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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1990 1
1995 1
1996 1
1997 1
1999 2
2000 3
2001 4
2002 7
2003 7
2004 9
2005 12
2006 11
2007 36
2008 45
2009 60
2010 87
2011 85
2012 127
2013 145
2014 145
2015 151
2016 184
2017 201
2018 189
2019 184
2020 216
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2024 80

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2,322 results

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Page 1
Targeting TSLP in Asthma.
Parnes JR, Molfino NA, Colice G, Martin U, Corren J, Menzies-Gow A. Parnes JR, et al. J Asthma Allergy. 2022 Jun 3;15:749-765. doi: 10.2147/JAA.S275039. eCollection 2022. J Asthma Allergy. 2022. PMID: 35685846 Free PMC article. Review.
Tezepelumab, the TSLP inhibitor farthest along in clinical development, is a human monoclonal antibody (IgG2lambda) that binds specifically to TSLP, preventing interactions with its heterodimeric receptor. ...This review presents the rationale for targeting TSLP …
Tezepelumab, the TSLP inhibitor farthest along in clinical development, is a human monoclonal antibody (IgG2lambda) that binds specif …
Development of an inhaled anti-TSLP therapy for asthma.
O'Byrne PM, Panettieri RA Jr, Taube C, Brindicci C, Fleming M, Altman P. O'Byrne PM, et al. Pulm Pharmacol Ther. 2023 Feb;78:102184. doi: 10.1016/j.pupt.2022.102184. Epub 2022 Dec 17. Pulm Pharmacol Ther. 2023. PMID: 36535465 Review.
TSLP plays a role in asthma pathogenesis as an upstream cytokine, and data suggest that TSLP blockade with the anti-TSLP monoclonal antibody, tezepelumab, could be efficacious in a broad asthma population. ...Currently in development, ecleralimab (CSJ117) rep …
TSLP plays a role in asthma pathogenesis as an upstream cytokine, and data suggest that TSLP blockade with the anti-TSLP …
Anti-TSLP antibodies: Targeting a master regulator of type 2 immune responses.
Nakajima S, Kabata H, Kabashima K, Asano K. Nakajima S, et al. Allergol Int. 2020 Apr;69(2):197-203. doi: 10.1016/j.alit.2020.01.001. Epub 2020 Jan 21. Allergol Int. 2020. PMID: 31974038 Free article. Review.
Biological functions of TSLP require heterodimer formation between the TSLP receptor (TSLPR) and IL-7 receptor-alpha, which polarize dendritic cells to induce type 2 inflammation and directly expand and/or activate Th2 cells, group 2 innate lymphoid cells, basophils …
Biological functions of TSLP require heterodimer formation between the TSLP receptor (TSLPR) and IL-7 receptor-alpha, which po …
TSLP: from allergy to cancer.
Corren J, Ziegler SF. Corren J, et al. Nat Immunol. 2019 Dec;20(12):1603-1609. doi: 10.1038/s41590-019-0524-9. Epub 2019 Nov 19. Nat Immunol. 2019. PMID: 31745338 Review.
While the role of TSLP in type 2 immune responses has been investigated extensively, recent studies have found an expanding role for TSLP in inflammatory diseases and cancer. In this Review, we will highlight major recent advances in TSLP biology, along with …
While the role of TSLP in type 2 immune responses has been investigated extensively, recent studies have found an expanding role for …
Severe Asthmatic Responses: The Impact of TSLP.
Theofani E, Tsitsopoulou A, Morianos I, Semitekolou M. Theofani E, et al. Int J Mol Sci. 2023 Apr 20;24(8):7581. doi: 10.3390/ijms24087581. Int J Mol Sci. 2023. PMID: 37108740 Free PMC article. Review.
