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Items: 1 to 50 of 80

1.

PGC1α repression in IPF fibroblasts drives a pathologic metabolic, secretory and fibrogenic state.

Caporarello N, Meridew JA, Jones DL, Tan Q, Haak AJ, Choi KM, Manlove LJ, Prakash YS, Tschumperlin DJ, Ligresti G.

Thorax. 2019 Aug;74(8):749-760. doi: 10.1136/thoraxjnl-2019-213064. Epub 2019 Jun 10.

2.

CBX5/G9a/H3K9me-mediated gene repression is essential to fibroblast activation during lung fibrosis.

Ligresti G, Caporarello N, Meridew JA, Jones DL, Tan Q, Choi KM, Haak AJ, Aravamudhan A, Roden AC, Prakash YS, Lomberk G, Urrutia RA, Tschumperlin DJ.

JCI Insight. 2019 May 16;5. pii: 127111. doi: 10.1172/jci.insight.127111.

3.

Nascent Lung Organoids Reveal Epithelium- and BMP-Mediated Suppression of Fibroblast Activation.

Tan Q, Ma XY, Liu W, Meridew JA, Jones DL, Haak AJ, Sicard D, Ligresti G, Tschumperlin DJ.

Am J Respir Cell Mol Biol. 2019 May 3. doi: 10.1165/rcmb.2018-0390OC. [Epub ahead of print]

PMID:
31050552
4.

Profibrotic effect of IL-17A and elevated IL-17RA in idiopathic pulmonary fibrosis and rheumatoid arthritis-associated lung disease support a direct role for IL-17A/IL-17RA in human fibrotic interstitial lung disease.

Zhang J, Wang D, Wang L, Wang S, Roden AC, Zhao H, Li X, Prakash YS, Matteson EL, Tschumperlin DJ, Vassallo R.

Am J Physiol Lung Cell Mol Physiol. 2019 Mar 1;316(3):L487-L497. doi: 10.1152/ajplung.00301.2018. Epub 2019 Jan 3.

PMID:
30604628
5.

Hyperoxia-induced Cellular Senescence in Fetal Airway Smooth Muscle Cells.

Parikh P, Britt RD Jr, Manlove LJ, Wicher SA, Roesler A, Ravix J, Teske J, Thompson MA, Sieck GC, Kirkland JL, LeBrasseur N, Tschumperlin DJ, Pabelick CM, Prakash YS.

Am J Respir Cell Mol Biol. 2019 Jul;61(1):51-60. doi: 10.1165/rcmb.2018-0176OC.

PMID:
30508396
6.

Mechanobiological Feedback in Pulmonary Vascular Disease.

Dieffenbach PB, Maracle M, Tschumperlin DJ, Fredenburgh LE.

Front Physiol. 2018 Jul 25;9:951. doi: 10.3389/fphys.2018.00951. eCollection 2018. Review.

7.

Epigenome Editing Enters the Arena. A New Tool to Reveal (and Reverse?) Pathologic Gene Regulation.

Tan Q, Tschumperlin DJ.

Am J Respir Crit Care Med. 2018 Sep 1;198(5):549-551. doi: 10.1164/rccm.201807-1239ED. No abstract available.

PMID:
30016116
8.

Regulation of fibroblast Fas expression by soluble and mechanical pro-fibrotic stimuli.

Dodi AE, Ajayi IO, Chang C, Beard M, Ashley SL, Huang SK, Thannickal VJ, Tschumperlin DJ, Sisson TH, Horowitz JC.

Respir Res. 2018 May 10;19(1):91. doi: 10.1186/s12931-018-0801-4.

9.

RNAi screening identifies a mechanosensitive ROCK-JAK2-STAT3 network central to myofibroblast activation.

Oh RS, Haak AJ, Smith KMJ, Ligresti G, Choi KM, Xie T, Wang S, Walters PR, Thompson MA, Freeman MR, Manlove LJ, Chu VM, Feghali-Bostwick C, Roden AC, Schymeinsky J, Pabelick CM, Prakash YS, Vassallo R, Tschumperlin DJ.

J Cell Sci. 2018 May 15;131(10). pii: jcs209932. doi: 10.1242/jcs.209932.

