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Items: 1 to 50 of 54

1.

The impact of age and frailty on ventricular structure and function in C57BL/6J mice.

Feridooni HA, Kane AE, Ayaz O, Boroumandi A, Polidovitch N, Tsushima RG, Rose RA, Howlett SE.

J Physiol. 2017 Jun 15;595(12):3721-3742. doi: 10.1113/JP274134. Epub 2017 May 14.

2.

Cross-talk between glycogen synthase kinase 3β (GSK3β) and p38MAPK regulates myocyte enhancer factor 2 (MEF2) activity in skeletal and cardiac muscle.

Dionyssiou MG, Nowacki NB, Hashemi S, Zhao J, Kerr A, Tsushima RG, McDermott JC.

J Mol Cell Cardiol. 2013 Jan;54:35-44. doi: 10.1016/j.yjmcc.2012.10.013. Epub 2012 Nov 5.

PMID:
23137781
3.

Second-phase insulin secretion gets cool.

Tsushima RG.

Am J Physiol Endocrinol Metab. 2011 Dec;301(6):E1070-1. doi: 10.1152/ajpendo.00491.2011. Epub 2011 Sep 20. No abstract available.

4.

Nutrient responsive nesfatin-1 regulates energy balance and induces glucose-stimulated insulin secretion in rats.

Gonzalez R, Perry RL, Gao X, Gaidhu MP, Tsushima RG, Ceddia RB, Unniappan S.

Endocrinology. 2011 Oct;152(10):3628-37. doi: 10.1210/en.2010-1471. Epub 2011 Aug 9.

PMID:
21828181
5.

Trafficking defect and proteasomal degradation contribute to the phenotype of a novel KCNH2 long QT syndrome mutation.

Mihic A, Chauhan VS, Gao X, Oudit GY, Tsushima RG.

PLoS One. 2011 Mar 31;6(3):e18273. doi: 10.1371/journal.pone.0018273.

6.

Nesfatin-1 exerts a direct, glucose-dependent insulinotropic action on mouse islet β- and MIN6 cells.

Gonzalez R, Reingold BK, Gao X, Gaidhu MP, Tsushima RG, Unniappan S.

J Endocrinol. 2011 Mar;208(3):R9-R16. doi: 10.1530/JOE-10-0492. Epub 2011 Jan 11.

PMID:
21224288
7.

ATP modulates interaction of syntaxin-1A with sulfonylurea receptor 1 to regulate pancreatic beta-cell KATP channels.

Kang Y, Zhang Y, Liang T, Leung YM, Ng B, Xie H, Chang N, Chan J, Shyng SL, Tsushima RG, Gaisano HY.

J Biol Chem. 2011 Feb 18;286(7):5876-83. doi: 10.1074/jbc.M109.089607. Epub 2010 Dec 20.

8.

SNARE protein regulation of cardiac potassium channels and atrial natriuretic factor secretion.

Chao CC, Mihic A, Tsushima RG, Gaisano HY.

J Mol Cell Cardiol. 2011 Mar;50(3):401-7. doi: 10.1016/j.yjmcc.2010.11.018. Epub 2010 Nov 30. Review.

PMID:
21129378
9.

Role of phosphoinositide 3-kinase {alpha}, protein kinase C, and L-type Ca2+ channels in mediating the complex actions of angiotensin II on mouse cardiac contractility.

Liang W, Oudit GY, Patel MM, Shah AM, Woodgett JR, Tsushima RG, Ward ME, Backx PH.

Hypertension. 2010 Sep;56(3):422-9. doi: 10.1161/HYPERTENSIONAHA.109.149344. Epub 2010 Aug 9.

10.

Phosphatidylinositol 3-kinase gamma is a critical mediator of myocardial ischemic and adenosine-mediated preconditioning.

Ban K, Cooper AJ, Samuel S, Bhatti A, Patel M, Izumo S, Penninger JM, Backx PH, Oudit GY, Tsushima RG.

Circ Res. 2008 Sep 12;103(6):643-53. doi: 10.1161/CIRCRESAHA.108.175018. Epub 2008 Aug 7.

PMID:
18688045
11.

Inhibition of cholesterol biosynthesis impairs insulin secretion and voltage-gated calcium channel function in pancreatic beta-cells.

