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Items: 38

1.

Direct Binding between Pre-S1 and TRP-like Domains in TRPP Channels Mediates Gating and Functional Regulation by PIP2.

Zheng W, Cai R, Hofmann L, Nesin V, Hu Q, Long W, Fatehi M, Liu X, Hussein S, Kong T, Li J, Light PE, Tang J, Flockerzi V, Tsiokas L, Chen XZ.

Cell Rep. 2018 Feb 6;22(6):1560-1573. doi: 10.1016/j.celrep.2018.01.042.

2.

The Sorting Nexin 3 Retromer Pathway Regulates the Cell Surface Localization and Activity of a Wnt-Activated Polycystin Channel Complex.

Feng S, Streets AJ, Nesin V, Tran U, Nie H, Onopiuk M, Wessely O, Tsiokas L, Ong ACM.

J Am Soc Nephrol. 2017 Oct;28(10):2973-2984. doi: 10.1681/ASN.2016121349. Epub 2017 Jun 15.

3.

MICU1 drives glycolysis and chemoresistance in ovarian cancer.

Chakraborty PK, Mustafi SB, Xiong X, Dwivedi SKD, Nesin V, Saha S, Zhang M, Dhanasekaran D, Jayaraman M, Mannel R, Moore K, McMeekin S, Yang D, Zuna R, Ding K, Tsiokas L, Bhattacharya R, Mukherjee P.

Nat Commun. 2017 May 22;8:14634. doi: 10.1038/ncomms14634.

4.

The polycystin complex mediates Wnt/Ca(2+) signalling.

Kim S, Nie H, Nesin V, Tran U, Outeda P, Bai CX, Keeling J, Maskey D, Watnick T, Wessely O, Tsiokas L.

Nat Cell Biol. 2016 Jul;18(7):752-764. doi: 10.1038/ncb3363. Epub 2016 May 23.

5.

Cellular Mechanisms of Ciliary Length Control.

Keeling J, Tsiokas L, Maskey D.

Cells. 2016 Jan 29;5(1). pii: E6. doi: 10.3390/cells5010006. Review.

6.

Cell cycle-dependent ubiquitylation and destruction of NDE1 by CDK5-FBW7 regulates ciliary length.

Maskey D, Marlin MC, Kim S, Kim S, Ong EC, Li G, Tsiokas L.

EMBO J. 2015 Oct 1;34(19):2424-40. doi: 10.15252/embj.201490831. Epub 2015 Jul 23.

7.

TRPC1.

Nesin V, Tsiokas L.

Handb Exp Pharmacol. 2014;222:15-51. doi: 10.1007/978-3-642-54215-2_2. Review.

PMID:
24756701
8.

Activating mutations in STIM1 and ORAI1 cause overlapping syndromes of tubular myopathy and congenital miosis.

Nesin V, Wiley G, Kousi M, Ong EC, Lehmann T, Nicholl DJ, Suri M, Shahrizaila N, Katsanis N, Gaffney PM, Wierenga KJ, Tsiokas L.

Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4197-202. doi: 10.1073/pnas.1312520111. Epub 2014 Mar 3.

9.

A TRPC1 protein-dependent pathway regulates osteoclast formation and function.

Ong EC, Nesin V, Long CL, Bai CX, Guz JL, Ivanov IP, Abramowitz J, Birnbaumer L, Humphrey MB, Tsiokas L.

J Biol Chem. 2013 Aug 2;288(31):22219-32. doi: 10.1074/jbc.M113.459826. Epub 2013 Jun 14.

10.

Polycystin-1 regulates the stability and ubiquitination of transcription factor Jade-1.

Foy RL, Chitalia VC, Panchenko MV, Zeng L, Lopez D, Lee JW, Rana SV, Boletta A, Qian F, Tsiokas L, Piontek KB, Germino GG, Zhou MI, Cohen HT.

Hum Mol Genet. 2012 Dec 15;21(26):5456-71. doi: 10.1093/hmg/dds391. Epub 2012 Sep 21.

11.

Cilia and cell cycle re-entry: more than a coincidence.

Kim S, Tsiokas L.

Cell Cycle. 2011 Aug 15;10(16):2683-90. Epub 2011 Aug 15. Review.

12.

Nde1-mediated inhibition of ciliogenesis affects cell cycle re-entry.

Kim S, Zaghloul NA, Bubenshchikova E, Oh EC, Rankin S, Katsanis N, Obara T, Tsiokas L.

Nat Cell Biol. 2011 Apr;13(4):351-60. doi: 10.1038/ncb2183. Epub 2011 Mar 13.

13.

TRPC1 channels are critical for hypertrophic signaling in the heart.

Seth M, Zhang ZS, Mao L, Graham V, Burch J, Stiber J, Tsiokas L, Winn M, Abramowitz J, Rockman HA, Birnbaumer L, Rosenberg P.

Circ Res. 2009 Nov 6;105(10):1023-30. doi: 10.1161/CIRCRESAHA.109.206581. Epub 2009 Sep 24.

14.

Function and regulation of TRPP2 at the plasma membrane.

Tsiokas L.

Am J Physiol Renal Physiol. 2009 Jul;297(1):F1-9. doi: 10.1152/ajprenal.90277.2008. Epub 2009 Feb 25. Review.

15.

Mutant polycystin-2 induces proliferation in primary rat tubular epithelial cells in a STAT-1/p21-independent fashion accompanied instead by alterations in expression of p57KIP2 and Cdk2.

