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Items: 1 to 50 of 349

1.

Tissue-specific autoimmunity controlled by Aire in thymic and peripheral tolerance mechanism.

Matsumoto M, Tsuneyama K, Morimoto J, Hosomichi K, Matsumoto M, Nishijima H.

Int Immunol. 2019 Oct 5. pii: dxz066. doi: 10.1093/intimm/dxz066. [Epub ahead of print]

PMID:
31586207
2.

Dietary fat, cholesterol, and cholic acid affect the histopathologic severity of nonalcoholic steatohepatitis in Sprague-Dawley rats.

Fukuda A, Sasao M, Asakawa E, Narita S, Hisano M, Suruga K, Ichimura M, Tsuneyama K, Tanaka K, Omagari K.

Pathol Res Pract. 2019 Aug 26:152599. doi: 10.1016/j.prp.2019.152599. [Epub ahead of print]

PMID:
31564568
3.

The challenges of primary biliary cholangitis: What is new and what needs to be done.

Terziroli Beretta-Piccoli B, Mieli-Vergani G, Vergani D, Vierling JM, Adams D, Alpini G, Banales JM, Beuers U, Björnsson E, Bowlus C, Carbone M, Chazouillères O, Dalekos G, De Gottardi A, Harada K, Hirschfield G, Invernizzi P, Jones D, Krawitt E, Lanzavecchia A, Lian ZX, Ma X, Manns M, Mavilio D, Quigley EM, Sallusto F, Shimoda S, Strazzabosco M, Swain M, Tanaka A, Trauner M, Tsuneyama K, Zigmond E, Gershwin ME.

J Autoimmun. 2019 Sep 20:102328. doi: 10.1016/j.jaut.2019.102328. [Epub ahead of print] Review.

PMID:
31548157
4.

Age-Related Alterations of Nonalcoholic Steatohepatitis in Sprague-Dawley Rats Fed a High-Fat and High-Cholesterol Diet.

Omagari K, Asakawa E, Sasao M, Narita S, Hisano M, Fukuda A, Suruga K, Ichimura M, Tsuneyama K.

J Nutr Sci Vitaminol (Tokyo). 2019;65(4):349-356. doi: 10.3177/jnsv.65.349.

5.

Two cases of non-mucinous cystadenomas of the pancreas with pancreatobiliary phenotype and ovarian-like stroma.

Yamashita S, Ikemoto T, Morine Y, Imura S, Iwahashi S, Saito Y, Yamada S, Yoshimoto T, Tsuneyama K, Shimada M.

Surg Case Rep. 2019 Jul 23;5(1):117. doi: 10.1186/s40792-019-0673-y.

6.

Establishment of a mouse model of troglitazone-induced liver injury and analysis of its hepatotoxic mechanism.

Jia R, Oda S, Tsuneyama K, Urano Y, Yokoi T.

J Appl Toxicol. 2019 Jul 11. doi: 10.1002/jat.3838. [Epub ahead of print]

PMID:
31294483
7.

Inhibition of EP2/EP4 prostanoid receptor-mediated signaling suppresses IGF-1-induced proliferation of pancreatic cancer BxPC-3 cells via upregulating γ-glutamyl cyclotransferase expression.

Takahashi T, Ichikawa H, Morimoto Y, Tsuneyama K, Hijikata T.

Biochem Biophys Res Commun. 2019 Aug 20;516(2):388-396. doi: 10.1016/j.bbrc.2019.06.054. Epub 2019 Jun 16.

PMID:
31217077
8.

Analysis of amino acid profiles of blood over time and biomarkers associated with non-alcoholic steatohepatitis in STAM mice.

Iida A, Kuranuki S, Yamamoto R, Uchida M, Ohta M, Ichimura M, Tsuneyama K, Masaki T, Seike M, Nakamura T.

Exp Anim. 2019 Jun 1. doi: 10.1538/expanim.18-0152. [Epub ahead of print]

9.

