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Items: 1 to 50 of 81

1.

In vivo epigenetic CRISPR screen identifies Asf1a as an immunotherapeutic target in Kras-mutant lung adenocarcinoma.

Li F, Huang Q, Luster TA, Hu H, Zhang H, Ng WL, Khodadadi-Jamayran A, Wang W, Chen T, Deng J, Ranieri M, Fang Z, Pyon V, Dowling CM, Bagdatlioglu E, Almonte C, Labbe K, Silver H, Rabin AR, Jani K, Tsirigos A, Papagiannakopoulos T, Hammerman PS, Velcheti V, Freeman GJ, Qi J, Miller G, Wong KK.

Cancer Discov. 2019 Nov 19. pii: CD-19-0780. doi: 10.1158/2159-8290.CD-19-0780. [Epub ahead of print]

PMID:
31744829
2.

Functional and topographic effects on DNA methylation in IDH1/2 mutant cancers.

Bledea R, Vasudevaraja V, Patel S, Stafford J, Serrano J, Esposito G, Tredwin LM, Goodman N, Kloetgen A, Golfinos JG, Zagzag D, Weigelt B, Iafrate AJ, Sulman EP, Chi AS, Dogan S, Reis-Filho JS, Chiang S, Placantonakis D, Tsirigos A, Snuderl M.

Sci Rep. 2019 Nov 14;9(1):16830. doi: 10.1038/s41598-019-53262-7.

3.

Histone 1 Mutations Drive Lymphomagenesis By Inducing Primitive Stem Cell Functions and Epigenetic Instructions through Profound 3D Re-Organization of the B-Cell Genome.

Yusufova N, Teater MR, Soshnev A, Kloetgen A, Osunsade A, Conway J, Doane A, Skoultchi A, Tsirigos A, David Y, Allis CD, Cesarman E, Melnick A.

Blood. 2019 Nov 13;134(Supplement_1):23. doi: 10.1182/blood-2019-127774.

PMID:
31723979
4.

NSD2 overexpression drives clustered chromatin and transcriptional changes in a subset of insulated domains.

Lhoumaud P, Badri S, Rodriguez-Hernaez J, Sakellaropoulos T, Sethia G, Kloetgen A, Cornwell M, Bhattacharyya S, Ay F, Bonneau R, Tsirigos A, Skok JA.

Nat Commun. 2019 Oct 24;10(1):4843. doi: 10.1038/s41467-019-12811-4.

5.

KLF4 is involved in the organization and regulation of pluripotency-associated three-dimensional enhancer networks.

Di Giammartino DC, Kloetgen A, Polyzos A, Liu Y, Kim D, Murphy D, Abuhashem A, Cavaliere P, Aronson B, Shah V, Dephoure N, Stadtfeld M, Tsirigos A, Apostolou E.

Nat Cell Biol. 2019 Oct;21(10):1179-1190. doi: 10.1038/s41556-019-0390-6. Epub 2019 Sep 23.

PMID:
31548608
6.

RNA Interactions Are Essential for CTCF-Mediated Genome Organization.

Saldaña-Meyer R, Rodriguez-Hernaez J, Escobar T, Nishana M, Jácome-López K, Nora EP, Bruneau BG, Tsirigos A, Furlan-Magaril M, Skok J, Reinberg D.

Mol Cell. 2019 Nov 7;76(3):412-422.e5. doi: 10.1016/j.molcel.2019.08.015. Epub 2019 Sep 12.

PMID:
31522988
7.

3D Chromosomal Landscapes in Hematopoiesis and Immunity.

Kloetgen A, Thandapani P, Tsirigos A, Aifantis I.

Trends Immunol. 2019 Sep;40(9):809-824. doi: 10.1016/j.it.2019.07.003. Epub 2019 Aug 15. Review.

PMID:
31422902
8.

The E3 ubiquitin ligase SPOP controls resolution of systemic inflammation by triggering MYD88 degradation.

