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Items: 1 to 50 of 512

1.

TARGETING TARGETED TREATMENT FOR IMMUNE AND NON-IMMUNE KIDNEY DISEASES.

Tsokos GC, Tsokos MG.

Trans Am Clin Climatol Assoc. 2019;130:88-99.

2.

Splicing factor SRSF1 controls T cell hyperactivity and systemic autoimmunity.

Katsuyama T, Li H, Comte D, Tsokos GC, Moulton VR.

J Clin Invest. 2019 Sep 5. pii: 127949. doi: 10.1172/JCI127949. [Epub ahead of print]

3.

SLAMF6 as a Regulator of Exhausted CD8+ T Cells in Cancer.

Yigit B, Wang N, Ten Hacken E, Chen SS, Bhan AK, Suarez-Fueyo A, Katsuyama E, Tsokos GC, Chiorazzi N, Wu CJ, Burger JA, Herzog RW, Engel P, Terhorst C.

Cancer Immunol Res. 2019 Sep;7(9):1485-1496. doi: 10.1158/2326-6066.CIR-18-0664. Epub 2019 Jul 17.

PMID:
31315913
4.

Glutaminase 1 Inhibition Reduces Glycolysis and Ameliorates Lupus-like Disease in MRL/lpr Mice and Experimental Autoimmune Encephalomyelitis.

Kono M, Yoshida N, Maeda K, Suárez-Fueyo A, Kyttaris VC, Tsokos GC.

Arthritis Rheumatol. 2019 Jun 24. doi: 10.1002/art.41019. [Epub ahead of print]

PMID:
31233276
5.

Pyruvate kinase M2 is requisite for Th1 and Th17 differentiation.

Kono M, Maeda K, Stocton-Gavanescu I, Pan W, Umeda M, Katsuyama E, Burbano C, Orite SYK, Vukelic M, Tsokos MG, Yoshida N, Tsokos GC.

JCI Insight. 2019 Jun 20;4(12). pii: 127395. doi: 10.1172/jci.insight.127395. eCollection 2019 Jun 20.

6.

CD25 and Protein Phosphatase 2A Cooperate to Enhance IL-2R Signaling in Human Regulatory T Cells.

Ding Y, Yu A, Tsokos GC, Malek TR.

J Immunol. 2019 Jul 1;203(1):93-104. doi: 10.4049/jimmunol.1801570. Epub 2019 May 13.

PMID:
31085588
7.

Complement Deposition on the Surface of RBC After Trauma Serves A Biomarker of Moderate Trauma Severity: A Prospective Study.

Satyam A, Andreo K, Lapchak PH, Dalle Lucca JJ, Davis RB, Tsokos MG, Shapiro NI, Tsokos GC.

Shock. 2019 Apr 12. doi: 10.1097/SHK.0000000000001348. [Epub ahead of print]

PMID:
30998651
8.

PP2A enables IL-2 signaling by preserving IL-2Rβ chain expression during Treg development.

Sharabi A, Li H, Kasper IR, Pan W, Meidan E, Tsokos MG, Moulton VR, Tsokos GC.

JCI Insight. 2019 Mar 26;5. pii: 126294. doi: 10.1172/jci.insight.126294.

9.

The role of IL-17 in systemic lupus erythematosus and its potential as a therapeutic target.

Koga T, Ichinose K, Kawakami A, Tsokos GC.

Expert Rev Clin Immunol. 2019 Jun;15(6):629-637. doi: 10.1080/1744666X.2019.1593141. Epub 2019 Mar 25.

PMID:
30874446
10.

Editorial: Systemic Lupus Erythematosus and Antiphospholipid Syndrome.

Meroni PL, Tsokos GC.

Front Immunol. 2019 Feb 25;10:199. doi: 10.3389/fimmu.2019.00199. eCollection 2019. No abstract available.

11.

A new checkpoint in lupus.

Tsokos GC.

