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Proceedings from the Albert Charitable Trust Inaugural Workshop on white matter and cognition in aging.

Sorond FA, Whitehead S, Arai K, Arnold D, Carmichael ST, De Carli C, Duering M, Fornage M, Flores-Obando RE, Graff-Radford J, Hamel E, Hess DC, Ihara M, Jensen MK, Markus HS, Montagne A, Rosenberg G, Shih AY, Smith EE, Thiel A, Tse KH, Wilcock D, Barone F.

Geroscience. 2019 Dec 6. doi: 10.1007/s11357-019-00141-8. [Epub ahead of print] Review.


Pretreatment Prediction of Adaptive Radiation Therapy Eligibility Using MRI-Based Radiomics for Advanced Nasopharyngeal Carcinoma Patients.

Yu TT, Lam SK, To LH, Tse KY, Cheng NY, Fan YN, Lo CL, Or KW, Chan ML, Hui KC, Chan FC, Hui WM, Ngai LK, Lee FK, Au KH, Yip CW, Zhang Y, Cai J.

Front Oncol. 2019 Oct 16;9:1050. doi: 10.3389/fonc.2019.01050. eCollection 2019.


The Value of Contrast-Enhanced CT in the Detection of Residual Disease After Neo-Adjuvant Chemotherapy in Ovarian Cancer.

An H, Chiu KWH, Tse KY, Ngan HYS, Khong PL, Lee EYP.

Acad Radiol. 2019 Oct 16. pii: S1076-6332(19)30452-0. doi: 10.1016/j.acra.2019.09.019. [Epub ahead of print]


Global consensus building and prioritisation of fundamental lupus challenges: the ALPHA project.

Manzi S, Raymond S, Tse K, Peña Y, Anderson A, Arntsen K, Bae SC, Bruce I, Dörner T, Getz K, Hanrahan L, Kao A, Morand E, Rovin B, Schanberg LE, Von Feldt JM, Werth VP, Costenbader K.

Lupus Sci Med. 2019 Jul 19;6(1):e000342. doi: 10.1136/lupus-2019-000342. eCollection 2019.


Genetic alterations in primary melanoma in Taiwan.

Sheen YS, Tan KT, Tse KP, Liao YH, Lin MH, Chen JS, Liau JY, Tseng YJ, Lee CH, Hong CH, Liao JB, Chang HT, Chu CY.

Br J Dermatol. 2019 Aug 13. doi: 10.1111/bjd.18425. [Epub ahead of print]


Predictive biomarkers and tumor microenvironment in female genital melanomas: a multi-institutional study of 55 cases.

Yu Y, Tse KY, Lee HHY, Chow KL, Tsang HW, Wong RWC, Cheung ETY, Cheuk W, Lee VWK, Chan WK, Wong AST, Loong HHF, Chan KKL, Ngan HYS, Cheung ANY, Ip PPC.

Mod Pathol. 2019 Aug 5. doi: 10.1038/s41379-019-0345-2. [Epub ahead of print]


Cortical and Trabecular Bone Fracture Characterisation in the Vertebral Body Using Acoustic Emission.

Robinson DL, Tse KM, Franklyn M, Zhang J, Ackland D, Lee PVS.

Ann Biomed Eng. 2019 Dec;47(12):2384-2401. doi: 10.1007/s10439-019-02316-y. Epub 2019 Jul 23.


Diffusion Kurtosis Imaging in the Assessment of Cervical Carcinoma.

Wang M, Perucho JAU, Chan Q, Sun J, Ip P, Tse KY, Lee EYP.

Acad Radiol. 2019 Jul 16. pii: S1076-6332(19)30328-9. doi: 10.1016/j.acra.2019.06.022. [Epub ahead of print]


Research priorities in childhood-onset lupus: results of a multidisciplinary prioritization exercise.