Experimental Evidence of Liver Injury by BSEP-Inhibiting Drugs With a Bile Salt Supplementation in Rats.

Yang F, Takeuchi T, Tsuneyama K, Yokoi T, Oda S.

Toxicol Sci. 2019 Jul 1;170(1):95-108. doi: 10.1093/toxsci/kfz088.

PMID:
30985903
10.

Macrophage-specific hypoxia-inducible factor-1α deletion suppresses the development of liver tumors in high-fat diet-fed obese and diabetic mice.

Takikawa A, Usui I, Fujisaka S, Tsuneyama K, Okabe K, Nakagawa T, Nawaz A, Kado T, Jojima T, Aso Y, Hayakawa Y, Yagi K, Tobe K.

J Diabetes Investig. 2019 Mar 21. doi: 10.1111/jdi.13047. [Epub ahead of print]

11.

Apolipoprotein M suppresses the phenotypes of IgA nephropathy in hyper-IgA mice.

Kurano M, Tsuneyama K, Morimoto Y, Nishikawa M, Yatomi Y.

FASEB J. 2019 Apr;33(4):5181-5195. doi: 10.1096/fj.201801748R. Epub 2019 Jan 10.

PMID:
30629456
12.

Anti-drug Antibodies Against a Novel Humanized Anti-CD20 Antibody Impair Its Therapeutic Effect on Primary Biliary Cholangitis in Human CD20- and FcγR-Expressing Mice.

Moritoki Y, Tsuneyama K, Nakamura Y, Kikuchi K, Shiota A, Ohsugi Y, Lian ZX, Zhang W, Yang GX, Ueki S, Takeda M, Omokawa A, Saga T, Saga A, Watanabe D, Miura M, Ueno Y, Leung PSC, Tanaka A, Gershwin ME, Hirokawa M.

Front Immunol. 2018 Nov 2;9:2534. doi: 10.3389/fimmu.2018.02534. eCollection 2018.

13.

Aire Controls in Trans the Production of Medullary Thymic Epithelial Cells Expressing Ly-6C/Ly-6G.

Morimoto J, Nishikawa Y, Kakimoto T, Furutani K, Kihara N, Matsumoto M, Tsuneyama K, Kozono Y, Kozono H, Hozumi K, Hosomichi K, Nishijima H, Matsumoto M.

J Immunol. 2018 Dec 1;201(11):3244-3257. doi: 10.4049/jimmunol.1800950. Epub 2018 Nov 2.

PMID:
30389776
14.

Effect of coffee or coffee components on gut microbiome and short-chain fatty acids in a mouse model of metabolic syndrome.

Nishitsuji K, Watanabe S, Xiao J, Nagatomo R, Ogawa H, Tsunematsu T, Umemoto H, Morimoto Y, Akatsu H, Inoue K, Tsuneyama K.

Sci Rep. 2018 Nov 1;8(1):16173. doi: 10.1038/s41598-018-34571-9.

15.

Gut microbiota translocation promotes autoimmune cholangitis.

Ma HD, Zhao ZB, Ma WT, Liu QZ, Gao CY, Li L, Wang J, Tsuneyama K, Liu B, Zhang W, Zhou Y, Gershwin ME, Lian ZX.

J Autoimmun. 2018 Dec;95:47-57. doi: 10.1016/j.jaut.2018.09.010. Epub 2018 Oct 17.

PMID:
30340822
16.

Development of a novel aortic dissection mouse model and evaluation of drug efficacy using in-vivo assays and database analyses.

Izawa-Ishizawa Y, Imanishi M, Zamami Y, Toya H, Nagao T, Morishita M, Tsuneyama K, Horinouchi Y, Kihira Y, Takechi K, Ikeda Y, Tsuchiya K, Yoshizumi M, Tamaki T, Ishizawa K.

J Hypertens. 2019 Jan;37(1):73-83. doi: 10.1097/HJH.0000000000001898.

