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Items: 1 to 50 of 238

1.

Transgenic Archaerhodopsin-3 Expression in Hypocretin/Orexin Neurons Engenders Cellular Dysfunction and Features of Type 2 Narcolepsy.

Williams RH, Tsunematsu T, Thomas AM, Bogyo K, Yamanaka A, Kilduff TS.

J Neurosci. 2019 Nov 20;39(47):9435-9452. doi: 10.1523/JNEUROSCI.0311-19.2019. Epub 2019 Oct 18.

PMID:
31628177
2.

Achaete-Scute Homologue 2-Regulated Follicular Helper T Cells Promote Autoimmunity in a Murine Model for Sjögren Syndrome.

Otsuka K, Yamada A, Saito M, Ushio A, Sato M, Kisoda S, Shao W, Tsunematsu T, Kudo Y, Arakaki R, Ishimaru N.

Am J Pathol. 2019 Dec;189(12):2414-2427. doi: 10.1016/j.ajpath.2019.08.008. Epub 2019 Sep 17.

PMID:
31539517
3.

Comparison of anti-inflammatory effects of rivaroxaban vs. dabigatran in patients with non-valvular atrial fibrillation (RIVAL-AF study): multicenter randomized study.

Kikuchi S, Tsukahara K, Sakamaki K, Morita Y, Takamura T, Fukui K, Endo T, Shimizu M, Sawada R, Sugano T, Himeno H, Kobayashi S, Arakawa K, Mochida Y, Tsunematsu T, Shigemasa T, Okuda J, Ishikawa T, Kimura K, Tamura K.

Heart Vessels. 2019 Jun;34(6):1002-1013. doi: 10.1007/s00380-018-01324-7. Epub 2019 Jan 1.

PMID:
30599063
4.

CCL22-Producing Resident Macrophages Enhance T Cell Response in Sjögren's Syndrome.

Ushio A, Arakaki R, Otsuka K, Yamada A, Tsunematsu T, Kudo Y, Aota K, Azuma M, Ishimaru N.

Front Immunol. 2018 Nov 8;9:2594. doi: 10.3389/fimmu.2018.02594. eCollection 2018.

5.

Effect of coffee or coffee components on gut microbiome and short-chain fatty acids in a mouse model of metabolic syndrome.

Nishitsuji K, Watanabe S, Xiao J, Nagatomo R, Ogawa H, Tsunematsu T, Umemoto H, Morimoto Y, Akatsu H, Inoue K, Tsuneyama K.

Sci Rep. 2018 Nov 1;8(1):16173. doi: 10.1038/s41598-018-34571-9.

6.

Long-term polarization of alveolar macrophages to a profibrotic phenotype after inhalation exposure to multi-wall carbon nanotubes.

Otsuka K, Yamada K, Taquahashi Y, Arakaki R, Ushio A, Saito M, Yamada A, Tsunematsu T, Kudo Y, Kanno J, Ishimaru N.

PLoS One. 2018 Oct 29;13(10):e0205702. doi: 10.1371/journal.pone.0205702. eCollection 2018.

7.

Neutrophils induce smooth muscle hyperplasia via neutrophil elastase-induced FGF-2 in a mouse model of asthma with mixed inflammation.

Ogawa H, Azuma M, Tsunematsu T, Morimoto Y, Kondo M, Tezuka T, Nishioka Y, Tsuneyama K.

Clin Exp Allergy. 2018 Dec;48(12):1715-1725. doi: 10.1111/cea.13263. Epub 2018 Sep 24.

PMID:
30171733
8.

Invasion-Related Factors as Potential Diagnostic and Therapeutic Targets in Oral Squamous Cell Carcinoma-A Review.

Siriwardena SBSM, Tsunematsu T, Qi G, Ishimaru N, Kudo Y.

Int J Mol Sci. 2018 May 14;19(5). pii: E1462. doi: 10.3390/ijms19051462. Review.

9.

Preventive effects of mouthguard use while sleeping on recurrent aphthous stomatitis: Preliminary interventional study.

Tada H, Fujiwara N, Tsunematsu T, Tada Y, Arakaki R, Tamaki N, Ishimaru N, Kudo Y.

Clin Exp Dent Res. 2017 Oct 11;3(5):198-203. doi: 10.1002/cre2.88. eCollection 2017 Oct.

10.

The microRNA-15a-PAI-2 axis in cholangiocarcinoma-associated fibroblasts promotes migration of cancer cells.