Guillamot M, Ouazia D, Dolgalev I, Yeung ST, Kourtis N, Dai Y, Corrigan K, Zea-Redondo L, Saraf A, Florens L, Washburn MP, Tikhonova AN, Malumbres M, Gong Y, Tsirigos A, Park C, Barbieri C, Khanna KM, Busino L, Aifantis I.

Nat Immunol. 2019 Sep;20(9):1196-1207. doi: 10.1038/s41590-019-0454-6. Epub 2019 Aug 12.

PMID:
31406379
9.

Machine learning and data mining frameworks for predicting drug response in cancer: An overview and a novel in silico screening process based on association rule mining.

Vougas K, Sakellaropoulos T, Kotsinas A, Foukas GP, Ntargaras A, Koinis F, Polyzos A, Myrianthopoulos V, Zhou H, Narang S, Georgoulias V, Alexopoulos L, Aifantis I, Townsend PA, Sfikakis P, Fitzgerald R, Thanos D, Bartek J, Petty R, Tsirigos A, Gorgoulis VG.

Pharmacol Ther. 2019 Nov;203:107395. doi: 10.1016/j.pharmthera.2019.107395. Epub 2019 Jul 30. Review.

PMID:
31374225
10.

Molecular and metabolic pathways mediating curative treatment of a non-Hodgkin B cell lymphoma by Sindbis viral vectors and anti-4-1BB monoclonal antibody.

Yu M, Scherwitzl I, Opp S, Tsirigos A, Meruelo D.

J Immunother Cancer. 2019 Jul 15;7(1):185. doi: 10.1186/s40425-019-0664-3.

11.

Author Correction: The bone marrow microenvironment at single-cell resolution.

Tikhonova AN, Dolgalev I, Hu H, Sivaraj KK, Hoxha E, Cuesta-Domínguez Á, Pinho S, Akhmetzyanova I, Gao J, Witkowski M, Guillamot M, Gutkin MC, Zhang Y, Marier C, Diefenbach C, Kousteni S, Heguy A, Zhong H, Fooksman DR, Butler JM, Economides A, Frenette PS, Adams RH, Satija R, Tsirigos A, Aifantis I.

Nature. 2019 Aug;572(7767):E6. doi: 10.1038/s41586-019-1394-x.

PMID:
31296938
12.

Nrf2 Activation Promotes Lung Cancer Metastasis by Inhibiting the Degradation of Bach1.

Lignitto L, LeBoeuf SE, Homer H, Jiang S, Askenazi M, Karakousi TR, Pass HI, Bhutkar AJ, Tsirigos A, Ueberheide B, Sayin VI, Papagiannakopoulos T, Pagano M.

Cell. 2019 Jul 11;178(2):316-329.e18. doi: 10.1016/j.cell.2019.06.003. Epub 2019 Jun 27.

PMID:
31257023
13.

Targeting Mitochondrial Structure Sensitizes Acute Myeloid Leukemia to Venetoclax Treatment.

Chen X, Glytsou C, Zhou H, Narang S, Reyna DE, Lopez A, Sakellaropoulos T, Gong Y, Kloetgen A, Yap YS, Wang E, Gavathiotis E, Tsirigos A, Tibes R, Aifantis I.

Cancer Discov. 2019 Jul;9(7):890-909. doi: 10.1158/2159-8290.CD-19-0117. Epub 2019 May 2.

PMID:
31048321
14.

The bone marrow microenvironment at single-cell resolution.

Tikhonova AN, Dolgalev I, Hu H, Sivaraj KK, Hoxha E, Cuesta-Domínguez Á, Pinho S, Akhmetzyanova I, Gao J, Witkowski M, Guillamot M, Gutkin MC, Zhang Y, Marier C, Diefenbach C, Kousteni S, Heguy A, Zhong H, Fooksman DR, Butler JM, Economides A, Frenette PS, Adams RH, Satija R, Tsirigos A, Aifantis I.

Nature. 2019 May;569(7755):222-228. doi: 10.1038/s41586-019-1104-8. Epub 2019 Apr 10. Erratum in: Nature. 2019 Aug;572(7767):E6.

15.

Draft Genome Sequence of Streptococcus halitosis sp. nov., Isolated from the Dorsal Surface of the Tongue of a Patient with Halitosis.

