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Items: 27


Stable and Highly Immunogenic MicroRNA-Targeted Single-Dose Live Attenuated Vaccine Candidate against Tick-Borne Encephalitis Constructed Using Genetic Backbone of Langat Virus.

Tsetsarkin KA, Maximova OA, Liu G, Kenney H, Teterina NL, Pletnev AG.

MBio. 2019 Apr 23;10(2). pii: e02904-18. doi: 10.1128/mBio.02904-18.


The Roles of prM-E Proteins in Historical and Epidemic Zika Virus-mediated Infection and Neurocytotoxicity.

Li G, Bos S, Tsetsarkin KA, Pletnev AG, Desprès P, Gadea G, Zhao RY.

Viruses. 2019 Feb 14;11(2). pii: E157. doi: 10.3390/v11020157.


Routes of Zika virus dissemination in the testis and epididymis of immunodeficient mice.

Tsetsarkin KA, Maximova OA, Liu G, Kenney H, Teterina N, Bloom ME, Grabowski JM, Mlera L, Nagata BM, Moore I, Martens C, Amaro-Carambot E, Lamirande EW, Whitehead SS, Pletnev AG.

Nat Commun. 2018 Dec 17;9(1):5350. doi: 10.1038/s41467-018-07782-x.


Decreased accumulation of subgenomic RNA in human cells infected with vaccine candidate DEN4Δ30 increases viral susceptibility to type I interferon.

Bustos-Arriaga J, Gromowski GD, Tsetsarkin KA, Firestone CY, Castro-Jiménez T, Pletnev AG, Cedillo-Barrón L, Whitehead SS.

Vaccine. 2018 Jun 7;36(24):3460-3467. doi: 10.1016/j.vaccine.2018.04.087. Epub 2018 May 8.


Flavivirus Infection of Ixodes scapularis (Black-Legged Tick) Ex Vivo Organotypic Cultures and Applications for Disease Control.

Grabowski JM, Tsetsarkin KA, Long D, Scott DP, Rosenke R, Schwan TG, Mlera L, Offerdahl DK, Pletnev AG, Bloom ME.

MBio. 2017 Aug 22;8(4). pii: e01255-17. doi: 10.1128/mBio.01255-17.


Synergistic Internal Ribosome Entry Site/MicroRNA-Based Approach for Flavivirus Attenuation and Live Vaccine Development.

Tsetsarkin KA, Liu G, Volkova E, Pletnev AG.

MBio. 2017 Apr 18;8(2). pii: e02326-16. doi: 10.1128/mBio.02326-16.


Concurrent micro-RNA mediated silencing of tick-borne flavivirus replication in tick vector and in the brain of vertebrate host.

Tsetsarkin KA, Liu G, Kenney H, Hermance M, Thangamani S, Pletnev AG.

Sci Rep. 2016 Sep 13;6:33088. doi: 10.1038/srep33088.


A Full-Length Infectious cDNA Clone of Zika Virus from the 2015 Epidemic in Brazil as a Genetic Platform for Studies of Virus-Host Interactions and Vaccine Development.

Tsetsarkin KA, Kenney H, Chen R, Liu G, Manukyan H, Whitehead SS, Laassri M, Chumakov K, Pletnev AG.

MBio. 2016 Aug 23;7(4). pii: e01114-16. doi: 10.1128/mBio.01114-16.


Interspecies transmission and chikungunya virus emergence.

Tsetsarkin KA, Chen R, Weaver SC.

Curr Opin Virol. 2016 Feb;16:143-150. doi: 10.1016/j.coviro.2016.02.007. Epub 2016 Mar 14. Review.


Dual miRNA targeting restricts host range and attenuates neurovirulence of flaviviruses.

Tsetsarkin KA, Liu G, Kenney H, Bustos-Arriaga J, Hanson CT, Whitehead SS, Pletnev AG.

PLoS Pathog. 2015 Apr 23;11(4):e1004852. doi: 10.1371/journal.ppat.1004852. eCollection 2015 Apr.


Multi-peaked adaptive landscape for chikungunya virus evolution predicts continued fitness optimization in Aedes albopictus mosquitoes.

Tsetsarkin KA, Chen R, Yun R, Rossi SL, Plante KS, Guerbois M, Forrester N, Perng GC, Sreekumar E, Leal G, Huang J, Mukhopadhyay S, Weaver SC.

Nat Commun. 2014 Jun 16;5:4084. doi: 10.1038/ncomms5084.


