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Items: 1 to 50 of 558

1.

Real-time three-dimensional tracking of single synaptic vesicles reveals that synaptic vesicles undergoing kiss-and-run fusion remain close to their original fusion site before reuse.

Qin X, Tsien RW, Park H.

Biochem Biophys Res Commun. 2019 Jun 30;514(3):1004-1008. doi: 10.1016/j.bbrc.2019.05.043. Epub 2019 May 12.

PMID:
31092326
2.

Weakening synapses to cull memories.

Mandelberg NJ, Tsien R.

Science. 2019 Jan 4;363(6422):31-32. doi: 10.1126/science.aaw1675. No abstract available.

3.

Fluorous-Soluble Metal Chelate for Sensitive Fluorine-19 Magnetic Resonance Imaging Nanoemulsion Probes.

Jahromi AH, Wang C, Adams SR, Zhu W, Narsinh K, Xu H, Gray DL, Tsien RY, Ahrens ET.

ACS Nano. 2019 Jan 22;13(1):143-151. doi: 10.1021/acsnano.8b04881. Epub 2018 Dec 7.

4.

Oxytocin Transforms Firing Mode of CA2 Hippocampal Neurons.

Tirko NN, Eyring KW, Carcea I, Mitre M, Chao MV, Froemke RC, Tsien RW.

Neuron. 2018 Nov 7;100(3):593-608.e3. doi: 10.1016/j.neuron.2018.09.008. Epub 2018 Oct 4.

5.

Impact of MMP-2 and MMP-9 enzyme activity on wound healing, tumor growth and RACPP cleavage.

Hingorani DV, Lippert CN, Crisp JL, Savariar EN, Hasselmann JPC, Kuo C, Nguyen QT, Tsien RY, Whitney MA, Ellies LG.

PLoS One. 2018 Sep 24;13(9):e0198464. doi: 10.1371/journal.pone.0198464. eCollection 2018.

6.

Nerve-targeted probes for fluorescence-guided intraoperative imaging.

Hingorani DV, Whitney MA, Friedman B, Kwon JK, Crisp JL, Xiong Q, Gross L, Kane CJ, Tsien RY, Nguyen QT.

Theranostics. 2018 Jul 30;8(15):4226-4237. doi: 10.7150/thno.23084. eCollection 2018.

7.

Calmodulin shuttling mediates cytonuclear signaling to trigger experience-dependent transcription and memory.

Cohen SM, Suutari B, He X, Wang Y, Sanchez S, Tirko NN, Mandelberg NJ, Mullins C, Zhou G, Wang S, Kats I, Salah A, Tsien RW, Ma H.

Nat Commun. 2018 Jun 22;9(1):2451. doi: 10.1038/s41467-018-04705-8.

8.

Direct Visualization of Wide Fusion-Fission Pores and Their Highly Varied Dynamics.

Eyring KW, Tsien RW.

Cell. 2018 May 3;173(4):819-821. doi: 10.1016/j.cell.2018.04.016.

9.

Detection of Subclinical Arthritis in Mice by a Thrombin Receptor-Derived Imaging Agent.

Friedman B, Whitney MA, Savariar EN, Caneda C, Steinbach P, Xiong Q, Hingorani DV, Crisp J, Adams SR, Kenner M, Lippert CN, Nguyen QT, Guma M, Tsien RY, Corr M.

Arthritis Rheumatol. 2018 Jan;70(1):69-79. doi: 10.1002/art.40316. Epub 2017 Nov 29.

10.

Sensitive in vivo Visualization of Breast Cancer Using Ratiometric Protease-activatable Fluorescent Imaging Agent, AVB-620.

Miampamba M, Liu J, Harootunian A, Gale AJ, Baird S, Chen SL, Nguyen QT, Tsien RY, González JE.

Theranostics. 2017 Aug 11;7(13):3369-3386. doi: 10.7150/thno.20678. eCollection 2017.

11.

Discovery of peptide ligands through docking and virtual screening at nicotinic acetylcholine receptor homology models.

