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Guideline-Based Critical Care Pathway Improves Long-Term Clinical Outcomes in Patients with Acute Coronary Syndrome.

Hai JJ, Wong CK, Un KC, Wong KL, Zhang ZY, Chan PH, Lam YM, Chan WS, Lam CC, Tam CC, Wong YT, Yung SY, Chan KW, Siu CW, Lau CP, Tse HF.

Sci Rep. 2019 Nov 14;9(1):16814. doi: 10.1038/s41598-019-53348-2.


Effect of Alirocumab on Stroke in ODYSSEY OUTCOMES.

Jukema JW, Zijlstra LE, Bhatt DL, Bittner VA, Diaz R, Drexel H, Goodman SG, Kim YU, Pordy R, Reiner Z, Roe MT, Tse HF, Valdovinos PCM, White HD, Zeiher AM, Szarek M, Schwartz GG, Steg PG; ODYSSEY OUTCOMES Investigators.

Circulation. 2019 Nov 11. doi: 10.1161/CIRCULATIONAHA.119.043826. [Epub ahead of print] No abstract available.


Expression of Lmna-R225X nonsense mutation results in dilated cardiomyopathy and conduction disorders (DCM-CD) in mice: Impact of exercise training.

Cai ZJ, Lee YK, Lau YM, Ho JC, Lai WH, Wong NL, Huang D, Hai JJ, Ng KM, Tse HF, Siu CW.

Int J Cardiol. 2019 Oct 17. pii: S0167-5273(19)30259-1. doi: 10.1016/j.ijcard.2019.09.058. [Epub ahead of print]


Adoption of the New CLSI Fluoroquinolone Breakpoints for Enterobacteriaceae.

Chu YW, Tse H, Tsang D.

J Clin Microbiol. 2019 Oct 23;57(11). pii: e01176-19. doi: 10.1128/JCM.01176-19. Print 2019 Nov. No abstract available.


Isoflavone-mediated radioprotection involves regulation of early endothelial cell death and inflammatory signaling in Radiation-Induced lung injury.

Fountain MD, McLellan LA, Smith NL, Loughery BF, Rakowski JT, Tse HY, Hillman GG.

Int J Radiat Biol. 2019 Nov 4:1-12. doi: 10.1080/09553002.2020.1683642. [Epub ahead of print]


Ventricular Capture During Shockwave Intravascular Lithotripsy.

Kwok OH, Tse HF.

JACC Cardiovasc Interv. 2019 Oct 28;12(20):e175-e179. doi: 10.1016/j.jcin.2019.06.046. Epub 2019 Sep 25. No abstract available.


Prognostic Value of Tricuspid Valve Geometry and Leaflet Coaptation Status in Patients Undergoing Tricuspid Annuloplasty: A Three-Dimensional Echocardiography Study.

Chen Y, Liu YX, Yu YJ, Wu MZ, Lam YM, Sit KY, Chan DT, Ho CK, Ho LM, Fang LG, Zhang SY, Lau CP, Au WK, Tse HF, Yiu KH.

J Am Soc Echocardiogr. 2019 Sep 25. pii: S0894-7317(19)30827-2. doi: 10.1016/j.echo.2019.07.002. [Epub ahead of print]


Age-Related Gene Expression Signature in Rats Demonstrate Early, Late, and Linear Transcriptional Changes from Multiple Tissues.

Shavlakadze T, Morris M, Fang J, Wang SX, Zhu J, Zhou W, Tse HW, Mondragon-Gonzalez R, Roma G, Glass DJ.

Cell Rep. 2019 Sep 17;28(12):3263-3273.e3. doi: 10.1016/j.celrep.2019.08.043.


Potassium homeostasis in patients with atrial fibrillation.

Chan YH, Tse HF.

Eur Heart J Cardiovasc Pharmacother. 2019 Aug 21. pii: pvz034. doi: 10.1093/ehjcvp/pvz034. [Epub ahead of print] No abstract available.


The applications of metabolomics in the molecular diagnostics of cancer.

Cheung PK, Ma MH, Tse HF, Yeung KF, Tsang HF, Chu MKM, Kan CM, Cho WCS, Ng LBW, Chan LWC, Wong SCC.

Expert Rev Mol Diagn. 2019 Sep;19(9):785-793. doi: 10.1080/14737159.2019.1656530. Epub 2019 Aug 21.


Serum miR-204 is an early biomarker of type 1 diabetes-associated pancreatic beta-cell loss.

