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Items: 45

1.

Structure-based design of a quadrivalent fusion glycoprotein vaccine for human parainfluenza virus types 1-4.

Stewart-Jones GBE, Chuang GY, Xu K, Zhou T, Acharya P, Tsybovsky Y, Ou L, Zhang B, Fernandez-Rodriguez B, Gilardi V, Silacci-Fregni C, Beltramello M, Baxa U, Druz A, Kong WP, Thomas PV, Yang Y, Foulds KE, Todd JP, Wei H, Salazar AM, Scorpio DG, Carragher B, Potter CS, Corti D, Mascola JR, Lanzavecchia A, Kwong PD.

Proc Natl Acad Sci U S A. 2018 Nov 27;115(48):12265-12270. doi: 10.1073/pnas.1811980115. Epub 2018 Nov 12.

PMID:
30420505
2.

Vaccine-Mediated Induction of an Ebolavirus Cross-Species Antibody Binding to Conserved Epitopes on the Glycoprotein Heptad Repeat 2/Membrane-Proximal External Junction.

Cagigi A, Ploquin A, Niezold T, Zhou Y, Tsybovsky Y, Misasi J, Sullivan NJ.

J Infect Dis. 2018 Nov 22;218(suppl_5):S537-S544. doi: 10.1093/infdis/jiy450.

PMID:
30137549
3.

Glycan Masking Focuses Immune Responses to the HIV-1 CD4-Binding Site and Enhances Elicitation of VRC01-Class Precursor Antibodies.

Duan H, Chen X, Boyington JC, Cheng C, Zhang Y, Jafari AJ, Stephens T, Tsybovsky Y, Kalyuzhniy O, Zhao P, Menis S, Nason MC, Normandin E, Mukhamedova M, DeKosky BJ, Wells L, Schief WR, Tian M, Alt FW, Kwong PD, Mascola JR.

Immunity. 2018 Aug 21;49(2):301-311.e5. doi: 10.1016/j.immuni.2018.07.005. Epub 2018 Jul 31.

PMID:
30076101
4.

Vaccine Generation of Protective Ebola Antibodies and Identification of Conserved B-Cell Signatures.

Cagigi A, Misasi J, Ploquin A, Stanley DA, Ambrozak D, Tsybovsky Y, Mason RD, Roederer M, Sullivan NJ.

J Infect Dis. 2018 Nov 22;218(suppl_5):S528-S536. doi: 10.1093/infdis/jiy333.

PMID:
30010811
5.

Interdomain Stabilization Impairs CD4 Binding and Improves Immunogenicity of the HIV-1 Envelope Trimer.

Zhang P, Gorman J, Geng H, Liu Q, Lin Y, Tsybovsky Y, Go EP, Dey B, Andine T, Kwon A, Patel M, Gururani D, Uddin F, Guzzo C, Cimbro R, Miao H, McKee K, Chuang GY, Martin L, Sironi F, Malnati MS, Desaire H, Berger EA, Mascola JR, Dolan MA, Kwong PD, Lusso P.

Cell Host Microbe. 2018 Jun 13;23(6):832-844.e6. doi: 10.1016/j.chom.2018.05.002.

PMID:
29902444
6.

Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1.

Xu K, Acharya P, Kong R, Cheng C, Chuang GY, Liu K, Louder MK, O'Dell S, Rawi R, Sastry M, Shen CH, Zhang B, Zhou T, Asokan M, Bailer RT, Chambers M, Chen X, Choi CW, Dandey VP, Doria-Rose NA, Druz A, Eng ET, Farney SK, Foulds KE, Geng H, Georgiev IS, Gorman J, Hill KR, Jafari AJ, Kwon YD, Lai YT, Lemmin T, McKee K, Ohr TY, Ou L, Peng D, Rowshan AP, Sheng Z, Todd JP, Tsybovsky Y, Viox EG, Wang Y, Wei H, Yang Y, Zhou AF, Chen R, Yang L, Scorpio DG, McDermott AB, Shapiro L, Carragher B, Potter CS, Mascola JR, Kwong PD.

Nat Med. 2018 Jun;24(6):857-867. doi: 10.1038/s41591-018-0042-6. Epub 2018 Jun 4.

PMID:
29867235
7.

A Neutralizing Antibody Recognizing Primarily N-Linked Glycan Targets the Silent Face of the HIV Envelope.