PMID:
30303488
17.

Comparative hepatic transcriptome analyses revealed possible pathogenic mechanisms of fasiglifam (TAK-875)-induced acute liver injury in mice.

Urano Y, Oda S, Tsuneyama K, Yokoi T.

Chem Biol Interact. 2018 Dec 25;296:185-197. doi: 10.1016/j.cbi.2018.09.011. Epub 2018 Sep 20.

PMID:
30243991
18.

Neutrophils induce smooth muscle hyperplasia via neutrophil elastase-induced FGF-2 in a mouse model of asthma with mixed inflammation.

Ogawa H, Azuma M, Tsunematsu T, Morimoto Y, Kondo M, Tezuka T, Nishioka Y, Tsuneyama K.

Clin Exp Allergy. 2018 Dec;48(12):1715-1725. doi: 10.1111/cea.13263. Epub 2018 Sep 24.

PMID:
30171733
19.

Detection of aberrant crypt foci with image-enhanced endoscopy.

Kagemoto K, Okamoto K, Takaoka T, Sato Y, Kitamura S, Kimura T, Sogabe M, Miyamoto H, Muguruma N, Tsuneyama K, Takayama T.

Endosc Int Open. 2018 Aug;6(8):E924-E933. doi: 10.1055/a-0621-8794. Epub 2018 Aug 1.

20.

A case of pulmonary pleomorphic carcinoma with malignant phenotypes induced by ZEB1-associated epithelial-mesenchymal transition.

Kondo M, Ogino H, Ogawa H, Afroj T, Toyoda Y, Sakaguchi S, Tsuboi M, Bando Y, Goto H, Tsuneyama K, Nishioka Y.

Respir Med Case Rep. 2018 Aug 3;25:119-121. doi: 10.1016/j.rmcr.2018.07.008. eCollection 2018.

21.

Application of 2-Picolylamine Derivatized Ultra-high Performance Liquid Chromatography Tandem Mass Spectrometry for the Determination of Short-chain Fatty Acids in Feces Samples.

Nagatomo R, Okada Y, Ichimura M, Tsuneyama K, Inoue K.

Anal Sci. 2018 Sep 10;34(9):1031-1036. doi: 10.2116/analsci.18SCP10. Epub 2018 Aug 3.

22.

A fermented mixed tea made with camellia (Camellia japonica) and third-crop green tea leaves prevents nonalcoholic steatohepatitis in Sprague-Dawley rats fed a high-fat and high-cholesterol diet.

Omagari K, Suruga K, Kyogoku A, Nakamura S, Sakamoto A, Nishioka S, Ichimura M, Miyata Y, Tajima K, Tsuneyama K, Tanaka K.

Hepatobiliary Surg Nutr. 2018 Jun;7(3):175-184. doi: 10.21037/hbsn.2017.08.03.

23.

Tissue-Resident Memory CD8+ T Cells Acting as Mediators of Salivary Gland Damage in a Murine Model of Sjögren's Syndrome.

Gao CY, Yao Y, Li L, Yang SH, Chu H, Tsuneyama K, Li XM, Gershwin ME, Lian ZX.

Arthritis Rheumatol. 2019 Jan;71(1):121-132. doi: 10.1002/art.40676. Epub 2018 Dec 4.

PMID:
30035379
24.

Comprehensive analysis of serum microRNAs in hepatic sinusoidal obstruction syndrome (SOS) in rats: implication as early phase biomarkers for SOS.

Takeuchi M, Oda S, Tsuneyama K, Yokoi T.

Arch Toxicol. 2018 Sep;92(9):2947-2962. doi: 10.1007/s00204-018-2269-x. Epub 2018 Jul 17.

PMID:
30019166
25.

A Novel Theranostic Combination of Near-infrared Fluorescence Imaging and Laser Irradiation Targeting c-KIT for Gastrointestinal Stromal Tumors.