Xu G, Thielen LA, Chen J, Grayson TB, Grimes T, Bridges SL Jr, Tse HM, Smith B, Patel R, Li P, Evans-Molina C, Ovalle F, Shalev A.

Am J Physiol Endocrinol Metab. 2019 Oct 1;317(4):E723-E730. doi: 10.1152/ajpendo.00122.2019. Epub 2019 Aug 13.


Chromatin compartment dynamics in a haploinsufficient model of cardiac laminopathy.

Bertero A, Fields PA, Smith AST, Leonard A, Beussman K, Sniadecki NJ, Kim DH, Tse HF, Pabon L, Shendure J, Noble WS, Murry CE.

J Cell Biol. 2019 Sep 2;218(9):2919-2944. doi: 10.1083/jcb.201902117. Epub 2019 Aug 8.


Incidence of dual antiplatelet therapy interruption within 1 year after primary percutaneous coronary intervention in patients with acute ST elevation myocardial infarction.

Tam CC, Lee J, Chan KW, Lam CC, Wong YT, Chan E, Sze M, Lam YM, Chan C, Tse HF, Siu CW.

Postgrad Med J. 2019 Jul 19. pii: postgradmedj-2019-136760. doi: 10.1136/postgradmedj-2019-136760. [Epub ahead of print]


Partial Inhibition of mTORC1 in Aged Rats Counteracts the Decline in Muscle Mass and Reverses Molecular Signaling Associated with Sarcopenia.

Joseph GA, Wang SX, Jacobs CE, Zhou W, Kimble GC, Tse HW, Eash JK, Shavlakadze T, Glass DJ.

Mol Cell Biol. 2019 Sep 11;39(19). pii: e00141-19. doi: 10.1128/MCB.00141-19. Print 2019 Oct 1.


Prognostic implications of statin intolerance in stable coronary artery disease patients with different levels of high-sensitive troponin.

Hai JJ, Wong YK, Wong CK, Un KC, Chan PH, Siu CW, Yiu KH, Lau CP, Tse HF.

BMC Cardiovasc Disord. 2019 Jul 15;19(1):168. doi: 10.1186/s12872-019-1152-x.


Effect of gamma aminobutyric acid (GABA) or GABA with glutamic acid decarboxylase (GAD) on the progression of type 1 diabetes mellitus in children: Trial design and methodology.

Choat HM, Martin A, Mick GJ, Heath KE, Tse HM, McGwin G Jr, McCormick KL.

Contemp Clin Trials. 2019 Jul;82:93-100. doi: 10.1016/j.cct.2019.06.007. Epub 2019 Jun 20.


LIM-domain transcription complexes interact with ring-finger ubiquitin ligases and thereby impact islet β-cell function.

Wade AK, Liu Y, Bethea MM, Toren E, Tse HM, Hunter CS.

J Biol Chem. 2019 Aug 2;294(31):11728-11740. doi: 10.1074/jbc.RA118.006985. Epub 2019 Jun 11.


Editorial: Fresh Ideas, Foundational Experiments: Immunology and Diabetes.

Spanier JA, Tse HM, Horwitz MS, Fife BT.

Front Endocrinol (Lausanne). 2019 May 16;10:315. doi: 10.3389/fendo.2019.00315. eCollection 2019. No abstract available.


Donation of mitochondria by iPSC-derived mesenchymal stem cells protects retinal ganglion cells against mitochondrial complex I defect-induced degeneration.

Jiang D, Xiong G, Feng H, Zhang Z, Chen P, Yan B, Chen L, Gandhervin K, Ma C, Li C, Han S, Zhang Y, Liao C, Lee TL, Tse HF, Fu QL, Chiu K, Lian Q.

Theranostics. 2019 Apr 13;9(8):2395-2410. doi: 10.7150/thno.29422. eCollection 2019.


Catheter-Based Splanchnic Denervation for Treatment of Hypertensive Cardiomyopathy.

Zhen Z, Liao SY, Zhu ZY, Sijia S, Au KW, Lai WH, Tsang A, Hai JSH, Tse HF.

Hypertension. 2019 Jul;74(1):47-55. doi: 10.1161/HYPERTENSIONAHA.118.12601. Epub 2019 May 28.


Cumulative Rheumatic Inflammation Modulates the Bone-Vascular Axis and Risk of Coronary Calcification.

Chan YH, Ngai MC, Chen Y, Wu MZ, Yu YJ, Zhen Z, Lai K, Cheung T, Ho LM, Chung HY, Lau CS, Tse HF, Yiu KH.