Leffler AE, Kuryatov A, Zebroski HA, Powell SR, Filipenko P, Hussein AK, Gorson J, Heizmann A, Lyskov S, Tsien RW, Poget SF, Nicke A, Lindstrom J, Rudy B, Bonneau R, Holford M.

Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):E8100-E8109. doi: 10.1073/pnas.1703952114. Epub 2017 Sep 5.

12.

Early detection of squamous cell carcinoma in carcinogen induced oral cancer rodent model by ratiometric activatable cell penetrating peptides.

Hingorani DV, Lemieux AJ, Acevedo JR, Glasgow HL, Kedarisetty S, Whitney MA, Molinolo AA, Tsien RY, Nguyen QT.

Oral Oncol. 2017 Aug;71:156-162. doi: 10.1016/j.oraloncology.2017.06.009. Epub 2017 Jun 27.

13.

18F-positron-emitting/fluorescent labeled erythrocytes allow imaging of internal hemorrhage in a murine intracranial hemorrhage model.

Wang Y, An FF, Chan M, Friedman B, Rodriguez EA, Tsien RY, Aras O, Ting R.

J Cereb Blood Flow Metab. 2017 Mar;37(3):776-786. doi: 10.1177/0271678X16682510. Epub 2017 Jan 5.

14.

Multicolor Electron Microscopy for Simultaneous Visualization of Multiple Molecular Species.

Adams SR, Mackey MR, Ramachandra R, Palida Lemieux SF, Steinbach P, Bushong EA, Butko MT, Giepmans BNG, Ellisman MH, Tsien RY.

Cell Chem Biol. 2016 Nov 17;23(11):1417-1427. doi: 10.1016/j.chembiol.2016.10.006. Epub 2016 Nov 3.

15.

The Growing and Glowing Toolbox of Fluorescent and Photoactive Proteins.

Rodriguez EA, Campbell RE, Lin JY, Lin MZ, Miyawaki A, Palmer AE, Shu X, Zhang J, Tsien RY.

Trends Biochem Sci. 2017 Feb;42(2):111-129. doi: 10.1016/j.tibs.2016.09.010. Epub 2016 Nov 1. Review.

16.

Laminin targeting of a peripheral nerve-highlighting peptide enables degenerated nerve visualization.

Glasgow HL, Whitney MA, Gross LA, Friedman B, Adams SR, Crisp JL, Hussain T, Frei AP, Novy K, Wollscheid B, Nguyen QT, Tsien RY.

Proc Natl Acad Sci U S A. 2016 Nov 8;113(45):12774-12779. doi: 10.1073/pnas.1611642113. Epub 2016 Oct 20.

17.

Roger Yonchien Tsien (1952-2016).

Rink TJ, Tsien LY, Tsien RW.

Nature. 2016 Oct 13;538(7624):172. doi: 10.1038/538172a. No abstract available.

18.

Anti-tubulin drugs conjugated to anti-ErbB antibodies selectively radiosensitize.

Adams SR, Yang HC, Savariar EN, Aguilera J, Crisp JL, Jones KA, Whitney MA, Lippman SM, Cohen EE, Tsien RY, Advani SJ.

Nat Commun. 2016 Oct 4;7:13019. doi: 10.1038/ncomms13019.

19.

A far-red fluorescent protein evolved from a cyanobacterial phycobiliprotein.

Rodriguez EA, Tran GN, Gross LA, Crisp JL, Shu X, Lin JY, Tsien RY.

Nat Methods. 2016 Sep;13(9):763-9. doi: 10.1038/nmeth.3935. Epub 2016 Aug 1.

20.

What is memory? The present state of the engram.

Poo MM, Pignatelli M, Ryan TJ, Tonegawa S, Bonhoeffer T, Martin KC, Rudenko A, Tsai LH, Tsien RW, Fishell G, Mullins C, Gonçalves JT, Shtrahman M, Johnston ST, Gage FH, Dan Y, Long J, Buzsáki G, Stevens C.

BMC Biol. 2016 May 19;14:40. doi: 10.1186/s12915-016-0261-6.

21.

Click-EM for imaging metabolically tagged nonprotein biomolecules.

