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BQ323636.1, a Novel Splice Variant to NCOR2, as a Predictor for Tamoxifen-Resistant Breast Cancer.

Gong C, Man EPS, Tsoi H, Lee TKW, Lee P, Ma ST, Wong LS, Luk MY, Rakha EA, Green AR, Ellis IO, Lam EW, Cheung KL, Khoo US.

Clin Cancer Res. 2018 Aug 1;24(15):3681-3691. doi: 10.1158/1078-0432.CCR-17-2259. Epub 2018 Feb 2.


Bats host diverse parvoviruses as possible origin of mammalian dependoparvoviruses and source for bat-swine interspecies transmission.

Lau SKP, Ahmed SS, Tsoi HW, Yeung HC, Li KSM, Fan RYY, Zhao PSH, Lau CCC, Lam CSF, Choi KKF, Chan BCH, Cai JP, Wong SSY, Chen H, Zhang HL, Zhang L, Wang M, Woo PCY, Yuen KY.

J Gen Virol. 2017 Nov 6. doi: 10.1099/jgv.0.000969. [Epub ahead of print]


Gavage of Fecal Samples From Patients With Colorectal CancerĀ Promotes Intestinal Carcinogenesis in Germ-Free andĀ Conventional Mice.

Wong SH, Zhao L, Zhang X, Nakatsu G, Han J, Xu W, Xiao X, Kwong TNY, Tsoi H, Wu WKK, Zeng B, Chan FKL, Sung JJY, Wei H, Yu J.

Gastroenterology. 2017 Dec;153(6):1621-1633.e6. doi: 10.1053/j.gastro.2017.08.022. Epub 2017 Aug 18.


Pre-45s rRNA promotes colon cancer and is associated with poor survival of CRC patients.

Tsoi H, Lam KC, Dong Y, Zhang X, Lee CK, Zhang J, Ng SC, Ng SSM, Zheng S, Chen Y, Fang J, Yu J.

Oncogene. 2017 Nov 2;36(44):6109-6118. doi: 10.1038/onc.2017.86. Epub 2017 Jul 10.


Two novel dromedary camel bocaparvoviruses from dromedaries in the Middle East with unique genomic features.

Woo PCY, Lau SKP, Tsoi HW, Patteril NG, Yeung HC, Joseph S, Wong EYM, Muhammed R, Chow FWN, Wernery U, Yuen KY.

J Gen Virol. 2017 Jun;98(6):1349-1359. doi: 10.1099/jgv.0.000775. Epub 2017 Jun 14.


Peptostreptococcus anaerobius Induces Intracellular Cholesterol Biosynthesis in Colon Cells to Induce Proliferation and Causes Dysplasia in Mice.

Tsoi H, Chu ESH, Zhang X, Sheng J, Nakatsu G, Ng SC, Chan AWH, Chan FKL, Sung JJY, Yu J.

Gastroenterology. 2017 May;152(6):1419-1433.e5. doi: 10.1053/j.gastro.2017.01.009. Epub 2017 Jan 23.


Oncogenic mutations and dysregulated pathways in obesity-associated hepatocellular carcinoma.

Shen J, Tsoi H, Liang Q, Chu ES, Liu D, Yu AC, Chan TF, Li X, Sung JJ, Wong VW, Yu J.

Oncogene. 2016 Dec 8;35(49):6271-6280. doi: 10.1038/onc.2016.162. Epub 2016 May 2.


Molecular epidemiology of canine picornavirus in Hong Kong and Dubai and proposal of a novel genus in Picornaviridae.

Woo PCY, Lau SKP, Choi GKY, Huang Y, Sivakumar S, Tsoi HW, Yip CCY, Jose SV, Bai R, Wong EYM, Joseph M, Li T, Wernery U, Yuen KY.

Infect Genet Evol. 2016 Jul;41:191-200. doi: 10.1016/j.meegid.2016.03.033. Epub 2016 Apr 3.


Assessing a peptidylic inhibitor-based therapeutic approach that simultaneously suppresses polyglutamine RNA- and protein-mediated toxicities in patient cells and Drosophila.

