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Items: 1 to 50 of 168

1.

X-ray structural analyses of azide-bound cytochrome c oxidases reveal that the H-pathway is critically important for the proton-pumping activity.

Shimada A, Hatano K, Tadehara H, Yano N, Shinzawa-Itoh K, Yamashita E, Muramoto K, Tsukihara T, Yoshikawa S.

J Biol Chem. 2018 Aug 3. pii: jbc.RA118.003123. doi: 10.1074/jbc.RA118.003123. [Epub ahead of print]

2.

Structure of bovine cytochrome c oxidase in the ligand-free reduced state at neutral pH.

Luo F, Shinzawa-Itoh K, Hagimoto K, Shimada A, Shimada S, Yamashita E, Yoshikawa S, Tsukihara T.

Acta Crystallogr F Struct Biol Commun. 2018 Feb 1;74(Pt 2):92-98. doi: 10.1107/S2053230X17018532. Epub 2018 Jan 26.

3.

A unique respiratory adaptation in Drosophila independent of supercomplex formation.

Shimada S, Oosaki M, Takahashi R, Uene S, Yanagisawa S, Tsukihara T, Shinzawa-Itoh K.

Biochim Biophys Acta. 2018 Feb;1859(2):154-163. doi: 10.1016/j.bbabio.2017.11.007. Epub 2017 Dec 2.

4.

A nanosecond time-resolved XFEL analysis of structural changes associated with CO release from cytochrome c oxidase.

Shimada A, Kubo M, Baba S, Yamashita K, Hirata K, Ueno G, Nomura T, Kimura T, Shinzawa-Itoh K, Baba J, Hatano K, Eto Y, Miyamoto A, Murakami H, Kumasaka T, Owada S, Tono K, Yabashi M, Yamaguchi Y, Yanagisawa S, Sakaguchi M, Ogura T, Komiya R, Yan J, Yamashita E, Yamamoto M, Ago H, Yoshikawa S, Tsukihara T.

Sci Adv. 2017 Jul 14;3(7):e1603042. doi: 10.1126/sciadv.1603042. eCollection 2017 Jul.

5.

Structure of bovine cytochrome c oxidase crystallized at a neutral pH using a fluorinated detergent.

Luo F, Shinzawa-Itoh K, Hagimoto K, Shimada A, Shimada S, Yamashita E, Yoshikawa S, Tsukihara T.

Acta Crystallogr F Struct Biol Commun. 2017 Jul 1;73(Pt 7):416-422. doi: 10.1107/S2053230X17008834. Epub 2017 Jun 20.

6.

Sleep quality among elderly high-altitude dwellers in Ladakh.

Sakamoto R, Okumiya K, Norboo T, Tsering N, Yamaguchi T, Nose M, Takeda S, Tsukihara T, Ishikawa M, Nakajima S, Wada T, Fujisawa M, Imai H, Ishimoto Y, Kimura Y, Fukutomi E, Chen W, Otsuka K, Matsubayashi K.

Psychiatry Res. 2017 Mar;249:51-57. doi: 10.1016/j.psychres.2016.12.043. Epub 2016 Dec 29.

PMID:
28063399
7.

Complex structure of cytochrome c-cytochrome c oxidase reveals a novel protein-protein interaction mode.

Shimada S, Shinzawa-Itoh K, Baba J, Aoe S, Shimada A, Yamashita E, Kang J, Tateno M, Yoshikawa S, Tsukihara T.

EMBO J. 2017 Feb 1;36(3):291-300. doi: 10.15252/embj.201695021. Epub 2016 Dec 15.

8.

The Mg2+-containing Water Cluster of Mammalian Cytochrome c Oxidase Collects Four Pumping Proton Equivalents in Each Catalytic Cycle.

Yano N, Muramoto K, Shimada A, Takemura S, Baba J, Fujisawa H, Mochizuki M, Shinzawa-Itoh K, Yamashita E, Tsukihara T, Yoshikawa S.

J Biol Chem. 2016 Nov 11;291(46):23882-23894. Epub 2016 Sep 7.

9.

Glucose intolerance associated with hypoxia in people living at high altitudes in the Tibetan highland.

