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Items: 1 to 50 of 274

1.

Oligoarginine Peptides, a New Family of nAChR Inhibitors.

Lebedev D, Kryukova E, Ivanov I, Egorova N, Timofeev N, Spirova E, Tufanova E, Siniavin A, Kudryavtsev D, Kasheverov I, Zouridakis M, Katsarava R, Zavradashvili N, Iagorshvili I, Tzartos S, Tsetlin V.

Mol Pharmacol. 2019 Sep 6. pii: mol.119.117713. doi: 10.1124/mol.119.117713. [Epub ahead of print]

2.

Isomerization of Asp7 in Beta-Amyloid Enhances Inhibition of the α7 Nicotinic Receptor and Promotes Neurotoxicity.

Barykin EP, Garifulina AI, Kruykova EV, Spirova EN, Anashkina AA, Adzhubei AA, Shelukhina IV, Kasheverov IE, Mitkevich VA, Kozin SA, Hollmann M, Tsetlin VI, Makarov AA.

Cells. 2019 Jul 25;8(8). pii: E771. doi: 10.3390/cells8080771.

3.

From Synthetic Fragments of Endogenous Three-Finger Proteins to Potential Drugs.

Kryukova EV, Egorova NS, Kudryavtsev DS, Lebedev DS, Spirova EN, Zhmak MN, Garifulina AI, Kasheverov IE, Utkin YN, Tsetlin VI.

Front Pharmacol. 2019 Jul 3;10:748. doi: 10.3389/fphar.2019.00748. eCollection 2019.

4.

Scorpion toxins interact with nicotinic acetylcholine receptors.

Kasheverov IE, Oparin PB, Zhmak MN, Egorova NS, Ivanov IA, Gigolaev AM, Nekrasova OV, Serebryakova MV, Kudryavtsev DS, Prokopev NA, Hoang AN, Tsetlin VI, Vassilevski AA, Utkin YN.

FEBS Lett. 2019 Jul 5. doi: 10.1002/1873-3468.13530. [Epub ahead of print]

PMID:
31276191
5.

Crystal Structure of the Monomeric Extracellular Domain of α9 Nicotinic Receptor Subunit in Complex With α-Conotoxin RgIA: Molecular Dynamics Insights Into RgIA Binding to α9α10 Nicotinic Receptors.

Zouridakis M, Papakyriakou A, Ivanov IA, Kasheverov IE, Tsetlin V, Tzartos S, Giastas P.

Front Pharmacol. 2019 May 1;10:474. doi: 10.3389/fphar.2019.00474. eCollection 2019.

6.

Novel long-chain neurotoxins from Bungarus candidus distinguish the two binding sites in muscle-type nicotinic acetylcholine receptors.

Utkin YN, Kuch U, Kasheverov IE, Lebedev DS, Cederlund E, Molles BE, Polyak I, Ivanov IA, Prokopev NA, Ziganshin RH, Jornvall H, Alvelius G, Chanhome L, Warrell DA, Mebs D, Bergman T, Tsetlin VI.

Biochem J. 2019 Apr 26;476(8):1285-1302. doi: 10.1042/BCJ20180909.

PMID:
30944155
7.

New Rigid Nicotine Analogues, Carrying a Norbornane Moiety, Are Potent Agonists of α7 and α3* Nicotinic Receptors.

Manetti D, Garifulina A, Bartolucci G, Bazzicalupi C, Bellucci C, Chiaramonte N, Dei S, Di Cesare Mannelli L, Ghelardini C, Gratteri P, Spirova E, Shelukhina I, Teodori E, Varani K, Tsetlin V, Romanelli MN.

J Med Chem. 2019 Feb 28;62(4):1887-1901. doi: 10.1021/acs.jmedchem.8b01372. Epub 2019 Feb 8.

PMID:
30681854
8.

Curare alkaloids from Matis Dart Poison: Comparison with d-tubocurarine in interactions with nicotinic, 5-HT3 serotonin and GABAA receptors.