J Am Heart Assoc. 2019 Jun 4;8(11):e011540. doi: 10.1161/JAHA.118.011540.


TIMI risk score for secondary prevention of recurrent cardiovascular events in a real-world cohort of post-non-ST-elevation myocardial infarction patients.

Huang D, Cheng YY, Wong YT, Yung SY, Chan KW, Lam CC, Hai J, Lau CP, Wong KL, Feng YQ, Tan N, Chen JY, Wu MX, Su X, Yan H, Song D, Tse HF, Chan PH, Siu CW, Tam CC.

Postgrad Med J. 2019 Jul;95(1125):372-377. doi: 10.1136/postgradmedj-2019-136404. Epub 2019 May 23.


Amelioration of Endoplasmic Reticulum Stress by Mesenchymal Stem Cells via Hepatocyte Growth Factor/c-Met Signaling in Obesity-Associated Kidney Injury.

Li B, Leung JCK, Chan LYY, Yiu WH, Li Y, Lok SWY, Liu WH, Chan KW, Tse HF, Lai KN, Tang SCW.

Stem Cells Transl Med. 2019 Sep;8(9):898-910. doi: 10.1002/sctm.18-0265. Epub 2019 May 3.


Osteogenic circulating endothelial progenitor cells are linked to electrocardiographic conduction abnormalities in rheumatic patients.

Chan YH, Ngai MC, Chen Y, Wu MZ, Yu YJ, Zhen Z, Lai K, Cheung T, Ho LM, Chung HY, Lau CS, Lau CP, Tse HF, Yiu KH.

Ann Noninvasive Electrocardiol. 2019 Sep;24(5):e12651. doi: 10.1111/anec.12651. Epub 2019 Apr 24.


Generation of the human induced pluripotent stem cell (hiPSC) line PSMi005-A from a patient carrying the KCNQ1-R190W mutation.

Mura M, Lee YK, Pisano F, Ginevrino M, Boni M, Calabrò F, Crotti L, Valente EM, Schwartz PJ, Tse HF, Gnecchi M.

Stem Cell Res. 2019 May;37:101437. doi: 10.1016/j.scr.2019.101437. Epub 2019 Apr 13.


Generation of the human induced pluripotent stem cell (hiPSC) line PSMi004-A from a carrier of the KCNQ1-R594Q mutation.

Mura M, Lee YK, Pisano F, Ginevrino M, Boni M, Calabrò F, Crotti L, Valente EM, Schwartz PJ, Tse HF, Gnecchi M.

Stem Cell Res. 2019 May;37:101431. doi: 10.1016/j.scr.2019.101431. Epub 2019 Mar 27.


Lymphocyte Activation Gene-3 Maintains Mitochondrial and Metabolic Quiescence in Naive CD4+ T Cells.

Previte DM, Martins CP, O'Connor EC, Marre ML, Coudriet GM, Beck NW, Menk AV, Wright RH, Tse HM, Delgoffe GM, Piganelli JD.

Cell Rep. 2019 Apr 2;27(1):129-141.e4. doi: 10.1016/j.celrep.2019.03.004.


Correction: Hsa-miRNA-765 as a Key Mediator for Inhibiting Growth, Migration and Invasion in Fulvestrant-Treated Prostate Cancer.

Leung YK, Chan QK, Ng CF, Ma FM, Tse HM, To KF, Maranchie J, Ho SM, Lau KM.

PLoS One. 2019 Mar 18;14(3):e0214184. doi: 10.1371/journal.pone.0214184. eCollection 2019.


Potent immunomodulation and angiogenic effects of mesenchymal stem cells versus cardiomyocytes derived from pluripotent stem cells for treatment of heart failure.

Liao S, Zhang Y, Ting S, Zhen Z, Luo F, Zhu Z, Jiang Y, Sun S, Lai WH, Lian Q, Tse HF.

Stem Cell Res Ther. 2019 Mar 7;10(1):78. doi: 10.1186/s13287-019-1183-3.


Thrombolysis in Myocardial Infarction Risk Score for Secondary Prevention of Recurrent Cardiovascular Events in a Real-World Cohort of Post-Acute Myocardial Infarction Patients.

Huang D, Cheng YY, Wong YA, Yung SA, Tam CF, Chan KK, Lam CS, Yiu KH, Hai JJ, Lau CP, Chan EW, Chiang CE, Wong KL, Cheung T, Cheung BM, Feng YQ, Tan N, Chen JY, Yue WS, Hu HX, Chen L, Tse HF, Chan PH, Siu CW.

