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Items: 1 to 50 of 493

1.

SLAMF1 engagement inhibits T cell-B cell interaction and diminishes IL-6 production and plasmablast differentiation in systemic lupus erythematosus.

Karampetsou MP, Comte D, Suárez-Fueyo A, Katsuyama E, Yoshida N, Kono M, Kyttaris VC, Tsokos GC.

Arthritis Rheumatol. 2018 Jul 29. doi: 10.1002/art.40682. [Epub ahead of print]

PMID:
30058241
2.

CaMK4 compromises podocyte function in autoimmune and nonautoimmune kidney disease.

Maeda K, Otomo K, Yoshida N, Abu-Asab MS, Ichinose K, Nishino T, Kono M, Ferretti A, Bhargava R, Maruyama S, Bickerton S, Fahmy TM, Tsokos MG, Tsokos GC.

J Clin Invest. 2018 Aug 1;128(8):3445-3459. doi: 10.1172/JCI99507. Epub 2018 Jul 9.

3.

Correction: Downregulation of miR-200a-3p, Targeting CtBP2 Complex, Is Involved in the Hypoproduction of IL-2 in Systemic Lupus Erythematosus-Derived T Cells.

Katsuyama E, Yan M, Watanabe KS, Narazaki M, Matsushima S, Yamamura Y, Hiramatsu S, Ohashi K, Watanabe H, Katsuyama T, Zeggar S, Yoshida N, Moulton VR, Tsokos GC, Sada KE, Wada J.

J Immunol. 2018 Aug 1;201(3):1104. doi: 10.4049/jimmunol.1800810. Epub 2018 Jun 25. No abstract available.

PMID:
29941662
4.

Decreased expression of Serine/arginine-rich splicing factor 1 in T cells from patients with active systemic lupus erythematosus accounts for reduced expression of RasGRP1 and DNA methyltransferase 1.

Kono M, Kurita T, Yasuda S, Kono M, Fujieda Y, Bohgaki T, Katsuyama T, Tsokos GC, Moulton VR, Atsumi T.

Arthritis Rheumatol. 2018 Jun 14. doi: 10.1002/art.40585. [Epub ahead of print]

PMID:
29905030
5.

Aberrant T Cell Signaling and Subsets in Systemic Lupus Erythematosus.

Katsuyama T, Tsokos GC, Moulton VR.

Front Immunol. 2018 May 17;9:1088. doi: 10.3389/fimmu.2018.01088. eCollection 2018. Review.

6.

Targeting Regulatory T Cells to Treat Patients With Systemic Lupus Erythematosus.

Mizui M, Tsokos GC.

Front Immunol. 2018 Apr 17;9:786. doi: 10.3389/fimmu.2018.00786. eCollection 2018. Review.

7.

Downregulation of CD3ζ in NK Cells from Systemic Lupus Erythematosus Patients Confers a Proinflammatory Phenotype.

Suárez-Fueyo A, Bradley SJ, Katsuyama T, Solomon S, Katsuyama E, Kyttaris VC, Moulton VR, Tsokos GC.

J Immunol. 2018 May 1;200(9):3077-3086. doi: 10.4049/jimmunol.1700588. Epub 2018 Mar 30.

PMID:
29602774
8.

Transcriptional factor ICER promotes glutaminolysis and the generation of Th17 cells.

Kono M, Yoshida N, Maeda K, Tsokos GC.

Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):2478-2483. doi: 10.1073/pnas.1714717115. Epub 2018 Feb 20.

PMID:
29463741
9.

SLE-Associated Defects Promote Altered T Cell Function.

Crispin JC, Hedrich CM, Suárez-Fueyo A, Comte D, Tsokos GC.

Crit Rev Immunol. 2017;37(1):39-58. doi: 10.1615/CritRevImmunol.2018025213.

PMID:
29431078
10.

New insights into the role of renal resident cells in the pathogenesis of lupus nephritis.

