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Items: 42

1.

Quantifying the influence of global warming on unprecedented extreme climate events.

Diffenbaugh NS, Singh D, Mankin JS, Horton DE, Swain DL, Touma D, Charland A, Liu Y, Haugen M, Tsiang M, Rajaratnam B.

Proc Natl Acad Sci U S A. 2017 May 9;114(19):4881-4886. doi: 10.1073/pnas.1618082114. Epub 2017 Apr 24.

2.

Antiviral Activity of Bictegravir (GS-9883), a Novel Potent HIV-1 Integrase Strand Transfer Inhibitor with an Improved Resistance Profile.

Tsiang M, Jones GS, Goldsmith J, Mulato A, Hansen D, Kan E, Tsai L, Bam RA, Stepan G, Stray KM, Niedziela-Majka A, Yant SR, Yu H, Kukolj G, Cihlar T, Lazerwith SE, White KL, Jin H.

Antimicrob Agents Chemother. 2016 Nov 21;60(12):7086-7097. Print 2016 Dec.

3.

Abyssomicin 2 reactivates latent HIV-1 by a PKC- and HDAC-independent mechanism.

León B, Navarro G, Dickey BJ, Stepan G, Tsai A, Jones GS, Morales ME, Barnes T, Ahmadyar S, Tsiang M, Geleziunas R, Cihlar T, Pagratis N, Tian Y, Yu H, Linington RG.

Org Lett. 2015 Jan 16;17(2):262-5. doi: 10.1021/ol503349y. Epub 2015 Jan 5.

4.

A cell-based strategy to assess intrinsic inhibition efficiencies of HIV-1 reverse transcriptase inhibitors.

Abram ME, Tsiang M, White KL, Callebaut C, Miller MD.

Antimicrob Agents Chemother. 2015 Feb;59(2):838-48. doi: 10.1128/AAC.04163-14. Epub 2014 Nov 17.

5.

Study of marine natural products including resorcyclic acid lactones from Humicola fuscoatra that reactivate latent HIV-1 expression in an in vitro model of central memory CD4+ T cells.

Mejia EJ, Loveridge ST, Stepan G, Tsai A, Jones GS, Barnes T, White KN, Drašković M, Tenney K, Tsiang M, Geleziunas R, Cihlar T, Pagratis N, Tian Y, Yu H, Crews P.

J Nat Prod. 2014 Mar 28;77(3):618-24. doi: 10.1021/np400889x. Epub 2014 Feb 4.

6.

A trimer of dimers is the basic building block for human immunodeficiency virus-1 capsid assembly.

Tsiang M, Niedziela-Majka A, Hung M, Jin D, Hu E, Yant S, Samuel D, Liu X, Sakowicz R.

Biochemistry. 2012 Jun 5;51(22):4416-28. Epub 2012 May 18.

PMID:
22564075
7.

New class of HIV-1 integrase (IN) inhibitors with a dual mode of action.

Tsiang M, Jones GS, Niedziela-Majka A, Kan E, Lansdon EB, Huang W, Hung M, Samuel D, Novikov N, Xu Y, Mitchell M, Guo H, Babaoglu K, Liu X, Geleziunas R, Sakowicz R.

J Biol Chem. 2012 Jun 15;287(25):21189-203. doi: 10.1074/jbc.M112.347534. Epub 2012 Apr 25.

8.

In vitro resistance selections using elvitegravir, raltegravir, and two metabolites of elvitegravir M1 and M4.

Margot NA, Hluhanich RM, Jones GS, Andreatta KN, Tsiang M, McColl DJ, White KL, Miller MD.

Antiviral Res. 2012 Feb;93(2):288-96. doi: 10.1016/j.antiviral.2011.12.008. Epub 2011 Dec 16.

PMID:
22197635
9.

Dithiothreitol causes HIV-1 integrase dimer dissociation while agents interacting with the integrase dimer interface promote dimer formation.

Tsiang M, Jones GS, Hung M, Samuel D, Novikov N, Mukund S, Brendza KM, Niedziela-Majka A, Jin D, Liu X, Mitchell M, Sakowicz R, Geleziunas R.

Biochemistry. 2011 Mar 15;50(10):1567-81. doi: 10.1021/bi101504w. Epub 2011 Feb 21.

PMID:
21222490
10.

Affinities between the binding partners of the HIV-1 integrase dimer-lens epithelium-derived growth factor (IN dimer-LEDGF) complex.