Ardoin SP, Daly RP, Merzoug L, Tse K, Ardalan K, Arkin L, Knight A, Rubinstein T, Ruth N, Wenderfer SE, Hersh AO; Childhood Arthritis and Rheumatology Research Alliance and Lupus Foundation of America.

Pediatr Rheumatol Online J. 2019 Jul 1;17(1):32. doi: 10.1186/s12969-019-0327-4.


The Genome of the Steller Sea Lion (Eumetopias jubatus).

Kwan HH, Culibrk L, Taylor GA, Leelakumari S, Tan R, Jackman SD, Tse K, MacLeod T, Cheng D, Chuah E, Kirk H, Pandoh P, Carlsen R, Zhao Y, Mungall AJ, Moore R, Birol I, Marra MA, Rosen DAS, Haulena M, Jones SJM.

Genes (Basel). 2019 Jun 26;10(7). pii: E486. doi: 10.3390/genes10070486.


Neurofunctional test batteries in safety pharmacology - Current and emerging considerations for the drug development process.

Jackson SJ, Authier S, Brohmann H, Goody SMG, Jones D, Prior H, Rosch A, Traebert M, Tse K, Valentin JP, Milne A.

J Pharmacol Toxicol Methods. 2019 Nov - Dec;100:106602. doi: 10.1016/j.vascn.2019.106602. Epub 2019 Jun 22.


The impact of postsynaptic density 95 blocking peptide (Tat-NR2B9c) and an iNOS inhibitor (1400W) on proteomic profile of the hippocampus in C57BL/6J mouse model of kainate-induced epileptogenesis.

Tse K, Hammond D, Simpson D, Beynon RJ, Beamer E, Tymianski M, Salter MW, Sills GJ, Thippeswamy T.

J Neurosci Res. 2019 Nov;97(11):1378-1392. doi: 10.1002/jnr.24441. Epub 2019 May 15.


Manipulating the Mixed-Perovskite Crystallization Pathway Unveiled by In Situ GIWAXS.

Qin M, Tse K, Lau TK, Li Y, Su CJ, Yang G, Chen J, Zhu J, Jeng US, Li G, Chen H, Lu X.

Adv Mater. 2019 Jun;31(25):e1901284. doi: 10.1002/adma.201901284. Epub 2019 Apr 30.


Molecular isoforms of high-mobility group box 1 are mechanistic biomarkers for epilepsy.

Walker LE, Frigerio F, Ravizza T, Ricci E, Tse K, Jenkins RE, Sills GJ, Jorgensen A, Porcu L, Thippeswamy T, Alapirtti T, Peltola J, Brodie MJ, Park BK, Marson AG, Antoine DJ, Vezzani A, Pirmohamed M.

J Clin Invest. 2019 Apr 8;129(5):2166. doi: 10.1172/JCI129285. eCollection 2019 Apr 8. No abstract available.


Implementing Workshops to Improve Radiation Therapists' Knowledge and Attitudes about Sexual Health Issues in Cancer Patients.

Feuz C, Tse K, Kwan M, Hill C, Rakaric P, Tan K, Rosewall T.

J Med Imaging Radiat Sci. 2019 Mar;50(1):98-105. doi: 10.1016/j.jmir.2018.08.001. Epub 2018 Sep 27.


Napsin A, Hepatocyte Nuclear Factor-1-Beta (HNF-1β), Estrogen and Progesterone Receptors Expression in Arias-Stella Reaction.

Ip PPC, Wang SY, Wong OGW, Chow KL, Lee HH, Cheung ANY, Tse KY.

Am J Surg Pathol. 2019 Mar;43(3):325-333. doi: 10.1097/PAS.0000000000001212.


The Genome of the North American Brown Bear or Grizzly: Ursus arctos ssp. horribilis.

Taylor GA, Kirk H, Coombe L, Jackman SD, Chu J, Tse K, Cheng D, Chuah E, Pandoh P, Carlsen R, Zhao Y, Mungall AJ, Moore R, Birol I, Franke M, Marra MA, Dutton C, Jones SJM.

