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Items: 35

1.

NLRP10 Enhances CD4+ T-Cell-Mediated IFNγ Response via Regulation of Dendritic Cell-Derived IL-12 Release.

Vacca M, Böhme J, Zambetti LP, Khameneh HJ, Paleja BS, Laudisi F, Ho AWS, Neo K, Leong KWK, Marzuki M, Lee B, Poidinger M, Santambrogio L, Tsenova L, Zolezzi F, De Libero G, Singhal A, Mortellaro A.

Front Immunol. 2017 Nov 2;8:1462. doi: 10.3389/fimmu.2017.01462. eCollection 2017.

2.

Host sirtuin 1 regulates mycobacterial immunopathogenesis and represents a therapeutic target against tuberculosis.

Cheng CY, Gutierrez NM, Marzuki MB, Lu X, Foreman TW, Paleja B, Lee B, Balachander A, Chen J, Tsenova L, Kurepina N, Teng KWW, West K, Mehra S, Zolezzi F, Poidinger M, Kreiswirth B, Kaushal D, Kornfeld H, Newell EW, Singhal A.

Sci Immunol. 2017 Mar;2(9). pii: eaaj1789. doi: 10.1126/sciimmunol.aaj1789. Epub 2017 Mar 24.

3.

Pharmacologic Inhibition of Host Phosphodiesterase-4 Improves Isoniazid-Mediated Clearance of Mycobacterium tuberculosis.

Subbian S, Koo MS, Tsenova L, Khetani V, Zeldis JB, Fallows D, Kaplan G.

Front Immunol. 2016 Jun 17;7:238. doi: 10.3389/fimmu.2016.00238. eCollection 2016.

4.

Adjunctive Phosphodiesterase-4 Inhibitor Therapy Improves Antibiotic Response to Pulmonary Tuberculosis in a Rabbit Model.

Subbian S, Tsenova L, Holloway J, Peixoto B, O'Brien P, Dartois V, Khetani V, Zeldis JB, Kaplan G.

EBioMedicine. 2016 Jan 14;4:104-14. doi: 10.1016/j.ebiom.2016.01.015. eCollection 2016 Feb.

5.

Examining the safety of respiratory and intravenous inoculation of Bdellovibrio bacteriovorus and Micavibrio aeruginosavorus in a mouse model.

Shatzkes K, Chae R, Tang C, Ramirez GC, Mukherjee S, Tsenova L, Connell ND, Kadouri DE.

Sci Rep. 2015 Aug 7;5:12899. doi: 10.1038/srep12899.

6.

Lesion-Specific Immune Response in Granulomas of Patients with Pulmonary Tuberculosis: A Pilot Study.

Subbian S, Tsenova L, Kim MJ, Wainwright HC, Visser A, Bandyopadhyay N, Bader JS, Karakousis PC, Murrmann GB, Bekker LG, Russell DG, Kaplan G.

PLoS One. 2015 Jul 2;10(7):e0132249. doi: 10.1371/journal.pone.0132249. eCollection 2015.

7.

Metformin as adjunct antituberculosis therapy.

Singhal A, Jie L, Kumar P, Hong GS, Leow MK, Paleja B, Tsenova L, Kurepina N, Chen J, Zolezzi F, Kreiswirth B, Poidinger M, Chee C, Kaplan G, Wang YT, De Libero G.

Sci Transl Med. 2014 Nov 19;6(263):263ra159. doi: 10.1126/scitranslmed.3009885.

8.

Etanercept exacerbates inflammation and pathology in a rabbit model of active pulmonary tuberculosis.

Tsenova L, O'Brien P, Holloway J, Peixoto B, Soteropoulos P, Fallows D, Kaplan G, Subbian S.

J Interferon Cytokine Res. 2014 Sep;34(9):716-26. doi: 10.1089/jir.2013.0123. Epub 2014 May 15.

9.

Early innate immunity determines outcome of Mycobacterium tuberculosis pulmonary infection in rabbits.

Subbian S, Bandyopadhyay N, Tsenova L, O'Brien P, Khetani V, Kushner NL, Peixoto B, Soteropoulos P, Bader JS, Karakousis PC, Fallows D, Kaplan G.

Cell Commun Signal. 2013 Aug 19;11:60. doi: 10.1186/1478-811X-11-60.

10.

Molecular immunologic correlates of spontaneous latency in a rabbit model of pulmonary tuberculosis.

Subbian S, O'Brien P, Kushner NL, Yang G, Tsenova L, Peixoto B, Bandyopadhyay N, Bader JS, Karakousis PC, Fallows D, Kaplan G.

Cell Commun Signal. 2013 Feb 28;11(1):16. doi: 10.1186/1478-811X-11-16.

11.

Spontaneous latency in a rabbit model of pulmonary tuberculosis.