Circ J. 2019 Mar 25;83(4):809-817. doi: 10.1253/circj.CJ-18-0308. Epub 2019 Feb 22.


Periodontitis links to exacerbation of myocardial dysfunction in subjects with type 2 diabetes.

Wang Y, Zhen Z, Liu HN, Lai I, Pelekos G, Tse HF, Yiu KH, Jin L.

J Periodontal Res. 2019 Aug;54(4):339-348. doi: 10.1111/jre.12634. Epub 2019 Jan 11.


Impact of obesity on longitudinal changes to cardiac structure and function in patients with Type 2 diabetes mellitus.

Wu MZ, Chen Y, Zou Y, Zhen Z, Yu YJ, Liu YX, Yuen M, Ho LM, Siu-Ling Lam K, Tse HF, Yiu KH.

Eur Heart J Cardiovasc Imaging. 2019 Jul 1;20(7):816-827. doi: 10.1093/ehjci/jey217.


Mid-term outcomes of concomitant left atrial appendage closure and catheter ablation for non-valvular atrial fibrillation: a multicenter registry.

Liu FZ, Lin WD, Liao HT, Peng J, Xue YM, Zhan XZ, Zhu JM, Yiu KH, Li YF, Tse HF, Shi L, Fang XH, Wu SL.

Heart Vessels. 2019 May;34(5):860-867. doi: 10.1007/s00380-018-1312-4. Epub 2019 Jan 1.


Sudden Cardiac Death in Mainland China.

Feng XF, Hai JJ, Ma Y, Wang ZQ, Tse HF.

Circ Arrhythm Electrophysiol. 2018 Nov;11(11):e006684. doi: 10.1161/CIRCEP.118.006684. No abstract available.


Safety and feasibility of a midseptal implantation technique of a leadless pacemaker.

Hai JJ, Fang J, Tam CC, Wong CK, Un KC, Siu CW, Lau CP, Tse HF.

Heart Rhythm. 2019 Jun;16(6):896-902. doi: 10.1016/j.hrthm.2018.12.007. Epub 2018 Dec 11.


Enantiopure Aromatic Saddles Bearing the Fenestrindane Core.

Wong WS, Tse HW, Cheung E, Kuck D, Chow HF.

J Org Chem. 2019 Jan 18;84(2):869-878. doi: 10.1021/acs.joc.8b02719. Epub 2018 Dec 28.


Characteristics, Mechanism and Long-Term Ablation Outcome of Atrial Tachycardias After Mitral Valvular Surgery and Concomitant Cox-MAZE IV Procedure.

Zhan XZ, Liu FZ, Guo HM, Liao HT, Fang XH, Liu J, Deng H, Huang HL, Hai JJ, Tse HF, Li YQ, Xue YM, Wu SL.

Int Heart J. 2019 Jan 25;60(1):71-77. doi: 10.1536/ihj.18-117. Epub 2018 Dec 5.


Untreated Obstructive Sleep Apnea Is Associated With Myocardial Injury Independent of Blood Pressure Control in Hypertension.

Lui MMS, Tse HF, Mak JCW, Lam DCL, Chan CWS, Chong PWC, Ip MSM.

J Clin Sleep Med. 2018 Nov 15;14(11):1841-1847. doi: 10.5664/jcsm.7476.


Age-Biomarkers-Clinical Risk Factors for Prediction of Cardiovascular Events in Patients With Coronary Artery Disease.

Wong YK, Cheung CYY, Tang CS, Au KW, Hai JSH, Lee CH, Lau KK, Cheung BMY, Sham PC, Xu A, Lam KSL, Tse HF.

Arterioscler Thromb Vasc Biol. 2018 Oct;38(10):2519-2527. doi: 10.1161/ATVBAHA.118.311726.


Connexin 43-Mediated Mitochondrial Transfer of iPSC-MSCs Alleviates Asthma Inflammation.

Yao Y, Fan XL, Jiang D, Zhang Y, Li X, Xu ZB, Fang SB, Chiu S, Tse HF, Lian Q, Fu QL.

Stem Cell Reports. 2018 Nov 13;11(5):1120-1135. doi: 10.1016/j.stemcr.2018.09.012. Epub 2018 Oct 18.