Zhang Q, Tsoi H, Peng S, Li PP, Lau KF, Rudnicki DD, Ngo JC, Chan HY.

Dis Model Mech. 2016 Mar;9(3):321-34. doi: 10.1242/dmm.022350. Epub 2016 Feb 2.


Gut mucosal microbiome across stages of colorectal carcinogenesis.

Nakatsu G, Li X, Zhou H, Sheng J, Wong SH, Wu WK, Ng SC, Tsoi H, Dong Y, Zhang N, He Y, Kang Q, Cao L, Wang K, Zhang J, Liang Q, Yu J, Sung JJ.

Nat Commun. 2015 Oct 30;6:8727. doi: 10.1038/ncomms9727.


MDGA2 is a novel tumour suppressor cooperating with DMAP1 in gastric cancer and is associated with disease outcome.

Wang K, Liang Q, Li X, Tsoi H, Zhang J, Wang H, Go MY, Chiu PW, Ng EK, Sung JJ, Yu J.

Gut. 2016 Oct;65(10):1619-31. doi: 10.1136/gutjnl-2015-309276. Epub 2015 Jul 23.


Carbonic anhydrase IV inhibits colon cancer development by inhibiting the Wnt signalling pathway through targeting the WTAP-WT1-TBL1 axis.

Zhang J, Tsoi H, Li X, Wang H, Gao J, Wang K, Go MY, Ng SC, Chan FK, Sung JJ, Yu J.

Gut. 2016 Sep;65(9):1482-93. doi: 10.1136/gutjnl-2014-308614. Epub 2015 Jun 12.


Detection of miRNA as non-invasive biomarkers of colorectal cancer.

Ren A, Dong Y, Tsoi H, Yu J.

Int J Mol Sci. 2015 Jan 27;16(2):2810-23. doi: 10.3390/ijms16022810. Review.


Fusobacterium and Escherichia: models of colorectal cancer driven by microbiota and the utility of microbiota in colorectal cancer screening.

Leung A, Tsoi H, Yu J.

Expert Rev Gastroenterol Hepatol. 2015 May;9(5):651-7. doi: 10.1586/17474124.2015.1001745. Epub 2015 Jan 12. Review.


The SARS-coronavirus membrane protein induces apoptosis via interfering with PDK1-PKB/Akt signalling.

Tsoi H, Li L, Chen ZS, Lau KF, Tsui SK, Chan HY.

Biochem J. 2014 Dec 15;464(3):439-47. doi: 10.1042/BJ20131461.


A novel missense mutation in CCDC88C activates the JNK pathway and causes a dominant form of spinocerebellar ataxia.

Tsoi H, Yu AC, Chen ZS, Ng NK, Chan AY, Yuen LY, Abrigo JM, Tsang SY, Tsui SK, Tong TM, Lo IF, Lam ST, Mok VC, Wong LK, Ngo JC, Lau KF, Chan TF, Chan HY.

J Med Genet. 2014 Sep;51(9):590-5. doi: 10.1136/jmedgenet-2014-102333. Epub 2014 Jul 25.


microRNA-139-5p exerts tumor suppressor function by targeting NOTCH1 in colorectal cancer.

Zhang L, Dong Y, Zhu N, Tsoi H, Zhao Z, Wu CW, Wang K, Zheng S, Ng SS, Chan FK, Sung JJ, Yu J.

Mol Cancer. 2014 May 26;13:124. doi: 10.1186/1476-4598-13-124.


Targeting toxic RNAs that cause myotonic dystrophy type 1 (DM1) with a bisamidinium inhibitor.

Wong CH, Nguyen L, Peh J, Luu LM, Sanchez JS, Richardson SL, Tuccinardi T, Tsoi H, Chan WY, Chan HY, Baranger AM, Hergenrother PJ, Zimmerman SC.

J Am Chem Soc. 2014 Apr 30;136(17):6355-61. doi: 10.1021/ja5012146. Epub 2014 Apr 22.