Tetz G, Vikina D, Brown S, Zappile P, Dolgalev I, Tsirigos A, Heguy A, Tetz V.

Microbiol Resour Announc. 2019 Jan 24;8(4). pii: e01704-18. doi: 10.1128/MRA.01704-18. eCollection 2019 Jan.

16.

KLF4, A Gene Regulating Prostate Stem Cell Homeostasis, Is a Barrier to Malignant Progression and Predictor of Good Prognosis in Prostate Cancer.

Xiong X, Schober M, Tassone E, Khodadadi-Jamayran A, Sastre-Perona A, Zhou H, Tsirigos A, Shen S, Chang M, Melamed J, Ossowski L, Wilson EL.

Cell Rep. 2018 Dec 11;25(11):3006-3020.e7. doi: 10.1016/j.celrep.2018.11.065.

17.

Cell Surface Notch Ligand DLL3 is a Therapeutic Target in Isocitrate Dehydrogenase-mutant Glioma.

Spino M, Kurz SC, Chiriboga L, Serrano J, Zeck B, Sen N, Patel S, Shen G, Vasudevaraja V, Tsirigos A, Suryadevara CM, Frenster JD, Tateishi K, Wakimoto H, Jain R, Riina HA, Nicolaides TP, Sulman EP, Cahill DP, Golfinos JG, Isse K, Saunders LR, Zagzag D, Placantonakis DG, Snuderl M, Chi AS.

Clin Cancer Res. 2019 Feb 15;25(4):1261-1271. doi: 10.1158/1078-0432.CCR-18-2312. Epub 2018 Nov 5.

PMID:
30397180
18.

Human blastocysts of normal and abnormal karyotypes display distinct transcriptome profiles.

Licciardi F, Lhakhang T, Kramer YG, Zhang Y, Heguy A, Tsirigos A.

Sci Rep. 2018 Oct 8;8(1):14906. doi: 10.1038/s41598-018-33279-0.

19.

Classification and mutation prediction from non-small cell lung cancer histopathology images using deep learning.

Coudray N, Ocampo PS, Sakellaropoulos T, Narula N, Snuderl M, Fenyö D, Moreira AL, Razavian N, Tsirigos A.

Nat Med. 2018 Oct;24(10):1559-1567. doi: 10.1038/s41591-018-0177-5. Epub 2018 Sep 17.

PMID:
30224757
20.

BET Bromodomain Inhibition Cooperates with PD-1 Blockade to Facilitate Antitumor Response in Kras-Mutant Non-Small Cell Lung Cancer.

Adeegbe DO, Liu S, Hattersley MM, Bowden M, Zhou CW, Li S, Vlahos R, Grondine M, Dolgalev I, Ivanova EV, Quinn MM, Gao P, Hammerman PS, Bradner JE, Diehl JA, Rustgi AK, Bass AJ, Tsirigos A, Freeman GJ, Chen H, Wong KK.

Cancer Immunol Res. 2018 Oct;6(10):1234-1245. doi: 10.1158/2326-6066.CIR-18-0077. Epub 2018 Aug 7.

21.

Platelet Transcriptome Profiling in HIV and ATP-Binding Cassette Subfamily C Member 4 (ABCC4) as a Mediator of Platelet Activity.

Marcantoni E, Allen N, Cambria MR, Dann R, Cammer M, Lhakhang T, O'Brien MP, Kim B, Worgall T, Heguy A, Tsirigos A, Berger JS.

JACC Basic Transl Sci. 2018 Mar 1;3(1):9-22. doi: 10.1016/j.jacbts.2017.10.005. eCollection 2018 Feb.

22.

Oncogenic hijacking of the stress response machinery in T cell acute lymphoblastic leukemia.

Kourtis N, Lazaris C, Hockemeyer K, Balandrán JC, Jimenez AR, Mullenders J, Gong Y, Trimarchi T, Bhatt K, Hu H, Shrestha L, Ambesi-Impiombato A, Kelliher M, Paietta E, Chiosis G, Guzman ML, Ferrando AA, Tsirigos A, Aifantis I.