Zhou T, Zheng A, Baxa U, Chuang GY, Georgiev IS, Kong R, O'Dell S, Shahzad-Ul-Hussan S, Shen CH, Tsybovsky Y, Bailer RT, Gift SK, Louder MK, McKee K, Rawi R, Stevenson CH, Stewart-Jones GBE, Taft JD, Waltari E, Yang Y, Zhang B, Shivatare SS, Shivatare VS, Lee CD, Wu CY; NISC Comparative Sequencing Program, Mullikin JC, Bewley CA, Burton DR, Polonis VR, Shapiro L, Wong CH, Mascola JR, Kwong PD, Wu X.

Immunity. 2018 Mar 20;48(3):500-513.e6. doi: 10.1016/j.immuni.2018.02.013. Epub 2018 Mar 13.

PMID:
29548671
8.

Two-Component Ferritin Nanoparticles for Multimerization of Diverse Trimeric Antigens.

Georgiev IS, Joyce MG, Chen RE, Leung K, McKee K, Druz A, Van Galen JG, Kanekiyo M, Tsybovsky Y, Yang ES, Yang Y, Acharya P, Pancera M, Thomas PV, Wanninger T, Yassine HM, Baxa U, Doria-Rose NA, Cheng C, Graham BS, Mascola JR, Kwong PD.

ACS Infect Dis. 2018 May 11;4(5):788-796. doi: 10.1021/acsinfecdis.7b00192. Epub 2018 Mar 6.

PMID:
29451984
9.

Soluble Prefusion Closed DS-SOSIP.664-Env Trimers of Diverse HIV-1 Strains.

Joyce MG, Georgiev IS, Yang Y, Druz A, Geng H, Chuang GY, Kwon YD, Pancera M, Rawi R, Sastry M, Stewart-Jones GBE, Zheng A, Zhou T, Choe M, Van Galen JG, Chen RE, Lees CR, Narpala S, Chambers M, Tsybovsky Y, Baxa U, McDermott AB, Mascola JR, Kwong PD.

Cell Rep. 2017 Dec 5;21(10):2992-3002. doi: 10.1016/j.celrep.2017.11.016.

10.

Protection of calves by a prefusion-stabilized bovine RSV F vaccine.

Zhang B, Chen L, Silacci C, Thom M, Boyington JC, Druz A, Joyce MG, Guzman E, Kong WP, Lai YT, Stewart-Jones GBE, Tsybovsky Y, Yang Y, Zhou T, Baxa U, Mascola JR, Corti D, Lanzavecchia A, Taylor G, Kwong PD.

NPJ Vaccines. 2017 Mar 8;2:7. doi: 10.1038/s41541-017-0005-9.

11.

Preferential induction of cross-group influenza A hemagglutinin stem-specific memory B cells after H7N9 immunization in humans.

Andrews SF, Joyce MG, Chambers MJ, Gillespie RA, Kanekiyo M, Leung K, Yang ES, Tsybovsky Y, Wheatley AK, Crank MC, Boyington JC, Prabhakaran MS, Narpala SR, Chen X, Bailer RT, Chen G, Coates E, Kwong PD, Koup RA, Mascola JR, Graham BS, Ledgerwood JE, McDermott AB.

Sci Immunol. 2017 Jul 14;2(13). pii: eaan2676. doi: 10.1126/sciimmunol.aan2676.

PMID:
28783708
12.

Quantification of the Impact of the HIV-1-Glycan Shield on Antibody Elicitation.

Zhou T, Doria-Rose NA, Cheng C, Stewart-Jones GBE, Chuang GY, Chambers M, Druz A, Geng H, McKee K, Kwon YD, O'Dell S, Sastry M, Schmidt SD, Xu K, Chen L, Chen RE, Louder MK, Pancera M, Wanninger TG, Zhang B, Zheng A, Farney SK, Foulds KE, Georgiev IS, Joyce MG, Lemmin T, Narpala S, Rawi R, Soto C, Todd JP, Shen CH, Tsybovsky Y, Yang Y, Zhao P, Haynes BF, Stamatatos L, Tiemeyer M, Wells L, Scorpio DG, Shapiro L, McDermott AB, Mascola JR, Kwong PD.

Cell Rep. 2017 Apr 25;19(4):719-732. doi: 10.1016/j.celrep.2017.04.013.

13.

Structure-Based Design of a Soluble Prefusion-Closed HIV-1 Env Trimer with Reduced CD4 Affinity and Improved Immunogenicity.

Chuang GY, Geng H, Pancera M, Xu K, Cheng C, Acharya P, Chambers M, Druz A, Tsybovsky Y, Wanninger TG, Yang Y, Doria-Rose NA, Georgiev IS, Gorman J, Joyce MG, O'Dell S, Zhou T, McDermott AB, Mascola JR, Kwong PD.