Utaijaratrasmi P, Vaeteewoottacharn K, Tsunematsu T, Jamjantra P, Wongkham S, Pairojkul C, Khuntikeo N, Ishimaru N, Sirivatanauksorn Y, Pongpaibul A, Thuwajit P, Thuwajit C, Kudo Y.

Mol Cancer. 2018 Jan 18;17(1):10. doi: 10.1186/s12943-018-0760-x.

11.

Aurora Kinase Inhibitors in Head and Neck Cancer.

Qi G, Liu J, Mi S, Tsunematsu T, Jin S, Shao W, Liu T, Ishimaru N, Tang B, Kudo Y.

Curr Top Med Chem. 2018;18(3):199-213. doi: 10.2174/1568026618666180112163741. Review.

PMID:
29332580
12.

Animal models for analyzing metabolic syndrome-associated liver diseases.

Tsuneyama K, Nishitsuji K, Matsumoto M, Kobayashi T, Morimoto Y, Tsunematsu T, Ogawa H.

Pathol Int. 2017 Nov;67(11):539-546. doi: 10.1111/pin.12600. Epub 2017 Oct 12. Review.

PMID:
29027308
13.

Distinct Temporal Coordination of Spontaneous Population Activity between Basal Forebrain and Auditory Cortex.

Yague JG, Tsunematsu T, Sakata S.

Front Neural Circuits. 2017 Sep 14;11:64. doi: 10.3389/fncir.2017.00064. eCollection 2017.

14.

NF-κB2 Controls the Migratory Activity of Memory T Cells by Regulating Expression of CXCR4 in a Mouse Model of Sjögren's Syndrome.

Kurosawa M, Arakaki R, Yamada A, Tsunematsu T, Kudo Y, Sprent J, Ishimaru N.

Arthritis Rheumatol. 2017 Nov;69(11):2193-2202. doi: 10.1002/art.40230. Epub 2017 Oct 17.

15.

Establishment and characterization of a clear cell odontogenic carcinoma cell line with EWSR1-ATF1 fusion gene.

Kujiraoka S, Tsunematsu T, Sato Y, Yoshida M, Ishikawa A, Tohyama R, Tanaka M, Kobayashi Y, Kondo T, Ushio A, Otsuka K, Kurosawa M, Saito M, Yamada A, Arakaki R, Nagai H, Nikai H, Takeuchi K, Nagao T, Miyamoto Y, Ishimaru N, Kudo Y.

Oral Oncol. 2017 Jun;69:46-55. doi: 10.1016/j.oraloncology.2017.04.003. Epub 2017 Apr 10.

PMID:
28559020
16.

Primary Biliary Cholangitis: Its Pathological Characteristics and Immunopathological Mechanisms.

Tsuneyama K, Baba H, Morimoto Y, Tsunematsu T, Ogawa H.

J Med Invest. 2017;64(1.2):7-13. doi: 10.2152/jmi.64.7. Review.

17.

Daily Coffee Intake Inhibits Pancreatic Beta Cell Damage and Nonalcoholic Steatohepatitis in a Mouse Model of Spontaneous Metabolic Syndrome, Tsumura-Suzuki Obese Diabetic Mice.

Watanabe S, Takahashi T, Ogawa H, Uehara H, Tsunematsu T, Baba H, Morimoto Y, Tsuneyama K.

Metab Syndr Relat Disord. 2017 May;15(4):170-177. doi: 10.1089/met.2016.0114. Epub 2017 Mar 30.

PMID:
28358620
18.

A case of heparin-induced thrombocytopenia with subacute stent thrombosis, multiple cerebral infarction, and acute limb ischemia.

Suzuki H, Tsunematsu T, Takahashi H, Yasuda S, Gyotoku D, Miyajima K, Takahashi M, Umemura S, Kimura K.

J Cardiol Cases. 2017 Mar 7;15(5):145-149. doi: 10.1016/j.jccase.2016.12.013. eCollection 2017 May.

19.

Ameloblastin induces tumor suppressive phenotype and enhances chemosensitivity to doxorubicin via Src-Stat3 inactivation in osteosarcoma.

Ando T, Kudo Y, Iizuka S, Tsunematsu T, Umehara H, Shrestha M, Matsuo T, Kubo T, Shimose S, Arihiro K, Ogawa I, Ochi M, Takata T.

Sci Rep. 2017 Jan 5;7:40187. doi: 10.1038/srep40187.

20.