Roles of the nucleolus in the CAG RNA-mediated toxicity.

Tsoi H, Chan HY.

Biochim Biophys Acta. 2014 Jun;1842(6):779-84. doi: 10.1016/j.bbadis.2013.11.015. Epub 2013 Nov 20. Review.


Identification and characterization of a novel paramyxovirus, porcine parainfluenza virus 1, from deceased pigs.

Lau SK, Woo PC, Wu Y, Wong AY, Wong BH, Lau CC, Fan RY, Cai JP, Tsoi HW, Chan KH, Yuen KY.

J Gen Virol. 2013 Oct;94(Pt 10):2184-90. doi: 10.1099/vir.0.052985-0. Epub 2013 Aug 5.


Human infections with the emerging avian influenza A H7N9 virus from wet market poultry: clinical analysis and characterisation of viral genome.

Chen Y, Liang W, Yang S, Wu N, Gao H, Sheng J, Yao H, Wo J, Fang Q, Cui D, Li Y, Yao X, Zhang Y, Wu H, Zheng S, Diao H, Xia S, Zhang Y, Chan KH, Tsoi HW, Teng JL, Song W, Wang P, Lau SY, Zheng M, Chan JF, To KK, Chen H, Li L, Yuen KY.

Lancet. 2013 Jun 1;381(9881):1916-25. doi: 10.1016/S0140-6736(13)60903-4. Epub 2013 Apr 25.


Expression of expanded CAG transcripts triggers nucleolar stress in Huntington's disease.

Tsoi H, Chan HY.

Cerebellum. 2013 Jun;12(3):310-2. doi: 10.1007/s12311-012-0447-6.


Identification of a novel bat papillomavirus by metagenomics.

Tse H, Tsang AK, Tsoi HW, Leung AS, Ho CC, Lau SK, Woo PC, Yuen KY.

PLoS One. 2012;7(8):e43986. doi: 10.1371/journal.pone.0043986. Epub 2012 Aug 24.


CAG expansion induces nucleolar stress in polyglutamine diseases.

Tsoi H, Lau TC, Tsang SY, Lau KF, Chan HY.

Proc Natl Acad Sci U S A. 2012 Aug 14;109(33):13428-33. doi: 10.1073/pnas.1204089109. Epub 2012 Jul 30.


Molecular characterization of the 2011 Hong Kong scarlet fever outbreak.

Tse H, Bao JY, Davies MR, Maamary P, Tsoi HW, Tong AH, Ho TC, Lin CH, Gillen CM, Barnett TC, Chen JH, Lee M, Yam WC, Wong CK, Ong CL, Chan YW, Wu CW, Ng T, Lim WW, Tsang TH, Tse CW, Dougan G, Walker MJ, Lok S, Yuen KY.

J Infect Dis. 2012 Aug 1;206(3):341-51. doi: 10.1093/infdis/jis362. Epub 2012 May 21.


Complete genome sequence of a novel picornavirus, canine picornavirus, discovered in dogs.

Woo PC, Lau SK, Choi GK, Yip CC, Huang Y, Tsoi HW, Yuen KY.

J Virol. 2012 Mar;86(6):3402-3. doi: 10.1128/JVI.07228-11.


Natural occurrence and characterization of two internal ribosome entry site elements in a novel virus, canine picodicistrovirus, in the picornavirus-like superfamily.

Woo PC, Lau SK, Choi GK, Huang Y, Teng JL, Tsoi HW, Tse H, Yeung ML, Chan KH, Jin DY, Yuen KY.

J Virol. 2012 Mar;86(5):2797-808. doi: 10.1128/JVI.05481-11. Epub 2011 Dec 28.


Discovery and genomic characterization of a novel ovine partetravirus and a new genotype of bovine partetravirus.

Tse H, Tsoi HW, Teng JL, Chen XC, Liu H, Zhou B, Zheng BJ, Woo PC, Lau SK, Yuen KY.

PLoS One. 2011;6(9):e25619. doi: 10.1371/journal.pone.0025619. Epub 2011 Sep 27.