J Allergy Clin Immunol. 2019 Apr;143(4):1351-1352. doi: 10.1016/j.jaci.2018.12.996. Epub 2019 Jan 9. No abstract available.

PMID:
30639348
12.

The immune podocyte.

Bhargava R, Tsokos GC.

Curr Opin Rheumatol. 2019 Mar;31(2):167-174. doi: 10.1097/BOR.0000000000000578.

PMID:
30562182
13.

Signaling lymphocyte activation molecule family in systemic lupus erythematosus.

Comte D, Karampetsou MP, Humbel M, Tsokos GC.

Clin Immunol. 2019 Jul;204:57-63. doi: 10.1016/j.clim.2018.11.001. Epub 2018 Nov 8. Review.

PMID:
30415085
14.

Calcium/Calmodulin Kinase IV Controls the Function of Both T Cells and Kidney Resident Cells.

Ferretti AP, Bhargava R, Dahan S, Tsokos MG, Tsokos GC.

Front Immunol. 2018 Oct 1;9:2113. doi: 10.3389/fimmu.2018.02113. eCollection 2018. Review.

15.

Regulatory T cells in the treatment of disease.

Sharabi A, Tsokos MG, Ding Y, Malek TR, Klatzmann D, Tsokos GC.

Nat Rev Drug Discov. 2018 Nov;17(11):823-844. doi: 10.1038/nrd.2018.148. Epub 2018 Oct 12. Review.

PMID:
30310234
16.

Efficacy and safety of ustekinumab, an IL-12 and IL-23 inhibitor, in patients with active systemic lupus erythematosus: results of a multicentre, double-blind, phase 2, randomised, controlled study.

van Vollenhoven RF, Hahn BH, Tsokos GC, Wagner CL, Lipsky P, Touma Z, Werth VP, Gordon RM, Zhou B, Hsu B, Chevrier M, Triebel M, Jordan JL, Rose S.

Lancet. 2018 Oct 13;392(10155):1330-1339. doi: 10.1016/S0140-6736(18)32167-6. Epub 2018 Sep 21.

PMID:
30249507
17.

Genome-Wide Association Study Reveals Genetic Link between Diarrhea-Associated Entamoeba histolytica Infection and Inflammatory Bowel Disease.

Wojcik GL, Marie C, Abhyankar MM, Yoshida N, Watanabe K, Mentzer AJ, Carstensen T, Mychaleckyj J, Kirkpatrick BD, Rich SS, Concannon P, Haque R, Tsokos GC, Petri WA Jr, Duggal P.

MBio. 2018 Sep 18;9(5). pii: e01668-18. doi: 10.1128/mBio.01668-18.

18.

Pyruvate dehydrogenase phosphatase catalytic subunit 2 limits Th17 differentiation.

Kono M, Yoshida N, Maeda K, Skinner NE, Pan W, Kyttaris VC, Tsokos MG, Tsokos GC.

Proc Natl Acad Sci U S A. 2018 Sep 11;115(37):9288-9293. doi: 10.1073/pnas.1805717115. Epub 2018 Aug 27.

19.

Precision DNA demethylation ameliorates disease in lupus-prone mice.

Li H, Tsokos MG, Bickerton S, Sharabi A, Li Y, Moulton VR, Kong P, Fahmy TM, Tsokos GC.

JCI Insight. 2018 Aug 23;3(16). pii: 120880. doi: 10.1172/jci.insight.120880. eCollection 2018 Aug 23.

20.

Signaling Lymphocytic Activation Molecule Family Member 1 Engagement Inhibits T Cell-B Cell Interaction and Diminishes Interleukin-6 Production and Plasmablast Differentiation in Systemic Lupus Erythematosus.

Karampetsou MP, Comte D, Suárez-Fueyo A, Katsuyama E, Yoshida N, Kono M, Kyttaris VC, Tsokos GC.

Arthritis Rheumatol. 2019 Jan;71(1):99-108. doi: 10.1002/art.40682.