Subbian S, Tsenova L, O'Brien P, Yang G, Kushner NL, Parsons S, Peixoto B, Fallows D, Kaplan G.

Am J Pathol. 2012 Nov;181(5):1711-24. doi: 10.1016/j.ajpath.2012.07.019. Epub 2012 Sep 5.

12.

Chronic pulmonary cavitary tuberculosis in rabbits: a failed host immune response.

Subbian S, Tsenova L, Yang G, O'Brien P, Parsons S, Peixoto B, Taylor L, Fallows D, Kaplan G.

Open Biol. 2011 Dec;1(4):110016. doi: 10.1098/rsob.110016.

13.

Phosphodiesterase-4 inhibition alters gene expression and improves isoniazid-mediated clearance of Mycobacterium tuberculosis in rabbit lungs.

Subbian S, Tsenova L, O'Brien P, Yang G, Koo MS, Peixoto B, Fallows D, Dartois V, Muller G, Kaplan G.

PLoS Pathog. 2011 Sep;7(9):e1002262. doi: 10.1371/journal.ppat.1002262. Epub 2011 Sep 15.

14.

Phosphodiesterase-4 inhibition combined with isoniazid treatment of rabbits with pulmonary tuberculosis reduces macrophage activation and lung pathology.

Subbian S, Tsenova L, O'Brien P, Yang G, Koo MS, Peixoto B, Fallows D, Zeldis JB, Muller G, Kaplan G.

Am J Pathol. 2011 Jul;179(1):289-301. doi: 10.1016/j.ajpath.2011.03.039. Epub 2011 May 7.

15.

Experimental tuberculosis in the Wistar rat: a model for protective immunity and control of infection.

Singhal A, Aliouat el M, Hervé M, Mathys V, Kiass M, Creusy C, Delaire B, Tsenova L, Fleurisse L, Bertout J, Camacho L, Foo D, Tay HC, Siew JY, Boukhouchi W, Romano M, Mathema B, Dartois V, Kaplan G, Bifani P.

PLoS One. 2011 Apr 12;6(4):e18632. doi: 10.1371/journal.pone.0018632.

16.

Phosphodiesterase 4 inhibition reduces innate immunity and improves isoniazid clearance of Mycobacterium tuberculosis in the lungs of infected mice.

Koo MS, Manca C, Yang G, O'Brien P, Sung N, Tsenova L, Subbian S, Fallows D, Muller G, Ehrt S, Kaplan G.

PLoS One. 2011 Feb 25;6(2):e17091. doi: 10.1371/journal.pone.0017091.

17.

Caseation of human tuberculosis granulomas correlates with elevated host lipid metabolism.

Kim MJ, Wainwright HC, Locketz M, Bekker LG, Walther GB, Dittrich C, Visser A, Wang W, Hsu FF, Wiehart U, Tsenova L, Kaplan G, Russell DG.

EMBO Mol Med. 2010 Jul;2(7):258-74. doi: 10.1002/emmm.201000079.

18.

Role of the DinB homologs Rv1537 and Rv3056 in Mycobacterium tuberculosis.

Kana BD, Abrahams GL, Sung N, Warner DF, Gordhan BG, Machowski EE, Tsenova L, Sacchettini JC, Stoker NG, Kaplan G, Mizrahi V.

J Bacteriol. 2010 Apr;192(8):2220-7. doi: 10.1128/JB.01135-09. Epub 2010 Feb 5.

19.

The phenolic glycolipid of Mycobacterium tuberculosis differentially modulates the early host cytokine response but does not in itself confer hypervirulence.

Sinsimer D, Huet G, Manca C, Tsenova L, Koo MS, Kurepina N, Kana B, Mathema B, Marras SA, Kreiswirth BN, Guilhot C, Kaplan G.

Infect Immun. 2008 Jul;76(7):3027-36. doi: 10.1128/IAI.01663-07. Epub 2008 Apr 28.

20.

The resuscitation-promoting factors of Mycobacterium tuberculosis are required for virulence and resuscitation from dormancy but are collectively dispensable for growth in vitro.

Kana BD, Gordhan BG, Downing KJ, Sung N, Vostroktunova G, Machowski EE, Tsenova L, Young M, Kaprelyants A, Kaplan G, Mizrahi V.

Mol Microbiol. 2008 Feb;67(3):672-84. doi: 10.1111/j.1365-2958.2007.06078.x.

21.

BCG vaccination confers poor protection against M. tuberculosis HN878-induced central nervous system disease.

Tsenova L, Harbacheuski R, Sung N, Ellison E, Fallows D, Kaplan G.

Vaccine. 2007 Jul 9;25(28):5126-32. Epub 2006 Nov 27.

22.

Evaluation of the Mtb72F polyprotein vaccine in a rabbit model of tuberculous meningitis.

