1073/pnas.2211522120. Epub 2023 Mar 14. Proc Natl Acad Sci U S A. 2023. PMID: 36917672 Free PMC article.
However, the overaccumulated TTC3 protein in turn caused dendritic abnormalities and reduced surface-localized GABA(A) receptors during neuronal development. Ltn1 KO mice showed behavioral deficits associated with cognitive disorders, a subset of which were restored by …
However, the overaccumulated TTC3 protein in turn caused dendritic abnormalities and reduced surface-localized GABA(A) receptors duri …
TTC3 contributes to TGF-beta(1)-induced epithelial-mesenchymal transition and myofibroblast differentiation, potentially through SMURF2 ubiquitylation and degradation.
Kim JH, Ham S, Lee Y, Suh GY, Lee YS. Kim JH, et al. Cell Death Dis. 2019 Jan 29;10(2):92. doi: 10.1038/s41419-019-1308-8. Cell Death Dis. 2019. PMID: 30696809 Free PMC article.
TGF-beta(1) reduced SMURF2 levels and TTC3 overexpression led to a further decrease in SMURF2 levels, while TTC3 knockdown inhibited TGF-beta(1)-induced SMURF2 reduction. In cell and in vitro ubiquitylation assays demonstrated TTC3-mediated SMURF2 ubiquitylat …
TGF-beta(1) reduced SMURF2 levels and TTC3 overexpression led to a further decrease in SMURF2 levels, while TTC3 knockdown inh …
Circular RNA Ttc3 regulates cardiac function after myocardial infarction by sponging miR-15b.
Cai L, Qi B, Wu X, Peng S, Zhou G, Wei Y, Xu J, Chen S, Liu S. Cai L, et al. J Mol Cell Cardiol. 2019 May;130:10-22. doi: 10.1016/j.yjmcc.2019.03.007. Epub 2019 Mar 12. J Mol Cell Cardiol. 2019. PMID: 30876857
Forced expression of circ-Ttc3 in cardiomyocytes counteracted hypoxia-induced ATP depletion and apoptotic death, in sharp contrast to circ-Ttc3 knockdown. ...Thus, our findings revealed the cardioprotective role of circ-Ttc3 in MI. The miR-15b-Arl2 regulatory …
Forced expression of circ-Ttc3 in cardiomyocytes counteracted hypoxia-induced ATP depletion and apoptotic death, in sharp contrast to …
Overexpressed TTC3 Protein Tends to be Cleaved into Fragments and Form Aggregates in the Nucleus.
Gong Y, Wang K, Xiao SP, Mi P, Li W, Shang Y, Dou F. Gong Y, et al. Neuromolecular Med. 2019 Mar;21(1):85-96. doi: 10.1007/s12017-018-8509-7. Epub 2018 Sep 10. Neuromolecular Med. 2019. PMID: 30203323
Several groups also reported the involvement of TTC3 in familial Alzheimer's disease recently. In addition, our previous work shows that TTC3 also regulates the degradation of DNA polymerase gamma and over-expressed TTC3 protein tends to form insoluble aggreg …
Several groups also reported the involvement of TTC3 in familial Alzheimer's disease recently. In addition, our previous work shows t …
Circular RNA circ-Ttc3 protects HaCaT cells from hypoxic injury by downregulation of miR-449a.
Yu L, Wang Q, Liu N, Zhao J, Yu J, Tao S. Yu L, et al. IUBMB Life. 2020 Mar;72(3):505-514. doi: 10.1002/iub.2236. Epub 2020 Feb 11. IUBMB Life. 2020. PMID: 32043754 Free article.
RESULTS: Hypoxia induced apoptosis and declined viability in HaCaT cells. Circ-Ttc3 expression was enhanced after transfection with circ-Ttc3 expressing vector. Overexpressing circ-Ttc3 raised viability and reduced apoptosis in HaCaT cells. Moreover, miR-449a …
RESULTS: Hypoxia induced apoptosis and declined viability in HaCaT cells. Circ-Ttc3 expression was enhanced after transfection with c …
TTC3 ubiquitination terminates Akt-ivation.
Toker A. Toker A. Dev Cell. 2009 Dec;17(6):752-4. doi: 10.1016/j.devcel.2009.12.003. Dev Cell. 2009. PMID: 20059946 Free article.
In this issue of Developmental Cell, Suizu et al. (2009) describe a new mechanism for posttranslational regulation of the Akt serine/threonine protein kinase involving ubiquitination. They show that the E3 ubiquitin ligase TTC3 modifies phosphorylated and activated Akt and …
In this issue of Developmental Cell, Suizu et al. (2009) describe a new mechanism for posttranslational regulation of the Akt serine/threoni …
lncRNA Ttc3-209 Promotes the Apoptosis of Retinal Ganglion Cells in Retinal Ischemia Reperfusion Injury by Targeting the miR-484/Wnt8a Axis.
Zhang R, Feng Y, Lu J, Ge Y, Li H. Zhang R, et al. Invest Ophthalmol Vis Sci. 2021 Mar 1;62(3):13. doi: 10.1167/iovs.62.3.13. Invest Ophthalmol Vis Sci. 2021. PMID: 33687475 Free PMC article.
Mechanistically, lncRNA Ttc3-209 is a ceRNA that competitively binds to miR-484 and upregulates the translation of its target (Wnt8a mRNA), thus promoting apoptosis in RGCs. CONCLUSIONS: Reducing the expression of lncRNA Ttc3-209 had a protective effect against apop …
Mechanistically, lncRNA Ttc3-209 is a ceRNA that competitively binds to miR-484 and upregulates the translation of its target (Wnt8a …
An Alzheimer's disease risk variant in TTC3 modifies the actin cytoskeleton organization and the PI3K-Akt signaling pathway in iPSC-derived forebrain neurons.
Cukier HN, Duarte CL, Laverde-Paz MJ, Simon SA, Van Booven DJ, Miyares AT, Whitehead PL, Hamilton-Nelson KL, Adams LD, Carney RM, Cuccaro ML, Vance JM, Pericak-Vance MA, Griswold AJ, Dykxhoorn DM. Cukier HN, et al. Neurobiol Aging. 2023 Nov;131:182-195. doi: 10.1016/j.neurobiolaging.2023.07.007. Epub 2023 Jul 17. Neurobiol Aging. 2023. PMID: 37677864 Free article.
A missense variant in the tetratricopeptide repeat domain 3 (TTC3) gene (rs377155188, p.S1038C, NM_003316.4:c 0.3113C>G) was found to segregate with disease in a multigenerational family with late-onset Alzheimer's disease. ...Pharmacological treatment with small molecu …
A missense variant in the tetratricopeptide repeat domain 3 (TTC3) gene (rs377155188, p.S1038C, NM_003316.4:c 0.3113C>G) was found …
72 results