Xia F, Xie L, Mihic A, Gao X, Chen Y, Gaisano HY, Tsushima RG.

Endocrinology. 2008 Oct;149(10):5136-45. doi: 10.1210/en.2008-0161. Epub 2008 Jul 3.

PMID:
18599549
12.

Botulinum neurotoxin A and neurotoxin E cleavage products of synaptosome-associated protein of 25 kd exhibit distinct actions on pancreatic islet beta-cell Kv2.1 channel gating.

He Y, Elias CL, Huang YC, Gao X, Leung YM, Kang Y, Xie H, Chaddock JA, Tsushima RG, Gaisano HY.

Pancreas. 2008 Jan;36(1):10-7. doi: 10.1097/mpa.0b013e31812eee28.

PMID:
18192874
13.

Interaction of syntaxin 1A with the N-terminus of Kv4.2 modulates channel surface expression and gating.

Yamakawa T, Saith S, Li Y, Gao X, Gaisano HY, Tsushima RG.

Biochemistry. 2007 Sep 25;46(38):10942-9. Epub 2007 Aug 29.

PMID:
17725325
14.

Angiotensin II-mediated oxidative stress and inflammation mediate the age-dependent cardiomyopathy in ACE2 null mice.

Oudit GY, Kassiri Z, Patel MP, Chappell M, Butany J, Backx PH, Tsushima RG, Scholey JW, Khokha R, Penninger JM.

Cardiovasc Res. 2007 Jul 1;75(1):29-39. Epub 2007 Apr 21.

PMID:
17499227
15.

Targeting of voltage-gated K+ and Ca2+ channels and soluble N-ethylmaleimide-sensitive factor attachment protein receptor proteins to cholesterol-rich lipid rafts in pancreatic alpha-cells: effects on glucagon stimulus-secretion coupling.

Xia F, Leung YM, Gaisano G, Gao X, Chen Y, Fox JE, Bhattacharjee A, Wheeler MB, Gaisano HY, Tsushima RG.

Endocrinology. 2007 May;148(5):2157-67. Epub 2007 Feb 15.

PMID:
17303668
16.

Distinct modulation of Kv1.2 channel gating by wild type, but not open form, of syntaxin-1A.

Neshatian L, Leung YM, Kang Y, Gao X, Xie H, Tsushima RG, Gaisano HY, Diamant NE.

Am J Physiol Gastrointest Liver Physiol. 2007 May;292(5):G1233-42. Epub 2007 Jan 18.

17.

Hyperpolarization-activated cyclic nucleotide-gated channels in pancreatic beta-cells.

El-Kholy W, MacDonald PE, Fox JM, Bhattacharjee A, Xue T, Gao X, Zhang Y, Stieber J, Li RA, Tsushima RG, Wheeler MB.

Mol Endocrinol. 2007 Mar;21(3):753-64. Epub 2006 Dec 7.

PMID:
17158221
18.

Two populations of pancreatic islet alpha-cells displaying distinct Ca2+ channel properties.

Leung YM, Ahmed I, Sheu L, Tsushima RG, Diamant NE, Gaisano HY.

Biochem Biophys Res Commun. 2006 Jun 23;345(1):340-4. Epub 2006 Apr 25.

PMID:
16678791
19.

Syntaxin-1A actions on sulfonylurea receptor 2A can block acidic pH-induced cardiac K(ATP) channel activation.

Kang Y, Ng B, Leung YM, He Y, Xie H, Lodwick D, Norman RI, Tinker A, Tsushima RG, Gaisano HY.

J Biol Chem. 2006 Jul 14;281(28):19019-28. Epub 2006 May 3.

20.

Modulation of Kv2.1 channel gating and TEA sensitivity by distinct domains of SNAP-25.

He Y, Kang Y, Leung YM, Xia F, Gao X, Xie H, Gaisano HY, Tsushima RG.

Biochem J. 2006 Jun 1;396(2):363-9.

21.

Insulin regulates islet alpha-cell function by reducing KATP channel sensitivity to adenosine 5'-triphosphate inhibition.

Leung YM, Ahmed I, Sheu L, Gao X, Hara M, Tsushima RG, Diamant NE, Gaisano HY.