Tsiang M, Jones GS, Hung M, Mukund S, Han B, Liu X, Babaoglu K, Lansdon E, Chen X, Todd J, Cai T, Pagratis N, Sakowicz R, Geleziunas R.

J Biol Chem. 2009 Nov 27;284(48):33580-99. doi: 10.1074/jbc.M109.040121. Epub 2009 Sep 28.

11.

Catalytically-active complex of HIV-1 integrase with a viral DNA substrate binds anti-integrase drugs.

Alian A, Griner SL, Chiang V, Tsiang M, Jones G, Birkus G, Geleziunas R, Leavitt AD, Stroud RM.

Proc Natl Acad Sci U S A. 2009 May 19;106(20):8192-7. doi: 10.1073/pnas.0811919106. Epub 2009 May 4.

12.

Tricyclic HIV integrase inhibitors V. SAR studies on the benzyl moiety.

Jin H, Metobo S, Jabri S, Mish M, Lansdown R, Chen X, Tsiang M, Wright M, Kim CU.

Bioorg Med Chem Lett. 2009 Apr 15;19(8):2263-5. doi: 10.1016/j.bmcl.2009.02.092. Epub 2009 Feb 27.

PMID:
19285389
13.

Tricyclic HIV integrase inhibitors: VI. SAR studies of 'benzyl flipped' C3-substituted pyrroloquinolines.

Metobo S, Mish M, Jin H, Jabri S, Lansdown R, Chen X, Tsiang M, Wright M, Kim CU.

Bioorg Med Chem Lett. 2009 Feb 15;19(4):1187-90. doi: 10.1016/j.bmcl.2008.12.079. Epub 2008 Dec 25.

PMID:
19167883
14.

Preclinical evaluation of GS-9160, a novel inhibitor of human immunodeficiency virus type 1 integrase.

Jones GS, Yu F, Zeynalzadegan A, Hesselgesser J, Chen X, Chen J, Jin H, Kim CU, Wright M, Geleziunas R, Tsiang M.

Antimicrob Agents Chemother. 2009 Mar;53(3):1194-203. doi: 10.1128/AAC.00984-08. Epub 2008 Dec 22.

15.

Modeling, analysis, and validation of a novel HIV integrase structure provide insights into the binding modes of potent integrase inhibitors.

Chen X, Tsiang M, Yu F, Hung M, Jones GS, Zeynalzadegan A, Qi X, Jin H, Kim CU, Swaminathan S, Chen JM.

J Mol Biol. 2008 Jul 11;380(3):504-19. doi: 10.1016/j.jmb.2008.04.054. Epub 2008 May 1.

PMID:
18565342
16.

Tricyclic HIV integrase inhibitors: potent and orally bioavailable C5-aza analogs.

Jin H, Wright M, Pastor R, Mish M, Metobo S, Jabri S, Lansdown R, Cai R, Pyun P, Tsiang M, Chen X, Kim CU.

Bioorg Med Chem Lett. 2008 Feb 15;18(4):1388-91. doi: 10.1016/j.bmcl.2008.01.018. Epub 2008 Jan 9.

PMID:
18207398
17.

HIV-1 integrase preassembled on donor DNA is refractory to activity stimulation by LEDGF/p75.

Yu F, Jones GS, Hung M, Wagner AH, MacArthur HL, Liu X, Leavitt S, McDermott MJ, Tsiang M.

Biochemistry. 2007 Mar 13;46(10):2899-908. Epub 2007 Feb 14.

PMID:
17298035
18.
19.

Design, synthesis, and biological evaluation of novel tricyclic HIV-1 integrase inhibitors by modification of its pyridine ring.

Metobo SE, Jin H, Tsiang M, Kim CU.

Bioorg Med Chem Lett. 2006 Aug 1;16(15):3985-8. Epub 2006 May 24.

PMID:
16723226
20.

Design, synthesis, and SAR studies of novel and highly active tri-cyclic HIV integrase inhibitors.

Jin H, Cai RZ, Schacherer L, Jabri S, Tsiang M, Fardis M, Chen X, Chen JM, Kim CU.

Bioorg Med Chem Lett. 2006 Aug 1;16(15):3989-92. Epub 2006 May 24.

PMID:
16723225
21.

Effect of substitution on novel tricyclic HIV-1 integrase inhibitors.

Fardis M, Jin H, Jabri S, Cai RZ, Mish M, Tsiang M, Kim CU.