Chikungunya virus 3' untranslated region: adaptation to mosquitoes and a population bottleneck as major evolutionary forces.

Chen R, Wang E, Tsetsarkin KA, Weaver SC.

PLoS Pathog. 2013;9(8):e1003591. doi: 10.1371/journal.ppat.1003591. Epub 2013 Aug 29.


Photochemical inactivation of chikungunya virus in human apheresis platelet components by amotosalen and UVA light.

Tsetsarkin KA, Sampson-Johannes A, Sawyer L, Kinsey J, Higgs S, Vanlandingham DL.

Am J Trop Med Hyg. 2013 Jun;88(6):1163-9. doi: 10.4269/ajtmh.12-0603. Epub 2013 Mar 25.


Sequential adaptive mutations enhance efficient vector switching by Chikungunya virus and its epidemic emergence.

Tsetsarkin KA, Weaver SC.

PLoS Pathog. 2011 Dec;7(12):e1002412. doi: 10.1371/journal.ppat.1002412. Epub 2011 Dec 8.


Chikungunya virus: evolution and genetic determinants of emergence.

Tsetsarkin KA, Chen R, Sherman MB, Weaver SC.

Curr Opin Virol. 2011 Oct;1(4):310-7. doi: 10.1016/j.coviro.2011.07.004. Review.


Stability of yellow fever virus under recombinatory pressure as compared with chikungunya virus.

McGee CE, Tsetsarkin KA, Guy B, Lang J, Plante K, Vanlandingham DL, Higgs S.

PLoS One. 2011;6(8):e23247. doi: 10.1371/journal.pone.0023247. Epub 2011 Aug 3.


Chikungunya virus emergence is constrained in Asia by lineage-specific adaptive landscapes.

Tsetsarkin KA, Chen R, Leal G, Forrester N, Higgs S, Huang J, Weaver SC.

Proc Natl Acad Sci U S A. 2011 May 10;108(19):7872-7. doi: 10.1073/pnas.1018344108. Epub 2011 Apr 25.


Genome-scale phylogenetic analyses of chikungunya virus reveal independent emergences of recent epidemics and various evolutionary rates.

Volk SM, Chen R, Tsetsarkin KA, Adams AP, Garcia TI, Sall AA, Nasar F, Schuh AJ, Holmes EC, Higgs S, Maharaj PD, Brault AC, Weaver SC.

J Virol. 2010 Jul;84(13):6497-504. doi: 10.1128/JVI.01603-09. Epub 2010 Apr 21. Erratum in: J Virol. 2011 Jun;85(11):5706.


Epistatic roles of E2 glycoprotein mutations in adaption of chikungunya virus to Aedes albopictus and Ae. aegypti mosquitoes.

Tsetsarkin KA, McGee CE, Volk SM, Vanlandingham DL, Weaver SC, Higgs S.

PLoS One. 2009 Aug 31;4(8):e6835. doi: 10.1371/journal.pone.0006835.


Characterization of the antigen distribution and tissue tropisms of three phenotypically distinct yellow fever virus variants in orally infected Aedes aegypti mosquitoes.

McElroy KL, Girard YA, McGee CE, Tsetsarkin KA, Vanlandingham DL, Higgs S.

Vector Borne Zoonotic Dis. 2008 Oct;8(5):675-87. doi: 10.1089/vbz.2007.0269.


A single mutation in chikungunya virus affects vector specificity and epidemic potential.

Tsetsarkin KA, Vanlandingham DL, McGee CE, Higgs S.

PLoS Pathog. 2007 Dec;3(12):e201.


Anopheles gambiae heat shock protein cognate 70B impedes o'nyong-nyong virus replication.

Sim C, Hong YS, Tsetsarkin KA, Vanlandingham DL, Higgs S, Collins FH.

BMC Genomics. 2007 Jul 11;8:231.


Role of the yellow fever virus structural protein genes in viral dissemination from the Aedes aegypti mosquito midgut.

McElroy KL, Tsetsarkin KA, Vanlandingham DL, Higgs S.

J Gen Virol. 2006 Oct;87(Pt 10):2993-3001.


Characterization of an infectious clone of the wild-type yellow fever virus Asibi strain that is able to infect and disseminate in mosquitoes.

McElroy KL, Tsetsarkin KA, Vanlandingham DL, Higgs S.

J Gen Virol. 2005 Jun;86(Pt 6):1747-51.


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