Ngo JT, Adams SR, Deerinck TJ, Boassa D, Rodriguez-Rivera F, Palida SF, Bertozzi CR, Ellisman MH, Tsien RY.

Nat Chem Biol. 2016 Jun;12(6):459-65. doi: 10.1038/nchembio.2076. Epub 2016 Apr 25.

22.

New Dioxaborolane Chemistry Enables [(18)F]-Positron-Emitting, Fluorescent [(18)F]-Multimodality Biomolecule Generation from the Solid Phase.

Rodriguez EA, Wang Y, Crisp JL, Vera DR, Tsien RY, Ting R.

Bioconjug Chem. 2016 May 18;27(5):1390-1399. doi: 10.1021/acs.bioconjchem.6b00164. Epub 2016 Apr 27.

23.

Excitation-Transcription Coupling in Parvalbumin-Positive Interneurons Employs a Novel CaM Kinase-Dependent Pathway Distinct from Excitatory Neurons.

Cohen SM, Ma H, Kuchibhotla KV, Watson BO, Buzsáki G, Froemke RC, Tsien RW.

Neuron. 2016 Apr 20;90(2):292-307. doi: 10.1016/j.neuron.2016.03.001. Epub 2016 Mar 31.

24.

Unifying Views of Autism Spectrum Disorders: A Consideration of Autoregulatory Feedback Loops.

Mullins C, Fishell G, Tsien RW.

Neuron. 2016 Mar 16;89(6):1131-1156. doi: 10.1016/j.neuron.2016.02.017. Review.

25.

Paramagnetic fluorinated nanoemulsions for sensitive cellular fluorine-19 magnetic resonance imaging.

Kislukhin AA, Xu H, Adams SR, Narsinh KH, Tsien RY, Ahrens ET.

Nat Mater. 2016 Jun;15(6):662-8. doi: 10.1038/nmat4585. Epub 2016 Mar 14.

26.

Sequential ionic and conformational signaling by calcium channels drives neuronal gene expression.

Li B, Tadross MR, Tsien RW.

Science. 2016 Feb 19;351(6275):863-7. doi: 10.1126/science.aad3647.

27.

Molecular targeting of papillary thyroid carcinoma with fluorescently labeled ratiometric activatable cell penetrating peptides in a transgenic murine model.

Orosco RK, Savariar EN, Weissbrod PA, Diaz-Perez JA, Bouvet M, Tsien RY, Nguyen QT.

J Surg Oncol. 2016 Feb;113(2):138-43. doi: 10.1002/jso.24129. Epub 2016 Jan 12.

28.

Gelatinase activity imaged by activatable cell-penetrating peptides in cell-based and in vivo models of stroke.

Chen S, Cui J, Jiang T, Olson ES, Cai QY, Yang M, Wu W, Guthrie JM, Robertson JD, Lipton SA, Ma L, Tsien RY, Gu Z.

J Cereb Blood Flow Metab. 2017 Jan;37(1):188-200. Epub 2015 Dec 17.

29.

Identification of High-Risk Plaques by MRI and Fluorescence Imaging in a Rabbit Model of Atherothrombosis.

Hua N, Baik F, Pham T, Phinikaridou A, Giordano N, Friedman B, Whitney M, Nguyen QT, Tsien RY, Hamilton JA.

PLoS One. 2015 Oct 8;10(10):e0139833. doi: 10.1371/journal.pone.0139833. eCollection 2015.

30.

Tumor Detection at 3 Tesla with an Activatable Cell Penetrating Peptide Dendrimer (ACPPD-Gd), a T1 Magnetic Resonance (MR) Molecular Imaging Agent.

Malone CD, Olson ES, Mattrey RF, Jiang T, Tsien RY, Nguyen QT.

PLoS One. 2015 Sep 3;10(9):e0137104. doi: 10.1371/journal.pone.0137104. eCollection 2015.

31.

Optogenetics: 10 years after ChR2 in neurons--views from the community.