Clinical and virological factors associated with viremia in pandemic influenza A/H1N1/2009 virus infection.

Tse H, To KK, Wen X, Chen H, Chan KH, Tsoi HW, Li IW, Yuen KY.

PLoS One. 2011;6(9):e22534. doi: 10.1371/journal.pone.0022534. Epub 2011 Sep 27.


Perturbation of U2AF65/NXF1-mediated RNA nuclear export enhances RNA toxicity in polyQ diseases.

Tsoi H, Lau CK, Lau KF, Chan HY.

Hum Mol Genet. 2011 Oct 1;20(19):3787-97. doi: 10.1093/hmg/ddr297. Epub 2011 Jul 1.


Rediscovery and genomic characterization of bovine astroviruses.

Tse H, Chan WM, Tsoi HW, Fan RY, Lau CC, Lau SK, Woo PC, Yuen KY.

J Gen Virol. 2011 Aug;92(Pt 8):1888-98. doi: 10.1099/vir.0.030817-0. Epub 2011 Apr 20.


Expanded polyglutamine domain possesses nuclear export activity which modulates subcellular localization and toxicity of polyQ disease protein via exportin-1.

Chan WM, Tsoi H, Wu CC, Wong CH, Cheng TC, Li HY, Lau KF, Shaw PC, Perrimon N, Chan HY.

Hum Mol Genet. 2011 May 1;20(9):1738-50. doi: 10.1093/hmg/ddr049. Epub 2011 Feb 7.


Complete genome sequence of the veterinary pathogen Staphylococcus pseudintermedius strain HKU10-03, isolated in a case of canine pyoderma.

Tse H, Tsoi HW, Leung SP, Urquhart IJ, Lau SK, Woo PC, Yuen KY.

J Bacteriol. 2011 Apr;193(7):1783-4. doi: 10.1128/JB.00023-11. Epub 2011 Jan 28.


Staphylococcus lugdunensis is the likely origin of the ornithine decarboxylase operon in Staphylococcus epidermidis 2015B.

Tsoi HW, Tse H.

Appl Environ Microbiol. 2011 Jan;77(1):392-3. doi: 10.1128/AEM.02213-10. No abstract available.


Natural selection retains overrepresented out-of-frame stop codons against frameshift peptides in prokaryotes.

Tse H, Cai JJ, Tsoi HW, Lam EP, Yuen KY.

BMC Genomics. 2010 Sep 9;11:491. doi: 10.1186/1471-2164-11-491.


Comparative analysis of six genome sequences of three novel picornaviruses, turdiviruses 1, 2 and 3, in dead wild birds, and proposal of two novel genera, Orthoturdivirus and Paraturdivirus, in the family Picornaviridae.

Woo PC, Lau SK, Huang Y, Lam CS, Poon RW, Tsoi HW, Lee P, Tse H, Chan AS, Luk G, Chan KH, Yuen KY.

J Gen Virol. 2010 Oct;91(Pt 10):2433-48. doi: 10.1099/vir.0.021717-0. Epub 2010 Jun 16.


Emergence of enterovirus 71 "double-recombinant" strains belonging to a novel genotype D originating from southern China: first evidence for combination of intratypic and intertypic recombination events in EV71.

Yip CC, Lau SK, Zhou B, Zhang MX, Tsoi HW, Chan KH, Chen XC, Woo PC, Yuen KY.

Arch Virol. 2010 Sep;155(9):1413-24. doi: 10.1007/s00705-010-0722-0. Epub 2010 Jun 13.


Identification and complete genome analysis of three novel paramyxoviruses, Tuhoko virus 1, 2 and 3, in fruit bats from China.

Lau SK, Woo PC, Wong BH, Wong AY, Tsoi HW, Wang M, Lee P, Xu H, Poon RW, Guo R, Li KS, Chan KH, Zheng BJ, Yuen KY.

Virology. 2010 Aug 15;404(1):106-16. doi: 10.1016/j.virol.2010.03.049.