The Nuclear Receptor AhR Controls Bone Homeostasis by Regulating Osteoclast Differentiation via the RANK/c-Fos Signaling Axis.

Izawa T, Arakaki R, Mori H, Tsunematsu T, Kudo Y, Tanaka E, Ishimaru N.

J Immunol. 2016 Dec 15;197(12):4639-4650. Epub 2016 Nov 14.

21.

Oral environment and cancer.

Kudo Y, Tada H, Fujiwara N, Tada Y, Tsunematsu T, Miyake Y, Ishimaru N.

Genes Environ. 2016 Aug 1;38:13. doi: 10.1186/s41021-016-0042-z. eCollection 2016. Review.

22.

Human odontogenic epithelial cells derived from epithelial rests of Malassez possess stem cell properties.

Tsunematsu T, Fujiwara N, Yoshida M, Takayama Y, Kujiraoka S, Qi G, Kitagawa M, Kondo T, Yamada A, Arakaki R, Miyauchi M, Ogawa I, Abiko Y, Nikawa H, Murakami S, Takata T, Ishimaru N, Kudo Y.

Lab Invest. 2016 Oct;96(10):1063-75. doi: 10.1038/labinvest.2016.85. Epub 2016 Aug 1.

23.

Depth-specific optogenetic control in vivo with a scalable, high-density μLED neural probe.

Scharf R, Tsunematsu T, McAlinden N, Dawson MD, Sakata S, Mathieson K.

Sci Rep. 2016 Jun 23;6:28381. doi: 10.1038/srep28381.

24.

PARP6 acts as a tumor suppressor via downregulating Survivin expression in colorectal cancer.

Qi G, Kudo Y, Tang B, Liu T, Jin S, Liu J, Zuo X, Mi S, Shao W, Ma X, Tsunematsu T, Ishimaru N, Zeng S, Tatsuka M, Shimamoto F.

Oncotarget. 2016 Apr 5;7(14):18812-24. doi: 10.18632/oncotarget.7712.

25.

Role of regulatory T cell in the pathogenesis of inflammatory bowel disease.

Yamada A, Arakaki R, Saito M, Tsunematsu T, Kudo Y, Ishimaru N.

World J Gastroenterol. 2016 Feb 21;22(7):2195-205. doi: 10.3748/wjg.v22.i7.2195. Review.

26.

microRNA-203 suppresses invasion and epithelial-mesenchymal transition induction via targeting NUAK1 in head and neck cancer.

Obayashi M, Yoshida M, Tsunematsu T, Ogawa I, Sasahira T, Kuniyasu H, Imoto I, Abiko Y, Xu D, Fukunaga S, Tahara H, Kudo Y, Nagao T, Takata T.

Oncotarget. 2016 Feb 16;7(7):8223-39. doi: 10.18632/oncotarget.6972.

27.

Molecular Mechanisms of Nickel Allergy.

Saito M, Arakaki R, Yamada A, Tsunematsu T, Kudo Y, Ishimaru N.

Int J Mol Sci. 2016 Feb 2;17(2). pii: E202. doi: 10.3390/ijms17020202. Review.

28.

Acceleration of tumor growth due to dysfunction in M1 macrophages and enhanced angiogenesis in an animal model of autoimmune disease.

Kondo T, Tsunematsu T, Yamada A, Arakaki R, Saito M, Otsuka K, Kujiraoka S, Ushio A, Kurosawa M, Kudo Y, Ishimaru N.

Lab Invest. 2016 Apr;96(4):468-80. doi: 10.1038/labinvest.2015.166. Epub 2016 Jan 25.

29.

The Non-Canonical Role of Aurora-A in DNA Replication.

Tsunematsu T, Arakaki R, Yamada A, Ishimaru N, Kudo Y.

Front Oncol. 2015 Aug 25;5:187. doi: 10.3389/fonc.2015.00187. eCollection 2015. Review.

30.

Impaired expansion of regulatory T cells in a neonatal thymectomy-induced autoimmune mouse model.

Yamada A, Ushio A, Arakaki R, Tsunematsu T, Kudo Y, Hayashi Y, Ishimaru N.

Am J Pathol. 2015 Nov;185(11):2886-97. doi: 10.1016/j.ajpath.2015.07.007. Epub 2015 Sep 4.

PMID:
26343329
31.

Coupling of β1-adrenergic receptor to type 5 adenylyl cyclase and its physiological relevance in cardiac myocytes.