J Virol. 2017 Apr 28;91(10). pii: e02268-16. doi: 10.1128/JVI.02268-16. Print 2017 May 15.

14.

Molecular-level analysis of the serum antibody repertoire in young adults before and after seasonal influenza vaccination.

Lee J, Boutz DR, Chromikova V, Joyce MG, Vollmers C, Leung K, Horton AP, DeKosky BJ, Lee CH, Lavinder JJ, Murrin EM, Chrysostomou C, Hoi KH, Tsybovsky Y, Thomas PV, Druz A, Zhang B, Zhang Y, Wang L, Kong WP, Park D, Popova LI, Dekker CL, Davis MM, Carter CE, Ross TM, Ellington AD, Wilson PC, Marcotte EM, Mascola JR, Ippolito GC, Krammer F, Quake SR, Kwong PD, Georgiou G.

Nat Med. 2016 Dec;22(12):1456-1464. doi: 10.1038/nm.4224. Epub 2016 Nov 7.

15.

Structural Insights into the Drosophila melanogaster Retinol Dehydrogenase, a Member of the Short-Chain Dehydrogenase/Reductase Family.

Hofmann L, Tsybovsky Y, Alexander NS, Babino D, Leung NY, Montell C, Banerjee S, von Lintig J, Palczewski K.

Biochemistry. 2016 Nov 29;55(47):6545-6557. Epub 2016 Nov 16.

16.

Rapid development of a DNA vaccine for Zika virus.

Dowd KA, Ko SY, Morabito KM, Yang ES, Pelc RS, DeMaso CR, Castilho LR, Abbink P, Boyd M, Nityanandam R, Gordon DN, Gallagher JR, Chen X, Todd JP, Tsybovsky Y, Harris A, Huang YS, Higgs S, Vanlandingham DL, Andersen H, Lewis MG, De La Barrera R, Eckels KH, Jarman RG, Nason MC, Barouch DH, Roederer M, Kong WP, Mascola JR, Pierson TC, Graham BS.

Science. 2016 Oct 14;354(6309):237-240. Epub 2016 Sep 22.

17.

Platelet-derived growth factor-α receptor is the cellular receptor for human cytomegalovirus gHgLgO trimer.

Kabanova A, Marcandalli J, Zhou T, Bianchi S, Baxa U, Tsybovsky Y, Lilleri D, Silacci-Fregni C, Foglierini M, Fernandez-Rodriguez BM, Druz A, Zhang B, Geiger R, Pagani M, Sallusto F, Kwong PD, Corti D, Lanzavecchia A, Perez L.

Nat Microbiol. 2016 Jun 6;1(8):16082. doi: 10.1038/nmicrobiol.2016.82.

18.

Iterative structure-based improvement of a fusion-glycoprotein vaccine against RSV.

Joyce MG, Zhang B, Ou L, Chen M, Chuang GY, Druz A, Kong WP, Lai YT, Rundlet EJ, Tsybovsky Y, Yang Y, Georgiev IS, Guttman M, Lees CR, Pancera M, Sastry M, Soto C, Stewart-Jones GBE, Thomas PV, Van Galen JG, Baxa U, Lee KK, Mascola JR, Graham BS, Kwong PD.

Nat Struct Mol Biol. 2016 Sep;23(9):811-820. doi: 10.1038/nsmb.3267. Epub 2016 Aug 1.

19.

Structure-Based Design of Head-Only Fusion Glycoprotein Immunogens for Respiratory Syncytial Virus.

Boyington JC, Joyce MG, Sastry M, Stewart-Jones GB, Chen M, Kong WP, Ngwuta JO, Thomas PV, Tsybovsky Y, Yang Y, Zhang B, Chen L, Druz A, Georgiev IS, Ko K, Zhou T, Mascola JR, Graham BS, Kwong PD.

PLoS One. 2016 Jul 27;11(7):e0159709. doi: 10.1371/journal.pone.0159709. eCollection 2016.

20.

Vaccine-Induced Antibodies that Neutralize Group 1 and Group 2 Influenza A Viruses.

