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Items: 31

1.

Muscarinic receptor 1 allosteric modulators stimulate colorectal emptying in dog, mouse and rat and resolve constipation.

Pustovit RV, Itomi Y, Ringuet M, Diwakarla S, Chai XY, McQuade RM, Tsukimi Y, Furness JB.

Neurogastroenterol Motil. 2019 Aug 2:e13692. doi: 10.1111/nmo.13692. [Epub ahead of print]

PMID:
31374156
2.

Pharmacological effects of TAK-828F: an orally available RORγt inverse agonist, in mouse colitis model and human blood cells of inflammatory bowel disease.

Igaki K, Nakamura Y, Tanaka M, Mizuno S, Yoshimatsu Y, Komoike Y, Uga K, Shibata A, Imaichi H, Takayuki S, Ishimura Y, Yamasaki M, Kanai T, Tsukimi Y, Tsuchimori N.

Inflamm Res. 2019 Jun;68(6):493-509. doi: 10.1007/s00011-019-01234-y. Epub 2019 Apr 10.

PMID:
30972425
3.

Pharmacological Inhibition of Toll-Like Receptor-4 Signaling by TAK242 Prevents and Induces Regression of Experimental Organ Fibrosis.

Bhattacharyya S, Wang W, Tamaki Z, Shi B, Yeldandi A, Tsukimi Y, Yamasaki M, Varga J.

Front Immunol. 2018 Oct 23;9:2434. doi: 10.3389/fimmu.2018.02434. eCollection 2018.

4.

[Pharmacological characteristics and clinical efficacies of a novel potassium-competitive acid blocker, vonoprazan fumarate].

Matsukawa J, Inatomi N, Nishida H, Tsukimi Y.

Nihon Yakurigaku Zasshi. 2018;152(3):104-110. doi: 10.1254/fpj.152.104. Japanese.

PMID:
30185727
5.

Pharmacological Evaluation of TAK-828F, a Novel Orally Available RORγt Inverse Agonist, on Murine Colitis Model.

Igaki K, Nakamura Y, Komoike Y, Uga K, Shibata A, Ishimura Y, Yamasaki M, Tsukimi Y, Tsuchimori N.

Inflammation. 2019 Feb;42(1):91-102. doi: 10.1007/s10753-018-0875-7.

PMID:
30121880
6.

Impaired diffuse noxious inhibitory controls in specific alternation of rhythm in temperature-stressed rats.

Itomi Y, Tsukimi Y, Kawamura T.

Eur J Pharmacol. 2016 Aug 5;784:61-8. doi: 10.1016/j.ejphar.2016.05.011. Epub 2016 May 10.

PMID:
27178898
7.

Specific alteration of rhythm in temperature-stressed rats possess features of abdominal pain in IBS patients.

Itomi Y, Kawamura T, Tsukimi Y.

J Pharmacol Sci. 2015 Sep;129(1):26-30. doi: 10.1016/j.jphs.2015.07.044. Epub 2015 Aug 20.

8.

Effects of TAK-480, a novel tachykinin NK(2)-receptor antagonist, on visceral hypersensitivity in rabbits and ricinoleic acid-induced defecation in guinea pigs.

Tanaka T, Tanaka A, Nakamura A, Matsushita K, Imanishi A, Matsumoto-Okano S, Inatomi N, Miura K, Toyoda M, Mizojiri G, Tsukimi Y.

J Pharmacol Sci. 2012;120(1):15-25. Epub 2012 Aug 11.

9.

Establishment and validation of a rabbit model for in vivo pharmacodynamic screening of tachykinin NK2 antagonists.

Tanaka T, Matsumoto-Okano S, Inatomi N, Fujioka Y, Kamiguchi H, Yamaguchi M, Imanishi A, Kawamoto M, Miura K, Nishikawa Y, Tsukimi Y.

J Pharmacol Sci. 2012;118(4):487-95. Epub 2012 Mar 22.

10.