Okumiya K, Sakamoto R, Ishimoto Y, Kimura Y, Fukutomi E, Ishikawa M, Suwa K, Imai H, Chen W, Kato E, Nakatsuka M, Kasahara Y, Fujisawa M, Wada T, Wang H, Dai Q, Xu H, Qiao H, Ge RL, Norboo T, Tsering N, Kosaka Y, Nose M, Yamaguchi T, Tsukihara T, Ando K, Inamura T, Takeda S, Ishine M, Otsuka K, Matsubayashi K.

BMJ Open. 2016 Feb 23;6(2):e009728. doi: 10.1136/bmjopen-2015-009728.

10.

J-Curve Association Between Glucose Intolerance and Hemoglobin and Ferritin Levels at High Altitude.

Okumiya K, Sakamoto R, Ishikawa M, Kimura Y, Fukutomi E, Ishimoto Y, Chen WL, Imai H, Kato E, Kasahara Y, Fujisawa M, Wada T, Ishine M, Kosaka Y, Nose M, Yamaguchi T, Tsukihara T, Otsuka K, Norboo T, Matsubayashi K.

J Am Geriatr Soc. 2016 Jan;64(1):207-10. doi: 10.1111/jgs.13915. No abstract available.

PMID:
26782878
11.

Two-dimensional crystallization of monomeric bovine cytochrome c oxidase with bound cytochrome c in reconstituted lipid membranes.

Osuda Y, Shinzawa-Itoh K, Tani K, Maeda S, Yoshikawa S, Tsukihara T, Gerle C.

Microscopy (Oxf). 2016 Jun;65(3):263-7. doi: 10.1093/jmicro/dfv381. Epub 2016 Jan 10.

12.

The pathological effects of connexin 26 variants related to hearing loss by in silico and in vitro analysis.

Kim HR, Oh SK, Lee ES, Choi SY, Roh SE, Kim SJ, Tsukihara T, Lee KY, Jeon CJ, Kim UK.

Hum Genet. 2016 Mar;135(3):287-98. doi: 10.1007/s00439-015-1625-7. Epub 2016 Jan 9.

PMID:
26749107
13.

Purification of Active Respiratory Supercomplex from Bovine Heart Mitochondria Enables Functional Studies.

Shinzawa-Itoh K, Shimomura H, Yanagisawa S, Shimada S, Takahashi R, Oosaki M, Ogura T, Tsukihara T.

J Biol Chem. 2016 Feb 19;291(8):4178-84. doi: 10.1074/jbc.M115.680553. Epub 2015 Dec 23.

14.

Structural Analysis of Streptococcus pyogenes NADH Oxidase: Conformational Dynamics Involved in Formation of the C(4a)-Peroxyflavin Intermediate.

Wallen JR, Mallett TC, Okuno T, Parsonage D, Sakai H, Tsukihara T, Claiborne A.

Biochemistry. 2015 Nov 17;54(45):6815-29. doi: 10.1021/acs.biochem.5b00676. Epub 2015 Nov 6.

PMID:
26506002
15.

Crystal Structures of a Piscine Betanodavirus: Mechanisms of Capsid Assembly and Viral Infection.

Chen NC, Yoshimura M, Guan HH, Wang TY, Misumi Y, Lin CC, Chuankhayan P, Nakagawa A, Chan SI, Tsukihara T, Chen TY, Chen CJ.

PLoS Pathog. 2015 Oct 22;11(10):e1005203. doi: 10.1371/journal.ppat.1005203. eCollection 2015 Oct.

16.

X-ray structure of cyanide-bound bovine heart cytochrome c oxidase in the fully oxidized state at 2.0 Å resolution.

Yano N, Muramoto K, Mochizuki M, Shinzawa-Itoh K, Yamashita E, Yoshikawa S, Tsukihara T.

Acta Crystallogr F Struct Biol Commun. 2015 Jun;71(Pt 6):726-30. doi: 10.1107/S2053230X15007025. Epub 2015 May 22.

17.

Prevalence of hypertension at high altitude: cross-sectional survey in Ladakh, Northern India 2007-2011.

Norboo T, Stobdan T, Tsering N, Angchuk N, Tsering P, Ahmed I, Chorol T, Kumar Sharma V, Reddy P, Singh SB, Kimura Y, Sakamoto R, Fukutomi E, Ishikawa M, Suwa K, Kosaka Y, Nose M, Yamaguchi T, Tsukihara T, Matsubayashi K, Otsuka K, Okumiya K.

BMJ Open. 2015 Apr 20;5(4):e007026. doi: 10.1136/bmjopen-2014-007026.

18.

