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Association of Cerebral Oximetry with Outcomes after Extracorporeal Membrane Oxygenation.

Tsou PY, Garcia AV, Yiu A, Vaidya DM, Bembea MM.

Neurocrit Care. 2020 Jan 10. doi: 10.1007/s12028-019-00892-4. [Epub ahead of print]


Epigenetic Control of Scleroderma: Current Knowledge and Future Perspectives.

Tsou PS.

Curr Rheumatol Rep. 2019 Dec 7;21(12):69. doi: 10.1007/s11926-019-0877-y. Review.


Association between multiple respiratory viral infections and pediatric intensive care unit admission among infants with bronchiolitis.

Tsou P, Vadivelan A, Kovvuri M, Garg N, Thangavelu M, Wang Y, Raj S.

Arch Pediatr. 2020 Jan;27(1):39-44. doi: 10.1016/j.arcped.2019.11.006. Epub 2019 Nov 25.


The effect of dog allergen exposure on asthma morbidity among inner-city children with asthma.

Tsou PY, McCormack MC, Matsui EC, Peng RD, Diette GB, Hansel NN, Davis MF.

Pediatr Allergy Immunol. 2020 Feb;31(2):210-213. doi: 10.1111/pai.13144. Epub 2019 Nov 26. No abstract available.


A multicenter randomized, double-blind, placebo-controlled pilot study to assess the efficacy and safety of riociguat in systemic sclerosis-associated digital ulcers.

Nagaraja V, Spino C, Bush E, Tsou PS, Domsic RT, Lafyatis R, Frech T, Gordon JK, Steen VD, Khanna D.

Arthritis Res Ther. 2019 Sep 3;21(1):202. doi: 10.1186/s13075-019-1979-7.


Impact of post-sepsis cardiovascular complications on mortality in sepsis survivors: a population-based study.

Wu MH, Tsou PY, Wang YH, Lee MG, Chao CCT, Lee WC, Lee SH, Hu JR, Wu JY, Chang SS, Lee CC.

Crit Care. 2019 Sep 2;23(1):293. doi: 10.1186/s13054-019-2579-2.


Diagnostic Accuracy of Lung Ultrasound Performed by Novice Versus Advanced Sonographers for Pneumonia in Children: A Systematic Review and Meta-analysis.

Tsou PY, Chen KP, Wang YH, Fishe J, Gillon J, Lee CC, Deanehan JK, Kuo PL, Yu DTY.

Acad Emerg Med. 2019 Sep;26(9):1074-1088. doi: 10.1111/acem.13818. Epub 2019 Jul 16. Review.


Accuracy of point-of-care ultrasound and radiology-performed ultrasound for intussusception: A systematic review and meta-analysis.

Tsou PY, Wang YH, Ma YK, Deanehan JK, Gillon J, Chou EH, Hsu TC, Huang YC, Lin J, Lee CC.

Am J Emerg Med. 2019 Sep;37(9):1760-1769. doi: 10.1016/j.ajem.2019.06.006. Epub 2019 Jun 4. Review.


Rapid and Safe Isolation of Human Peripheral Blood B and T Lymphocytes through Spiral Microfluidic Channels.

Chiu PL, Chang CH, Lin YL, Tsou PH, Li BR.

Sci Rep. 2019 May 31;9(1):8145. doi: 10.1038/s41598-019-44677-3.


Inhibition of EZH2 Ameliorates Lupus-Like Disease in MRL/lpr Mice.

Rohraff DM, He Y, Farkash EA, Schonfeld M, Tsou PS, Sawalha AH.

Arthritis Rheumatol. 2019 Oct;71(10):1681-1690. doi: 10.1002/art.40931. Epub 2019 Aug 12.


Risk Factors for Myocardial Infarction and Stroke Among Sepsis Survivors: A Competing Risks Analysis.

Hsieh YC, Tsou PY, Wang YH, Chao CC, Lee WC, Lee MG, Wu JY, Chang SS, Chen PY, Lee CC.

J Intensive Care Med. 2020 Jan;35(1):34-41. doi: 10.1177/0885066619844936. Epub 2019 May 12.


A plasma protein derived TGFβ signature is a prognostic indicator in triple negative breast cancer.

Katayama H, Tsou P, Kobayashi M, Capello M, Wang H, Esteva F, Disis ML, Hanash S.

NPJ Precis Oncol. 2019 Apr 2;3:10. doi: 10.1038/s41698-019-0082-5. eCollection 2019.


5-Aryl-1,3,4-oxadiazol-2-ylthioalkanoic Acids: A Highly Potent New Class of Inhibitors of Rho/Myocardin-Related Transcription Factor (MRTF)/Serum Response Factor (SRF)-Mediated Gene Transcription as Potential Antifibrotic Agents for Scleroderma.