Nat Med. 2018 Aug;24(8):1157-1166. doi: 10.1038/s41591-018-0105-8. Epub 2018 Jul 23.

23.

The Transcription Factor Zfx Regulates Peripheral T Cell Self-Renewal and Proliferation.

Smith-Raska MR, Arenzana TL, D'Cruz LM, Khodadadi-Jamayran A, Tsirigos A, Goldrath AW, Reizis B.

Front Immunol. 2018 Jul 4;9:1482. doi: 10.3389/fimmu.2018.01482. eCollection 2018.

24.

ETV1 activates a rapid conduction transcriptional program in rodent and human cardiomyocytes.

Shekhar A, Lin X, Lin B, Liu FY, Zhang J, Khodadadi-Jamayran A, Tsirigos A, Bu L, Fishman GI, Park DS.

Sci Rep. 2018 Jul 2;8(1):9944. doi: 10.1038/s41598-018-28239-7.

25.

Notch Signaling Facilitates In Vitro Generation of Cross-Presenting Classical Dendritic Cells.

Kirkling ME, Cytlak U, Lau CM, Lewis KL, Resteu A, Khodadadi-Jamayran A, Siebel CW, Salmon H, Merad M, Tsirigos A, Collin M, Bigley V, Reizis B.

Cell Rep. 2018 Jun 19;23(12):3658-3672.e6. doi: 10.1016/j.celrep.2018.05.068.

26.

Airway Microbiota Is Associated with Upregulation of the PI3K Pathway in Lung Cancer.

Tsay JJ, Wu BG, Badri MH, Clemente JC, Shen N, Meyn P, Li Y, Yie TA, Lhakhang T, Olsen E, Murthy V, Michaud G, Sulaiman I, Tsirigos A, Heguy A, Pass H, Weiden MD, Rom WN, Sterman DH, Bonneau R, Blaser MJ, Segal LN.

Am J Respir Crit Care Med. 2018 Nov 1;198(9):1188-1198. doi: 10.1164/rccm.201710-2118OC.

27.

Apoptotic cell-induced AhR activity is required for immunological tolerance and suppression of systemic lupus erythematosus in mice and humans.

Shinde R, Hezaveh K, Halaby MJ, Kloetgen A, Chakravarthy A, da Silva Medina T, Deol R, Manion KP, Baglaenko Y, Eldh M, Lamorte S, Wallace D, Chodisetti SB, Ravishankar B, Liu H, Chaudhary K, Munn DH, Tsirigos A, Madaio M, Gabrielsson S, Touma Z, Wither J, De Carvalho DD, McGaha TL.

Nat Immunol. 2018 Jun;19(6):571-582. doi: 10.1038/s41590-018-0107-1. Epub 2018 May 14.

28.

Prognostic role of elevated mir-24-3p in breast cancer and its association with the metastatic process.

Khodadadi-Jamayran A, Akgol-Oksuz B, Afanasyeva Y, Heguy A, Thompson M, Ray K, Giro-Perafita A, Sánchez I, Wu X, Tripathy D, Zeleniuch-Jacquotte A, Tsirigos A, Esteva FJ.

Oncotarget. 2018 Feb 5;9(16):12868-12878. doi: 10.18632/oncotarget.24403. eCollection 2018 Feb 27.

29.

DNA methylation-based classification of central nervous system tumours.

