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Items: 1 to 50 of 299

1.

Fluorous-Soluble Metal Chelate for Sensitive Fluorine-19 Magnetic Resonance Imaging Nanoemulsion Probes.

Jahromi AH, Wang C, Adams SR, Zhu W, Narsinh K, Xu H, Gray DL, Tsien RY, Ahrens ET.

ACS Nano. 2018 Dec 7. doi: 10.1021/acsnano.8b04881. [Epub ahead of print]

PMID:
30525446
2.

Impact of MMP-2 and MMP-9 enzyme activity on wound healing, tumor growth and RACPP cleavage.

Hingorani DV, Lippert CN, Crisp JL, Savariar EN, Hasselmann JPC, Kuo C, Nguyen QT, Tsien RY, Whitney MA, Ellies LG.

PLoS One. 2018 Sep 24;13(9):e0198464. doi: 10.1371/journal.pone.0198464. eCollection 2018.

3.

Nerve-targeted probes for fluorescence-guided intraoperative imaging.

Hingorani DV, Whitney MA, Friedman B, Kwon JK, Crisp JL, Xiong Q, Gross L, Kane CJ, Tsien RY, Nguyen QT.

Theranostics. 2018 Jul 30;8(15):4226-4237. doi: 10.7150/thno.23084. eCollection 2018.

4.

Detection of Subclinical Arthritis in Mice by a Thrombin Receptor-Derived Imaging Agent.

Friedman B, Whitney MA, Savariar EN, Caneda C, Steinbach P, Xiong Q, Hingorani DV, Crisp J, Adams SR, Kenner M, Lippert CN, Nguyen QT, Guma M, Tsien RY, Corr M.

Arthritis Rheumatol. 2018 Jan;70(1):69-79. doi: 10.1002/art.40316. Epub 2017 Nov 29.

5.

Sensitive in vivo Visualization of Breast Cancer Using Ratiometric Protease-activatable Fluorescent Imaging Agent, AVB-620.

Miampamba M, Liu J, Harootunian A, Gale AJ, Baird S, Chen SL, Nguyen QT, Tsien RY, González JE.

Theranostics. 2017 Aug 11;7(13):3369-3386. doi: 10.7150/thno.20678. eCollection 2017.

6.

Early detection of squamous cell carcinoma in carcinogen induced oral cancer rodent model by ratiometric activatable cell penetrating peptides.

Hingorani DV, Lemieux AJ, Acevedo JR, Glasgow HL, Kedarisetty S, Whitney MA, Molinolo AA, Tsien RY, Nguyen QT.

Oral Oncol. 2017 Aug;71:156-162. doi: 10.1016/j.oraloncology.2017.06.009. Epub 2017 Jun 27.

7.

18F-positron-emitting/fluorescent labeled erythrocytes allow imaging of internal hemorrhage in a murine intracranial hemorrhage model.

Wang Y, An FF, Chan M, Friedman B, Rodriguez EA, Tsien RY, Aras O, Ting R.

J Cereb Blood Flow Metab. 2017 Mar;37(3):776-786. doi: 10.1177/0271678X16682510. Epub 2017 Jan 5.

8.

Multicolor Electron Microscopy for Simultaneous Visualization of Multiple Molecular Species.

Adams SR, Mackey MR, Ramachandra R, Palida Lemieux SF, Steinbach P, Bushong EA, Butko MT, Giepmans BNG, Ellisman MH, Tsien RY.

Cell Chem Biol. 2016 Nov 17;23(11):1417-1427. doi: 10.1016/j.chembiol.2016.10.006. Epub 2016 Nov 3.

9.

The Growing and Glowing Toolbox of Fluorescent and Photoactive Proteins.

Rodriguez EA, Campbell RE, Lin JY, Lin MZ, Miyawaki A, Palmer AE, Shu X, Zhang J, Tsien RY.

Trends Biochem Sci. 2017 Feb;42(2):111-129. doi: 10.1016/j.tibs.2016.09.010. Epub 2016 Nov 1. Review.

10.

Laminin targeting of a peripheral nerve-highlighting peptide enables degenerated nerve visualization.