Joyce MG, Wheatley AK, Thomas PV, Chuang GY, Soto C, Bailer RT, Druz A, Georgiev IS, Gillespie RA, Kanekiyo M, Kong WP, Leung K, Narpala SN, Prabhakaran MS, Yang ES, Zhang B, Zhang Y, Asokan M, Boyington JC, Bylund T, Darko S, Lees CR, Ransier A, Shen CH, Wang L, Whittle JR, Wu X, Yassine HM, Santos C, Matsuoka Y, Tsybovsky Y, Baxa U; NISC Comparative Sequencing Program, Mullikin JC, Subbarao K, Douek DC, Graham BS, Koup RA, Ledgerwood JE, Roederer M, Shapiro L, Kwong PD, Mascola JR, McDermott AB.

Cell. 2016 Jul 28;166(3):609-623. doi: 10.1016/j.cell.2016.06.043. Epub 2016 Jul 21.

21.

Protein misfolding and the pathogenesis of ABCA4-associated retinal degenerations.

Zhang N, Tsybovsky Y, Kolesnikov AV, Rozanowska M, Swider M, Schwartz SB, Stone EM, Palczewska G, Maeda A, Kefalov VJ, Jacobson SG, Cideciyan AV, Palczewski K.

Hum Mol Genet. 2015 Jun 1;24(11):3220-37. doi: 10.1093/hmg/ddv073. Epub 2015 Feb 24.

22.

Probing conformational changes in rhodopsin using hydrogen-deuterium exchange coupled to mass spectrometry.

Orban T, Tsybovsky Y.

Methods Mol Biol. 2015;1271:113-21. doi: 10.1007/978-1-4939-2330-4_8.

PMID:
25697520
23.

Aldehyde dehydrogenase homologous folate enzymes: Evolutionary switch between cytoplasmic and mitochondrial localization.

Krupenko NI, Holmes RS, Tsybovsky Y, Krupenko SA.

Chem Biol Interact. 2015 Jun 5;234:12-7. doi: 10.1016/j.cbi.2014.12.022. Epub 2014 Dec 27.

24.

Expression, purification and structural properties of ABC transporter ABCA4 and its individual domains.

Tsybovsky Y, Palczewski K.

Protein Expr Purif. 2014 May;97:50-60. doi: 10.1016/j.pep.2014.02.010. Epub 2014 Feb 28.

25.

Reliable determination of site-specific in vivo protein N-glycosylation based on collision-induced MS/MS and chromatographic retention time.

Wang B, Tsybovsky Y, Palczewski K, Chance MR.

J Am Soc Mass Spectrom. 2014 May;25(5):729-41. doi: 10.1007/s13361-013-0823-6. Epub 2014 Feb 19.

26.

Structural and functional analysis of the native peripherin-ROM1 complex isolated from photoreceptor cells.

Kevany BM, Tsybovsky Y, Campuzano ID, Schnier PD, Engel A, Palczewski K.

J Biol Chem. 2013 Dec 20;288(51):36272-84. doi: 10.1074/jbc.M113.520700. Epub 2013 Nov 6.

27.

Molecular organization and ATP-induced conformational changes of ABCA4, the photoreceptor-specific ABC transporter.

Tsybovsky Y, Orban T, Molday RS, Taylor D, Palczewski K.

Structure. 2013 May 7;21(5):854-60. doi: 10.1016/j.str.2013.03.001. Epub 2013 Apr 4.

28.

The mechanism of discrimination between oxidized and reduced coenzyme in the aldehyde dehydrogenase domain of Aldh1l1.

Tsybovsky Y, Malakhau Y, Strickland KC, Krupenko SA.

Chem Biol Interact. 2013 Feb 25;202(1-3):62-9. doi: 10.1016/j.cbi.2012.12.015. Epub 2013 Jan 5.

29.

Posttranslational modifications of the photoreceptor-specific ABC transporter ABCA4.

Tsybovsky Y, Wang B, Quazi F, Molday RS, Palczewski K.

Biochemistry. 2011 Aug 16;50(32):6855-66. doi: 10.1021/bi200774w. Epub 2011 Jul 8.

30.

Conserved catalytic residues of the ALDH1L1 aldehyde dehydrogenase domain control binding and discharging of the coenzyme.

Tsybovsky Y, Krupenko SA.

J Biol Chem. 2011 Jul 1;286(26):23357-67. doi: 10.1074/jbc.M111.221069. Epub 2011 May 3.

31.

Enzymatic properties of ALDH1L2, a mitochondrial 10-formyltetrahydrofolate dehydrogenase.

Strickland KC, Krupenko NI, Dubard ME, Hu CJ, Tsybovsky Y, Krupenko SA.

Chem Biol Interact. 2011 May 30;191(1-3):129-36. doi: 10.1016/j.cbi.2011.01.008. Epub 2011 Jan 14.