Tsunematsu T, Okumura S, Mototani Y, Ohnuki Y, Jin H, Cai W, Suita K, Sato I, Umemura M, Yokoyama U, Sato M, Fujita T, Ishikawa Y.

Biochem Biophys Res Commun. 2015 Mar 13;458(3):531-535. doi: 10.1016/j.bbrc.2015.01.149. Epub 2015 Feb 9.

PMID:
25677623
32.

Aromatase controls Sjögren syndrome-like lesions through monocyte chemotactic protein-1 in target organ and adipose tissue-associated macrophages.

Iwasa A, Arakaki R, Honma N, Ushio A, Yamada A, Kondo T, Kurosawa E, Kujiraoka S, Tsunematsu T, Kudo Y, Tanaka E, Yoshimura N, Harada N, Hayashi Y, Ishimaru N.

Am J Pathol. 2015 Jan;185(1):151-61. doi: 10.1016/j.ajpath.2014.09.006. Epub 2014 Oct 31.

PMID:
25447050
33.

Concurrent and robust regulation of feeding behaviors and metabolism by orexin neurons.

Inutsuka A, Inui A, Tabuchi S, Tsunematsu T, Lazarus M, Yamanaka A.

Neuropharmacology. 2014 Oct;85:451-60. doi: 10.1016/j.neuropharm.2014.06.015. Epub 2014 Jun 18.

34.

Epac1-dependent phospholamban phosphorylation mediates the cardiac response to stresses.

Okumura S, Fujita T, Cai W, Jin M, Namekata I, Mototani Y, Jin H, Ohnuki Y, Tsuneoka Y, Kurotani R, Suita K, Kawakami Y, Hamaguchi S, Abe T, Kiyonari H, Tsunematsu T, Bai Y, Suzuki S, Hidaka Y, Umemura M, Ichikawa Y, Yokoyama U, Sato M, Ishikawa F, Izumi-Nakaseko H, Adachi-Akahane S, Tanaka H, Ishikawa Y.

J Clin Invest. 2014 Jun;124(6):2785-801. doi: 10.1172/JCI64784. Epub 2014 Apr 24.

35.

Optogenetic activation of serotonergic neurons enhances anxiety-like behaviour in mice.

Ohmura Y, Tanaka KF, Tsunematsu T, Yamanaka A, Yoshioka M.

Int J Neuropsychopharmacol. 2014 Nov;17(11):1777-83. doi: 10.1017/S1461145714000637. Epub 2014 May 21.

PMID:
24834486
36.

Optogenetic manipulation of activity and temporally controlled cell-specific ablation reveal a role for MCH neurons in sleep/wake regulation.

Tsunematsu T, Ueno T, Tabuchi S, Inutsuka A, Tanaka KF, Hasuwa H, Kilduff TS, Terao A, Yamanaka A.

J Neurosci. 2014 May 14;34(20):6896-909. doi: 10.1523/JNEUROSCI.5344-13.2014.

37.

Conditional ablation of orexin/hypocretin neurons: a new mouse model for the study of narcolepsy and orexin system function.

Tabuchi S, Tsunematsu T, Black SW, Tominaga M, Maruyama M, Takagi K, Minokoshi Y, Sakurai T, Kilduff TS, Yamanaka A.

J Neurosci. 2014 May 7;34(19):6495-509. doi: 10.1523/JNEUROSCI.0073-14.2014.

38.

The FGFR1 inhibitor PD173074 induces mesenchymal-epithelial transition through the transcription factor AP-1.

Nguyen PT, Tsunematsu T, Yanagisawa S, Kudo Y, Miyauchi M, Kamata N, Takata T.

Br J Cancer. 2013 Oct 15;109(8):2248-58. doi: 10.1038/bjc.2013.550. Epub 2013 Sep 17.

39.

Influence of inhibitory serotonergic inputs to orexin/hypocretin neurons on the diurnal rhythm of sleep and wakefulness.

Tabuchi S, Tsunematsu T, Kilduff TS, Sugio S, Xu M, Tanaka KF, Takahashi S, Tominaga M, Yamanaka A.

Sleep. 2013 Sep 1;36(9):1391-404. doi: 10.5665/sleep.2972.

40.

Chronic alterations in monoaminergic cells in the locus coeruleus in orexin neuron-ablated narcoleptic mice.

Tsujino N, Tsunematsu T, Uchigashima M, Konno K, Yamanaka A, Kobayashi K, Watanabe M, Koyama Y, Sakurai T.