Spirova EN, Ivanov IA, Kasheverov IE, Kudryavtsev DS, Shelukhina IV, Garifulina AI, Son LV, Lummis SCR, Malca-Garcia GR, Bussmann RW, Hennig L, Giannis A, Tsetlin VI.

PLoS One. 2019 Jan 4;14(1):e0210182. doi: 10.1371/journal.pone.0210182. eCollection 2019.

9.

Polyarginine Peptides As a New Class of Ligands of Nicotinic Acetylcholine Receptors.

Kryukova EV, Ivanov IA, Lebedev DS, Spirova EN, Senko DA, Egorova NS, Kasheverov IE, Tsetlin VI.

Dokl Biochem Biophys. 2018 Nov;483(1):313-315. doi: 10.1134/S1607672918060017. Epub 2019 Jan 3.

PMID:
30607728
10.

Orthosteric and/or Allosteric Binding of α-Conotoxins to Nicotinic Acetylcholine Receptors and Their Models.

Kryukova EV, Ivanov IA, Lebedev DS, Spirova EN, Egorova NS, Zouridakis M, Kasheverov IE, Tzartos SJ, Tsetlin VI.

Mar Drugs. 2018 Nov 22;16(12). pii: E460. doi: 10.3390/md16120460.

11.

Species specificity of rat and human α7 nicotinic acetylcholine receptors towards different classes of peptide and protein antagonists.

Yu J, Zhu X, Zhang L, Kudryavtsev D, Kasheverov I, Lei Y, Zhangsun D, Tsetlin V, Luo S.

Neuropharmacology. 2018 Sep 1;139:226-237. doi: 10.1016/j.neuropharm.2018.07.019. Epub 2018 Jul 17.

PMID:
30025921
12.

The First Recombinant Viper Three-Finger Toxins: Inhibition of Muscle and Neuronal Nicotinic Acetylcholine Receptors.

Makarova YV, Kryukova EV, Shelukhina IV, Lebedev DS, Andreeva TV, Ryazantsev DY, Balandin SV, Ovchinnikova TV, Tsetlin VI, Utkin YN.

Dokl Biochem Biophys. 2018 Mar;479(1):127-130. doi: 10.1134/S1607672918020205. Epub 2018 May 19.

PMID:
29779115
13.

Makaluvamine G from the Marine Sponge Zyzzia fuliginosa Inhibits Muscle nAChR by Binding at the Orthosteric and Allosteric Sites.

Kudryavtsev DS, Spirova EN, Shelukhina IV, Son LV, Makarova YV, Utkina NK, Kasheverov IE, Tsetlin VI.

Mar Drugs. 2018 Mar 28;16(4). pii: E109. doi: 10.3390/md16040109.

14.

Azemiopsin, a Selective Peptide Antagonist of Muscle Nicotinic Acetylcholine Receptor: Preclinical Evaluation as a Local Muscle Relaxant.

Shelukhina IV, Zhmak MN, Lobanov AV, Ivanov IA, Garifulina AI, Kravchenko IN, Rasskazova EA, Salmova MA, Tukhovskaya EA, Rykov VA, Slashcheva GA, Egorova NS, Muzyka IS, Tsetlin VI, Utkin YN.

Toxins (Basel). 2018 Jan 7;10(1). pii: E34. doi: 10.3390/toxins10010034.

15.

Interaction of Synthetic Human SLURP-1 with the Nicotinic Acetylcholine Receptors.

Durek T, Shelukhina IV, Tae HS, Thongyoo P, Spirova EN, Kudryavtsev DS, Kasheverov IE, Faure G, Corringer PJ, Craik DJ, Adams DJ, Tsetlin VI.

Sci Rep. 2017 Nov 30;7(1):16606. doi: 10.1038/s41598-017-16809-0.

16.

Low-molecular-weight compounds with anticoagulant activity from the scorpion Heterometrus laoticus venom.

Thien TV, Anh HN, Trang NTT, Trung PV, Khoa NC, Osipov AV, Dubovskii PV, Ivanov IA, Arseniev AS, Tsetlin VI, Utkin YN.

Dokl Biochem Biophys. 2017 Sep;476(1):316-319. doi: 10.1134/S1607672917050052. Epub 2017 Nov 4.