Endocrinology. 2006 May;147(5):2155-62. Epub 2006 Feb 2.

PMID:
16455778
22.

Transgenic mouse overexpressing syntaxin-1A as a diabetes model.

Lam PP, Leung YM, Sheu L, Ellis J, Tsushima RG, Osborne LR, Gaisano HY.

Diabetes. 2005 Sep;54(9):2744-54.

23.

Electrophysiological characterization of pancreatic islet cells in the mouse insulin promoter-green fluorescent protein mouse.

Leung YM, Ahmed I, Sheu L, Tsushima RG, Diamant NE, Hara M, Gaisano HY.

Endocrinology. 2005 Nov;146(11):4766-75. Epub 2005 Aug 18.

PMID:
16109783
24.

Cloning and characterization of a family C orphan G-protein coupled receptor.

Kuang D, Yao Y, Lam J, Tsushima RG, Hampson DR.

J Neurochem. 2005 Apr;93(2):383-91.

25.

A multifunctional aromatic residue in the external pore vestibule of Na+ channels contributes to the local anesthetic receptor.

Tsang SY, Tsushima RG, Tomaselli GF, Li RA, Backx PH.

Mol Pharmacol. 2005 Feb;67(2):424-34.

PMID:
15659774
26.

Open form of syntaxin-1A is a more potent inhibitor than wild-type syntaxin-1A of Kv2.1 channels.

Leung YM, Kang Y, Xia F, Sheu L, Gao X, Xie H, Tsushima RG, Gaisano HY.

Biochem J. 2005 Apr 1;387(Pt 1):195-202.

27.

H3 domain of syntaxin 1A inhibits KATP channels by its actions on the sulfonylurea receptor 1 nucleotide-binding folds-1 and -2.

Cui N, Kang Y, He Y, Leung YM, Xie H, Pasyk EA, Gao X, Sheu L, Hansen JB, Wahl P, Tsushima RG, Gaisano HY.

J Biol Chem. 2004 Dec 17;279(51):53259-65. Epub 2004 Oct 13.

28.

Syntaxin-1A inhibits cardiac KATP channels by its actions on nucleotide binding folds 1 and 2 of sulfonylurea receptor 2A.

Kang Y, Leung YM, Manning-Fox JE, Xia F, Xie H, Sheu L, Tsushima RG, Light PE, Gaisano HY.

J Biol Chem. 2004 Nov 5;279(45):47125-31. Epub 2004 Aug 31.

29.

Disruption of pancreatic beta-cell lipid rafts modifies Kv2.1 channel gating and insulin exocytosis.

Xia F, Gao X, Kwan E, Lam PP, Chan L, Sy K, Sheu L, Wheeler MB, Gaisano HY, Tsushima RG.

J Biol Chem. 2004 Jun 4;279(23):24685-91. Epub 2004 Apr 8.

30.

Antagonism of rat beta-cell voltage-dependent K+ currents by exendin 4 requires dual activation of the cAMP/protein kinase A and phosphatidylinositol 3-kinase signaling pathways.

MacDonald PE, Wang X, Xia F, El-kholy W, Targonsky ED, Tsushima RG, Wheeler MB.

J Biol Chem. 2003 Dec 26;278(52):52446-53. Epub 2003 Oct 16.

31.

Syntaxin 1A binds to the cytoplasmic C terminus of Kv2.1 to regulate channel gating and trafficking.

Leung YM, Kang Y, Gao X, Xia F, Xie H, Sheu L, Tsuk S, Lotan I, Tsushima RG, Gaisano HY.

J Biol Chem. 2003 May 9;278(19):17532-8. Epub 2003 Mar 5.

32.

The phosphatidylinositol 3-kinase inhibitor LY294002 potently blocks K(V) currents via a direct mechanism.

El-Kholy W, Macdonald PE, Lin JH, Wang J, Fox JM, Light PE, Wang Q, Tsushima RG, Wheeler MB.

FASEB J. 2003 Apr;17(6):720-2. Epub 2003 Feb 5.

PMID:
12586735
33.

Inhibition of Kv2.1 voltage-dependent K+ channels in pancreatic beta-cells enhances glucose-dependent insulin secretion.