Felekkis KN, Koupepidou P, Kastanos E, Witzgall R, Bai CX, Li L, Tsiokas L, Gretz N, Deltas C.

BMC Nephrol. 2008 Aug 25;9:10. doi: 10.1186/1471-2369-9-10.

16.

Identification and functional characterization of an N-terminal oligomerization domain for polycystin-2.

Feng S, Okenka GM, Bai CX, Streets AJ, Newby LJ, DeChant BT, Tsiokas L, Obara T, Ong AC.

J Biol Chem. 2008 Oct 17;283(42):28471-9. doi: 10.1074/jbc.M803834200. Epub 2008 Aug 13.

17.

Activation of TRPP2 through mDia1-dependent voltage gating.

Bai CX, Kim S, Li WP, Streets AJ, Ong AC, Tsiokas L.

EMBO J. 2008 May 7;27(9):1345-56. doi: 10.1038/emboj.2008.70. Epub 2008 Apr 3.

18.

Formation of a new receptor-operated channel by heteromeric assembly of TRPP2 and TRPC1 subunits.

Bai CX, Giamarchi A, Rodat-Despoix L, Padilla F, Downs T, Tsiokas L, Delmas P.

EMBO Rep. 2008 May;9(5):472-9. doi: 10.1038/embor.2008.29. Epub 2008 Mar 7.

19.

Suppression of TRPC3 leads to disappearance of store-operated channels and formation of a new type of store-independent channels in A431 cells.

Kaznacheyeva E, Glushankova L, Bugaj V, Zimina O, Skopin A, Alexeenko V, Tsiokas L, Bezprozvanny I, Mozhayeva GN.

J Biol Chem. 2007 Aug 10;282(32):23655-62. Epub 2007 Jun 14.

20.

Cell biology of polycystin-2.

Tsiokas L, Kim S, Ong EC.

Cell Signal. 2007 Mar;19(3):444-53. Epub 2006 Nov 3. Review.

21.

Beta-catenin regulates myogenesis by relieving I-mfa-mediated suppression of myogenic regulatory factors in P19 cells.

Pan W, Jia Y, Wang J, Tao D, Gan X, Tsiokas L, Jing N, Wu D, Li L.

Proc Natl Acad Sci U S A. 2005 Nov 29;102(48):17378-83. Epub 2005 Nov 21.

22.

PKD2 functions as an epidermal growth factor-activated plasma membrane channel.

Ma R, Li WP, Rundle D, Kong J, Akbarali HI, Tsiokas L.

Mol Cell Biol. 2005 Sep;25(18):8285-98.

23.

Interaction of the retinal insulin receptor beta-subunit with the p85 subunit of phosphoinositide 3-kinase.

Rajala RV, McClellan ME, Chan MD, Tsiokas L, Anderson RE.

Biochemistry. 2004 May 18;43(19):5637-50.

PMID:
15134438
24.
25.
26.

Inhibitor of myogenic family, a novel suppressor of store-operated currents through an interaction with TRPC1.

Ma R, Rundle D, Jacks J, Koch M, Downs T, Tsiokas L.

J Biol Chem. 2003 Dec 26;278(52):52763-72. Epub 2003 Oct 6.

27.
28.

Cell surface glypicans are low-affinity endostatin receptors.

Karumanchi SA, Jha V, Ramchandran R, Karihaloo A, Tsiokas L, Chan B, Dhanabal M, Hanai JI, Venkataraman G, Shriver Z, Keiser N, Kalluri R, Zeng H, Mukhopadhyay D, Chen RL, Lander AD, Hagihara K, Yamaguchi Y, Sasisekharan R, Cantley L, Sukhatme VP.

Mol Cell. 2001 Apr;7(4):811-22.

29.

Co-assembly of polycystin-1 and -2 produces unique cation-permeable currents.

Hanaoka K, Qian F, Boletta A, Bhunia AK, Piontek K, Tsiokas L, Sukhatme VP, Guggino WB, Germino GG.

Nature. 2000 Dec 21-28;408(6815):990-4.

PMID:
11140688
30.

Interaction between RGS7 and polycystin.

Kim E, Arnould T, Sellin L, Benzing T, Comella N, Kocher O, Tsiokas L, Sukhatme VP, Walz G.

Proc Natl Acad Sci U S A. 1999 May 25;96(11):6371-6.

31.

Cellular activation triggered by the autosomal dominant polycystic kidney disease gene product PKD2.

Arnould T, Sellin L, Benzing T, Tsiokas L, Cohen HT, Kim E, Walz G.

Mol Cell Biol. 1999 May;19(5):3423-34.

32.

Specific association of the gene product of PKD2 with the TRPC1 channel.

Tsiokas L, Arnould T, Zhu C, Kim E, Walz G, Sukhatme VP.

Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3934-9.

33.
34.
35.

Homo- and heterodimeric interactions between the gene products of PKD1 and PKD2.

Tsiokas L, Kim E, Arnould T, Sukhatme VP, Walz G.

Proc Natl Acad Sci U S A. 1997 Jun 24;94(13):6965-70.

36.

Wild-type p53 and v-Src exert opposing influences on human vascular endothelial growth factor gene expression.

Mukhopadhyay D, Tsiokas L, Sukhatme VP.

Cancer Res. 1995 Dec 15;55(24):6161-5.

37.

Hypoxic induction of human vascular endothelial growth factor expression through c-Src activation.

Mukhopadhyay D, Tsiokas L, Zhou XM, Foster D, Brugge JS, Sukhatme VP.

Nature. 1995 Jun 15;375(6532):577-81.

PMID:
7540725

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