Glasgow HL, Whitney MA, Gross LA, Friedman B, Adams SR, Crisp JL, Hussain T, Frei AP, Novy K, Wollscheid B, Nguyen QT, Tsien RY.

Proc Natl Acad Sci U S A. 2016 Nov 8;113(45):12774-12779. doi: 10.1073/pnas.1611642113. Epub 2016 Oct 20.

11.

Anti-tubulin drugs conjugated to anti-ErbB antibodies selectively radiosensitize.

Adams SR, Yang HC, Savariar EN, Aguilera J, Crisp JL, Jones KA, Whitney MA, Lippman SM, Cohen EE, Tsien RY, Advani SJ.

Nat Commun. 2016 Oct 4;7:13019. doi: 10.1038/ncomms13019.

12.

A far-red fluorescent protein evolved from a cyanobacterial phycobiliprotein.

Rodriguez EA, Tran GN, Gross LA, Crisp JL, Shu X, Lin JY, Tsien RY.

Nat Methods. 2016 Sep;13(9):763-9. doi: 10.1038/nmeth.3935. Epub 2016 Aug 1.

13.

Click-EM for imaging metabolically tagged nonprotein biomolecules.

Ngo JT, Adams SR, Deerinck TJ, Boassa D, Rodriguez-Rivera F, Palida SF, Bertozzi CR, Ellisman MH, Tsien RY.

Nat Chem Biol. 2016 Jun;12(6):459-65. doi: 10.1038/nchembio.2076. Epub 2016 Apr 25.

14.

New Dioxaborolane Chemistry Enables [(18)F]-Positron-Emitting, Fluorescent [(18)F]-Multimodality Biomolecule Generation from the Solid Phase.

Rodriguez EA, Wang Y, Crisp JL, Vera DR, Tsien RY, Ting R.

Bioconjug Chem. 2016 May 18;27(5):1390-1399. doi: 10.1021/acs.bioconjchem.6b00164. Epub 2016 Apr 27.

15.

Paramagnetic fluorinated nanoemulsions for sensitive cellular fluorine-19 magnetic resonance imaging.

Kislukhin AA, Xu H, Adams SR, Narsinh KH, Tsien RY, Ahrens ET.

Nat Mater. 2016 Jun;15(6):662-8. doi: 10.1038/nmat4585. Epub 2016 Mar 14.

16.

Molecular targeting of papillary thyroid carcinoma with fluorescently labeled ratiometric activatable cell penetrating peptides in a transgenic murine model.

Orosco RK, Savariar EN, Weissbrod PA, Diaz-Perez JA, Bouvet M, Tsien RY, Nguyen QT.

J Surg Oncol. 2016 Feb;113(2):138-43. doi: 10.1002/jso.24129. Epub 2016 Jan 12.

17.

Gelatinase activity imaged by activatable cell-penetrating peptides in cell-based and in vivo models of stroke.

Chen S, Cui J, Jiang T, Olson ES, Cai QY, Yang M, Wu W, Guthrie JM, Robertson JD, Lipton SA, Ma L, Tsien RY, Gu Z.

J Cereb Blood Flow Metab. 2017 Jan;37(1):188-200. Epub 2015 Dec 17.

18.

Identification of High-Risk Plaques by MRI and Fluorescence Imaging in a Rabbit Model of Atherothrombosis.

Hua N, Baik F, Pham T, Phinikaridou A, Giordano N, Friedman B, Whitney M, Nguyen QT, Tsien RY, Hamilton JA.

PLoS One. 2015 Oct 8;10(10):e0139833. doi: 10.1371/journal.pone.0139833. eCollection 2015.

19.

Tumor Detection at 3 Tesla with an Activatable Cell Penetrating Peptide Dendrimer (ACPPD-Gd), a T1 Magnetic Resonance (MR) Molecular Imaging Agent.

Malone CD, Olson ES, Mattrey RF, Jiang T, Tsien RY, Nguyen QT.

PLoS One. 2015 Sep 3;10(9):e0137104. doi: 10.1371/journal.pone.0137104. eCollection 2015.