Kwok SK, Tsokos GC.

Korean J Intern Med. 2018 Mar;33(2):284-289. doi: 10.3904/kjim.2017.383. Epub 2018 Jan 12. Review.

11.

Recent developments in systemic lupus erythematosus pathogenesis and applications for therapy.

Lo MS, Tsokos GC.

Curr Opin Rheumatol. 2018 Mar;30(2):222-228. doi: 10.1097/BOR.0000000000000474.

PMID:
29206660
12.

Expression patterns of signaling lymphocytic activation molecule family members in peripheral blood mononuclear cell subsets in patients with systemic lupus erythematosus.

Karampetsou MP, Comte D, Kis-Toth K, Kyttaris VC, Tsokos GC.

PLoS One. 2017 Oct 11;12(10):e0186073. doi: 10.1371/journal.pone.0186073. eCollection 2017.

13.

C3a Enhances the Formation of Intestinal Organoids through C3aR1.

Matsumoto N, Satyam A, Geha M, Lapchak PH, Dalle Lucca JJ, Tsokos MG, Tsokos GC.

Front Immunol. 2017 Sep 4;8:1046. doi: 10.3389/fimmu.2017.01046. eCollection 2017.

14.

Neutrophil FcγRIIA promotes IgG-mediated glomerular neutrophil capture via Abl/Src kinases.

Nishi H, Furuhashi K, Cullere X, Saggu G, Miller MJ, Chen Y, Rosetti F, Hamilton SL, Yang L, Pittman SP, Liao J, Herter JM, Berry JC, DeAngelo DJ, Zhu C, Tsokos GC, Mayadas TN.

J Clin Invest. 2017 Oct 2;127(10):3810-3826. doi: 10.1172/JCI94039. Epub 2017 Sep 11.

15.

IL-17A Produced by Innate Lymphoid Cells Is Essential for Intestinal Ischemia-Reperfusion Injury.

Geha M, Tsokos MG, Bosse RE, Sannikova T, Iwakura Y, Dalle Lucca JJ, De Waal Malefyt R, Tsokos GC.

J Immunol. 2017 Oct 15;199(8):2921-2929. doi: 10.4049/jimmunol.1700655. Epub 2017 Sep 6.

PMID:
28877988
16.

Fat T cells go to the joint.

Tsokos GC.

Nat Immunol. 2017 Aug 22;18(9):955-956. doi: 10.1038/ni.3810. No abstract available.

PMID:
28829450
17.

The serine/threonine protein phosphatase 2A controls autoimmunity.

Sharabi A, Kasper IR, Tsokos GC.

Clin Immunol. 2018 Jan;186:38-42. doi: 10.1016/j.clim.2017.07.012. Epub 2017 Jul 21.

PMID:
28736280
18.

IL-23 Limits the Production of IL-2 and Promotes Autoimmunity in Lupus.

Dai H, He F, Tsokos GC, Kyttaris VC.

J Immunol. 2017 Aug 1;199(3):903-910. doi: 10.4049/jimmunol.1700418. Epub 2017 Jun 23.

19.

Aneurysm of the ascending aorta in systemic lupus erythematosus: Case report and review of the literature.

Corominas H, Tsokos M, Quezado M, Tsokos GC.

Eur J Rheumatol. 2017 Jun;4(2):133-135. doi: 10.5152/eurjrheum.2017.17066. Epub 2017 Jun 1.

20.

Pathogenesis of Human Systemic Lupus Erythematosus: A Cellular Perspective.

Moulton VR, Suarez-Fueyo A, Meidan E, Li H, Mizui M, Tsokos GC.

Trends Mol Med. 2017 Jul;23(7):615-635. doi: 10.1016/j.molmed.2017.05.006. Epub 2017 Jun 13. Review.

21.

Microglia-dependent synapse loss in type I interferon-mediated lupus.