PLoS One. 2013 Jul 29;8(7):e70012. doi: 10.1371/journal.pone.0070012. Print 2013.

41.

Long-lasting silencing of orexin/hypocretin neurons using archaerhodopsin induces slow-wave sleep in mice.

Tsunematsu T, Tabuchi S, Tanaka KF, Boyden ES, Tominaga M, Yamanaka A.

Behav Brain Res. 2013 Oct 15;255:64-74. doi: 10.1016/j.bbr.2013.05.021. Epub 2013 May 21.

42.

Aurora-A controls pre-replicative complex assembly and DNA replication by stabilizing geminin in mitosis.

Tsunematsu T, Takihara Y, Ishimaru N, Pagano M, Takata T, Kudo Y.

Nat Commun. 2013;4:1885. doi: 10.1038/ncomms2859.

43.

Selective enhancing effect of early mitotic inhibitor 1 (Emi1) depletion on the sensitivity of doxorubicin or X-ray treatment in human cancer cells.

Shimizu N, Nakajima NI, Tsunematsu T, Ogawa I, Kawai H, Hirayama R, Fujimori A, Yamada A, Okayasu R, Ishimaru N, Takata T, Kudo Y.

J Biol Chem. 2013 Jun 14;288(24):17238-52. doi: 10.1074/jbc.M112.446351. Epub 2013 May 3.

44.

Ectomesenchymal chondromyxoid tumor of the tongue: insights on histogenesis.

Yoshioka Y, Ogawa I, Tsunematsu T, Sakaue T, Yamasaki S, Fukui Y, Hayashido Y, Toratani S, Okamoto T.

Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 Feb;115(2):233-40. doi: 10.1016/j.oooo.2012.11.008.

PMID:
23312916
45.

BDNF, produced by a TPO-stimulated megakaryocytic cell line, regulates autocrine proliferation.

Tamura S, Nagasawa A, Masuda Y, Tsunematsu T, Hayasaka K, Matsuno K, Shimizu C, Ozaki Y, Moriyama T.

Biochem Biophys Res Commun. 2012 Oct 26;427(3):542-6. doi: 10.1016/j.bbrc.2012.09.093. Epub 2012 Sep 26.

PMID:
23022197
46.

Matrix metalloproteinase-13 (MMP-13) directly and indirectly promotes tumor angiogenesis.

Kudo Y, Iizuka S, Yoshida M, Tsunematsu T, Kondo T, Subarnbhesaj A, Deraz EM, Siriwardena SB, Tahara H, Ishimaru N, Ogawa I, Takata T.

J Biol Chem. 2012 Nov 9;287(46):38716-28. doi: 10.1074/jbc.M112.373159. Epub 2012 Sep 19.

47.

Periostin directly and indirectly promotes tumor lymphangiogenesis of head and neck cancer.

Kudo Y, Iizuka S, Yoshida M, Nguyen PT, Siriwardena SB, Tsunematsu T, Ohbayashi M, Ando T, Hatakeyama D, Shibata T, Koizumi K, Maeda M, Ishimaru N, Ogawa I, Takata T.

PLoS One. 2012;7(8):e44488. doi: 10.1371/journal.pone.0044488. Epub 2012 Aug 30.

48.

Ectopic expression of melanopsin in orexin/hypocretin neurons enables control of wakefulness of mice in vivo by blue light.

Tsunematsu T, Tanaka KF, Yamanaka A, Koizumi A.

Neurosci Res. 2013 Jan;75(1):23-8. doi: 10.1016/j.neures.2012.07.005. Epub 2012 Jul 31.

PMID:
22868039
49.

Pharmacological stimulation of type 5 adenylyl cyclase stabilizes heart rate under both microgravity and hypergravity induced by parabolic flight.

Bai Y, Tsunematsu T, Jiao Q, Ohnuki Y, Mototani Y, Shiozawa K, Jin M, Cai W, Jin HL, Fujita T, Ichikawa Y, Suita K, Kurotani R, Yokoyama U, Sato M, Iwatsubo K, Ishikawa Y, Okumura S.

J Pharmacol Sci. 2012;119(4):381-9. Epub 2012 Jul 31.

50.

The role of orexin/hypocretin in the central nervous system and peripheral tissues.

Tsunematsu T, Yamanaka A.

Vitam Horm. 2012;89:19-33. doi: 10.1016/B978-0-12-394623-2.00002-0. Review.

PMID:
22640606

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