20.

Optogenetics: 10 years after ChR2 in neurons--views from the community.

Adamantidis A, Arber S, Bains JS, Bamberg E, Bonci A, Buzsáki G, Cardin JA, Costa RM, Dan Y, Goda Y, Graybiel AM, Häusser M, Hegemann P, Huguenard JR, Insel TR, Janak PH, Johnston D, Josselyn SA, Koch C, Kreitzer AC, Lüscher C, Malenka RC, Miesenböck G, Nagel G, Roska B, Schnitzer MJ, Shenoy KV, Soltesz I, Sternson SM, Tsien RW, Tsien RY, Turrigiano GG, Tye KM, Wilson RI.

Nat Neurosci. 2015 Sep;18(9):1202-12. doi: 10.1038/nn.4106. Review. No abstract available.

PMID:
26308981
21.

Monitoring Integrated Activity of Individual Neurons Using FRET-Based Voltage-Sensitive Dyes.

Briggman KL, Kristan WB, González JE, Kleinfeld D, Tsien RY.

Adv Exp Med Biol. 2015;859:149-69. doi: 10.1007/978-3-319-17641-3_6. Review.

PMID:
26238052
22.

Tunable and reversible drug control of protein production via a self-excising degron.

Chung HK, Jacobs CL, Huo Y, Yang J, Krumm SA, Plemper RK, Tsien RY, Lin MZ.

Nat Chem Biol. 2015 Sep;11(9):713-20. doi: 10.1038/nchembio.1869. Epub 2015 Jul 27.

23.

PKMζ, but not PKCλ, is rapidly synthesized and degraded at the neuronal synapse.

Palida SF, Butko MT, Ngo JT, Mackey MR, Gross LA, Ellisman MH, Tsien RY.

J Neurosci. 2015 May 20;35(20):7736-49. doi: 10.1523/JNEUROSCI.0004-15.2015.

24.

The BRAIN Initiative: developing technology to catalyse neuroscience discovery.

Jorgenson LA, Newsome WT, Anderson DJ, Bargmann CI, Brown EN, Deisseroth K, Donoghue JP, Hudson KL, Ling GS, MacLeish PR, Marder E, Normann RA, Sanes JR, Schnitzer MJ, Sejnowski TJ, Tank DW, Tsien RY, Ugurbil K, Wingfield JC.

Philos Trans R Soc Lond B Biol Sci. 2015 May 19;370(1668). pii: 20140164. doi: 10.1098/rstb.2014.0164. Review.

25.

Fluorescently labeled peptide increases identification of degenerated facial nerve branches during surgery and improves functional outcome.

Hussain T, Mastrodimos MB, Raju SC, Glasgow HL, Whitney M, Friedman B, Moore JD, Kleinfeld D, Steinbach P, Messer K, Pu M, Tsien RY, Nguyen QT.

PLoS One. 2015 Mar 9;10(3):e0119600. doi: 10.1371/journal.pone.0119600. eCollection 2015.

26.

Combined TP53 mutation/3p loss correlates with decreased radiosensitivity and increased matrix-metalloproteinase activity in head and neck carcinoma.

Raju SC, Hauff SJ, Lemieux AJ, Orosco RK, Gross AM, Nguyen LT, Savariar E, Moss W, Whitney M, Cohen EE, Lippman SM, Tsien RY, Ideker T, Advani SJ, Nguyen QT.

Oral Oncol. 2015 May;51(5):470-5. doi: 10.1016/j.oraloncology.2015.01.014. Epub 2015 Feb 27.

27.

Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery.

Buckel L, Savariar EN, Crisp JL, Jones KA, Hicks AM, Scanderbeg DJ, Nguyen QT, Sicklick JK, Lowy AM, Tsien RY, Advani SJ.

Cancer Res. 2015 Apr 1;75(7):1376-1387. doi: 10.1158/0008-5472.CAN-14-1931. Epub 2015 Feb 13.

28.

Improved PeT molecules for optically sensing voltage in neurons.

Woodford CR, Frady EP, Smith RS, Morey B, Canzi G, Palida SF, Araneda RC, Kristan WB Jr, Kubiak CP, Miller EW, Tsien RY.