Genes (Basel). 2018 Nov 30;9(12). pii: E598. doi: 10.3390/genes9120598.


A computational study of the EN 1078 impact test for bicycle helmets using a realistic subject-specific finite element head model.

Sandberg M, Tse KM, Tan LB, Lee HP.

Comput Methods Biomech Biomed Engin. 2018 Sep;21(12):684-692. doi: 10.1080/10255842.2018.1511775. Epub 2018 Nov 8.


The influence of rotator cuff tears on muscle and joint-contact loading after reverse total shoulder arthroplasty.

Ackland DC, Robinson DL, Wilkosz A, Wu W, Richardson M, Lee P, Tse KM.

J Orthop Res. 2019 Jan;37(1):211-219. doi: 10.1002/jor.24152. Epub 2018 Nov 1.


Feasibility of using computer simulation to predict the postoperative outcome of the minimally invasive Nuss procedure: Simulation prediction vs. postoperative clinical observation.

Tse KM, Tan LB, Lee SJ, Rasheed MZ, Tan BK, Lee HP.

J Plast Reconstr Aesthet Surg. 2018 Oct;71(10):1496-1506. doi: 10.1016/j.bjps.2018.05.026. Epub 2018 Jun 9.


Dingchuan tang essential oil inhibits the production of inflammatory mediators via suppressing the IRAK/NF-κB, IRAK/AP-1, and TBK1/IRF3 pathways in lipopolysaccharide-stimulated RAW264.7 cells.

Zhang Y, Guo H, Cheng BC, Su T, Fu XQ, Li T, Zhu PL, Tse KW, Pan SY, Yu ZL.

Drug Des Devel Ther. 2018 Sep 4;12:2731-2748. doi: 10.2147/DDDT.S160645. eCollection 2018.


Oncogenic microRNA signature for early diagnosis of cervical intraepithelial neoplasia and cancer.

Liu SS, Chan KKL, Chu DKH, Wei TN, Lau LSK, Ngu SF, Chu MMY, Tse KY, Ip PPC, Ng EKO, Cheung ANY, Ngan HYS.

Mol Oncol. 2018 Dec;12(12):2009-2022. doi: 10.1002/1878-0261.12383. Epub 2018 Sep 27.


Crystallographic study of dioxygen chemistry in a copper-containing nitrite reductase from Geobacillus thermodenitrificans.

Fukuda Y, Matsusaki T, Tse KM, Mizohata E, Murphy MEP, Inoue T.

Acta Crystallogr D Struct Biol. 2018 Aug 1;74(Pt 8):769-777. doi: 10.1107/S2059798318010082. Epub 2018 Jul 24.


First case of neurofibromatosis with posterior reversible encephalopathy syndrome showing spinal cord involvement.

Chan PKJ, Tse KS, Fok WSE, Poon WL.

Indian J Radiol Imaging. 2018 Apr-Jun;28(2):161-164. doi: 10.4103/ijri.IJRI_320_17.


A Case Series of Five Patients With Pure or Mixed Gestational Epithelioid Trophoblastic Tumors and a Literature Review on Mixed Tumors.

Tse KY, Chiu KWH, Chan KKL, Chu MMY, Ngu SF, Cheung ANY, Ngan HYS, Ip PPC.

Am J Clin Pathol. 2018 Aug 30;150(4):318-332. doi: 10.1093/ajcp/aqy039. Review.


Soluble E-cadherin promotes tumor angiogenesis and localizes to exosome surface.

Tang MKS, Yue PYK, Ip PP, Huang RL, Lai HC, Cheung ANY, Tse KY, Ngan HYS, Wong AST.

Nat Commun. 2018 Jun 11;9(1):2270. doi: 10.1038/s41467-018-04695-7.