Adamantidis A, Arber S, Bains JS, Bamberg E, Bonci A, Buzsáki G, Cardin JA, Costa RM, Dan Y, Goda Y, Graybiel AM, Häusser M, Hegemann P, Huguenard JR, Insel TR, Janak PH, Johnston D, Josselyn SA, Koch C, Kreitzer AC, Lüscher C, Malenka RC, Miesenböck G, Nagel G, Roska B, Schnitzer MJ, Shenoy KV, Soltesz I, Sternson SM, Tsien RW, Tsien RY, Turrigiano GG, Tye KM, Wilson RI.

Nat Neurosci. 2015 Sep;18(9):1202-12. doi: 10.1038/nn.4106. Review. No abstract available.

32.

Cannabinoids and Epilepsy.

Rosenberg EC, Tsien RW, Whalley BJ, Devinsky O.

Neurotherapeutics. 2015 Oct;12(4):747-68. doi: 10.1007/s13311-015-0375-5. Review.

33.

Monitoring Integrated Activity of Individual Neurons Using FRET-Based Voltage-Sensitive Dyes.

Briggman KL, Kristan WB, González JE, Kleinfeld D, Tsien RY.

Adv Exp Med Biol. 2015;859:149-69. doi: 10.1007/978-3-319-17641-3_6. Review.

PMID:
26238052
34.

Tunable and reversible drug control of protein production via a self-excising degron.

Chung HK, Jacobs CL, Huo Y, Yang J, Krumm SA, Plemper RK, Tsien RY, Lin MZ.

Nat Chem Biol. 2015 Sep;11(9):713-20. doi: 10.1038/nchembio.1869. Epub 2015 Jul 27.

35.

Evolutionary and functional perspectives on signaling from neuronal surface to nucleus.

Cohen SM, Li B, Tsien RW, Ma H.

Biochem Biophys Res Commun. 2015 Apr 24;460(1):88-99. doi: 10.1016/j.bbrc.2015.02.146. Review.

36.

PKMζ, but not PKCλ, is rapidly synthesized and degraded at the neuronal synapse.

Palida SF, Butko MT, Ngo JT, Mackey MR, Gross LA, Ellisman MH, Tsien RY.

J Neurosci. 2015 May 20;35(20):7736-49. doi: 10.1523/JNEUROSCI.0004-15.2015.

37.

The BRAIN Initiative: developing technology to catalyse neuroscience discovery.

Jorgenson LA, Newsome WT, Anderson DJ, Bargmann CI, Brown EN, Deisseroth K, Donoghue JP, Hudson KL, Ling GS, MacLeish PR, Marder E, Normann RA, Sanes JR, Schnitzer MJ, Sejnowski TJ, Tank DW, Tsien RY, Ugurbil K, Wingfield JC.

Philos Trans R Soc Lond B Biol Sci. 2015 May 19;370(1668). pii: 20140164. doi: 10.1098/rstb.2014.0164. Review.

38.

Fluorescently labeled peptide increases identification of degenerated facial nerve branches during surgery and improves functional outcome.

Hussain T, Mastrodimos MB, Raju SC, Glasgow HL, Whitney M, Friedman B, Moore JD, Kleinfeld D, Steinbach P, Messer K, Pu M, Tsien RY, Nguyen QT.

PLoS One. 2015 Mar 9;10(3):e0119600. doi: 10.1371/journal.pone.0119600. eCollection 2015.

39.

Combined TP53 mutation/3p loss correlates with decreased radiosensitivity and increased matrix-metalloproteinase activity in head and neck carcinoma.

Raju SC, Hauff SJ, Lemieux AJ, Orosco RK, Gross AM, Nguyen LT, Savariar E, Moss W, Whitney M, Cohen EE, Lippman SM, Tsien RY, Ideker T, Advani SJ, Nguyen QT.

Oral Oncol. 2015 May;51(5):470-5. doi: 10.1016/j.oraloncology.2015.01.014. Epub 2015 Feb 27.

40.

Protein mutated in paroxysmal dyskinesia interacts with the active zone protein RIM and suppresses synaptic vesicle exocytosis.

Shen Y, Ge WP, Li Y, Hirano A, Lee HY, Rohlmann A, Missler M, Tsien RW, Jan LY, Fu YH, Ptáček LJ.