PMID:
30058241
21.

CaMK4 compromises podocyte function in autoimmune and nonautoimmune kidney disease.

Maeda K, Otomo K, Yoshida N, Abu-Asab MS, Ichinose K, Nishino T, Kono M, Ferretti A, Bhargava R, Maruyama S, Bickerton S, Fahmy TM, Tsokos MG, Tsokos GC.

J Clin Invest. 2018 Aug 1;128(8):3445-3459. doi: 10.1172/JCI99507. Epub 2018 Jul 9.

22.

Correction: Downregulation of miR-200a-3p, Targeting CtBP2 Complex, Is Involved in the Hypoproduction of IL-2 in Systemic Lupus Erythematosus-Derived T Cells.

Katsuyama E, Yan M, Watanabe KS, Narazaki M, Matsushima S, Yamamura Y, Hiramatsu S, Ohashi K, Watanabe H, Katsuyama T, Zeggar S, Yoshida N, Moulton VR, Tsokos GC, Sada KE, Wada J.

J Immunol. 2018 Aug 1;201(3):1104. doi: 10.4049/jimmunol.1800810. Epub 2018 Jun 25. No abstract available.

23.

Decreased Expression of Serine/Arginine-Rich Splicing Factor 1 in T Cells From Patients With Active Systemic Lupus Erythematosus Accounts for Reduced Expression of RasGRP1 and DNA Methyltransferase 1.

Kono M, Kurita T, Yasuda S, Kono M, Fujieda Y, Bohgaki T, Katsuyama T, Tsokos GC, Moulton VR, Atsumi T.

Arthritis Rheumatol. 2018 Dec;70(12):2046-2056. doi: 10.1002/art.40585. Epub 2018 Oct 1.

PMID:
29905030
24.

Aberrant T Cell Signaling and Subsets in Systemic Lupus Erythematosus.

Katsuyama T, Tsokos GC, Moulton VR.

Front Immunol. 2018 May 17;9:1088. doi: 10.3389/fimmu.2018.01088. eCollection 2018. Review.

25.

Targeting Regulatory T Cells to Treat Patients With Systemic Lupus Erythematosus.

Mizui M, Tsokos GC.

Front Immunol. 2018 Apr 17;9:786. doi: 10.3389/fimmu.2018.00786. eCollection 2018. Review.

26.

Downregulation of CD3ζ in NK Cells from Systemic Lupus Erythematosus Patients Confers a Proinflammatory Phenotype.

Suárez-Fueyo A, Bradley SJ, Katsuyama T, Solomon S, Katsuyama E, Kyttaris VC, Moulton VR, Tsokos GC.

J Immunol. 2018 May 1;200(9):3077-3086. doi: 10.4049/jimmunol.1700588. Epub 2018 Mar 30.

27.

Transcriptional factor ICER promotes glutaminolysis and the generation of Th17 cells.

Kono M, Yoshida N, Maeda K, Tsokos GC.

Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):2478-2483. doi: 10.1073/pnas.1714717115. Epub 2018 Feb 20.

28.

SLE-Associated Defects Promote Altered T Cell Function.

Crispin JC, Hedrich CM, Suárez-Fueyo A, Comte D, Tsokos GC.

Crit Rev Immunol. 2017;37(1):39-58. doi: 10.1615/CritRevImmunol.2018025213. Review.

29.

New insights into the role of renal resident cells in the pathogenesis of lupus nephritis.

Kwok SK, Tsokos GC.

Korean J Intern Med. 2018 Mar;33(2):284-289. doi: 10.3904/kjim.2017.383. Epub 2018 Jan 12. Review.

30.

Recent developments in systemic lupus erythematosus pathogenesis and applications for therapy.

Lo MS, Tsokos GC.

Curr Opin Rheumatol. 2018 Mar;30(2):222-228. doi: 10.1097/BOR.0000000000000474. Review.