Tsenova L, Harbacheuski R, Moreira AL, Ellison E, Dalemans W, Alderson MR, Mathema B, Reed SG, Skeiky YA, Kaplan G.

Infect Immun. 2006 Apr;74(4):2392-401.

23.

Hypervirulent M. tuberculosis W/Beijing strains upregulate type I IFNs and increase expression of negative regulators of the Jak-Stat pathway.

Manca C, Tsenova L, Freeman S, Barczak AK, Tovey M, Murray PJ, Barry C, Kaplan G.

J Interferon Cytokine Res. 2005 Nov;25(11):694-701.

PMID:
16318583
24.

Virulence of selected Mycobacterium tuberculosis clinical isolates in the rabbit model of meningitis is dependent on phenolic glycolipid produced by the bacilli.

Tsenova L, Ellison E, Harbacheuski R, Moreira AL, Kurepina N, Reed MB, Mathema B, Barry CE 3rd, Kaplan G.

J Infect Dis. 2005 Jul 1;192(1):98-106. Epub 2005 May 26.

PMID:
15942899
25.

Differential expression of iron-, carbon-, and oxygen-responsive mycobacterial genes in the lungs of chronically infected mice and tuberculosis patients.

Timm J, Post FA, Bekker LG, Walther GB, Wainwright HC, Manganelli R, Chan WT, Tsenova L, Gold B, Smith I, Kaplan G, McKinney JD.

Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14321-6. Epub 2003 Nov 17.

26.

Ribonucleotide reduction in Mycobacterium tuberculosis: function and expression of genes encoding class Ib and class II ribonucleotide reductases.

Dawes SS, Warner DF, Tsenova L, Timm J, McKinney JD, Kaplan G, Rubin H, Mizrahi V.

Infect Immun. 2003 Nov;71(11):6124-31.

27.

Use of IMiD3, a thalidomide analog, as an adjunct to therapy for experimental tuberculous meningitis.

Tsenova L, Mangaliso B, Muller G, Chen Y, Freedman VH, Stirling D, Kaplan G.

Antimicrob Agents Chemother. 2002 Jun;46(6):1887-95. Erratum in: Antimicrob Agents Chemother 2002 Jul;46(7):2313.

28.

Mycobacterial antigens exacerbate disease manifestations in Mycobacterium tuberculosis-infected mice.

Moreira AL, Tsenova L, Aman MH, Bekker LG, Freeman S, Mangaliso B, Schröder U, Jagirdar J, Rom WN, Tovey MG, Freedman VH, Kaplan G.

Infect Immun. 2002 Apr;70(4):2100-7.

29.

Virulence of a Mycobacterium tuberculosis clinical isolate in mice is determined by failure to induce Th1 type immunity and is associated with induction of IFN-alpha /beta.

Manca C, Tsenova L, Bergtold A, Freeman S, Tovey M, Musser JM, Barry CE 3rd, Freedman VH, Kaplan G.

Proc Natl Acad Sci U S A. 2001 May 8;98(10):5752-7. Epub 2001 Apr 24.

30.

Cryptococcal glucuronoxylomannan delays translocation of leukocytes across the blood-brain barrier in an animal model of acute bacterial meningitis.

Lipovsky MM, Tsenova L, Coenjaerts FE, Kaplan G, Cherniak R, Hoepelman AI.

J Neuroimmunol. 2000 Nov 1;111(1-2):10-4.

PMID:
11063816
31.

Aerosol infection of mice with recombinant BCG secreting murine IFN-gamma partially reconstitutes local protective immunity.

Moreira AL, Tsenova L, Murray PJ, Freeman S, Bergtold A, Chiriboga L, Kaplan G.

Microb Pathog. 2000 Sep;29(3):175-85.

PMID:
10968949
32.

Mycobacterium tuberculosis CDC1551 induces a more vigorous host response in vivo and in vitro, but is not more virulent than other clinical isolates.

Manca C, Tsenova L, Barry CE 3rd, Bergtold A, Freeman S, Haslett PA, Musser JM, Freedman VH, Kaplan G.

J Immunol. 1999 Jun 1;162(11):6740-6.

33.

Tumor necrosis factor alpha is a determinant of pathogenesis and disease progression in mycobacterial infection in the central nervous system.

Tsenova L, Bergtold A, Freedman VH, Young RA, Kaplan G.

Proc Natl Acad Sci U S A. 1999 May 11;96(10):5657-62.

34.

A combination of thalidomide plus antibiotics protects rabbits from mycobacterial meningitis-associated death.

Tsenova L, Sokol K, Freedman VH, Kaplan G.

J Infect Dis. 1998 Jun;177(6):1563-72.

PMID:
9607834
35.

Early Lyme disease: Humoral immune status and treatment.

Karaivanova LA, Tsenova LG, Zarcheva VD.

Clin Microbiol Infect. 1997 Feb;3(1):41-44.

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