TRPV6 protects ER stress-induced apoptosis via ATF6α-TRPV6-JNK pathway in human embryonic stem cell-derived cardiomyocytes.

Li Z, Meng Z, Lu J, Chen FM, Wong WT, Tse G, Zheng C, Keung W, Tse K, Li RA, Jiang L, Yao X.

J Mol Cell Cardiol. 2018 Jul;120:1-11. doi: 10.1016/j.yjmcc.2018.05.008. Epub 2018 May 16.


Interfaces of Malignant and Immunologic Clonal Dynamics in Ovarian Cancer.

Zhang AW, McPherson A, Milne K, Kroeger DR, Hamilton PT, Miranda A, Funnell T, Little N, de Souza CPE, Laan S, LeDoux S, Cochrane DR, Lim JLP, Yang W, Roth A, Smith MA, Ho J, Tse K, Zeng T, Shlafman I, Mayo MR, Moore R, Failmezger H, Heindl A, Wang YK, Bashashati A, Grewal DS, Brown SD, Lai D, Wan ANC, Nielsen CB, Huebner C, Tessier-Cloutier B, Anglesio MS, Bouchard-Côté A, Yuan Y, Wasserman WW, Gilks CB, Karnezis AN, Aparicio S, McAlpine JN, Huntsman DG, Holt RA, Nelson BH, Shah SP.

Cell. 2018 Jun 14;173(7):1755-1769.e22. doi: 10.1016/j.cell.2018.03.073. Epub 2018 May 10.


Impact of iASPP on chemoresistance through PLK1 and autophagy in ovarian clear cell carcinoma.

Chan KK, Wong OG, Wong ES, Chan KK, Ip PP, Tse KY, Cheung AN.

Int J Cancer. 2018 Sep 15;143(6):1456-1469. doi: 10.1002/ijc.31535. Epub 2018 May 2.


Pancreatic pseudocyst rupture into the portal vein diagnosed by magnetic resonance imaging.

Lee HC, Tse KH.

Hong Kong Med J. 2018 Apr;24(2):206.e1-e2. doi: 10.12809/hkmj164980. No abstract available.


Pharmacological validation of individual animal locomotion, temperature and behavioural analysis in group-housed rats using a novel automated home cage analysis system: A comparison with the modified Irwin test.

Tse K, Sillito R, Keerie A, Collier R, Grant C, Karp NA, Vickers C, Chapman K, Armstrong JD, Redfern WS.

J Pharmacol Toxicol Methods. 2018 Nov - Dec;94(Pt 1):1-13. doi: 10.1016/j.vascn.2018.03.008. Epub 2018 Apr 1.


Regulatory CD4+ T Cells Recognize Major Histocompatibility Complex Class II Molecule-Restricted Peptide Epitopes of Apolipoprotein B.

Kimura T, Kobiyama K, Winkels H, Tse K, Miller J, Vassallo M, Wolf D, Ryden C, Orecchioni M, Dileepan T, Jenkins MK, James EA, Kwok WW, Hanna DB, Kaplan RC, Strickler HD, Durkin HG, Kassaye SG, Karim R, Tien PC, Landay AL, Gange SJ, Sidney J, Sette A, Ley K.

Circulation. 2018 Sep 11;138(11):1130-1143. doi: 10.1161/CIRCULATIONAHA.117.031420.


Non-invasive assessment of kidney allograft fibrosis with shear wave elastography: A radiological-pathological correlation analysis.

Ma MK, Law HK, Tse KS, Chan KW, Chan GC, Yap DY, Mok MM, Kwan LP, Tang SC, Choy BY, Chan TM.

Int J Urol. 2018 May;25(5):450-455. doi: 10.1111/iju.13536. Epub 2018 Feb 14.


DNA damage-associated oligodendrocyte degeneration precedes amyloid pathology and contributes to Alzheimer's disease and dementia.

Tse KH, Cheng A, Ma F, Herrup K.