J Am Chem Soc. 2015 Feb 11;137(5):1817-24. doi: 10.1021/ja510602z. Epub 2015 Jan 29.

29.

How FlAsH got its sparkle: historical recollections of the biarsenical-tetracysteine tag.

Griffin BA, Adams SR, Tsien RY.

Methods Mol Biol. 2015;1266:1-6. doi: 10.1007/978-1-4939-2272-7_1.

PMID:
25560064
30.

Surgical molecular navigation with ratiometric activatable cell penetrating peptide for intraoperative identification and resection of small salivary gland cancers.

Hussain T, Savariar EN, Diaz-Perez JA, Messer K, Pu M, Tsien RY, Nguyen QT.

Head Neck. 2016 May;38(5):715-23. doi: 10.1002/hed.23946. Epub 2015 Jun 22.

31.

Ratiometric activatable cell-penetrating peptides label pancreatic cancer, enabling fluorescence-guided surgery, which reduces metastases and recurrence in orthotopic mouse models.

Metildi CA, Felsen CN, Savariar EN, Nguyen QT, Kaushal S, Hoffman RM, Tsien RY, Bouvet M.

Ann Surg Oncol. 2015;22(6):2082-7. doi: 10.1245/s10434-014-4144-1. Epub 2014 Oct 16.

32.

Matrix-metalloproteinases in head and neck carcinoma-cancer genome atlas analysis and fluorescence imaging in mice.

Hauff SJ, Raju SC, Orosco RK, Gross AM, Diaz-Perez JA, Savariar E, Nashi N, Hasselman J, Whitney M, Myers JN, Lippman SM, Tsien RY, Ideker T, Nguyen QT.

Otolaryngol Head Neck Surg. 2014 Oct;151(4):612-8. doi: 10.1177/0194599814545083. Epub 2014 Aug 4.

33.

Engineering a memory with LTD and LTP.

Nabavi S, Fox R, Proulx CD, Lin JY, Tsien RY, Malinow R.

Nature. 2014 Jul 17;511(7509):348-52. doi: 10.1038/nature13294. Epub 2014 Jun 1.

34.

An optimized triple modality reporter for quantitative in vivo tumor imaging and therapy evaluation.

Levin RA, Felsen CN, Yang J, Lin JY, Whitney MA, Nguyen QT, Tsien RY.

PLoS One. 2014 May 9;9(5):e97415. doi: 10.1371/journal.pone.0097415. eCollection 2014.

35.

Early detection of thrombin activity in neuroinflammatory disease.

Davalos D, Baeten KM, Whitney MA, Mullins ES, Friedman B, Olson ES, Ryu JK, Smirnoff DS, Petersen MA, Bedard C, Degen JL, Tsien RY, Akassoglou K.

Ann Neurol. 2014 Feb;75(2):303-8. doi: 10.1002/ana.24078. Epub 2014 Feb 24.

36.

Dual targeting of integrin αvβ3 and matrix metalloproteinase-2 for optical imaging of tumors and chemotherapeutic delivery.

Crisp JL, Savariar EN, Glasgow HL, Ellies LG, Whitney MA, Tsien RY.

Mol Cancer Ther. 2014 Jun;13(6):1514-25. doi: 10.1158/1535-7163.MCT-13-1067. Epub 2014 Apr 15.

37.

Detection and monitoring of localized matrix metalloproteinase upregulation in a murine model of asthma.

Felsen CN, Savariar EN, Whitney M, Tsien RY.

Am J Physiol Lung Cell Mol Physiol. 2014 Apr 15;306(8):L764-74. doi: 10.1152/ajplung.00371.2013. Epub 2014 Feb 7.

38.

Dual-porosity hollow nanoparticles for the immunoprotection and delivery of nonhuman enzymes.

Ortac I, Simberg D, Yeh YS, Yang J, Messmer B, Trogler WC, Tsien RY, Esener S.

Nano Lett. 2014 Jun 11;14(6):3023-32. doi: 10.1021/nl404360k. Epub 2014 Feb 6.