Fujimoto S, Muguruma N, Okamoto K, Kurihara T, Sato Y, Miyamoto Y, Kitamura S, Miyamoto H, Taguchi T, Tsuneyama K, Takayama T.

Theranostics. 2018 Mar 21;8(9):2313-2328. doi: 10.7150/thno.22027. eCollection 2018.

26.

Establishment of a drug-induced rhabdomyolysis mouse model by co-administration of ciprofloxacin and atorvastatin.

Matsubara A, Oda S, Akai S, Tsuneyama K, Yokoi T.

Toxicol Lett. 2018 Jul;291:184-193. doi: 10.1016/j.toxlet.2018.04.016. Epub 2018 Apr 18.

PMID:
29679711
27.

Apolipoprotein M Protects Lipopolysaccharide-Treated Mice from Death and Organ Injury.

Kurano M, Tsuneyama K, Morimoto Y, Shimizu T, Jona M, Kassai H, Nakao K, Aiba A, Yatomi Y.

Thromb Haemost. 2018 Jun;118(6):1021-1035. doi: 10.1055/s-0038-1641750. Epub 2018 Apr 18.

PMID:
29669385
28.

Tsumura-Suzuki obese diabetic mice-derived hepatic tumors closely resemble human hepatocellular carcinomas in metabolism-related genes expression and bile acid accumulation.

Takahashi T, Deuschle U, Taira S, Nishida T, Fujimoto M, Hijikata T, Tsuneyama K.

Hepatol Int. 2018 May;12(3):254-261. doi: 10.1007/s12072-018-9860-3. Epub 2018 Apr 12.

PMID:
29651702
29.

A Patient with Non-alcoholic Steatohepatitis Complicated by Multiple Myeloma.

Akashi M, Tajiri K, Wada A, Tsuneyama K, Kawai K, Yasumura S, Minemura M, Takahara T, Sugiyama T.

Intern Med. 2018 Jul 15;57(14):2013-2018. doi: 10.2169/internalmedicine.0092-17. Epub 2018 Feb 28.

30.

Clinical features of autoimmune hepatitis with acute presentation: a Japanese nationwide survey.

Joshita S, Yoshizawa K, Umemura T, Ohira H, Takahashi A, Harada K, Hiep NC, Tsuneyama K, Kage M, Nakano M, Kang JH, Koike K, Zeniya M, Yasunaka T, Takaki A, Torimura T, Abe M, Yokosuka O, Tanaka A, Takikawa H; Japan Autoimmune Hepatitis Study Group (JAIHSG).

J Gastroenterol. 2018 Sep;53(9):1079-1088. doi: 10.1007/s00535-018-1444-4. Epub 2018 Feb 23.

PMID:
29476251
31.

miRNA in Rat Liver Sinusoidal Endothelial Cells and Hepatocytes and Application to Circulating Biomarkers that Discern Pathogenesis of Liver Injuries.

Oda S, Takeuchi M, Akai S, Shirai Y, Tsuneyama K, Yokoi T.

Am J Pathol. 2018 Apr;188(4):916-928. doi: 10.1016/j.ajpath.2017.12.007. Epub 2018 Jan 31.

PMID:
29353062
32.

Analysis of the gut microbiome and plasma short-chain fatty acid profiles in a spontaneous mouse model of metabolic syndrome.

Nishitsuji K, Xiao J, Nagatomo R, Umemoto H, Morimoto Y, Akatsu H, Inoue K, Tsuneyama K.

Sci Rep. 2017 Nov 20;7(1):15876. doi: 10.1038/s41598-017-16189-5.

33.

Neutrophil depletion protects against zomepirac-induced acute kidney injury in mice.

Yamashita S, Oda S, Endo H, Tsuneyama K, Yokoi T.

Chem Biol Interact. 2018 Jan 5;279:102-110. doi: 10.1016/j.cbi.2017.11.011. Epub 2017 Nov 14.

PMID:
29154782
34.