Alzheimers Dement. 2018 May;14(5):664-679. doi: 10.1016/j.jalz.2017.11.010. Epub 2018 Jan 9.


Lumbar model generator: a tool for the automated generation of a parametric scalable model of the lumbar spine.

Lavecchia CE, Espino DM, Moerman KM, Tse KM, Robinson D, Lee PVS, Shepherd DET.

J R Soc Interface. 2018 Jan;15(138). pii: 20170829. doi: 10.1098/rsif.2017.0829.


ATM and ATR play complementary roles in the behavior of excitatory and inhibitory vesicle populations.

Cheng A, Zhao T, Tse KH, Chow HM, Cui Y, Jiang L, Du S, Loy MMT, Herrup K.

Proc Natl Acad Sci U S A. 2018 Jan 9;115(2):E292-E301. doi: 10.1073/pnas.1716892115. Epub 2017 Dec 26.


The Genome of the Beluga Whale (Delphinapterus leucas).

Jones SJM, Taylor GA, Chan S, Warren RL, Hammond SA, Bilobram S, Mordecai G, Suttle CA, Miller KM, Schulze A, Chan AM, Jones SJ, Tse K, Li I, Cheung D, Mungall KL, Choo C, Ally A, Dhalla N, Tam AKY, Troussard A, Kirk H, Pandoh P, Paulino D, Coope RJN, Mungall AJ, Moore R, Zhao Y, Birol I, Ma Y, Marra M, Haulena M.

Genes (Basel). 2017 Dec 11;8(12). pii: E378. doi: 10.3390/genes8120378.


Well-differentiated papillary mesothelioma of tunica vaginalis testis of unknown malignant potential: Sonographic appearance.

Ko KWS, Tse KS, Shek KW, Hau MN, Ting SH.

J Clin Ultrasound. 2018 Jun;46(5):364-367. doi: 10.1002/jcu.22538. Epub 2017 Oct 9.


Hybrid method in severe pulmonary embolism not suitable for systemic fibrinolysis.

Hang Luk W, Chan HF, Pan NY, Tse KH, Cheng LF, Ma JKF.

Asian Cardiovasc Thorac Ann. 2017 Sep-Oct;25(7-8):544-546. doi: 10.1177/0218492317735722. Epub 2017 Sep 26.


Active site geometry of a novel aminopropyltransferase for biosynthesis of hyperthermophile-specific branched-chain polyamine.

Hidese R, Tse KM, Kimura S, Mizohata E, Fujita J, Horai Y, Umezawa N, Higuchi T, Niitsu M, Oshima T, Imanaka T, Inoue T, Fujiwara S.

FEBS J. 2017 Nov;284(21):3684-3701. doi: 10.1111/febs.14262. Epub 2017 Sep 22.


Automated recording of home cage activity and temperature of individual rats housed in social groups: The Rodent Big Brother project.

Redfern WS, Tse K, Grant C, Keerie A, Simpson DJ, Pedersen JC, Rimmer V, Leslie L, Klein SK, Karp NA, Sillito R, Chartsias A, Lukins T, Heward J, Vickers C, Chapman K, Armstrong JD.

PLoS One. 2017 Sep 6;12(9):e0181068. doi: 10.1371/journal.pone.0181068. eCollection 2017.


Loopholes in the DNA contract kill neurons.

Herrup K, Tse KH, Chow HM.

Nat Neurosci. 2017 Aug 29;20(9):1192-1194. doi: 10.1038/nn.4626. No abstract available.


An abnormal TRPV4-related cytosolic Ca2+ rise in response to uniaxial stretch in induced pluripotent stem cells-derived cardiomyocytes from dilated cardiomyopathy patients.

Lu J, Lee YK, Ran X, Lai WH, Li RA, Keung W, Tse K, Tse HF, Yao X.

Biochim Biophys Acta Mol Basis Dis. 2017 Nov;1863(11):2964-2972. doi: 10.1016/j.bbadis.2017.07.021. Epub 2017 Jul 25.