Kahl DJ, Hutchings KM, Lisabeth EM, Haak AJ, Leipprandt JR, Dexheimer T, Khanna D, Tsou PS, Campbell PL, Fox DA, Wen B, Sun D, Bailie M, Neubig RR, Larsen SD.

J Med Chem. 2019 May 9;62(9):4350-4369. doi: 10.1021/acs.jmedchem.8b01772. Epub 2019 Apr 18.


Identification of Cysteine-Rich Angiogenic Inducer 61 as a Potential Antifibrotic and Proangiogenic Mediator in Scleroderma.

Tsou PS, Khanna D, Sawalha AH.

Arthritis Rheumatol. 2019 Aug;71(8):1350-1359. doi: 10.1002/art.40890. Epub 2019 Jun 12.


Thermopneumatic suction integrated microfluidic blood analysis system.

Yang CH, Hsieh YL, Tsou PH, Li BR.

PLoS One. 2019 Mar 7;14(3):e0208676. doi: 10.1371/journal.pone.0208676. eCollection 2019.


Inhibition of EZH2 prevents fibrosis and restores normal angiogenesis in scleroderma.

Tsou PS, Campbell P, Amin MA, Coit P, Miller S, Fox DA, Khanna D, Sawalha AH.

Proc Natl Acad Sci U S A. 2019 Feb 26;116(9):3695-3702. doi: 10.1073/pnas.1813006116. Epub 2019 Feb 12.


Hypomethylation of STAT1 and HLA-DRB1 is associated with type-I interferon-dependent HLA-DRB1 expression in lupus CD8+ T cells.

Miller S, Tsou PS, Coit P, Gensterblum-Miller E, Renauer P, Rohraff DM, Kilian NC, Schonfeld M, Sawalha AH.

Ann Rheum Dis. 2019 Apr;78(4):519-528. doi: 10.1136/annrheumdis-2018-214323. Epub 2019 Jan 23.


Detection of Bartonella species, including Candidatus Bartonella ovis sp. nov, in ruminants from Mexico and lack of evidence of Bartonella DNA in saliva of common vampire bats (Desmodus rotundus) predating on them.

Raya AP, Jaffe DA, Chomel BB, Ota MS, Tsou PM, Davis AZ, Olave-Leyva JI, Galvez-Romero G, Stuckey MJ, Kasten RW, Obregón-Morales C, Aréchiga-Ceballos N, Martinez-Martinez F, Aguilar-Setién A.

Vet Microbiol. 2018 Aug;222:69-74. doi: 10.1016/j.vetmic.2018.06.018. Epub 2018 Jun 25.


Photosensitivity and type I IFN responses in cutaneous lupus are driven by epidermal-derived interferon kappa.

Sarkar MK, Hile GA, Tsoi LC, Xing X, Liu J, Liang Y, Berthier CC, Swindell WR, Patrick MT, Shao S, Tsou PS, Uppala R, Beamer MA, Srivastava A, Bielas SL, Harms PW, Getsios S, Elder JT, Voorhees JJ, Gudjonsson JE, Kahlenberg JM.

Ann Rheum Dis. 2018 Nov;77(11):1653-1664. doi: 10.1136/annrheumdis-2018-213197. Epub 2018 Jul 18.


A flow-proteometric platform for analyzing protein concentration (FAP): Proof of concept for quantification of PD-L1 protein in cells and tissues.

Chou CK, Huang PJ, Tsou PH, Wei Y, Lee HH, Wang YN, Liu YL, Shi C, Yeh HC, Kameoka J, Hung MC.

Biosens Bioelectron. 2018 Oct 15;117:97-103. doi: 10.1016/j.bios.2018.05.053. Epub 2018 May 29.


Methyl-CpG-binding protein 2 mediates antifibrotic effects in scleroderma fibroblasts.

He Y, Tsou PS, Khanna D, Sawalha AH.

Ann Rheum Dis. 2018 Aug;77(8):1208-1218. doi: 10.1136/annrheumdis-2018-213022. Epub 2018 May 14.


Caffeine inhibits STAT1 signaling and downregulates inflammatory pathways involved in autoimmunity.

Iris M, Tsou PS, Sawalha AH.

Clin Immunol. 2018 Jul;192:68-77. doi: 10.1016/j.clim.2018.04.008. Epub 2018 Apr 18.


Development of loop-mediated isothermal amplification (LAMP) assays for the rapid detection of allergic peanut in processed food.

Sheu SC, Tsou PC, Lien YY, Lee MS.

Food Chem. 2018 Aug 15;257:67-74. doi: 10.1016/j.foodchem.2018.02.124. Epub 2018 Feb 28.


A unique role for galectin-9 in angiogenesis and inflammatory arthritis.

