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Items: 1 to 50 of 217

1.

Ductal Carcinoma in Situ Biomarkers in a Precision Medicine Era: Current and Future Molecular-Based Testing.

Shee K, Muller KE, Marotti J, Miller TW, Wells WA, Tsongalis GJ.

Am J Pathol. 2018 Oct 29. pii: S0002-9440(18)30558-3. doi: 10.1016/j.ajpath.2018.08.020. [Epub ahead of print] Review.

PMID:
30385093
2.

Identifying aerosolized cyanobacteria in the human respiratory tract: A proposed mechanism for cyanotoxin-associated diseases.

Facciponte DN, Bough MW, Seidler D, Carroll JL, Ashare A, Andrew AS, Tsongalis GJ, Vaickus LJ, Henegan PL, Butt TH, Stommel EW.

Sci Total Environ. 2018 Dec 15;645:1003-1013. doi: 10.1016/j.scitotenv.2018.07.226. Epub 2018 Jul 20.

PMID:
30248825
3.

Implementation of Multicolor Melt Curve Analysis for High-Risk Human Papilloma Virus Detection in Low- and Middle-Income Countries: A Pilot Study for Expanded Cervical Cancer Screening in Honduras.

Turner SA, Deharvengt SJ, Lyons KD, Espinal JAP, LaRochelle EPM, Bejarano S, Kennedy L, Tsongalis GJ.

J Glob Oncol. 2018 Sep;(4):1-8. doi: 10.1200/JGO.17.00035. Epub 2017 Aug 28.

4.

Maternally inherited 133kb deletion of 14q32 causing Kagami-Ogata syndrome.

Jung HS, Vallee SE, Dinulos MB, Tsongalis GJ, Lefferts JA.

J Hum Genet. 2018 Dec;63(12):1231-1239. doi: 10.1038/s10038-018-0506-z. Epub 2018 Sep 19.

PMID:
30232357
5.

Identifying Associations between Somatic Mutations and Clinicopathologic Findings in Lung Cancer Pathology Reports.

Kumar N, Tafe LJ, Higgins JH, Peterson JD, de Abreu FB, Deharvengt SJ, Tsongalis GJ, Amos CI, Hassanpour S.

Methods Inf Med. 2018 Feb;57(1):63-73. doi: 10.3414/ME17-01-0039. Epub 2018 Apr 5.

PMID:
29621832
6.

Rural distribution of human papilloma virus in low- and middle-income countries.

Atkinson A, Studwell C, Bejarano S, Castell├│n AMZ, Espinal JAP, Deharvengt S, LaRochelle EPM, Kennedy LS, Tsongalis GJ.

Exp Mol Pathol. 2018 Apr;104(2):146-150. doi: 10.1016/j.yexmp.2018.03.001. Epub 2018 Mar 16.

PMID:
29551573
7.

Potential of STAT Somatic Mutation Testing at Resection.

Al-Turkmani MR, Schutz SN, Tsongalis GJ.

Clin Chem. 2018 May;64(5):865-866. doi: 10.1373/clinchem.2017.285759. Epub 2018 Feb 26. No abstract available.

PMID:
29483108
8.

Frequency of Somatic TP53 Mutations in Combination with Known Pathogenic Mutations in Colon Adenocarcinoma, Non-Small Cell Lung Carcinoma, and Gliomas as Identified by Next-Generation Sequencing.

Shajani-Yi Z, de Abreu FB, Peterson JD, Tsongalis GJ.

Neoplasia. 2018 Mar;20(3):256-262. doi: 10.1016/j.neo.2017.12.005. Epub 2018 Feb 16.

9.

Somatic Mutation Analysis of Human Cancers: Challenges in Clinical Practice.

Tsongalis GJ, Coleman WB.

J Clin Pharmacol. 2017 Oct;57 Suppl 10:S60-S66. doi: 10.1002/jcph.934.

PMID:
28921651
10.

Somatic mutation analysis in melanoma using targeted next generation sequencing.

Miraflor AP, de Abreu FB, Peterson JD, Turner SA, Amos CI, Tsongalis GJ, Yan S.

Exp Mol Pathol. 2017 Oct;103(2):172-177. doi: 10.1016/j.yexmp.2017.08.006. Epub 2017 Aug 16.

PMID:
28822769
11.

The Case for Laboratory Developed Procedures: Quality and Positive Impact on Patient Care.