The whole-genome landscape of medulloblastoma subtypes.

Northcott PA, Buchhalter I, Morrissy AS, Hovestadt V, Weischenfeldt J, Ehrenberger T, Gröbner S, Segura-Wang M, Zichner T, Rudneva VA, Warnatz HJ, Sidiropoulos N, Phillips AH, Schumacher S, Kleinheinz K, Waszak SM, Erkek S, Jones DTW, Worst BC, Kool M, Zapatka M, Jäger N, Chavez L, Hutter B, Bieg M, Paramasivam N, Heinold M, Gu Z, Ishaque N, Jäger-Schmidt C, Imbusch CD, Jugold A, Hübschmann D, Risch T, Amstislavskiy V, Gonzalez FGR, Weber UD, Wolf S, Robinson GW, Zhou X, Wu G, Finkelstein D, Liu Y, Cavalli FMG, Luu B, Ramaswamy V, Wu X, Koster J, Ryzhova M, Cho YJ, Pomeroy SL, Herold-Mende C, Schuhmann M, Ebinger M, Liau LM, Mora J, McLendon RE, Jabado N, Kumabe T, Chuah E, Ma Y, Moore RA, Mungall AJ, Mungall KL, Thiessen N, Tse K, Wong T, Jones SJM, Witt O, Milde T, Von Deimling A, Capper D, Korshunov A, Yaspo ML, Kriwacki R, Gajjar A, Zhang J, Beroukhim R, Fraenkel E, Korbel JO, Brors B, Schlesner M, Eils R, Marra MA, Pfister SM, Taylor MD, Lichter P.

Nature. 2017 Jul 19;547(7663):311-317. doi: 10.1038/nature22973.


A Randomized Controlled Trial of Chinese Medicine on Nonmotor Symptoms in Parkinson's Disease.

Chua KK, Wong A, Chan KW, Lau YK, Bian ZX, Lu JH, Liu LF, Chen LL, Chan KH, Tse KP, Chan A, Song JX, Wu J, Zhu LX, Mok V, Li M.

Parkinsons Dis. 2017;2017:1902708. doi: 10.1155/2017/1902708. Epub 2017 May 23.


The Utility of the Reflux Symptom Index for Diagnosis of Laryngopharyngeal Reflux in an Allergy Patient Population.

Brauer DL, Tse KY, Lin JC, Schatz MX, Simon RA.

J Allergy Clin Immunol Pract. 2018 Jan - Feb;6(1):132-138.e1. doi: 10.1016/j.jaip.2017.04.039. Epub 2017 Jun 9.


Re-imagining Alzheimer's disease - the diminishing importance of amyloid and a glimpse of what lies ahead.

Tse KH, Herrup K.

J Neurochem. 2017 Nov;143(4):432-444. doi: 10.1111/jnc.14079. Epub 2017 Jun 21. Review.


Robot-assisted gynaecological cancer surgery-complications and prevention.

Tse KY, Ngan HYS, Lim PC.

Best Pract Res Clin Obstet Gynaecol. 2017 Nov;45:94-106. doi: 10.1016/j.bpobgyn.2017.04.005. Epub 2017 Apr 23. Review.


Molecular isoforms of high-mobility group box 1 are mechanistic biomarkers for epilepsy.

Walker LE, Frigerio F, Ravizza T, Ricci E, Tse K, Jenkins RE, Sills GJ, Jorgensen A, Porcu L, Thippeswamy T, Alapirtti T, Peltola J, Brodie MJ, Park BK, Marson AG, Antoine DJ, Vezzani A, Pirmohamed M.

J Clin Invest. 2017 Jun 1;127(6):2118-2132. doi: 10.1172/JCI92001. Epub 2017 May 15. Retraction in: J Clin Invest. 2019 Apr 8;129(5):2166.

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