Genetic Regulation of Pigment Epithelium-Derived Factor (PEDF): An Exome-Chip Association Analysis in Chinese Subjects With Type 2 Diabetes.

Cheung CYY, Lee CH, Tang CS, Xu A, Au KW, Fong CHY, Ng KKK, Kwok KHM, Chow WS, Woo YC, Yuen MMA, Hai J, Tan KCB, Lam TH, Tse HF, Sham PC, Lam KSL.

Diabetes. 2019 Jan;68(1):198-206. doi: 10.2337/db18-0500. Epub 2018 Oct 10.


Empagliflozin Ammeliorates High Glucose Induced-Cardiac Dysfuntion in Human iPSC-Derived Cardiomyocytes.

Ng KM, Lau YM, Dhandhania V, Cai ZJ, Lee YK, Lai WH, Tse HF, Siu CW.

Sci Rep. 2018 Oct 5;8(1):14872. doi: 10.1038/s41598-018-33293-2.


A Familial Hypercholesterolemia Human Liver Chimeric Mouse Model Using Induced Pluripotent Stem Cell-derived Hepatocytes.

Yang J, Wong LY, Tian XY, Wei R, Lai WH, Au KW, Luo Z, Ward C, Ho WI, Ibañez DP, Liu H, Bao X, Qin B, Huang Y, Esteban MA, Tse HF.

J Vis Exp. 2018 Sep 15;(139). doi: 10.3791/57556.


Predictive value of red cell distribution width on left atrial thrombus or left atrial spontaneous echo contrast in patients with non-valvular atrial fibrillation.

Zhan XZ, Lin WD, Liu FZ, Xue YM, Liao HT, Li X, Fang XH, Deng H, Huang J, Li YQ, Hai JJ, Tse HF, Wu SL.

J Geriatr Cardiol. 2018 Jun;15(6):408-412. doi: 10.11909/j.issn.1671-5411.2018.06.007.


Coverage and diagnostic yield of Whole Exome Sequencing for the Evaluation of Cases with Dilated and Hypertrophic Cardiomyopathy.

Mak TSH, Lee YK, Tang CS, Hai JSH, Ran X, Sham PC, Tse HF.

Sci Rep. 2018 Jul 18;8(1):10846. doi: 10.1038/s41598-018-29263-3.


Prognostic Value of Hepatorenal Function By Modified Model for End-stage Liver Disease (MELD) Score in Patients Undergoing Tricuspid Annuloplasty.

Chen Y, Liu YX, Seto WK, Wu MZ, Yu YJ, Lam YM, Au WK, Chan D, Sit KY, Ho LM, Tse HF, Yiu KH.

J Am Heart Assoc. 2018 Jul 13;7(14). pii: e009020. doi: 10.1161/JAHA.118.009020.


Clinical Benefit of Valvular Surgery in Patients with Chronic Kidney Disease.

Chen Y, Au WK, Chan D, Sit KY, Zhen Z, Ho KL, Wong D, Ho LM, Yap D, Lam YM, Lau CP, Tse HF, Chan TM, Yiu KH.

Int Heart J. 2018 Jul 31;59(4):759-765. doi: 10.1536/ihj.17-460. Epub 2018 Jun 20.


Publisher Correction: NCoR/SMRT co-repressors cooperate with c-MYC to create an epigenetic barrier to somatic cell reprogramming.

Zhuang Q, Li W, Benda C, Huang Z, Ahmed T, Liu P, Guo X, Ibañez DP, Luo Z, Zhang M, Abdul MM, Yang Z, Yang J, Huang Y, Zhang H, Huang D, Zhou J, Zhong X, Zhu X, Fu X, Fan W, Liu Y, Xu Y, Ward C, Khan MJ, Kanwal S, Mirza B, Tortorella MD, Tse HF, Chen J, Qin B, Bao X, Gao S, Hutchins AP, Esteban MA.

Nat Cell Biol. 2018 Oct;20(10):1227. doi: 10.1038/s41556-018-0128-x.


Sex differences underlying pancreatic islet biology and its dysfunction.

Gannon M, Kulkarni RN, Tse HM, Mauvais-Jarvis F.

Mol Metab. 2018 Sep;15:82-91. doi: 10.1016/j.molmet.2018.05.017. Epub 2018 May 30. Review.


Hybrid cardiac resynchronization with leadless pacemaker and transvenous coronary sinus lead.

Kwok SY, Tse HF.

Europace. 2018 Sep 1;20(9):1505. doi: 10.1093/europace/euy105. No abstract available.


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