Kaul KL, Sabatini LM, Tsongalis GJ, Caliendo AM, Olsen RJ, Ashwood ER, Bale S, Benirschke R, Carlow D, Funke BH, Grody WW, Hayden RT, Hegde M, Lyon E, Murata K, Pessin M, Press RD, Thomson RB.

Acad Pathol. 2017 Jul 16;4:2374289517708309. doi: 10.1177/2374289517708309. eCollection 2017 Jan-Dec.

12.

Triple-Negative Breast Cancer: Next-Generation Sequencing for Target Identification.

Marotti JD, de Abreu FB, Wells WA, Tsongalis GJ.

Am J Pathol. 2017 Oct;187(10):2133-2138. doi: 10.1016/j.ajpath.2017.05.018. Epub 2017 Jul 20. Review.

PMID:
28734944
13.

Development of HLA-B*57:01 Genotyping Real-Time PCR with Optimized Hydrolysis Probe Design.

Jung HS, Tsongalis GJ, Lefferts JA.

J Mol Diagn. 2017 Sep;19(5):742-754. doi: 10.1016/j.jmoldx.2017.05.002. Epub 2017 Jul 18.

PMID:
28732216
14.

Not all good things come in big packages.

Guire V, Fabbri M, Tsongalis GJ.

Clin Chem Lab Med. 2017 May 1;55(5):605-607. doi: 10.1515/cclm-2017-0176. No abstract available.

15.

miRNA analysis in pancreatic cancer: the Dartmouth experience.

Abreu FB, Liu X, Tsongalis GJ.

Clin Chem Lab Med. 2017 May 1;55(5):755-762. doi: 10.1515/cclm-2017-0046. Review.

16.

Hyper-Methylated Loci Persisting from Sessile Serrated Polyps to Serrated Cancers.

Andrew AS, Baron JA, Butterly LF, Suriawinata AA, Tsongalis GJ, Robinson CM, Amos CI.

Int J Mol Sci. 2017 Mar 2;18(3). pii: E535. doi: 10.3390/ijms18030535.

17.

Variant call concordance between two laboratory-developed, solid tumor targeted genomic profiling assays using distinct workflows and sequencing instruments.

Hampel KJ, de Abreu FB, Sidiropoulos N, Peterson JD, Tsongalis GJ.

Exp Mol Pathol. 2017 Apr;102(2):215-218. doi: 10.1016/j.yexmp.2017.02.002. Epub 2017 Feb 10.

PMID:
28192086
18.

HS3ST1 genotype regulates antithrombin's inflammomodulatory tone and associates with atherosclerosis.

Smits NC, Kobayashi T, Srivastava PK, Skopelja S, Ivy JA, Elwood DJ, Stan RV, Tsongalis GJ, Sellke FW, Gross PL, Cole MD, DeVries JT, Kaplan AV, Robb JF, Williams SM, Shworak NW.

Matrix Biol. 2017 Nov;63:69-90. doi: 10.1016/j.matbio.2017.01.003. Epub 2017 Jan 23.

19.

Immune modulation associated with vascular endothelial growth factor (VEGF) blockade in patients with glioblastoma.

Thomas AA, Fisher JL, Hampton TH, Christensen BC, Tsongalis GJ, Rahme GJ, Whipple CA, Steel SE, Davis MC, Gaur AB, Lewis LD, Ernstoff MS, Fadul CE.

Cancer Immunol Immunother. 2017 Mar;66(3):379-389. doi: 10.1007/s00262-016-1941-3. Epub 2016 Dec 9.

PMID:
27942839
20.

A Phase II Trial of Dovitinib in BCG-Unresponsive Urothelial Carcinoma with FGFR3 Mutations or Overexpression: Hoosier Cancer Research Network Trial HCRN 12-157.

Hahn NM, Bivalacqua TJ, Ross AE, Netto GJ, Baras A, Park JC, Chapman C, Masterson TA, Koch MO, Bihrle R, Foster RS, Gardner TA, Cheng L, Jones DR, McElyea K, Sandusky GE, Breen T, Liu Z, Albany C, Moore ML, Loman RL, Reed A, Turner SA, De Abreu FB, Gallagher T, Tsongalis GJ, Plimack ER, Greenberg RE, Geynisman DM.

Clin Cancer Res. 2017 Jun 15;23(12):3003-3011. doi: 10.1158/1078-0432.CCR-16-2267. Epub 2016 Dec 8.

21.

Role of microRNAs in regulation of the TNF/TNFR gene superfamily in chronic lymphocytic leukemia.

Srivastava S, Tsongalis GJ, Kaur P.