39.

In vivo targeting of hydrogen peroxide by activatable cell-penetrating peptides.

Weinstain R, Savariar EN, Felsen CN, Tsien RY.

J Am Chem Soc. 2014 Jan 22;136(3):874-7. doi: 10.1021/ja411547j. Epub 2014 Jan 8.

40.

Optogenetic control of Drosophila using a red-shifted channelrhodopsin reveals experience-dependent influences on courtship.

Inagaki HK, Jung Y, Hoopfer ED, Wong AM, Mishra N, Lin JY, Tsien RY, Anderson DJ.

Nat Methods. 2014 Mar;11(3):325-32. doi: 10.1038/nmeth.2765. Epub 2013 Dec 22.

41.

ReaChR: a red-shifted variant of channelrhodopsin enables deep transcranial optogenetic excitation.

Lin JY, Knutsen PM, Muller A, Kleinfeld D, Tsien RY.

Nat Neurosci. 2013 Oct;16(10):1499-508. doi: 10.1038/nn.3502. Epub 2013 Sep 1.

42.

Fluorescence-guided surgery with live molecular navigation--a new cutting edge.

Nguyen QT, Tsien RY.

Nat Rev Cancer. 2013 Sep;13(9):653-62. doi: 10.1038/nrc3566. Epub 2013 Aug 8. Review.

43.

Optogenetic inhibition of synaptic release with chromophore-assisted light inactivation (CALI).

Lin JY, Sann SB, Zhou K, Nabavi S, Proulx CD, Malinow R, Jin Y, Tsien RY.

Neuron. 2013 Jul 24;79(2):241-53. doi: 10.1016/j.neuron.2013.05.022.

44.

Very long-term memories may be stored in the pattern of holes in the perineuronal net.

Tsien RY.

Proc Natl Acad Sci U S A. 2013 Jul 23;110(30):12456-61. doi: 10.1073/pnas.1310158110. Epub 2013 Jul 5.

45.

Fluorescent ligand for human progesterone receptor imaging in live cells.

Weinstain R, Kanter J, Friedman B, Ellies LG, Baker ME, Tsien RY.

Bioconjug Chem. 2013 May 15;24(5):766-71. doi: 10.1021/bc3006418. Epub 2013 Apr 29.

46.

In vivo quantitative proteomics of somatosensory cortical synapses shows which protein levels are modulated by sensory deprivation.

Butko MT, Savas JN, Friedman B, Delahunty C, Ebner F, Yates JR 3rd, Tsien RY.

Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):E726-35. doi: 10.1073/pnas.1300424110. Epub 2013 Feb 4.

47.

Gibberellins accumulate in the elongating endodermal cells of Arabidopsis root.

Shani E, Weinstain R, Zhang Y, Castillejo C, Kaiserli E, Chory J, Tsien RY, Estelle M.

Proc Natl Acad Sci U S A. 2013 Mar 19;110(12):4834-9. doi: 10.1073/pnas.1300436110. Epub 2013 Feb 4.

48.

Fluorescence imaging in surgery.

Orosco RK, Tsien RY, Nguyen QT.

IEEE Rev Biomed Eng. 2013;6:178-87. doi: 10.1109/RBME.2013.2240294. Epub 2013 Jan 15. Review.

49.

Real-time in vivo molecular detection of primary tumors and metastases with ratiometric activatable cell-penetrating peptides.

Savariar EN, Felsen CN, Nashi N, Jiang T, Ellies LG, Steinbach P, Tsien RY, Nguyen QT.

Cancer Res. 2013 Jan 15;73(2):855-64. doi: 10.1158/0008-5472.CAN-12-2969. Epub 2012 Nov 27.

50.

Fluorescent and photo-oxidizing TimeSTAMP tags track protein fates in light and electron microscopy.

Butko MT, Yang J, Geng Y, Kim HJ, Jeon NL, Shu X, Mackey MR, Ellisman MH, Tsien RY, Lin MZ.

Nat Neurosci. 2012 Dec;15(12):1742-51. doi: 10.1038/nn.3246. Epub 2012 Oct 28.

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