PMID:
29101740
17.

Anticoagulant Activity of Low-Molecular Weight Compounds from Heterometrus laoticus Scorpion Venom.

Tran TV, Hoang AN, Nguyen TTT, Phung TV, Nguyen KC, Osipov AV, Ivanov IA, Tsetlin VI, Utkin YN.

Toxins (Basel). 2017 Oct 26;9(11). pii: E343. doi: 10.3390/toxins9110343.

18.

Pancreatic and snake venom presynaptically active phospholipases A2 inhibit nicotinic acetylcholine receptors.

Vulfius CA, Kasheverov IE, Kryukova EV, Spirova EN, Shelukhina IV, Starkov VG, Andreeva TV, Faure G, Zouridakis M, Tsetlin VI, Utkin YN.

PLoS One. 2017 Oct 12;12(10):e0186206. doi: 10.1371/journal.pone.0186206. eCollection 2017.

19.

Detection of human neuronal α7 nicotinic acetylcholine receptors by conjugates of snake α-neurotoxin with quantum dots.

Makarova YV, Shelukhina IV, Mukherjee AK, Kuznetsov DV, Tsetlin VI, Utkin YN.

Dokl Biochem Biophys. 2017 Jul;475(1):253-255. doi: 10.1134/S1607672917040032. Epub 2017 Sep 2.

PMID:
28864899
20.

New paradoxical three-finger toxin from the cobra Naja kaouthia venom: Isolation and characterization.

Osipov AV, Meshcheryakova AV, Starkov VG, Ziganshin RK, Oustitch TL, Peters LE, Tsetlin VI, Utkin YN.

Dokl Biochem Biophys. 2017 Jul;475(1):264-266. doi: 10.1134/S1607672917040068. Epub 2017 Sep 2.

PMID:
28864897
21.

Calcium imaging with genetically encoded sensor Case12: Facile analysis of α7/α9 nAChR mutants.

Shelukhina I, Spirova E, Kudryavtsev D, Ojomoko L, Werner M, Methfessel C, Hollmann M, Tsetlin V.

PLoS One. 2017 Aug 10;12(8):e0181936. doi: 10.1371/journal.pone.0181936. eCollection 2017.

22.

[Possible involvement of neuronal nicotinic acetylcholine receptors in compensatory brain mechanisms at early stages of Parkinson's disease].

Kryukova EV, Shelukhina IV, Kolacheva AA, Alieva AK, Shadrina MI, Slominsky PA, Kasheverov IE, Utkin YN, Ugrumov MV, Tsetlin VI.

Biomed Khim. 2017 May;63(3):241-247. doi: 10.18097/PBMC20176303241. Russian.

PMID:
28781257
23.

Arginine derivatives of dicarboxylic acids from the parotid gland secretions of common toad Bufo bufo-New agonists of ionotropic γ-aminobutyric acid receptors.

Lebedev DS, Ivanov IA, Kryukova EV, Starkov VG, Tsetlin VI, Utkin YN.

Dokl Biochem Biophys. 2017 May;474(1):178-182. doi: 10.1134/S1607672917030127. Epub 2017 Jul 20.

PMID:
28726106
24.

Nicotinic acetylcholine receptor inhibitors derived from snake and snail venoms.

Dutertre S, Nicke A, Tsetlin VI.

Neuropharmacology. 2017 Dec;127:196-223. doi: 10.1016/j.neuropharm.2017.06.011. Epub 2017 Jun 13. Review.

PMID:
28623170
25.

N-methyl serotonin analogues from the Bufo bufo toad venom interact efficiently with the α7 nicotinic acetylcholine receptors.

Kryukova EV, Lebedev DS, Ivanov IA, Ivanov DA, Starkov VG, Tsetlin VI, Utkin YN.

Dokl Biochem Biophys. 2017 Jan;472(1):52-55. doi: 10.1134/S1607672917010136. Epub 2017 Apr 19.

PMID:
28421441
26.

High-Affinity α-Conotoxin PnIA Analogs Designed on the Basis of the Protein Surface Topography Method.