Clin Biochem. 2016 Nov;49(16-17):1307-1310. doi: 10.1016/j.clinbiochem.2016.08.010. Epub 2016 Aug 17.

PMID:
27544753
22.

Improving Adequacy of Small Biopsy and Fine-Needle Aspiration Specimens for Molecular Testing by Next-Generation Sequencing in Patients With Lung Cancer: A Quality Improvement Study at Dartmouth-Hitchcock Medical Center.

Padmanabhan V, Steinmetz HB, Rizzo EJ, Erskine AJ, Fairbank TL, de Abreu FB, Tsongalis GJ, Tafe LJ.

Arch Pathol Lab Med. 2017 Mar;141(3):402-409. doi: 10.5858/arpa.2016-0096-OA. Epub 2016 Oct 20.

PMID:
27763790
23.

Detection of CALR Mutation in Clonal and Nonclonal Hematologic Diseases Using Fragment Analysis and Next-Generation Sequencing.

Gardner JA, Peterson JD, Turner SA, Soares BL, Lancor CR, Dos Santos LL, Kaur P, Ornstein DL, Tsongalis GJ, de Abreu FB.

Am J Clin Pathol. 2016 Oct;146(4):448-55. doi: 10.1093/ajcp/aqw129.

PMID:
27686171
24.

The Use of Targeted Therapies for Precision Medicine in Oncology.

White Al-Habeeb N, Kulasingam V, Diamandis EP, Yousef GM, Tsongalis GJ, Vermeulen L, Zhu Z, Kamel-Reid S.

Clin Chem. 2016 Dec;62(12):1556-1564. Epub 2016 Sep 27. No abstract available.

25.

Clinical Genotyping of Non-Small Cell Lung Cancers Using Targeted Next-Generation Sequencing: Utility of Identifying Rare and Co-mutations in Oncogenic Driver Genes.

Tafe LJ, Pierce KJ, Peterson JD, de Abreu F, Memoli VA, Black CC, Pettus JR, Marotti JD, Gutmann EJ, Liu X, Shirai K, Dragnev KH, Amos CI, Tsongalis GJ.

Neoplasia. 2016 Sep;18(9):577-83. doi: 10.1016/j.neo.2016.07.010.

26.

The genomic profile of pancreatic adenocarcinoma and its relationship to metastatic disease.

Pierce KJ, de Abreu FB, Peterson JD, Suriawinata AA, Tsongalis GJ, Liu X.

Exp Mol Pathol. 2016 Oct;101(2):172-175. doi: 10.1016/j.yexmp.2016.07.011. Epub 2016 Aug 3. No abstract available.

PMID:
27498048
27.

Alpha-synuclein (SNCA) polymorphisms exert protective effects on memory after mild traumatic brain injury.

Shee K, Lucas A, Flashman LA, Nho K, Tsongalis GJ, McDonald BC, Saykin AJ, McAllister TW, Rhodes CH.

Neurosci Lett. 2016 Sep 6;630:241-246. doi: 10.1016/j.neulet.2016.07.057. Epub 2016 Jul 29.

28.

Somatic gene mutation analysis of triple negative breast cancers.

Dillon JL, Mockus SM, Ananda G, Spotlow V, Wells WA, Tsongalis GJ, Marotti JD.

Breast. 2016 Oct;29:202-7. doi: 10.1016/j.breast.2016.06.018. Epub 2016 Jul 7.

PMID:
27397723
29.

Targeted next-generation sequencing detects a high frequency of potentially actionable mutations in metastatic breast cancers.

Muller KE, Marotti JD, de Abreu FB, Peterson JD, Miller TW, Chamberlin MD, Tsongalis GJ, Tafe LJ.

Exp Mol Pathol. 2016 Jun;100(3):421-5. doi: 10.1016/j.yexmp.2016.04.002. Epub 2016 Apr 16.

PMID:
27095739
30.

The potential utility of re-mining results of somatic mutation testing: KRAS status in lung adenocarcinoma.

Biernacka A, Tsongalis PD, Peterson JD, de Abreu FB, Black CC, Gutmann EJ, Liu X, Tafe LJ, Amos CI, Tsongalis GJ.

Cancer Genet. 2016 May;209(5):195-8. doi: 10.1016/j.cancergen.2016.03.001. Epub 2016 Mar 18.

31.

Rat-bite fever: An uncommon cause of fever and rash in a 9-year-old patient.