Mode of Tolerance Induction and Requirement for Aire Are Governed by the Cell Types That Express Self-Antigen and Those That Present Antigen.

Mouri Y, Ueda Y, Yamano T, Matsumoto M, Tsuneyama K, Kinashi T, Matsumoto M.

J Immunol. 2017 Dec 15;199(12):3959-3971. doi: 10.4049/jimmunol.1700892. Epub 2017 Nov 3.

35.

Clinicopathological Study of Autoimmune Hepatitis Cases That Were Difficult to Differentiate from Drug-Induced Liver Injury.

Tsutsui A, Harada K, Tsuneyama K, Senoh T, Nagano T, Takaguchi K, Ando M, Nakamura S, Mizobuchi K, Kudo M.

Dig Dis. 2017;35(6):506-514. doi: 10.1159/000480139. Epub 2017 Oct 17.

PMID:
29040982
36.

Animal models for analyzing metabolic syndrome-associated liver diseases.

Tsuneyama K, Nishitsuji K, Matsumoto M, Kobayashi T, Morimoto Y, Tsunematsu T, Ogawa H.

Pathol Int. 2017 Nov;67(11):539-546. doi: 10.1111/pin.12600. Epub 2017 Oct 12. Review.

PMID:
29027308
37.

Paradoxical development of polymyositis-like autoimmunity through augmented expression of autoimmune regulator (AIRE).

Nishijima H, Kajimoto T, Matsuoka Y, Mouri Y, Morimoto J, Matsumoto M, Kawano H, Nishioka Y, Uehara H, Izumi K, Tsuneyama K, Okazaki IM, Okazaki T, Hosomichi K, Shiraki A, Shibutani M, Mitsumori K, Matsumoto M.

J Autoimmun. 2018 Jan;86:75-92. doi: 10.1016/j.jaut.2017.09.006. Epub 2017 Sep 18.

38.

The interplay of type I and type II interferons in murine autoimmune cholangitis as a basis for sex-biased autoimmunity.

Bae HR, Hodge DL, Yang GX, Leung PSC, Chodisetti SB, Valencia JC, Sanford M, Fenimore JM, Rahman ZSM, Tsuneyama K, Norman GL, Gershwin ME, Young HA.

Hepatology. 2018 Apr;67(4):1408-1419. doi: 10.1002/hep.29524. Epub 2018 Feb 18.

39.

Facilitatory effect of insulin treatment on hepatocellular carcinoma development in diabetes.

Baba H, Kurano M, Nishida T, Hatta H, Hokao R, Tsuneyama K.

BMC Res Notes. 2017 Sep 13;10(1):478. doi: 10.1186/s13104-017-2783-6.

40.

CD206+ M2-like macrophages regulate systemic glucose metabolism by inhibiting proliferation of adipocyte progenitors.

Nawaz A, Aminuddin A, Kado T, Takikawa A, Yamamoto S, Tsuneyama K, Igarashi Y, Ikutani M, Nishida Y, Nagai Y, Takatsu K, Imura J, Sasahara M, Okazaki Y, Ueki K, Okamura T, Tokuyama K, Ando A, Matsumoto M, Mori H, Nakagawa T, Kobayashi N, Saeki K, Usui I, Fujisaka S, Tobe K.

Nat Commun. 2017 Aug 18;8(1):286. doi: 10.1038/s41467-017-00231-1.

41.

Fructo-oligosaccharides and intestinal barrier function in a methionine-choline-deficient mouse model of nonalcoholic steatohepatitis.

Matsumoto K, Ichimura M, Tsuneyama K, Moritoki Y, Tsunashima H, Omagari K, Hara M, Yasuda I, Miyakawa H, Kikuchi K.

PLoS One. 2017 Jun 20;12(6):e0175406. doi: 10.1371/journal.pone.0175406. eCollection 2017.

42.

Ovarian Large Cell Neuroendocrine Carcinoma Associated with Serous Carcinoma: Correlation of Pathology with MR Imaging.