Capper D, Jones DTW, Sill M, Hovestadt V, Schrimpf D, Sturm D, Koelsche C, Sahm F, Chavez L, Reuss DE, Kratz A, Wefers AK, Huang K, Pajtler KW, Schweizer L, Stichel D, Olar A, Engel NW, Lindenberg K, Harter PN, Braczynski AK, Plate KH, Dohmen H, Garvalov BK, Coras R, Hölsken A, Hewer E, Bewerunge-Hudler M, Schick M, Fischer R, Beschorner R, Schittenhelm J, Staszewski O, Wani K, Varlet P, Pages M, Temming P, Lohmann D, Selt F, Witt H, Milde T, Witt O, Aronica E, Giangaspero F, Rushing E, Scheurlen W, Geisenberger C, Rodriguez FJ, Becker A, Preusser M, Haberler C, Bjerkvig R, Cryan J, Farrell M, Deckert M, Hench J, Frank S, Serrano J, Kannan K, Tsirigos A, Brück W, Hofer S, Brehmer S, Seiz-Rosenhagen M, Hänggi D, Hans V, Rozsnoki S, Hansford JR, Kohlhof P, Kristensen BW, Lechner M, Lopes B, Mawrin C, Ketter R, Kulozik A, Khatib Z, Heppner F, Koch A, Jouvet A, Keohane C, Mühleisen H, Mueller W, Pohl U, Prinz M, Benner A, Zapatka M, Gottardo NG, Driever PH, Kramm CM, Müller HL, Rutkowski S, von Hoff K, Frühwald MC, Gnekow A, Fleischhack G, Tippelt S, Calaminus G, Monoranu CM, Perry A, Jones C, Jacques TS, Radlwimmer B, Gessi M, Pietsch T, Schramm J, Schackert G, Westphal M, Reifenberger G, Wesseling P, Weller M, Collins VP, Blümcke I, Bendszus M, Debus J, Huang A, Jabado N, Northcott PA, Paulus W, Gajjar A, Robinson GW, Taylor MD, Jaunmuktane Z, Ryzhova M, Platten M, Unterberg A, Wick W, Karajannis MA, Mittelbronn M, Acker T, Hartmann C, Aldape K, Schüller U, Buslei R, Lichter P, Kool M, Herold-Mende C, Ellison DW, Hasselblatt M, Snuderl M, Brandner S, Korshunov A, von Deimling A, Pfister SM.

Nature. 2018 Mar 22;555(7697):469-474. doi: 10.1038/nature26000. Epub 2018 Mar 14.

30.

Stratification of TAD boundaries reveals preferential insulation of super-enhancers by strong boundaries.

Gong Y, Lazaris C, Sakellaropoulos T, Lozano A, Kambadur P, Ntziachristos P, Aifantis I, Tsirigos A.

Nat Commun. 2018 Feb 7;9(1):542. doi: 10.1038/s41467-018-03017-1.

31.

Single-Cell RNA Sequencing of Glioblastoma Cells.

Sen R, Dolgalev I, Bayin NS, Heguy A, Tsirigos A, Placantonakis DG.

Methods Mol Biol. 2018;1741:151-170. doi: 10.1007/978-1-4939-7659-1_12.

PMID:
29392698
32.

Staphylococcus aureus Responds to the Central Metabolite Pyruvate To Regulate Virulence.

Harper L, Balasubramanian D, Ohneck EA, Sause WE, Chapman J, Mejia-Sosa B, Lhakhang T, Heguy A, Tsirigos A, Ueberheide B, Boyd JM, Lun DS, Torres VJ.

MBio. 2018 Jan 23;9(1). pii: e02272-17. doi: 10.1128/mBio.02272-17.

33.

H3K27me3 dynamics dictate evolving uterine states in pregnancy and parturition.

Nancy P, Siewiera J, Rizzuto G, Tagliani E, Osokine I, Manandhar P, Dolgalev I, Clementi C, Tsirigos A, Erlebacher A.

J Clin Invest. 2018 Jan 2;128(1):233-247. doi: 10.1172/JCI95937. Epub 2017 Nov 27.

34.

TGF-β-Induced Quiescence Mediates Chemoresistance of Tumor-Propagating Cells in Squamous Cell Carcinoma.

Brown JA, Yonekubo Y, Hanson N, Sastre-Perona A, Basin A, Rytlewski JA, Dolgalev I, Meehan S, Tsirigos A, Beronja S, Schober M.

Cell Stem Cell. 2017 Nov 2;21(5):650-664.e8. doi: 10.1016/j.stem.2017.10.001.

35.

Low-Grade Astrocytoma Mutations in IDH1, P53, and ATRX Cooperate to Block Differentiation of Human Neural Stem Cells via Repression of SOX2.