Bovine F1Fo ATP synthase monomers bend the lipid bilayer in 2D membrane crystals.

Jiko C, Davies KM, Shinzawa-Itoh K, Tani K, Maeda S, Mills DJ, Tsukihara T, Fujiyoshi Y, Kühlbrandt W, Gerle C.

Elife. 2015 Mar 27;4:e06119. doi: 10.7554/eLife.06119.

19.

Higd1a is a positive regulator of cytochrome c oxidase.

Hayashi T, Asano Y, Shintani Y, Aoyama H, Kioka H, Tsukamoto O, Hikita M, Shinzawa-Itoh K, Takafuji K, Higo S, Kato H, Yamazaki S, Matsuoka K, Nakano A, Asanuma H, Asakura M, Minamino T, Goto Y, Ogura T, Kitakaze M, Komuro I, Sakata Y, Tsukihara T, Yoshikawa S, Takashima S.

Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1553-8. doi: 10.1073/pnas.1419767112. Epub 2015 Jan 20.

20.

Charge at the 46th residue of connexin 50 is crucial for the gap-junctional unitary conductance and transjunctional voltage-dependent gating.

Tong X, Aoyama H, Tsukihara T, Bai D.

J Physiol. 2014 Dec 1;592(23):5187-202. doi: 10.1113/jphysiol.2014.280636. Epub 2014 Sep 25.

21.

Determination of damage-free crystal structure of an X-ray-sensitive protein using an XFEL.

Hirata K, Shinzawa-Itoh K, Yano N, Takemura S, Kato K, Hatanaka M, Muramoto K, Kawahara T, Tsukihara T, Yamashita E, Tono K, Ueno G, Hikima T, Murakami H, Inubushi Y, Yabashi M, Ishikawa T, Yamamoto M, Ogura T, Sugimoto H, Shen JR, Yoshikawa S, Ago H.

Nat Methods. 2014 Jul;11(7):734-6. doi: 10.1038/nmeth.2962. Epub 2014 May 11.

PMID:
24813624
22.

Three-dimensional structure of bovine heart NADH: ubiquinone oxidoreductase (complex I) by electron microscopy of a single negatively stained two-dimensional crystal.

Shimada S, Shinzawa-Itoh K, Amano S, Akira Y, Miyazawa A, Tsukihara T, Tani K, Gerle C, Yoshikawa S.

Microscopy (Oxf). 2014 Apr;63(2):167-74. doi: 10.1093/jmicro/dft082. Epub 2014 Feb 11.

PMID:
24523515
23.

New features of vault architecture and dynamics revealed by novel refinement using the deformable elastic network approach.

Casañas A, Querol-Audí J, Guerra P, Pous J, Tanaka H, Tsukihara T, Verdaguer N, Fita I.

Acta Crystallogr D Biol Crystallogr. 2013 Jun;69(Pt 6):1054-61. doi: 10.1107/S0907444913004472. Epub 2013 May 14.

24.

A mechanism of gap junction docking revealed by functional rescue of a human-disease-linked connexin mutant.

Gong XQ, Nakagawa S, Tsukihara T, Bai D.

J Cell Sci. 2013 Jul 15;126(Pt 14):3113-20. doi: 10.1242/jcs.123430. Epub 2013 May 17.

25.

Structural studies of large nucleoprotein particles, vaults.

Tanaka H, Tsukihara T.

Proc Jpn Acad Ser B Phys Biol Sci. 2012;88(8):416-33. Review.

26.

Aspartic acid residue D3 critically determines Cx50 gap junction channel transjunctional voltage-dependent gating and unitary conductance.

Xin L, Nakagawa S, Tsukihara T, Bai D.

Biophys J. 2012 Mar 7;102(5):1022-31. doi: 10.1016/j.bpj.2012.02.008. Epub 2012 Mar 6.

27.

Crystallographic analysis reveals octamerization of viroplasm matrix protein P9-1 of Rice black streaked dwarf virus.

Akita F, Higashiura A, Shimizu T, Pu Y, Suzuki M, Uehara-Ichiki T, Sasaya T, Kanamaru S, Arisaka F, Tsukihara T, Nakagawa A, Omura T.

J Virol. 2012 Jan;86(2):746-56. doi: 10.1128/JVI.00826-11. Epub 2011 Nov 9.

28.

Distinguishing between Cl- and O2(2-) as the bridging element between Fe3+ and Cu2+ in resting-oxidized cytochrome c oxidase.