Kasheverov IE, Chugunov AO, Kudryavtsev DS, Ivanov IA, Zhmak MN, Shelukhina IV, Spirova EN, Tabakmakher VM, Zelepuga EA, Efremov RG, Tsetlin VI.

Sci Rep. 2016 Nov 14;6:36848. doi: 10.1038/srep36848.

27.

Suppression of Ehrlich carcinoma growth by cobra venom factor.

Terpinskaya TI, Ulashchik VS, Osipov AV, Tsetlin VI, Utkin YN.

Dokl Biol Sci. 2016 Sep;470(1):240-243. Epub 2016 Nov 8.

PMID:
27822748
28.

Analysis of binding centers in nicotinic receptors with the aid of synthetic peptides.

Kasheverov IE, Kryukova EV, Kudryavtsev DS, Ivanov IA, Egorova NV, Zhmak MN, Spirova EN, Shelukhina IV, Odinokov AV, Alfimov MV, Tsetlin VI.

Dokl Biochem Biophys. 2016 Sep;470(1):338-341. Epub 2016 Nov 6.

PMID:
27817023
29.

Peptides from puff adder Bitis arietans venom, novel inhibitors of nicotinic acetylcholine receptors.

Vulfius CA, Spirova EN, Serebryakova MV, Shelukhina IV, Kudryavtsev DS, Kryukova EV, Starkov VG, Kopylova NV, Zhmak MN, Ivanov IA, Kudryashova KS, Andreeva TV, Tsetlin VI, Utkin YN.

Toxicon. 2016 Oct;121:70-76. doi: 10.1016/j.toxicon.2016.08.020. Epub 2016 Aug 26.

PMID:
27576061
30.

Interaction of three-finger proteins from snake venoms and from mammalian brain with the cys-loop receptors and their models.

Faure G, Shelukhina IV, Porowinska D, Shulepko MA, Lyukmanova EN, Dolgikh DA, Spirova EN, Kasheverov IE, Utkin YN, Corringer JP, Tsetlin VI.

Dokl Biochem Biophys. 2016 May;468(1):193-6. doi: 10.1134/S1607672916030091. Epub 2016 Jul 15.

PMID:
27417718
31.

Central loop of non-conventional toxin WTX from Naja kaouthia is important for interaction with nicotinic acetylcholine receptors.

Lyukmanova EN, Shulepko MA, Shenkarev ZO, Kasheverov IE, Chugunov AO, Kulbatskii DS, Myshkin MY, Utkin YN, Efremov RG, Tsetlin VI, Arseniev AS, Kirpichnikov MP, Dolgikh DA.

Toxicon. 2016 Sep 1;119:274-9. doi: 10.1016/j.toxicon.2016.06.012. Epub 2016 Jun 23.

PMID:
27343701
32.

Development of a recombinant immunotoxin for the immunotherapy of autoreactive lymphocytes expressing MOG-specific BCRs.

Stepanov A, Belyy A, Kasheverov I, Rybinets A, Dronina M, Dyachenko I, Murashev A, Knorre V, Sakharov D, Ponomarenko N, Tsetlin V, Tonevitsky A, Deyev S, Belogurov A Jr, Gabibov A.

Biotechnol Lett. 2016 Jul;38(7):1173-80. doi: 10.1007/s10529-016-2092-5. Epub 2016 Apr 21.

PMID:
27099070
33.

Quantitative Proteomic Analysis of Venoms from Russian Vipers of Pelias Group: Phospholipases A₂ are the Main Venom Components.

Kovalchuk SI, Ziganshin RH, Starkov VG, Tsetlin VI, Utkin YN.

Toxins (Basel). 2016 Apr 12;8(4):105. doi: 10.3390/toxins8040105.

34.

Nicotinic receptor involvement in regulation of functions of mouse neutrophils from inflammatory site.

Safronova VG, Vulfius CA, Shelukhina IV, Mal'tseva VN, Berezhnov AV, Fedotova EI, Miftahova RG, Kryukova EV, Grinevich AA, Tsetlin VI.