Miraflor AP, Davallow Ghajar L, Subramaniam S, de Abreu FB, Castanedo-Tardan MP, Samie FH, Mann JA, Holmes AV, Tsongalis GJ, Yan S.

JAAD Case Rep. 2015 Oct 24;1(6):371-4. doi: 10.1016/j.jdcr.2015.09.008. eCollection 2015 Nov. No abstract available.

32.

The mitogen-activated protein kinase pathway plays a critical role in regulating immunological properties of BRAF mutant cutaneous melanoma cells.

Whipple CA, Boni A, Fisher JL, Hampton TH, Tsongalis GJ, Mellinger DL, Yan S, Tafe LJ, Brinckerhoff CE, Turk MJ, Mullins DW, Fadul CE, Ernstoff MS.

Melanoma Res. 2016 Jun;26(3):223-35. doi: 10.1097/CMR.0000000000000244.

PMID:
26974965
33.

Genomic characterization of patient-derived xenograft models established from fine needle aspirate biopsies of a primary pancreatic ductal adenocarcinoma and from patient-matched metastatic sites.

Allaway RJ, Fischer DA, de Abreu FB, Gardner TB, Gordon SR, Barth RJ, Colacchio TA, Wood M, Kacsoh BZ, Bouley SJ, Cui J, Hamilton J, Choi JA, Lange JT, Peterson JD, Padmanabhan V, Tomlinson CR, Tsongalis GJ, Suriawinata AA, Greene CS, Sanchez Y, Smith KD.

Oncotarget. 2016 Mar 29;7(13):17087-102. doi: 10.18632/oncotarget.7718.

34.

The Pitfalls of Companion Diagnostics: Evaluation of Discordant EGFR Mutation Results from a Clinical Laboratory and a Central Laboratory.

Turner SA, Peterson JD, Pettus JR, de Abreu FB, Amos CI, Dragnev KH, Tsongalis GJ.

J Mol Diagn. 2016 May;18(3):331-335. doi: 10.1016/j.jmoldx.2015.12.004. Epub 2016 Mar 7.

35.

Effective quality management practices in routine clinical next-generation sequencing.

de Abreu FB, Peterson JD, Amos CI, Wells WA, Tsongalis GJ.

Clin Chem Lab Med. 2016 May;54(5):761-71. doi: 10.1515/cclm-2015-1190.

36.

An analysis of human papillomavirus testing and endocervical component on pap tests: A pilot study using the Roche Cobas(®) assay.

Pierce KJ, Currens HS, Tafe LJ, Tsongalis GJ, Padmanabhan V.

Diagn Cytopathol. 2016 Apr;44(4):280-2. doi: 10.1002/dc.23436. Epub 2016 Jan 23.

PMID:
26801205
37.

Molecular Genetic Analysis of Ovarian Brenner Tumors and Associated Mucinous Epithelial Neoplasms: High Variant Concordance and Identification of Mutually Exclusive RAS Driver Mutations and MYC Amplification.

Tafe LJ, Muller KE, Ananda G, Mitchell T, Spotlow V, Patterson SE, Tsongalis GJ, Mockus SM.

Am J Pathol. 2016 Mar;186(3):671-7. doi: 10.1016/j.ajpath.2015.11.008. Epub 2016 Jan 18.

38.

Clinical Trials in Precision Oncology.

Mockus SM, Patterson SE, Statz C, Bult CJ, Tsongalis GJ.

Clin Chem. 2016 Mar;62(3):442-8. doi: 10.1373/clinchem.2015.247437. Epub 2015 Nov 25. Review.

39.

Implementation of a Molecular Tumor Board: The Impact on Treatment Decisions for 35 Patients Evaluated at Dartmouth-Hitchcock Medical Center.

Tafe LJ, Gorlov IP, de Abreu FB, Lefferts JA, Liu X, Pettus JR, Marotti JD, Bloch KJ, Memoli VA, Suriawinata AA, Dragnev KH, Fadul CE, Schwartz GN, Morgan CR, Holderness BM, Peterson JD, Tsongalis GJ, Miller TW, Chamberlin MD.

Oncologist. 2015 Sep;20(9):1011-8. doi: 10.1634/theoncologist.2015-0097. Epub 2015 Jul 23.

40.

Molecular profiling of intrahepatic and extrahepatic cholangiocarcinoma using next generation sequencing.

Putra J, de Abreu FB, Peterson JD, Pipas JM, Mody K, Amos CI, Tsongalis GJ, Suriawinata AA.