32.

The ATP-binding cassette transporter ABCA4: structural and functional properties and role in retinal disease.

Tsybovsky Y, Molday RS, Palczewski K.

Adv Exp Med Biol. 2010;703:105-25. doi: 10.1007/978-1-4419-5635-4_8. Review.

33.

Complexes between photoactivated rhodopsin and transducin: progress and questions.

Jastrzebska B, Tsybovsky Y, Palczewski K.

Biochem J. 2010 Apr 28;428(1):1-10. doi: 10.1042/BJ20100270. Review.

34.

Fusion of barnase to antiferritin antibody F11 VH domain results in a partially folded functionally active protein.

Shubenok DV, Tsybovsky YI, Stremovskiy OA, Deyev SM, Martsev SP.

Biochemistry (Mosc). 2009 Jun;74(6):672-80.

PMID:
19645673
35.

ABCA4 disease progression and a proposed strategy for gene therapy.

Cideciyan AV, Swider M, Aleman TS, Tsybovsky Y, Schwartz SB, Windsor EA, Roman AJ, Sumaroka A, Steinberg JD, Jacobson SG, Stone EM, Palczewski K.

Hum Mol Genet. 2009 Mar 1;18(5):931-41. doi: 10.1093/hmg/ddn421. Epub 2008 Dec 12.

36.

Folding of an antibody variable domain in two functional conformations in vitro: calorimetric and spectroscopic study of the anti-ferritin antibody VL domain.

Tsybovsky Y, Shubenok DV, Kravchuk ZI, Martsev SP.

Protein Eng Des Sel. 2007 Oct;20(10):481-90. Epub 2007 Oct 24.

PMID:
17962224
37.

10-formyltetrahydrofolate dehydrogenase requires a 4'-phosphopantetheine prosthetic group for catalysis.

Donato H, Krupenko NI, Tsybovsky Y, Krupenko SA.

J Biol Chem. 2007 Nov 23;282(47):34159-66. Epub 2007 Sep 20.

38.

Crystal structures of the carboxyl terminal domain of rat 10-formyltetrahydrofolate dehydrogenase: implications for the catalytic mechanism of aldehyde dehydrogenases.

Tsybovsky Y, Donato H, Krupenko NI, Davies C, Krupenko SA.

Biochemistry. 2007 Mar 20;46(11):2917-29. Epub 2007 Feb 16.

PMID:
17302434
39.

Folding and stability of chimeric immunofusion VL-barstar.

Tsybovsky YI, Shubenok DV, Stremovskiy OA, Deyev SM, Martsev SP.

Biochemistry (Mosc). 2004 Sep;69(9):939-48.

40.

Fusion of the antiferritin antibody VL domain to barnase results in enhanced solubility and altered pH stability.

Martsev SP, Tsybovsky YI, Stremovskiy OA, Odintsov SG, Balandin TG, Arosio P, Kravchuk ZI, Deyev SM.

Protein Eng Des Sel. 2004 Jan;17(1):85-93.

PMID:
14985541
41.
42.

Partially structured state of the functional VH domain of the mouse anti-ferritin antibody F11.

Martsev SP, Dubnovitsky AP, Stremovsky OA, Chumanevich AA, Tsybovsky YI, Kravchuk ZI, Deyev SM.

FEBS Lett. 2002 May 8;518(1-3):177-82.

43.

Truncated aspartate aminotransferase from alkalophilic Bacillus circulans with deletion of N-terminal 32 amino acids is a non-functional monomer in a partially structured state.

Kravchuk Z, Tsybovsky Y, Koivulehto M, Vlasov A, Chumanevich A, Battchikova N, Martsev S, Korpela T.

Protein Eng. 2001 Apr;14(4):279-85.

PMID:
11391020
44.

Thermodynamic stability and functional activity of tumor-associated antibodies.

Bliznukov OP, Kozmin LD, Klimovich VB, Tsybovsky YI, Kravchuk ZI, Martsev SP.

Biochemistry (Mosc). 2001 Jan;66(1):27-33.

PMID:
11240389
45.

Antiferritin single-chain Fv fragment is a functional protein with properties of a partially structured state: comparison with the completely folded V(L) domain.

Martsev SP, Chumanevich AA, Vlasov AP, Dubnovitsky AP, Tsybovsky YI, Deyev SM, Cozzi A, Arosio P, Kravchuk ZI.

Biochemistry. 2000 Jul 11;39(27):8047-57.

PMID:
10891087

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