Numerous studies in both humans and mice have provided major insights pertinent to the role of TSLP in the initiation and propagation of asthmatic responses. Undoubtedly, the magnitude of TSLP in asthma pathogenesis is highlighted by the fact that the FDA recently a …
Numerous studies in both humans and mice have provided major insights pertinent to the role of TSLP in the initiation and propagation …
The Role of TSLP in Atopic Dermatitis: From Pathogenetic Molecule to Therapeutical Target.
Luo J, Zhu Z, Zhai Y, Zeng J, Li L, Wang D, Deng F, Chang B, Zhou J, Sun L. Luo J, et al. Mediators Inflamm. 2023 Apr 15;2023:7697699. doi: 10.1155/2023/7697699. eCollection 2023. Mediators Inflamm. 2023. PMID: 37096155 Free PMC article. Review.
Mainly secreted by keratinocytes, TSLP interacts with multiple immune cells (including dendritic cells, T cells, and mast cells), following induction of Th2-oriented immune response during the pathogenesis of AD. This article primarily focuses on the TSLP biological …
Mainly secreted by keratinocytes, TSLP interacts with multiple immune cells (including dendritic cells, T cells, and mast cells), fol …
The epithelial cell-derived atopic dermatitis cytokine TSLP activates neurons to induce itch.
Wilson SR, Thé L, Batia LM, Beattie K, Katibah GE, McClain SP, Pellegrino M, Estandian DM, Bautista DM. Wilson SR, et al. Cell. 2013 Oct 10;155(2):285-95. doi: 10.1016/j.cell.2013.08.057. Epub 2013 Oct 3. Cell. 2013. PMID: 24094650 Free PMC article.
Signaling between epithelial cells and innate immune cells via the cytokine thymic stromal lymphopoietin (TSLP) is thought to drive AD and the atopic march. Here, we report that epithelial cells directly communicate to cutaneous sensory neurons via TSLP to promote i …
Signaling between epithelial cells and innate immune cells via the cytokine thymic stromal lymphopoietin (TSLP) is thought to drive A …
TSLP Inhibitors for Asthma: Current Status and Future Prospects.
Matera MG, Rogliani P, Calzetta L, Cazzola M. Matera MG, et al. Drugs. 2020 Apr;80(5):449-458. doi: 10.1007/s40265-020-01273-4. Drugs. 2020. PMID: 32078149 Review.
Accordingly, targeting of TSLP and TSLP-mediated signalling is considered as an attractive therapeutic strategy to asthma. ...Since new information suggests that targeting TSLP may be more likely to improve day-to-day asthma symptoms, in contrast to targeting …
Accordingly, targeting of TSLP and TSLP-mediated signalling is considered as an attractive therapeutic strategy to asthma. ... …
TSLP as druggable target - a silver-lining for atopic diseases?
Adhikary PP, Tan Z, Page BDG, Hedtrich S. Adhikary PP, et al. Pharmacol Ther. 2021 Jan;217:107648. doi: 10.1016/j.pharmthera.2020.107648. Epub 2020 Aug 3. Pharmacol Ther. 2021. PMID: 32758645 Review.
It has been shown to be a master regulator of type 2 immune responses and atopic diseases. In experimental settings, the inhibition or knockout of TSLP signaling has shown great therapeutic potential. This, in conjunction with the increasing knowledge about the central rol …
It has been shown to be a master regulator of type 2 immune responses and atopic diseases. In experimental settings, the inhibition or knock …
[Search for Compounds Regulating TSLP Production].
Segawa R. Segawa R. Yakugaku Zasshi. 2021;141(10):1129-1135. doi: 10.1248/yakushi.21-00129. Yakugaku Zasshi. 2021. PMID: 34602509 Free article. Review. Japanese.
We aim to elucidate the detailed regulation of TSLP production from epithelial cells, and in doing so discovered new regulating factors and an inhibitor of TSLP production. This review article explains the role of TSLP in allergic diseases, its regulation, an …
We aim to elucidate the detailed regulation of TSLP production from epithelial cells, and in doing so discovered new regulating facto …
2,322 results