Suga M, Yano N, Muramoto K, Shinzawa-Itoh K, Maeda T, Yamashita E, Tsukihara T, Yoshikawa S.

Acta Crystallogr D Biol Crystallogr. 2011 Aug;67(Pt 8):742-4. doi: 10.1107/S0907444911022803. Epub 2011 Jul 12.

PMID:
21795816
29.

Viroplasm matrix protein Pns9 from rice gall dwarf virus forms an octameric cylindrical structure.

Akita F, Miyazaki N, Hibino H, Shimizu T, Higashiura A, Uehara-Ichiki T, Sasaya T, Tsukihara T, Nakagawa A, Iwasaki K, Omura T.

J Gen Virol. 2011 Sep;92(Pt 9):2214-21. doi: 10.1099/vir.0.032524-0. Epub 2011 May 25.

PMID:
21613445
30.

Asparagine 175 of connexin32 is a critical residue for docking and forming functional heterotypic gap junction channels with connexin26.

Nakagawa S, Gong XQ, Maeda S, Dong Y, Misumi Y, Tsukihara T, Bai D.

J Biol Chem. 2011 Jun 3;286(22):19672-81. doi: 10.1074/jbc.M110.204958. Epub 2011 Apr 8.

31.

Selective nuclear export mechanism of small RNAs.

Lee SJ, Jiko C, Yamashita E, Tsukihara T.

Curr Opin Struct Biol. 2011 Feb;21(1):101-8. doi: 10.1016/j.sbi.2010.11.004. Epub 2010 Dec 7. Review.

PMID:
21145229
32.

Structure of the gap junction channel and its implications for its biological functions.

Maeda S, Tsukihara T.

Cell Mol Life Sci. 2011 Apr;68(7):1115-29. doi: 10.1007/s00018-010-0551-z. Epub 2010 Oct 21. Review.

PMID:
20960023
33.

Structural and functional studies of gap junction channels.

Nakagawa S, Maeda S, Tsukihara T.

Curr Opin Struct Biol. 2010 Aug;20(4):423-30. doi: 10.1016/j.sbi.2010.05.003. Epub 2010 Jun 9. Review.

PMID:
20542681
34.

Bovine cytochrome c oxidase structures enable O2 reduction with minimization of reactive oxygens and provide a proton-pumping gate.

Muramoto K, Ohta K, Shinzawa-Itoh K, Kanda K, Taniguchi M, Nabekura H, Yamashita E, Tsukihara T, Yoshikawa S.

Proc Natl Acad Sci U S A. 2010 Apr 27;107(17):7740-5. doi: 10.1073/pnas.0910410107. Epub 2010 Apr 12.

35.

Cell-free synthesis of cytochrome c oxidase, a multicomponent membrane protein.

Katayama Y, Shimokata K, Suematsu M, Ogura T, Tsukihara T, Yoshikawa S, Shimada H.

J Bioenerg Biomembr. 2010 Jun;42(3):235-40. doi: 10.1007/s10863-010-9285-8. Epub 2010 Apr 6.

PMID:
20373004
36.

Large conformational changes in the Escherichia coli tryptophan synthase beta(2) subunit upon pyridoxal 5'-phosphate binding.

Nishio K, Ogasahara K, Morimoto Y, Tsukihara T, Lee SJ, Yutani K.

FEBS J. 2010 May;277(9):2157-70. doi: 10.1111/j.1742-4658.2010.07631.x. Epub 2010 Mar 27.

37.

X-ray structure of the NO-bound Cu(B) in bovine cytochrome c oxidase.

Ohta K, Muramoto K, Shinzawa-Itoh K, Yamashita E, Yoshikawa S, Tsukihara T.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Mar 1;66(Pt 3):251-3. doi: 10.1107/S1744309109055109. Epub 2010 Feb 23.

38.

The functional organization of the internal components of Rice dwarf virus.

Miyazaki N, Wu B, Hagiwara K, Wang CY, Xing L, Hammar L, Higashiura A, Tsukihara T, Nakagawa A, Omura T, Cheng RH.

J Biochem. 2010 Jun;147(6):843-50. doi: 10.1093/jb/mvq017. Epub 2010 Feb 26.

PMID:
20190042
39.

A high-resolution structure of the pre-microRNA nuclear export machinery.

Okada C, Yamashita E, Lee SJ, Shibata S, Katahira J, Nakagawa A, Yoneda Y, Tsukihara T.