Derivation of rat embryonic stem cells and generation of protease-activated receptor-2 knockout rats.

Yamamoto S, Nakata M, Sasada R, Ooshima Y, Yano T, Shinozawa T, Tsukimi Y, Takeyama M, Matsumoto Y, Hashimoto T.

Transgenic Res. 2012 Aug;21(4):743-55. doi: 10.1007/s11248-011-9564-0. Epub 2011 Oct 15.

PMID:
22002084
11.

Bidirectional regulation of human colonic smooth muscle contractility by tachykinin NK(2) receptors.

Nakamura A, Tanaka T, Imanishi A, Kawamoto M, Toyoda M, Mizojiri G, Tsukimi Y.

J Pharmacol Sci. 2011;117(2):106-15. Epub 2011 Sep 23.

12.

1-[5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine monofumarate (TAK-438), a novel and potent potassium-competitive acid blocker for the treatment of acid-related diseases.

Hori Y, Imanishi A, Matsukawa J, Tsukimi Y, Nishida H, Arikawa Y, Hirase K, Kajino M, Inatomi N.

J Pharmacol Exp Ther. 2010 Oct;335(1):231-8. doi: 10.1124/jpet.110.170274. Epub 2010 Jul 12. Erratum in: J Pharmacol Exp Ther. 2016 Jul;358(1):1-2.

PMID:
20624992
13.

Cold response of the bladder in guinea pig: involvement of transient receptor potential channel, TRPM8.

Tsukimi Y, Mizuyachi K, Yamasaki T, Niki T, Hayashi F.

Urology. 2005 Feb;65(2):406-10.

PMID:
15708076
14.
15.

Mechanism of action by which aspirin alleviates detrusor hyperactivity in rats.

Tsukimi Y, Mizuyachi K, Matsumoto H, Sato M, Ng B, Tajimi M.

J Pharmacol Sci. 2004 May;95(1):101-7.

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Involvement of heat shock proteins in the healing of acetic acid-induced gastric ulcers in rats.

Tsukimi Y, Nakai H, Itoh S, Amagase K, Okabe S.

J Physiol Pharmacol. 2001 Sep;52(3):391-406.

19.

Pharmacological analysis of wine-stimulated gastric acid secretion in dogs.

Tsukimi Y, Ogawa T, Okabe S.

J Physiol Paris. 2001 Jan-Dec;95(1-6):221-8.

PMID:
11595441
20.

Role of p38 mitogen-activated protein kinase in the healing of gastric ulcers in rats.

Kobayashi N, Kataoka T, Ono A, Tsukimi Y, Okabe S.

J Physiol Pharmacol. 2001 Jun;52(2):195-210.

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Studies on the mechanism of action of the gastric H+,K(+)-ATPase inhibitor SPI-447.

Tsukimi Y, Ushiro T, Yamazaki T, Ishikawa H, Hirase J, Narita M, Nishigaito T, Banno K, Ichihara T, Tanaka H.

Jpn J Pharmacol. 2000 Jan;82(1):21-8.

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Changes in gastric function and healing of chronic gastric ulcers in aged rats.

Tsukimi Y, Okabe S.

Jpn J Pharmacol. 1995 May;68(1):103-10.

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Validity of kissing gastric ulcers induced in rats for screening of antiulcer drugs.

Tsukimi Y, Okabe S.

J Gastroenterol Hepatol. 1994;9 Suppl 1:S60-5.

PMID:
7881021
30.

Characteristic induction of 70,000 da-heat shock protein and metallothionein by zinc in HeLa cells.

Hatayama T, Tsukimi Y, Wakatsuki T, Kitamura T, Imahara H.

Mol Cell Biochem. 1992 Jun 26;112(2):143-53.

PMID:
1640929
31.

Different induction of 70,000-Da heat shock protein and metallothionein in HeLa cells by copper.

Hatayama T, Tsukimi Y, Wakatsuki T, Kitamura T, Imahara H.

J Biochem. 1991 Nov;110(5):726-31.

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