Bialas AR, Presumey J, Das A, van der Poel CE, Lapchak PH, Mesin L, Victora G, Tsokos GC, Mawrin C, Herbst R, Carroll MC.

Nature. 2017 Jun 22;546(7659):539-543. doi: 10.1038/nature22821. Epub 2017 Jun 14.

PMID:
28614301
22.

Immune cell signaling in autoimmune diseases.

Tsokos GC, Rose NR.

Clin Immunol. 2017 Aug;181:1-8. doi: 10.1016/j.clim.2017.05.015. Epub 2017 May 19. Review.

PMID:
28531376
23.

Downregulation of miR-200a-3p, Targeting CtBP2 Complex, Is Involved in the Hypoproduction of IL-2 in Systemic Lupus Erythematosus-Derived T Cells.

Katsuyama E, Yan M, Watanabe KS, Matsushima S, Yamamura Y, Hiramatsu S, Ohashi K, Watanabe H, Katsuyama T, Zeggar S, Yoshida N, Moulton VR, Tsokos GC, Sada KE, Wada J.

J Immunol. 2017 Jun 1;198(11):4268-4276. doi: 10.4049/jimmunol.1601705. Epub 2017 Apr 24. Erratum in: J Immunol. 2018 Aug 1;201(3):1104.

24.

T cells and autoimmune kidney disease.

Suárez-Fueyo A, Bradley SJ, Klatzmann D, Tsokos GC.

Nat Rev Nephrol. 2017 Jun;13(6):329-343. doi: 10.1038/nrneph.2017.34. Epub 2017 Mar 13. Review.

PMID:
28287110
25.

CD74 Deficiency Mitigates Systemic Lupus Erythematosus-like Autoimmunity and Pathological Findings in Mice.

Zhou Y, Chen H, Liu L, Yu X, Sukhova GK, Yang M, Zhang L, Kyttaris VC, Tsokos GC, Stillman IE, Ichimura T, Bonventre JV, Libby P, Shi GP.

J Immunol. 2017 Apr 1;198(7):2568-2577. doi: 10.4049/jimmunol.1600028. Epub 2017 Feb 20.

26.

Cathepsin K Deficiency Ameliorates Systemic Lupus Erythematosus-like Manifestations in Faslpr Mice.

Zhou Y, Chen H, Liu L, Yu X, Sukhova GK, Yang M, Kyttaris VC, Stillman IE, Gelb B, Libby P, Tsokos GC, Shi GP.

J Immunol. 2017 Mar 1;198(5):1846-1854. doi: 10.4049/jimmunol.1501145. Epub 2017 Jan 16.

27.

Signaling Lymphocytic Activation Molecule Family Member 7 Engagement Restores Defective Effector CD8+ T Cell Function in Systemic Lupus Erythematosus.

Comte D, Karampetsou MP, Yoshida N, Kis-Toth K, Kyttaris VC, Tsokos GC.

Arthritis Rheumatol. 2017 May;69(5):1035-1044. doi: 10.1002/art.40038.

28.

Brief Report: CD4+ T Cells From Patients With Systemic Lupus Erythematosus Respond Poorly to Exogenous Interleukin-2.

Comte D, Karampetsou MP, Kis-Toth K, Yoshida N, Bradley SJ, Kyttaris VC, Tsokos GC.

Arthritis Rheumatol. 2017 Apr;69(4):808-813. doi: 10.1002/art.40014.

29.

Intracellular Activation of Complement 3 Is Responsible for Intestinal Tissue Damage during Mesenteric Ischemia.

Satyam A, Kannan L, Matsumoto N, Geha M, Lapchak PH, Bosse R, Shi GP, Dalle Lucca JJ, Tsokos MG, Tsokos GC.

J Immunol. 2017 Jan 15;198(2):788-797. doi: 10.4049/jimmunol.1502287. Epub 2016 Dec 2.

30.

DNA methylation in systemic lupus erythematosus.