Immunobiology. 2016 Jul;221(7):761-72. doi: 10.1016/j.imbio.2016.01.016. Epub 2016 Mar 4.

PMID:
26965141
35.

From crystal structure of α-conotoxin GIC in complex with Ac-AChBP to molecular determinants of its high selectivity for α3β2 nAChR.

Lin B, Xu M, Zhu X, Wu Y, Liu X, Zhangsun D, Hu Y, Xiang SH, Kasheverov IE, Tsetlin VI, Wang X, Luo S.

Sci Rep. 2016 Mar 1;6:22349. doi: 10.1038/srep22349.

36.

Human Secreted Ly-6/uPAR Related Protein-1 (SLURP-1) Is a Selective Allosteric Antagonist of α7 Nicotinic Acetylcholine Receptor.

Lyukmanova EN, Shulepko MA, Kudryavtsev D, Bychkov ML, Kulbatskii DS, Kasheverov IE, Astapova MV, Feofanov AV, Thomsen MS, Mikkelsen JD, Shenkarev ZO, Tsetlin VI, Dolgikh DA, Kirpichnikov MP.

PLoS One. 2016 Feb 23;11(2):e0149733. doi: 10.1371/journal.pone.0149733. eCollection 2016.

37.

New quinoline derivatives as nicotinic receptor modulators.

Manetti D, Bellucci C, Dei S, Teodori E, Varani K, Spirova E, Kudryavtsev D, Shelukhina I, Tsetlin V, Romanelli MN.

Eur J Med Chem. 2016 Mar 3;110:246-58. doi: 10.1016/j.ejmech.2016.01.025. Epub 2016 Jan 19.

PMID:
26840365
38.

EFFECTS OF VERY SMALL DOSES OF IONIZING RADIATION AND HYPOMAGNETIC FIELD CHANGE PHYSIOLOGICAL CHARACTERISTICS OF HIGHER PLANT SEEDS.

Tsetlin VV, Moisa SS, Levinskikh MA, Nefedova EL.

Aviakosm Ekolog Med. 2016;50(6):51-58. English, Russian.

PMID:
29553606
39.

Nonconventional three-finger toxin BMLCL from krait Bungarus multicinctus venom with high affinity interacts with nicotinic acetylcholine receptors.

Utkin YN, Kasheverov IE, Kudryavtsev DS, Andreeva TV, Starkov VG, Ziganshin RH, Kuznetsov DV, Anh HN, Thao NT, Khoa NC, Tsetlin VI.

Dokl Biochem Biophys. 2015;464:294-7. doi: 10.1134/S1607672915050099. Epub 2015 Oct 31.

PMID:
26518551
40.

Curare Alkaloids: Constituents of a Matis Dart Poison.

Malca Garcia GR, Hennig L, Shelukhina IV, Kudryavtsev DS, Bussmann RW, Tsetlin VI, Giannis A.

J Nat Prod. 2015 Nov 25;78(11):2537-44. doi: 10.1021/acs.jnatprod.5b00457. Epub 2015 Oct 23.

PMID:
26496427
41.

Quantitative proteomic analysis of Vietnamese krait venoms: Neurotoxins are the major components in Bungarus multicinctus and phospholipases A2 in Bungarus fasciatus.

Ziganshin RH, Kovalchuk SI, Arapidi GP, Starkov VG, Hoang AN, Thi Nguyen TT, Nguyen KC, Shoibonov BB, Tsetlin VI, Utkin YN.

Toxicon. 2015 Dec 1;107(Pt B):197-209. doi: 10.1016/j.toxicon.2015.08.026. Epub 2015 Sep 2.

PMID:
26341420
42.

α-conotoxins revealed different roles of nicotinic cholinergic receptor subtypes in oncogenesis of Ehrlich tumor and in the associated inflammation.

Terpinskaya TI, Osipov AV, Kuznetsova TE, Ryzhkovskaya EL, Ulaschik VS, Ivanov IA, Tsetlin VI, Utkin YN.

Dokl Biochem Biophys. 2015;463:216-9. doi: 10.1134/S1607672915040055. Epub 2015 Sep 3.