Bioorg Med Chem Lett. 2006 Aug 1;16(15):4031-5. Epub 2006 May 23.

PMID:
16716589
22.

Analysis of hepatitis B virus dynamics and its impact on antiviral development.

Tsiang M, Gibbs CS.

Methods Mol Med. 2004;96:361-77. No abstract available.

PMID:
14762282
23.

Biochemical characterization of rhinovirus RNA-dependent RNA polymerase.

Hung M, Gibbs CS, Tsiang M.

Antiviral Res. 2002 Nov;56(2):99-114.

PMID:
12367717
24.

Combination therapy with lamivudine and famciclovir for chronic hepatitis B-infected Chinese patients: a viral dynamics study.

Lau GK, Tsiang M, Hou J, Yuen S, Carman WF, Zhang L, Gibbs CS, Lam S.

Hepatology. 2000 Aug;32(2):394-9.

PMID:
10915748
25.

Biphasic clearance kinetics of hepatitis B virus from patients during adefovir dipivoxil therapy.

Tsiang M, Rooney JF, Toole JJ, Gibbs CS.

Hepatology. 1999 Jun;29(6):1863-9.

PMID:
10347131
26.

Allosteric effects of a monoclonal antibody against thrombin exosite II

Colwell NS, Blinder MA, Tsiang M, Gibbs CS, Bock PE, Tollefsen DM.

Biochemistry. 1999 Feb 23;38(8):2610. No abstract available.

PMID:
10029715
27.

Allosteric effects of a monoclonal antibody against thrombin exosite II.

Colwell NS, Blinder MA, Tsiang M, Gibbs CS, Bock PE, Tollefsen DM.

Biochemistry. 1998 Oct 27;37(43):15057-65.

PMID:
9790668
28.
29.

Protein engineering thrombin for optimal specificity and potency of anticoagulant activity in vivo.

Tsiang M, Paborsky LR, Li WX, Jain AK, Mao CT, Dunn KE, Lee DW, Matsumura SY, Matteucci MD, Coutré SE, Leung LL, Gibbs CS.

Biochemistry. 1996 Dec 24;35(51):16449-57.

PMID:
8987977
30.

Conversion of thrombin into an anticoagulant by protein engineering.

Gibbs CS, Coutré SE, Tsiang M, Li WX, Jain AK, Dunn KE, Law VS, Mao CT, Matsumura SY, Mejza SJ, et al.

Nature. 1995 Nov 23;378(6555):413-6.

PMID:
7477382
31.

Selection of a suppressor mutation that restores affinity of an oligonucleotide inhibitor for thrombin using in vitro genetics.

Tsiang M, Gibbs CS, Griffin LC, Dunn KE, Leung LL.

J Biol Chem. 1995 Aug 18;270(33):19370-6.

32.

Functional mapping of the surface residues of human thrombin.

Tsiang M, Jain AK, Dunn KE, Rojas ME, Leung LL, Gibbs CS.

J Biol Chem. 1995 Jul 14;270(28):16854-63.

33.

Structure-function relationships of the thrombin-thrombomodulin interaction.

Sadler JE, Lentz SR, Sheehan JP, Tsiang M, Wu Q.

Haemostasis. 1993 Mar;23 Suppl 1:183-93. Review.

PMID:
8388351
34.

Localization of the single-stranded DNA binding site in the thrombin anion-binding exosite.

Wu Q, Tsiang M, Sadler JE.

J Biol Chem. 1992 Dec 5;267(34):24408-12.

37.

Single amino acid substitutions dissociate fibrinogen-clotting and thrombomodulin-binding activities of human thrombin.

Wu QY, Sheehan JP, Tsiang M, Lentz SR, Birktoft JJ, Sadler JE.

Proc Natl Acad Sci U S A. 1991 Aug 1;88(15):6775-9.

39.

Equilibrium binding of thrombin to recombinant human thrombomodulin: effect of hirudin, fibrinogen, factor Va, and peptide analogues.

Tsiang M, Lentz SR, Dittman WA, Wen D, Scarpati EM, Sadler JE.

Biochemistry. 1990 Nov 27;29(47):10602-12.

PMID:
2176873
40.
41.

Deletion mapping of Sindbis virus DI RNAs derived from cDNAs defines the sequences essential for replication and packaging.

Levis R, Weiss BG, Tsiang M, Huang H, Schlesinger S.

Cell. 1986 Jan 17;44(1):137-45.

PMID:
3753584
42.

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