Hedrich CM, Mäbert K, Rauen T, Tsokos GC.

Epigenomics. 2017 Apr;9(4):505-525. doi: 10.2217/epi-2016-0096. Epub 2016 Nov 25. Review.

31.

New insights into the immunopathogenesis of systemic lupus erythematosus.

Tsokos GC, Lo MS, Costa Reis P, Sullivan KE.

Nat Rev Rheumatol. 2016 Nov 22;12(12):716-730. doi: 10.1038/nrrheum.2016.186. Review.

PMID:
27872476
32.

Deficiency of base excision repair enzyme NEIL3 drives increased predisposition to autoimmunity.

Massaad MJ, Zhou J, Tsuchimoto D, Chou J, Jabara H, Janssen E, Glauzy S, Olson BG, Morbach H, Ohsumi TK, Schmitz K, Kyriacos M, Kane J, Torisu K, Nakabeppu Y, Notarangelo LD, Chouery E, Megarbane A, Kang PB, Al-Idrissi E, Aldhekri H, Meffre E, Mizui M, Tsokos GC, Manis JP, Al-Herz W, Wallace SS, Geha RS.

J Clin Invest. 2016 Nov 1;126(11):4219-4236. doi: 10.1172/JCI85647. Epub 2016 Oct 17.

33.

What rheumatologists need to know about innate lymphocytes.

Exley MA, Tsokos GC, Mills KH, Elewaut D, Mulhearn B.

Nat Rev Rheumatol. 2016 Nov;12(11):658-668. doi: 10.1038/nrrheum.2016.140. Epub 2016 Sep 2. Review.

PMID:
27586381
34.

Low-Dose IL-2 in the Treatment of Lupus.

Mizui M, Tsokos GC.

Curr Rheumatol Rep. 2016 Nov;18(11):68. Review.

PMID:
27734211
35.

ICER is requisite for Th17 differentiation.

Yoshida N, Comte D, Mizui M, Otomo K, Rosetti F, Mayadas TN, Crispín JC, Bradley SJ, Koga T, Kono M, Karampetsou MP, Kyttaris VC, Tenbrock K, Tsokos GC.

Nat Commun. 2016 Sep 29;7:12993. doi: 10.1038/ncomms12993.

36.

T cells in Systemic Lupus Erythematosus.

Suárez-Fueyo A, Bradley SJ, Tsokos GC.

Curr Opin Immunol. 2016 Dec;43:32-38. doi: 10.1016/j.coi.2016.09.001. Epub 2016 Sep 13. Review.

37.

Engagement of SLAMF3 enhances CD4+ T-cell sensitivity to IL-2 and favors regulatory T-cell polarization in systemic lupus erythematosus.

Comte D, Karampetsou MP, Kis-Toth K, Yoshida N, Bradley SJ, Mizui M, Kono M, Solomon JR, Kyttaris VC, Tsokos GC.

Proc Natl Acad Sci U S A. 2016 Aug 16;113(33):9321-6. doi: 10.1073/pnas.1605081113. Epub 2016 Aug 1.

38.

Empowering Regulatory T Cells in Autoimmunity.

Kasper IR, Apostolidis SA, Sharabi A, Tsokos GC.

Trends Mol Med. 2016 Sep;22(9):784-797. doi: 10.1016/j.molmed.2016.07.003. Epub 2016 Jul 25. Review.

39.

C1 Inhibitor Limits Organ Injury and Prolongs Survival in Swine Subjected to Battlefield Simulated Injury.

Campbell JC, Li Y, van Amersfoort E, Relan A, Dubick M, Sheppard F, Pusateri A, Niemeyer D, Tsokos GC, Dalle Lucca JJ.

Shock. 2016 Sep;46(3 Suppl 1):177-88. doi: 10.1097/SHK.0000000000000677.

PMID:
27405065
40.

Complement Activation in Trauma Patients Alters Platelet Function.