Quasispecies of the D225G substitution in the hemagglutinin of pandemic influenza A(H1N1) 2009 virus from patients with severe disease in Hong Kong, China.

Chen H, Wen X, To KK, Wang P, Tse H, Chan JF, Tsoi HW, Fung KS, Tse CW, Lee RA, Chan KH, Yuen KY.

J Infect Dis. 2010 May 15;201(10):1517-21. doi: 10.1086/652661.


Complete genome sequence of Staphylococcus lugdunensis strain HKU09-01.

Tse H, Tsoi HW, Leung SP, Lau SK, Woo PC, Yuen KY.

J Bacteriol. 2010 Mar;192(5):1471-2. doi: 10.1128/JB.01627-09. Epub 2010 Jan 4.


Differential susceptibility of different cell lines to swine-origin influenza A H1N1, seasonal human influenza A H1N1, and avian influenza A H5N1 viruses.

Li IW, Chan KH, To KW, Wong SS, Ho PL, Lau SK, Woo PC, Tsoi HW, Chan JF, Cheng VC, Zheng BJ, Chen H, Yuen KY.

J Clin Virol. 2009 Dec;46(4):325-30. doi: 10.1016/j.jcv.2009.09.013. Epub 2009 Oct 3.


Outbreak of intestinal infection due to Rhizopus microsporus.

Cheng VC, Chan JF, Ngan AH, To KK, Leung SY, Tsoi HW, Yam WC, Tai JW, Wong SS, Tse H, Li IW, Lau SK, Woo PC, Leung AY, Lie AK, Liang RH, Que TL, Ho PL, Yuen KY.

J Clin Microbiol. 2009 Sep;47(9):2834-43. doi: 10.1128/JCM.00908-09. Epub 2009 Jul 29.


The ion channel activity of the SARS-coronavirus 3a protein is linked to its pro-apoptotic function.

Chan CM, Tsoi H, Chan WM, Zhai S, Wong CO, Yao X, Chan WY, Tsui SK, Chan HY.

Int J Biochem Cell Biol. 2009 Nov;41(11):2232-9. doi: 10.1016/j.biocel.2009.04.019. Epub 2009 May 4.


BK virus nephropathy due to KOM-3 strain.

Chan GS, Tsoi HW, Wong SS, Li CL, Tse H, Un I K, Yuen KY, Chan KW.

Am J Kidney Dis. 2009 Jul;54(1):122-6. doi: 10.1053/j.ajkd.2008.09.014. Epub 2008 Nov 20.


Identification of novel porcine and bovine parvoviruses closely related to human parvovirus 4.

Lau SK, Woo PC, Tse H, Fu CT, Au WK, Chen XC, Tsoi HW, Tsang TH, Chan JS, Tsang DN, Li KS, Tse CW, Ng TK, Tsang OT, Zheng BJ, Tam S, Chan KH, Zhou B, Yuen KY.

J Gen Virol. 2008 Aug;89(Pt 8):1840-8. doi: 10.1099/vir.0.2008/000380-0.


Comparative analysis of twelve genomes of three novel group 2c and group 2d coronaviruses reveals unique group and subgroup features.

Woo PC, Wang M, Lau SK, Xu H, Poon RW, Guo R, Wong BH, Gao K, Tsoi HW, Huang Y, Li KS, Lam CS, Chan KH, Zheng BJ, Yuen KY.

J Virol. 2007 Feb;81(4):1574-85. Epub 2006 Nov 22.


Coronavirus HKU1 and other coronavirus infections in Hong Kong.

Lau SK, Woo PC, Yip CC, Tse H, Tsoi HW, Cheng VC, Lee P, Tang BS, Cheung CH, Lee RA, So LY, Lau YL, Chan KH, Yuen KY.

J Clin Microbiol. 2006 Jun;44(6):2063-71.


Molecular diversity of coronaviruses in bats.

Woo PC, Lau SK, Li KS, Poon RW, Wong BH, Tsoi HW, Yip BC, Huang Y, Chan KH, Yuen KY.

Virology. 2006 Jul 20;351(1):180-7. Epub 2006 May 2.

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