Modrek AS, Golub D, Khan T, Bready D, Prado J, Bowman C, Deng J, Zhang G, Rocha PP, Raviram R, Lazaris C, Stafford JM, LeRoy G, Kader M, Dhaliwal J, Bayin NS, Frenster JD, Serrano J, Chiriboga L, Baitalmal R, Nanjangud G, Chi AS, Golfinos JG, Wang J, Karajannis MA, Bonneau RA, Reinberg D, Tsirigos A, Zagzag D, Snuderl M, Skok JA, Neubert TA, Placantonakis DG.

Cell Rep. 2017 Oct 31;21(5):1267-1280. doi: 10.1016/j.celrep.2017.10.009.

36.

Complete Genome Sequence of Kluyvera intestini sp. nov., Isolated from the Stomach of a Patient with Gastric Cancer.

Tetz G, Vecherkovskaya M, Zappile P, Dolgalev I, Tsirigos A, Heguy A, Tetz V.

Genome Announc. 2017 Oct 26;5(43). pii: e01184-17. doi: 10.1128/genomeA.01184-17.

37.

Notch signaling regulates metabolic heterogeneity in glioblastoma stem cells.

Bayin NS, Frenster JD, Sen R, Si S, Modrek AS, Galifianakis N, Dolgalev I, Ortenzi V, Illa-Bochaca I, Khahera A, Serrano J, Chiriboga L, Zagzag D, Golfinos JG, Doyle W, Tsirigos A, Heguy A, Chesler M, Barcellos-Hoff MH, Snuderl M, Placantonakis DG.

Oncotarget. 2017 May 23;8(39):64932-64953. doi: 10.18632/oncotarget.18117. eCollection 2017 Sep 12.

38.

Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression.

Cimmino L, Dolgalev I, Wang Y, Yoshimi A, Martin GH, Wang J, Ng V, Xia B, Witkowski MT, Mitchell-Flack M, Grillo I, Bakogianni S, Ndiaye-Lobry D, Martín MT, Guillamot M, Banh RS, Xu M, Figueroa ME, Dickins RA, Abdel-Wahab O, Park CY, Tsirigos A, Neel BG, Aifantis I.

Cell. 2017 Sep 7;170(6):1079-1095.e20. doi: 10.1016/j.cell.2017.07.032. Epub 2017 Aug 17.

39.

Bacteriophages as potential new mammalian pathogens.

Tetz GV, Ruggles KV, Zhou H, Heguy A, Tsirigos A, Tetz V.

Sci Rep. 2017 Aug 1;7(1):7043. doi: 10.1038/s41598-017-07278-6.

40.

lncRNA-screen: an interactive platform for computationally screening long non-coding RNAs in large genomics datasets.

Gong Y, Huang HT, Liang Y, Trimarchi T, Aifantis I, Tsirigos A.

BMC Genomics. 2017 Jun 5;18(1):434. doi: 10.1186/s12864-017-3817-0.

41.

N-BLR, a primate-specific non-coding transcript leads to colorectal cancer invasion and migration.

Rigoutsos I, Lee SK, Nam SY, Anfossi S, Pasculli B, Pichler M, Jing Y, Rodriguez-Aguayo C, Telonis AG, Rossi S, Ivan C, Catela Ivkovic T, Fabris L, Clark PM, Ling H, Shimizu M, Redis RS, Shah MY, Zhang X, Okugawa Y, Jung EJ, Tsirigos A, Huang L, Ferdin J, Gafà R, Spizzo R, Nicoloso MS, Paranjape AN, Shariati M, Tiron A, Yeh JJ, Teruel-Montoya R, Xiao L, Melo SA, Menter D, Jiang ZQ, Flores ER, Negrini M, Goel A, Bar-Eli M, Mani SA, Liu CG, Lopez-Berestein G, Berindan-Neagoe I, Esteller M, Kopetz S, Lanza G, Calin GA.

Genome Biol. 2017 May 24;18(1):98. doi: 10.1186/s13059-017-1224-0.

42.

Opposing functions of H2BK120 ubiquitylation and H3K79 methylation in the regulation of pluripotency by the Paf1 complex.