Atefi G, Aisiku O, Shapiro N, Hauser C, Dalle Lucca J, Flaumenhaft R, Tsokos GC.

Shock. 2016 Sep;46(3 Suppl 1):83-8. doi: 10.1097/SHK.0000000000000675.

PMID:
27355402
41.

Decreased SAP Expression in T Cells from Patients with Systemic Lupus Erythematosus Contributes to Early Signaling Abnormalities and Reduced IL-2 Production.

Karampetsou MP, Comte D, Kis-Toth K, Terhorst C, Kyttaris VC, Tsokos GC.

J Immunol. 2016 Jun 15;196(12):4915-24. doi: 10.4049/jimmunol.1501523. Epub 2016 May 11.

42.

Inhibition of SHP2 ameliorates the pathogenesis of systemic lupus erythematosus.

Wang J, Mizui M, Zeng LF, Bronson R, Finnell M, Terhorst C, Kyttaris VC, Tsokos GC, Zhang ZY, Kontaridis MI.

J Clin Invest. 2016 Jun 1;126(6):2077-92. doi: 10.1172/JCI87037. Epub 2016 May 16.

43.

Pin1-Targeted Therapy for Systemic Lupus Erythematosus.

Wei S, Yoshida N, Finn G, Kozono S, Nechama M, Kyttaris VC, Zhen Zhou X, Tsokos GC, Ping Lu K.

Arthritis Rheumatol. 2016 Oct;68(10):2503-13. doi: 10.1002/art.39741.

44.

T cells and IL-17 in lupus nephritis.

Koga T, Ichinose K, Tsokos GC.

Clin Immunol. 2017 Dec;185:95-99. doi: 10.1016/j.clim.2016.04.010. Epub 2016 Apr 21. Review.

PMID:
27109641
45.

Altered type II interferon precedes autoantibody accrual and elevated type I interferon activity prior to systemic lupus erythematosus classification.

Munroe ME, Lu R, Zhao YD, Fife DA, Robertson JM, Guthridge JM, Niewold TB, Tsokos GC, Keith MP, Harley JB, James JA.

Ann Rheum Dis. 2016 Nov;75(11):2014-2021. doi: 10.1136/annrheumdis-2015-208140. Epub 2016 Jan 25.

46.

Pro-inflammatory self-reactive T cells are found within murine TCR-αβ(+) CD4(-) CD8(-) PD-1(+) cells.

Rodríguez-Rodríguez N, Apostolidis SA, Fitzgerald L, Meehan BS, Corbett AJ, Martín-Villa JM, McCluskey J, Tsokos GC, Crispín JC.

Eur J Immunol. 2016 Jun;46(6):1383-91. doi: 10.1002/eji.201546056. Epub 2016 Apr 26.

47.

Targeting Syk in Autoimmune Rheumatic Diseases.

Deng GM, Kyttaris VC, Tsokos GC.

Front Immunol. 2016 Mar 7;7:78. doi: 10.3389/fimmu.2016.00078. eCollection 2016. Review.

48.

Metabolic control of arthritis: Switch pathways to treat.

Tsokos GC.

Sci Transl Med. 2016 Mar 23;8(331):331fs8. doi: 10.1126/scitranslmed.aaf4953. Review.

PMID:
27009266
49.

The role of Syk in cutaneous lupus erythematosus.

Deng GM, Tsokos GC.

Exp Dermatol. 2016 Sep;25(9):674-5. doi: 10.1111/exd.13018. Epub 2016 Aug 19. No abstract available.

PMID:
26999068
50.

Phosphatase PP2A is requisite for the function of regulatory T cells.

Apostolidis SA, Rodríguez-Rodríguez N, Suárez-Fueyo A, Dioufa N, Ozcan E, Crispín JC, Tsokos MG, Tsokos GC.

Nat Immunol. 2016 May;17(5):556-64. doi: 10.1038/ni.3390. Epub 2016 Mar 14.

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