Proc Natl Acad Sci U S A. 2015 Mar 10;112(10):2935-41. doi: 10.1073/pnas.1501364112. Epub 2015 Feb 17.

41.

Distinct roles of multiple isoforms of CaMKII in signaling to the nucleus.

Ma H, Li B, Tsien RW.

Biochim Biophys Acta. 2015 Sep;1853(9):1953-7. doi: 10.1016/j.bbamcr.2015.02.008. Epub 2015 Feb 17. Review.

42.

Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery.

Buckel L, Savariar EN, Crisp JL, Jones KA, Hicks AM, Scanderbeg DJ, Nguyen QT, Sicklick JK, Lowy AM, Tsien RY, Advani SJ.

Cancer Res. 2015 Apr 1;75(7):1376-1387. doi: 10.1158/0008-5472.CAN-14-1931. Epub 2015 Feb 13.

43.

Improved PeT molecules for optically sensing voltage in neurons.

Woodford CR, Frady EP, Smith RS, Morey B, Canzi G, Palida SF, Araneda RC, Kristan WB Jr, Kubiak CP, Miller EW, Tsien RY.

J Am Chem Soc. 2015 Feb 11;137(5):1817-24. doi: 10.1021/ja510602z. Epub 2015 Jan 29.

44.

The impact of NMDA receptor hypofunction on GABAergic neurons in the pathophysiology of schizophrenia.

Cohen SM, Tsien RW, Goff DC, Halassa MM.

Schizophr Res. 2015 Sep;167(1-3):98-107. doi: 10.1016/j.schres.2014.12.026. Epub 2015 Jan 9. Review.

45.

How FlAsH got its sparkle: historical recollections of the biarsenical-tetracysteine tag.

Griffin BA, Adams SR, Tsien RY.

Methods Mol Biol. 2015;1266:1-6. doi: 10.1007/978-1-4939-2272-7_1.

PMID:
25560064
46.

Surgical molecular navigation with ratiometric activatable cell penetrating peptide for intraoperative identification and resection of small salivary gland cancers.

Hussain T, Savariar EN, Diaz-Perez JA, Messer K, Pu M, Tsien RY, Nguyen QT.

Head Neck. 2016 May;38(5):715-23. doi: 10.1002/hed.23946. Epub 2015 Jun 22.

47.

Ratiometric activatable cell-penetrating peptides label pancreatic cancer, enabling fluorescence-guided surgery, which reduces metastases and recurrence in orthotopic mouse models.

Metildi CA, Felsen CN, Savariar EN, Nguyen QT, Kaushal S, Hoffman RM, Tsien RY, Bouvet M.

Ann Surg Oncol. 2015;22(6):2082-7. doi: 10.1245/s10434-014-4144-1. Epub 2014 Oct 16.

48.

γCaMKII shuttles Ca²⁺/CaM to the nucleus to trigger CREB phosphorylation and gene expression.

Ma H, Groth RD, Cohen SM, Emery JF, Li B, Hoedt E, Zhang G, Neubert TA, Tsien RW.

Cell. 2014 Oct 9;159(2):281-94. doi: 10.1016/j.cell.2014.09.019.

49.

Matrix-metalloproteinases in head and neck carcinoma-cancer genome atlas analysis and fluorescence imaging in mice.

Hauff SJ, Raju SC, Orosco RK, Gross AM, Diaz-Perez JA, Savariar E, Nashi N, Hasselman J, Whitney M, Myers JN, Lippman SM, Tsien RY, Ideker T, Nguyen QT.

Otolaryngol Head Neck Surg. 2014 Oct;151(4):612-8. doi: 10.1177/0194599814545083. Epub 2014 Aug 4.

50.

Virtual finger boosts three-dimensional imaging and microsurgery as well as terabyte volume image visualization and analysis.

Peng H, Tang J, Xiao H, Bria A, Zhou J, Butler V, Zhou Z, Gonzalez-Bellido PT, Oh SW, Chen J, Mitra A, Tsien RW, Zeng H, Ascoli GA, Iannello G, Hawrylycz M, Myers E, Long F.

Nat Commun. 2014 Jul 11;5:4342. doi: 10.1038/ncomms5342.

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