Strikoudis A, Lazaris C, Ntziachristos P, Tsirigos A, Aifantis I.

Cell Cycle. 2017;16(24):2315-2322. doi: 10.1080/15384101.2017.1295194.

43.

HiC-bench: comprehensive and reproducible Hi-C data analysis designed for parameter exploration and benchmarking.

Lazaris C, Kelly S, Ntziachristos P, Aifantis I, Tsirigos A.

BMC Genomics. 2017 Jan 5;18(1):22. doi: 10.1186/s12864-016-3387-6.

44.

Pancreatic β cell identity requires continual repression of non-β cell programs.

Gutiérrez GD, Bender AS, Cirulli V, Mastracci TL, Kelly SM, Tsirigos A, Kaestner KH, Sussel L.

J Clin Invest. 2017 Jan 3;127(1):244-259. doi: 10.1172/JCI88017. Epub 2016 Dec 12.

45.

Regulation of transcriptional elongation in pluripotency and cell differentiation by the PHD-finger protein Phf5a.

Strikoudis A, Lazaris C, Trimarchi T, Galvao Neto AL, Yang Y, Ntziachristos P, Rothbart S, Buckley S, Dolgalev I, Stadtfeld M, Strahl BD, Dynlacht BD, Tsirigos A, Aifantis I.

Nat Cell Biol. 2016 Nov;18(11):1127-1138. doi: 10.1038/ncb3424. Epub 2016 Oct 17.

46.

MED12 Regulates HSC-Specific Enhancers Independently of Mediator Kinase Activity to Control Hematopoiesis.

Aranda-Orgilles B, Saldaña-Meyer R, Wang E, Trompouki E, Fassl A, Lau S, Mullenders J, Rocha PP, Raviram R, Guillamot M, Sánchez-Díaz M, Wang K, Kayembe C, Zhang N, Amoasii L, Choudhuri A, Skok JA, Schober M, Reinberg D, Sicinski P, Schrewe H, Tsirigos A, Zon LI, Aifantis I.

Cell Stem Cell. 2016 Dec 1;19(6):784-799. doi: 10.1016/j.stem.2016.08.004. Epub 2016 Aug 25.

47.

Cohesin loss alters adult hematopoietic stem cell homeostasis, leading to myeloproliferative neoplasms.

Mullenders J, Aranda-Orgilles B, Lhoumaud P, Keller M, Pae J, Wang K, Kayembe C, Rocha PP, Raviram R, Gong Y, Premsrirut PK, Tsirigos A, Bonneau R, Skok JA, Cimmino L, Hoehn D, Aifantis I.

J Exp Med. 2015 Oct 19;212(11):1833-50. doi: 10.1084/jem.20151323. Epub 2015 Oct 5.

48.

CXCL12-Producing Vascular Endothelial Niches Control Acute T Cell Leukemia Maintenance.

Pitt LA, Tikhonova AN, Hu H, Trimarchi T, King B, Gong Y, Sanchez-Martin M, Tsirigos A, Littman DR, Ferrando AA, Morrison SJ, Fooksman DR, Aifantis I, Schwab SR.

Cancer Cell. 2015 Jun 8;27(6):755-68. doi: 10.1016/j.ccell.2015.05.002.

49.

FBXW7 modulates cellular stress response and metastatic potential through ​HSF1 post-translational modification.

Kourtis N, Moubarak RS, Aranda-Orgilles B, Lui K, Aydin IT, Trimarchi T, Darvishian F, Salvaggio C, Zhong J, Bhatt K, Chen EI, Celebi JT, Lazaris C, Tsirigos A, Osman I, Hernando E, Aifantis I.

Nat Cell Biol. 2015 Mar;17(3):322-332. doi: 10.1038/ncb3121.

50.

Combinatorial modulation of signaling pathways reveals cell-type-specific requirements for highly efficient and synchronous iPSC reprogramming.

Vidal SE, Amlani B, Chen T, Tsirigos A, Stadtfeld M.

Stem Cell Reports. 2014 Oct 14;3(4):574-84. doi: 10.1016/j.stemcr.2014.08.003.

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