Exp Mol Pathol. 2015 Oct;99(2):240-4. doi: 10.1016/j.yexmp.2015.07.005. Epub 2015 Jul 17.

41.

A 78-year-old woman with brain metastases.

Tafe LJ, Tsongalis GJ.

Clin Chem. 2015 Apr;61(4):584-6. doi: 10.1373/clinchem.2014.229864. No abstract available.

42.

Regulatory T cells are not a strong predictor of survival for patients with glioblastoma.

Thomas AA, Fisher JL, Rahme GJ, Hampton TH, Baron U, Olek S, Schwachula T, Rhodes CH, Gui J, Tafe LJ, Tsongalis GJ, Lefferts JA, Wishart H, Kleen J, Miller M, Whipple CA, de Abreu FB, Ernstoff MS, Fadul CE.

Neuro Oncol. 2015 Jun;17(6):801-9. doi: 10.1093/neuonc/nou363. Epub 2015 Jan 24.

43.

A multiplex PCR assay for the simultaneous detection of Chlamydia trachomatis, Neisseria gonorrhoeae, and Trichomonas vaginalis.

Abou Tayoun AN, Burchard PR, Caliendo AM, Scherer A, Tsongalis GJ.

Exp Mol Pathol. 2015 Apr;98(2):214-8. doi: 10.1016/j.yexmp.2015.01.011. Epub 2015 Jan 13.

PMID:
25595915
44.

Rapid fluorescence in situ hybridisation (FISH) for HER2 (ERBB2) assessment in breast and gastro-oesophageal cancer.

Tafe LJ, Steinmetz HB, Allen SF, Dokus BJ, Tsongalis GJ.

J Clin Pathol. 2015 Apr;68(4):306-8. doi: 10.1136/jclinpath-2014-202787. Epub 2015 Jan 9.

PMID:
25576545
45.

Variation in pre-PCR processing of FFPE samples leads to discrepancies in BRAF and EGFR mutation detection: a diagnostic RING trial.

Kapp JR, Diss T, Spicer J, Gandy M, Schrijver I, Jennings LJ, Li MM, Tsongalis GJ, de Castro DG, Bridge JA, Wallace A, Deignan JL, Hing S, Butler R, Verghese E, Latham GJ, Hamoudi RA.

J Clin Pathol. 2015 Feb;68(2):111-8. doi: 10.1136/jclinpath-2014-202644. Epub 2014 Nov 27.

46.

Biomarker testing for breast, lung, and gastroesophageal cancers at NCI designated cancer centers.

Schink JC, Trosman JR, Weldon CB, Siziopikou KP, Tsongalis GJ, Rademaker AW, Patel JD, Benson AB 3rd, Perez EA, Gradishar WJ.

J Natl Cancer Inst. 2014 Sep 12;106(10). pii: dju256. doi: 10.1093/jnci/dju256. Print 2014 Oct.

47.

Development of a rapid clinical TPMT genotyping assay.

Burchard PR, Abou Tayoun AN, Lefferts JA, Lewis LD, Tsongalis GJ, Cervinski MA.

Clin Biochem. 2014 Oct;47(15):126-9. doi: 10.1016/j.clinbiochem.2014.07.088. Epub 2014 Aug 2.

PMID:
25093923
48.

The effect of neoadjuvant chemoradiation on pancreatic cancer-associated diabetes mellitus.

Gardner TB, Hessami N, Smith KD, Ripple GH, Barth RJ, Klibansky DA, Colacchio TA, Zaki B, Tsapakos MJ, Suriawinata AA, Putra J, Tsongalis GJ, Mody K, Gordon SR, Pipas JM.

Pancreas. 2014 Oct;43(7):1018-21. doi: 10.1097/MPA.0000000000000162.

PMID:
25000339
49.

A rapid RT-PCR assay for the detection of HIV-1 in human plasma specimens.

Burchard PR, Abou Tayoun AN, Scherer A, Tsongalis GJ.

Exp Mol Pathol. 2014 Aug;97(1):111-5. doi: 10.1016/j.yexmp.2014.06.005. Epub 2014 Jun 16.

PMID:
24945443
50.

Automated processing of fluorescence in-situ hybridization slides for HER2 testing in breast and gastro-esophageal carcinomas.

Tafe LJ, Allen SF, Steinmetz HB, Dokus BA, Cook LJ, Marotti JD, Tsongalis GJ.

Exp Mol Pathol. 2014 Aug;97(1):116-9. doi: 10.1016/j.yexmp.2014.06.003. Epub 2014 Jun 11.

PMID:
24927872

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