Takeuchi M, Matsuzaki K, Tsuneyama K, Nishimura M, Takiguchi E, Harada M.

Magn Reson Med Sci. 2017 Oct 10;16(4):273-274. doi: 10.2463/mrms.ci.2016-0150. Epub 2017 May 31. No abstract available.

43.

Peritumoral Hyperplasia in Hepatic Sclerosed Hemangioma.

Shimada S, Tajiri K, Baba H, Minemura M, Tsuneyama K, Nakano M, Sugiyama T.

ACG Case Rep J. 2017 Apr 26;4:e61. doi: 10.14309/crj.2017.61. eCollection 2017.

44.

Acute presentation of autoimmune hepatitis: a multicentre study with detailed histological evaluation in a large cohort of patients.

Nguyen Canh H, Harada K, Ouchi H, Sato Y, Tsuneyama K, Kage M, Nakano M, Yoshizawa K, Takahashi A, Abe M, Kang JH, Koike K, Inui A, Fujisawa T, Takaki A, Arinaga-Hino T, Torimura T, Suzuki Y, Fujiwara K, Zeniya M, Ohira H, Tanaka A, Takikawa H; Intractable Liver and Biliary Diseases Study Group of Japan.

J Clin Pathol. 2017 Nov;70(11):961-969. doi: 10.1136/jclinpath-2016-204271. Epub 2017 Apr 20.

PMID:
28428284
45.

Prolonged activation of IL-5-producing ILC2 causes pulmonary arterial hypertrophy.

Ikutani M, Tsuneyama K, Kawaguchi M, Fukuoka J, Kudo F, Nakae S, Arita M, Nagai Y, Takaki S, Takatsu K.

JCI Insight. 2017 Apr 6;2(7):e90721. doi: 10.1172/jci.insight.90721.

46.

Primary Biliary Cholangitis: Its Pathological Characteristics and Immunopathological Mechanisms.

Tsuneyama K, Baba H, Morimoto Y, Tsunematsu T, Ogawa H.

J Med Invest. 2017;64(1.2):7-13. doi: 10.2152/jmi.64.7. Review.

47.

Daily Coffee Intake Inhibits Pancreatic Beta Cell Damage and Nonalcoholic Steatohepatitis in a Mouse Model of Spontaneous Metabolic Syndrome, Tsumura-Suzuki Obese Diabetic Mice.

Watanabe S, Takahashi T, Ogawa H, Uehara H, Tsunematsu T, Baba H, Morimoto Y, Tsuneyama K.

Metab Syndr Relat Disord. 2017 May;15(4):170-177. doi: 10.1089/met.2016.0114. Epub 2017 Mar 30.

PMID:
28358620
48.

Human β-Defensin 2 in Primary Sclerosing Cholangitis.

Chang C, Lleo A, Kananurak A, Grizzi F, Tsuneyama K, Invernizzi P, Bevins CL, Bowlus CL.

Clin Transl Gastroenterol. 2017 Mar 16;8(3):e80. doi: 10.1038/ctg.2017.8.

49.

Establishment of a mouse model of enalapril-induced liver injury and investigation of the pathogenesis.

Shirai Y, Oda S, Makino S, Tsuneyama K, Yokoi T.

Lab Invest. 2017 Jul;97(7):833-842. doi: 10.1038/labinvest.2017.22. Epub 2017 Mar 6.

50.

Chemokine receptor CXCR3 deficiency exacerbates murine autoimmune cholangitis by promoting pathogenic CD8+ T cell activation.

Ma HD, Ma WT, Liu QZ, Zhao ZB, Liu MZ, Tsuneyama K, Gao JM, Ridgway WM, Ansari AA, Gershwin ME, Fei YY, Lian ZX.

J Autoimmun. 2017 Mar;78:19-28. doi: 10.1016/j.jaut.2016.12.012. Epub 2017 Jan 24.

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