MacDonald PE, Sewing S, Wang J, Joseph JW, Smukler SR, Sakellaropoulos G, Wang J, Saleh MC, Chan CB, Tsushima RG, Salapatek AM, Wheeler MB.

J Biol Chem. 2002 Nov 22;277(47):44938-45. Epub 2002 Sep 20.

34.

Subconductance activity induced by quinidine and quinidinium in purified cardiac sarcoplasmic reticulum calcium release channels.

Tsushima RG, Kelly JE, Wasserstrom JA.

J Pharmacol Exp Ther. 2002 May;301(2):729-37.

PMID:
11961079
35.

Syntaxin-3 and syntaxin-1A inhibit L-type calcium channel activity, insulin biosynthesis and exocytosis in beta-cell lines.

Kang Y, Huang X, Pasyk EA, Ji J, Holz GG, Wheeler MB, Tsushima RG, Gaisano HY.

Diabetologia. 2002 Feb;45(2):231-41.

36.

Activation of cardiac ryanodine receptors by cardiac glycosides.

Sagawa T, Sagawa K, Kelly JE, Tsushima RG, Wasserstrom JA.

Am J Physiol Heart Circ Physiol. 2002 Mar;282(3):H1118-26.

37.

Increased uncoupling protein-2 levels in beta-cells are associated with impaired glucose-stimulated insulin secretion: mechanism of action.

Chan CB, De Leo D, Joseph JW, McQuaid TS, Ha XF, Xu F, Tsushima RG, Pennefather PS, Salapatek AM, Wheeler MB.

Diabetes. 2001 Jun;50(6):1302-10.

38.

Two critical cysteine residues implicated in disulfide bond formation and proper folding of Kir2.1.

Cho HC, Tsushima RG, Nguyen TT, Guy HR, Backx PH.

Biochemistry. 2000 Apr 25;39(16):4649-57.

PMID:
10769120
39.

Modification of cardiac Na(+) current by RWJ 24517 and its enantiomers in guinea pig ventricular myocytes.

Tsushima RG, Kelly JE, Salata JJ, Liberty KN, Wasserstrom JA.

J Pharmacol Exp Ther. 1999 Nov;291(2):845-55.

PMID:
10525108
40.

Local anesthetic anchoring to cardiac sodium channels. Implications into tissue-selective drug targeting.

Li RA, Tsushima RG, Himmeldirk K, Dime DS, Backx PH.

Circ Res. 1999 Jul 9;85(1):88-98.

PMID:
10400914
41.

Modulation of iron uptake in heart by L-type Ca2+ channel modifiers: possible implications in iron overload.

Tsushima RG, Wickenden AD, Bouchard RA, Oudit GY, Liu PP, Backx PH.

Circ Res. 1999 Jun 11;84(11):1302-9.

PMID:
10364568
42.

Effect of Cd2+ on Kv4.2 and Kv1.4 expressed in Xenopus oocytes and on the transient outward currents in rat and rabbit ventricular myocytes.

Wickenden AD, Tsushima RG, Losito VA, Kaprielian R, Backx PH.

Cell Physiol Biochem. 1999;9(1):11-28.

43.
44.

Inactivated state dependence of sodium channel modulation by beta-scorpion toxin.

Tsushima RG, Borges A, Backx PH.

Pflugers Arch. 1999 Apr;437(5):661-8.

PMID:
10087142
45.

Effects of local anesthetics on Na+ channels containing the equine hyperkalemic periodic paralysis mutation.

Sah RL, Tsushima RG, Backx PH.

Am J Physiol. 1998 Aug;275(2):C389-400. doi: 10.1152/ajpcell.1998.275.2.C389.

PMID:
9688593
46.

Preferential regulation of rabbit cardiac L-type Ca2+ current by glycolytic derived ATP via a direct allosteric pathway.

Losito VA, Tsushima RG, Diaz RJ, Wilson GJ, Backx PH.

J Physiol. 1998 Aug 15;511 ( Pt 1):67-78.

47.
48.
49.
50.

The equine periodic paralysis Na+ channel mutation alters molecular transitions between the open and inactivated states.

Hanna WJ, Tsushima RG, Sah R, McCutcheon LJ, Marban E, Backx PH.

J Physiol. 1996 Dec 1;497 ( Pt 2):349-64.

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