31.

Expression patterns of signaling lymphocytic activation molecule family members in peripheral blood mononuclear cell subsets in patients with systemic lupus erythematosus.

Karampetsou MP, Comte D, Kis-Toth K, Kyttaris VC, Tsokos GC.

PLoS One. 2017 Oct 11;12(10):e0186073. doi: 10.1371/journal.pone.0186073. eCollection 2017.

32.

C3a Enhances the Formation of Intestinal Organoids through C3aR1.

Matsumoto N, Satyam A, Geha M, Lapchak PH, Dalle Lucca JJ, Tsokos MG, Tsokos GC.

Front Immunol. 2017 Sep 4;8:1046. doi: 10.3389/fimmu.2017.01046. eCollection 2017.

33.

Neutrophil FcγRIIA promotes IgG-mediated glomerular neutrophil capture via Abl/Src kinases.

Nishi H, Furuhashi K, Cullere X, Saggu G, Miller MJ, Chen Y, Rosetti F, Hamilton SL, Yang L, Pittman SP, Liao J, Herter JM, Berry JC, DeAngelo DJ, Zhu C, Tsokos GC, Mayadas TN.

J Clin Invest. 2017 Oct 2;127(10):3810-3826. doi: 10.1172/JCI94039. Epub 2017 Sep 11.

34.

IL-17A Produced by Innate Lymphoid Cells Is Essential for Intestinal Ischemia-Reperfusion Injury.

Geha M, Tsokos MG, Bosse RE, Sannikova T, Iwakura Y, Dalle Lucca JJ, De Waal Malefyt R, Tsokos GC.

J Immunol. 2017 Oct 15;199(8):2921-2929. doi: 10.4049/jimmunol.1700655. Epub 2017 Sep 6.

35.

Fat T cells go to the joint.

Tsokos GC.

Nat Immunol. 2017 Aug 22;18(9):955-956. doi: 10.1038/ni.3810. No abstract available.

PMID:
28829450
36.

The serine/threonine protein phosphatase 2A controls autoimmunity.

Sharabi A, Kasper IR, Tsokos GC.

Clin Immunol. 2018 Jan;186:38-42. doi: 10.1016/j.clim.2017.07.012. Epub 2017 Jul 21. Review.

37.

IL-23 Limits the Production of IL-2 and Promotes Autoimmunity in Lupus.

Dai H, He F, Tsokos GC, Kyttaris VC.

J Immunol. 2017 Aug 1;199(3):903-910. doi: 10.4049/jimmunol.1700418. Epub 2017 Jun 23.

38.

Aneurysm of the ascending aorta in systemic lupus erythematosus: Case report and review of the literature.

Corominas H, Tsokos M, Quezado M, Tsokos GC.

Eur J Rheumatol. 2017 Jun;4(2):133-135. doi: 10.5152/eurjrheum.2017.17066. Epub 2017 Jun 1.

39.

Pathogenesis of Human Systemic Lupus Erythematosus: A Cellular Perspective.

Moulton VR, Suarez-Fueyo A, Meidan E, Li H, Mizui M, Tsokos GC.

Trends Mol Med. 2017 Jul;23(7):615-635. doi: 10.1016/j.molmed.2017.05.006. Epub 2017 Jun 13. Review.

40.

Microglia-dependent synapse loss in type I interferon-mediated lupus.

Bialas AR, Presumey J, Das A, van der Poel CE, Lapchak PH, Mesin L, Victora G, Tsokos GC, Mawrin C, Herbst R, Carroll MC.

Nature. 2017 Jun 22;546(7659):539-543. doi: 10.1038/nature22821. Epub 2017 Jun 14.

PMID:
28614301
41.

Immune cell signaling in autoimmune diseases.

Tsokos GC, Rose NR.

Clin Immunol. 2017 Aug;181:1-8. doi: 10.1016/j.clim.2017.05.015. Epub 2017 May 19. Review.