Science. 2009 Nov 27;326(5957):1275-9. doi: 10.1126/science.1178705.

40.

A description of the structural determination procedures of a gap junction channel at 3.5 A resolution.

Suga M, Maeda S, Nakagawa S, Yamashita E, Tsukihara T.

Acta Crystallogr D Biol Crystallogr. 2009 Aug;65(Pt 8):758-66. doi: 10.1107/S0907444909014711. Epub 2009 Jul 10.

41.

Biological and immunological characteristics of hepatitis E virus-like particles based on the crystal structure.

Yamashita T, Mori Y, Miyazaki N, Cheng RH, Yoshimura M, Unno H, Shima R, Moriishi K, Tsukihara T, Li TC, Takeda N, Miyamura T, Matsuura Y.

Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):12986-91. doi: 10.1073/pnas.0903699106. Epub 2009 Jul 20.

42.

Structure of the connexin 26 gap junction channel at 3.5 A resolution.

Maeda S, Nakagawa S, Suga M, Yamashita E, Oshima A, Fujiyoshi Y, Tsukihara T.

Nature. 2009 Apr 2;458(7238):597-602. doi: 10.1038/nature07869.

PMID:
19340074
43.

Substrate binding induces structural changes in cytochrome P450cam.

Sakurai K, Shimada H, Hayashi T, Tsukihara T.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Feb 1;65(Pt 2):80-3. doi: 10.1107/S1744309108044114. Epub 2009 Jan 31.

44.

A peroxide bridge between Fe and Cu ions in the O2 reduction site of fully oxidized cytochrome c oxidase could suppress the proton pump.

Aoyama H, Muramoto K, Shinzawa-Itoh K, Hirata K, Yamashita E, Tsukihara T, Ogura T, Yoshikawa S.

Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2165-9. doi: 10.1073/pnas.0806391106. Epub 2009 Jan 21.

45.

The structure of rat liver vault at 3.5 angstrom resolution.

Tanaka H, Kato K, Yamashita E, Sumizawa T, Zhou Y, Yao M, Iwasaki K, Yoshimura M, Tsukihara T.

Science. 2009 Jan 16;323(5912):384-8. doi: 10.1126/science.1164975.

46.

Red-excitation resonance Raman analysis of the nu(Fe=O) mode of ferryl-oxo hemoproteins.

Ikemura K, Mukai M, Shimada H, Tsukihara T, Yamaguchi S, Shinzawa-Itoh K, Yoshikawa S, Ogura T.

J Am Chem Soc. 2008 Nov 5;130(44):14384-5. doi: 10.1021/ja805735g. Epub 2008 Oct 11.

PMID:
18847201
47.

Structural analysis of Arabidopsis CnfU protein: an iron-sulfur cluster biosynthetic scaffold in chloroplasts.

Yabe T, Yamashita E, Kikuchi A, Morimoto K, Nakagawa A, Tsukihara T, Nakai M.

J Mol Biol. 2008 Aug 1;381(1):160-73. doi: 10.1016/j.jmb.2008.05.072. Epub 2008 Jun 4.

PMID:
18585737
48.

A vault ribonucleoprotein particle exhibiting 39-fold dihedral symmetry.

Kato K, Tanaka H, Sumizawa T, Yoshimura M, Yamashita E, Iwasaki K, Tsukihara T.

Acta Crystallogr D Biol Crystallogr. 2008 May;64(Pt 5):525-31. doi: 10.1107/S0907444908004277. Epub 2008 Apr 19. Erratum in: Acta Crystallogr D Biol Crystallogr. 2009 Mar;65(Pt 3):301.

49.

[Overview: Products of Protein 3000 project].

Nakamura H, Tsukihara T.

Tanpakushitsu Kakusan Koso. 2008 Apr;53(5):597-9. Japanese. No abstract available.

PMID:
18409545
50.

Crystallization and preliminary X-ray diffraction analysis of recombinant hepatitis E virus-like particle.

Wang CY, Miyazaki N, Yamashita T, Higashiura A, Nakagawa A, Li TC, Takeda N, Xing L, Hjalmarsson E, Friberg C, Liou DM, Sung YJ, Tsukihara T, Matsuura Y, Miyamura T, Cheng RH.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Apr 1;64(Pt 4):318-22. doi: 10.1107/S1744309108007197. Epub 2008 Mar 29.

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