O'Brien MJ, Shu Q, Stinson WA, Tsou PS, Ruth JH, Isozaki T, Campbell PL, Ohara RA, Koch AE, Fox DA, Amin MA.

Arthritis Res Ther. 2018 Feb 12;20(1):31. doi: 10.1186/s13075-018-1519-x.


Trend and outcome of sepsis in children: A nationwide cohort study.

Yo CH, Hsu TC, Gabriel Lee MT, Porta L, Tsou PY, Wang YH, Lee WC, Chen ST, Lee CC; National Taiwan University Hospital Health Economics and Outcome Research Group.

J Paediatr Child Health. 2018 Jul;54(7):776-783. doi: 10.1111/jpc.13849. Epub 2018 Feb 9.


A Pediatrician's Day in Immigration Court.

Tsou PY.

Pediatrics. 2018 Jan;141(1). pii: e20170921. doi: 10.1542/peds.2017-0921. Epub 2017 Dec 1. No abstract available.


CD4+CD28+KIR+CD11ahi T cells correlate with disease activity and are characterized by a pro-inflammatory epigenetic and transcriptional profile in lupus patients.

Gensterblum E, Renauer P, Coit P, Strickland FM, Kilian NC, Miller S, Ognenovski M, Wren JD, Tsou PS, Lewis EE, Maksimowicz-McKinnon K, McCune WJ, Richardson BC, Sawalha AH.

J Autoimmun. 2018 Jan;86:19-28. doi: 10.1016/j.jaut.2017.09.011. Epub 2017 Oct 20.


EZH2 Modulates the DNA Methylome and Controls T Cell Adhesion Through Junctional Adhesion Molecule A in Lupus Patients.

Tsou PS, Coit P, Kilian NC, Sawalha AH.

Arthritis Rheumatol. 2018 Jan;70(1):98-108. doi: 10.1002/art.40338. Epub 2017 Dec 15.


Scleroderma keratinocytes promote fibroblast activation independent of transforming growth factor beta.

McCoy SS, Reed TJ, Berthier CC, Tsou PS, Liu J, Gudjonsson JE, Khanna D, Kahlenberg JM.

Rheumatology (Oxford). 2017 Nov 1;56(11):1970-1981. doi: 10.1093/rheumatology/kex280.


Administration of Hypertonic Solutions for Hemorrhagic Shock: A Systematic Review and Meta-analysis of Clinical Trials.

Wu MC, Liao TY, Lee EM, Chen YS, Hsu WT, Lee MG, Tsou PY, Chen SC, Lee CC.

Anesth Analg. 2017 Nov;125(5):1549-1557. doi: 10.1213/ANE.0000000000002451. Review.


Unfolding the pathogenesis of scleroderma through genomics and epigenomics.

Tsou PS, Sawalha AH.

J Autoimmun. 2017 Sep;83:73-94. doi: 10.1016/j.jaut.2017.05.004. Epub 2017 May 16. Review.


Enantiodivergent Steglich rearrangement of O-carboxylazlactones catalyzed by a chirality switchable helicene containing a 4-aminopyridine unit.

Chen CT, Tsai CC, Tsou PK, Huang GT, Yu CH.

Chem Sci. 2017 Jan 1;8(1):524-529. doi: 10.1039/c6sc02646j. Epub 2016 Aug 25.


Pharmacokinetic optimitzation of CCG-203971: Novel inhibitors of the Rho/MRTF/SRF transcriptional pathway as potential antifibrotic therapeutics for systemic scleroderma.

Hutchings KM, Lisabeth EM, Rajeswaran W, Wilson MW, Sorenson RJ, Campbell PL, Ruth JH, Amin A, Tsou PS, Leipprandt JR, Olson SR, Wen B, Zhao T, Sun D, Khanna D, Fox DA, Neubig RR, Larsen SD.

Bioorg Med Chem Lett. 2017 Apr 15;27(8):1744-1749. doi: 10.1016/j.bmcl.2017.02.070. Epub 2017 Mar 10.


Accuracy of point-of-care focused echocardiography in predicting outcome of resuscitation in cardiac arrest patients: A systematic review and meta-analysis.

Tsou PY, Kurbedin J, Chen YS, Chou EH, Lee MG, Lee MC, Ma MH, Chen SC, Lee CC.

Resuscitation. 2017 May;114:92-99. doi: 10.1016/j.resuscitation.2017.02.021. Epub 2017 Mar 2. Review.


A Randomized Controlled Trial of Acupressure for the Treatment of Raynaud's Phenomenon: The difficulty of conducting a trial in Raynaud's phenomenon.

Gladue H, Berrocal V, Harris R, Tsou PS, Edhayan G, Ohara R, Khanna D.