PMID:
28531376
42.

Downregulation of miR-200a-3p, Targeting CtBP2 Complex, Is Involved in the Hypoproduction of IL-2 in Systemic Lupus Erythematosus-Derived T Cells.

Katsuyama E, Yan M, Watanabe KS, Narazaki M, Matsushima S, Yamamura Y, Hiramatsu S, Ohashi K, Watanabe H, Katsuyama T, Zeggar S, Yoshida N, Moulton VR, Tsokos GC, Sada KE, Wada J.

J Immunol. 2017 Jun 1;198(11):4268-4276. doi: 10.4049/jimmunol.1601705. Epub 2017 Apr 24. Erratum in: J Immunol. 2018 Aug 1;201(3):1104.

43.

T cells and autoimmune kidney disease.

Suárez-Fueyo A, Bradley SJ, Klatzmann D, Tsokos GC.

Nat Rev Nephrol. 2017 Jun;13(6):329-343. doi: 10.1038/nrneph.2017.34. Epub 2017 Mar 13. Review.

PMID:
28287110
44.

CD74 Deficiency Mitigates Systemic Lupus Erythematosus-like Autoimmunity and Pathological Findings in Mice.

Zhou Y, Chen H, Liu L, Yu X, Sukhova GK, Yang M, Zhang L, Kyttaris VC, Tsokos GC, Stillman IE, Ichimura T, Bonventre JV, Libby P, Shi GP.

J Immunol. 2017 Apr 1;198(7):2568-2577. doi: 10.4049/jimmunol.1600028. Epub 2017 Feb 20.

45.

Cathepsin K Deficiency Ameliorates Systemic Lupus Erythematosus-like Manifestations in Faslpr Mice.

Zhou Y, Chen H, Liu L, Yu X, Sukhova GK, Yang M, Kyttaris VC, Stillman IE, Gelb B, Libby P, Tsokos GC, Shi GP.

J Immunol. 2017 Mar 1;198(5):1846-1854. doi: 10.4049/jimmunol.1501145. Epub 2017 Jan 16.

46.

Signaling Lymphocytic Activation Molecule Family Member 7 Engagement Restores Defective Effector CD8+ T Cell Function in Systemic Lupus Erythematosus.

Comte D, Karampetsou MP, Yoshida N, Kis-Toth K, Kyttaris VC, Tsokos GC.

Arthritis Rheumatol. 2017 May;69(5):1035-1044. doi: 10.1002/art.40038.

47.

Brief Report: CD4+ T Cells From Patients With Systemic Lupus Erythematosus Respond Poorly to Exogenous Interleukin-2.

Comte D, Karampetsou MP, Kis-Toth K, Yoshida N, Bradley SJ, Kyttaris VC, Tsokos GC.

Arthritis Rheumatol. 2017 Apr;69(4):808-813. doi: 10.1002/art.40014.

48.

Intracellular Activation of Complement 3 Is Responsible for Intestinal Tissue Damage during Mesenteric Ischemia.

Satyam A, Kannan L, Matsumoto N, Geha M, Lapchak PH, Bosse R, Shi GP, Dalle Lucca JJ, Tsokos MG, Tsokos GC.

J Immunol. 2017 Jan 15;198(2):788-797. doi: 10.4049/jimmunol.1502287. Epub 2016 Dec 2.

49.

DNA methylation in systemic lupus erythematosus.

Hedrich CM, Mäbert K, Rauen T, Tsokos GC.

Epigenomics. 2017 Apr;9(4):505-525. doi: 10.2217/epi-2016-0096. Epub 2016 Nov 25. Review.

50.

New insights into the immunopathogenesis of systemic lupus erythematosus.

Tsokos GC, Lo MS, Costa Reis P, Sullivan KE.

Nat Rev Rheumatol. 2016 Nov 22;12(12):716-730. doi: 10.1038/nrrheum.2016.186. Review.

PMID:
27872476

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