PMID:
26335815
43.

Structural Insight into Specificity of Interactions between Nonconventional Three-finger Weak Toxin from Naja kaouthia (WTX) and Muscarinic Acetylcholine Receptors.

Lyukmanova EN, Shenkarev ZO, Shulepko MA, Paramonov AS, Chugunov AO, Janickova H, Dolejsi E, Dolezal V, Utkin YN, Tsetlin VI, Arseniev AS, Efremov RG, Dolgikh DA, Kirpichnikov MP.

J Biol Chem. 2015 Sep 25;290(39):23616-30. doi: 10.1074/jbc.M115.656595. Epub 2015 Aug 4.

44.

Neurotoxins from snake venoms and α-conotoxin ImI inhibit functionally active ionotropic γ-aminobutyric acid (GABA) receptors.

Kudryavtsev DS, Shelukhina IV, Son LV, Ojomoko LO, Kryukova EV, Lyukmanova EN, Zhmak MN, Dolgikh DA, Ivanov IA, Kasheverov IE, Starkov VG, Ramerstorfer J, Sieghart W, Tsetlin VI, Utkin YN.

J Biol Chem. 2015 Sep 11;290(37):22747-58. doi: 10.1074/jbc.M115.648824. Epub 2015 Jul 28.

45.

Cloning, synthesis, and characterization of αO-conotoxin GeXIVA, a potent α9α10 nicotinic acetylcholine receptor antagonist.

Luo S, Zhangsun D, Harvey PJ, Kaas Q, Wu Y, Zhu X, Hu Y, Li X, Tsetlin VI, Christensen S, Romero HK, McIntyre M, Dowell C, Baxter JC, Elmslie KS, Craik DJ, McIntosh JM.

Proc Natl Acad Sci U S A. 2015 Jul 28;112(30):E4026-35. doi: 10.1073/pnas.1503617112. Epub 2015 Jul 13.

46.

Natural compounds interacting with nicotinic acetylcholine receptors: from low-molecular weight ones to peptides and proteins.

Kudryavtsev D, Shelukhina I, Vulfius C, Makarieva T, Stonik V, Zhmak M, Ivanov I, Kasheverov I, Utkin Y, Tsetlin V.

Toxins (Basel). 2015 May 14;7(5):1683-701. doi: 10.3390/toxins7051683. Review.

47.

Novel antagonists of nicotinic acetylcholine receptors--proteins from venoms of Viperidae snakes.

Vulfius CA, Starkov VG, Andreeva TV, Tsetlin VI, Utkin YN.

Dokl Biochem Biophys. 2015;461:119-22. doi: 10.1134/S1607672915020143. Epub 2015 May 5. No abstract available.

PMID:
25937229
48.

Rational design of new ligands for nicotinic receptors on the basis of α-conotoxin PnIA.

Kasheverov IE, Kudryavtsev DS, Ivanov IA, Zhmak MN, Chugunov AO, Tabakmakher VM, Zelepuga EA, Efremov RG, Tsetlin VI.

Dokl Biochem Biophys. 2015;461:106-9. doi: 10.1134/S1607672915020118. Epub 2015 May 5. No abstract available.

PMID:
25937226
49.

6-bromohypaphorine from marine nudibranch mollusk Hermissenda crassicornis is an agonist of human α7 nicotinic acetylcholine receptor.

Kasheverov IE, Shelukhina IV, Kudryavtsev DS, Makarieva TN, Spirova EN, Guzii AG, Stonik VA, Tsetlin VI.

Mar Drugs. 2015 Mar 12;13(3):1255-66. doi: 10.3390/md13031255.

50.

Venoms of kraits Bungarus multicinctus and Bungarus fasciatus contain anticoagulant proteins.

Utkin YN, Gantsova EA, Andreeva TV, Starkov VG, Ziganshin RH, Anh HN, Thao NT, Khoa NC, Tsetlin VI.

Dokl Biochem Biophys. 2015;460:53-8. doi: 10.1134/S1607672915010159. Epub 2015 Mar 13. No abstract available.

PMID:
25772992

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