J Scleroderma Relat Disord. 2016 May-Aug;1(2):226-233. Epub 2016 May 2.


The Emerging Role of B Cells in Tumor Immunity.

Tsou P, Katayama H, Ostrin EJ, Hanash SM.

Cancer Res. 2016 Oct 1;76(19):5597-5601. Epub 2016 Sep 15. Review.


Histone Deacetylase 5 Is Overexpressed in Scleroderma Endothelial Cells and Impairs Angiogenesis via Repression of Proangiogenic Factors.

Tsou PS, Wren JD, Amin MA, Schiopu E, Fox DA, Khanna D, Sawalha AH.

Arthritis Rheumatol. 2016 Dec;68(12):2975-2985. doi: 10.1002/art.39828.


A conjugated fatty acid present at high levels in bitter melon seed favorably affects lipid metabolism in hepatocytes by increasing NAD(+)/NADH ratio and activating PPARα, AMPK and SIRT1 signaling pathway.

Chen GC, Su HM, Lin YS, Tsou PY, Chyuan JH, Chao PM.

J Nutr Biochem. 2016 Jul;33:28-35. doi: 10.1016/j.jnutbio.2016.03.009. Epub 2016 Apr 1.


Histone H2AX phosphorylation as a measure of DNA double-strand breaks and a marker of environmental stress and disease activity in lupus.

Namas R, Renauer P, Ognenovski M, Tsou PS, Sawalha AH.

Lupus Sci Med. 2016 Apr 29;3(1):e000148. doi: 10.1136/lupus-2016-000148. eCollection 2016.


Unusual ileus due to calcium polystyrene sulfonate.

Keng LT, Tsou PH.

Postgrad Med J. 2016 Sep;92(1091):563. doi: 10.1136/postgradmedj-2016-134107. Epub 2016 Apr 15. No abstract available.


Analysis of Individual Signaling Complexes by mMAPS, a Flow-Proteometric System.

Chou CK, Tsou PH, Hsu JL, Lee HH, Wang YN, Kameoka J, Hung MC.

Curr Protoc Mol Biol. 2016 Apr 1;114:20.11.1-20.11.22. doi: 10.1002/0471142727.mb2011s114.


Scleroderma dermal microvascular endothelial cells exhibit defective response to pro-angiogenic chemokines.

Tsou PS, Rabquer BJ, Ohara RA, Stinson WA, Campbell PL, Amin MA, Balogh B, Zakhem G, Renauer PA, Lozier A, Arasu E, Haines GK 3rd, Kahaleh B, Schiopu E, Khanna D, Koch AE.

Rheumatology (Oxford). 2016 Apr;55(4):745-54. doi: 10.1093/rheumatology/kev399. Epub 2015 Dec 24.


A comparative study of professional and interprofessional values between health professional associations.

Tsou P, Shih J, Ho MJ.

J Interprof Care. 2015;29(6):628-33. doi: 10.3109/13561820.2015.1046159. Review.


PRMT1-mediated methylation of the EGF receptor regulates signaling and cetuximab response.

Liao HW, Hsu JM, Xia W, Wang HL, Wang YN, Chang WC, Arold ST, Chou CK, Tsou PH, Yamaguchi H, Fang YF, Lee HJ, Lee HH, Tai SK, Yang MH, Morelli MP, Sen M, Ladbury JE, Chen CH, Grandis JR, Kopetz S, Hung MC.

J Clin Invest. 2015 Dec;125(12):4529-43. doi: 10.1172/JCI82826. Epub 2015 Nov 16.


Activation of the Thromboxane A2 Receptor by 8-Isoprostane Inhibits the Pro-Angiogenic Effect of Vascular Endothelial Growth Factor in Scleroderma.

Tsou PS, Amin MA, Campbell PL, Zakhem G, Balogh B, Edhayan G, Ohara RA, Schiopu E, Khanna D, Koch AE, Fox DA.

J Invest Dermatol. 2015 Dec;135(12):3153-3162. doi: 10.1038/jid.2015.323. Epub 2015 Aug 19.


Stereochemical Course of Wittig Rearrangements of Dihydropyran Allyl Propargyl Ethers.

Isobe M, Chang WC, Tsou PK, Ploysuk C, Yu CH.

J Org Chem. 2015 Jun 19;80(12):6222-37. doi: 10.1021/acs.joc.5b00678. Epub 2015 Jun 3.


Ultrasonography for confirmation of endotracheal tube placement: a systematic review and meta-analysis.

Chou EH, Dickman E, Tsou PY, Tessaro M, Tsai YM, Ma MH, Lee CC, Marshall J.

Resuscitation. 2015 May;90:97-103. doi: 10.1016/j.resuscitation.2015.02.013. Epub 2015 Feb 21. Review.


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