10.

Extracellular matrix in lung development, homeostasis and disease.

Zhou Y, Horowitz JC, Naba A, Ambalavanan N, Atabai K, Balestrini J, Bitterman PB, Corley RA, Ding BS, Engler AJ, Hansen KC, Hagood JS, Kheradmand F, Lin QS, Neptune E, Niklason L, Ortiz LA, Parks WC, Tschumperlin DJ, White ES, Chapman HA, Thannickal VJ.

Matrix Biol. 2018 Nov;73:77-104. doi: 10.1016/j.matbio.2018.03.005. Epub 2018 Mar 8. Review.

PMID:
29524630
11.

Aging and anatomical variations in lung tissue stiffness.

Sicard D, Haak AJ, Choi KM, Craig AR, Fredenburgh LE, Tschumperlin DJ.

Am J Physiol Lung Cell Mol Physiol. 2018 Jun 1;314(6):L946-L955. doi: 10.1152/ajplung.00415.2017. Epub 2018 Feb 22.

12.

Targeting Senescent Cells in Fibrosis: Pathology, Paradox, and Practical Considerations.

Schafer MJ, Haak AJ, Tschumperlin DJ, LeBrasseur NK.

Curr Rheumatol Rep. 2018 Jan 26;20(1):3. doi: 10.1007/s11926-018-0712-x. Review.

PMID:
29374361
13.

Mechanosensing and fibrosis.

Tschumperlin DJ, Ligresti G, Hilscher MB, Shah VH.

J Clin Invest. 2018 Jan 2;128(1):74-84. doi: 10.1172/JCI93561. Epub 2018 Jan 2. Review.

14.

Matrix biomechanics and dynamics in pulmonary fibrosis.

Haak AJ, Tan Q, Tschumperlin DJ.

Matrix Biol. 2018 Nov;73:64-76. doi: 10.1016/j.matbio.2017.12.004. Epub 2017 Dec 21. Review.

PMID:
29274939
15.

Synectin promotes fibrogenesis by regulating PDGFR isoforms through distinct mechanisms.

Drinane MC, Yaqoob U, Yu H, Luo F, Greuter T, Arab JP, Kostallari E, Verma VK, Maiers J, De Assuncao TM, Simons M, Mukhopadhyay D, Kisseleva T, Brenner DA, Urrutia R, Lomberk G, Gao Y, Ligresti G, Tschumperlin DJ, Revzin A, Cao S, Shah VH.

JCI Insight. 2017 Dec 21;2(24). pii: 92821. doi: 10.1172/jci.insight.92821.

16.

Correction: Lysyl oxidases regulate fibrillar collagen remodelling in idiopathic pulmonary fibrosis (doi: 10.1242/dmm.030114).

Tjin G, White ES, Faiz A, Sicard D, Tschumperlin DJ, Mahar A, Kable EPW, Burgess JK.

Dis Model Mech. 2017 Dec 19;10(12):1545. doi: 10.1242/dmm.033191. No abstract available.

17.

Targeted apoptosis of myofibroblasts with the BH3 mimetic ABT-263 reverses established fibrosis.

Lagares D, Santos A, Grasberger PE, Liu F, Probst CK, Rahimi RA, Sakai N, Kuehl T, Ryan J, Bhola P, Montero J, Kapoor M, Baron M, Varelas X, Tschumperlin DJ, Letai A, Tager AM.

Sci Transl Med. 2017 Dec 13;9(420). pii: eaal3765. doi: 10.1126/scitranslmed.aal3765.

PMID:
29237758
18.

Lysyl oxidases regulate fibrillar collagen remodelling in idiopathic pulmonary fibrosis.

Tjin G, White ES, Faiz A, Sicard D, Tschumperlin DJ, Mahar A, Kable EPW, Burgess JK.

Dis Model Mech. 2017 Nov 1;10(11):1301-1312. doi: 10.1242/dmm.030114. Erratum in: Dis Model Mech. 2017 Dec 19;10 (12 ):1545.

19.

Arterial stiffness induces remodeling phenotypes in pulmonary artery smooth muscle cells via YAP/TAZ-mediated repression of cyclooxygenase-2.

Dieffenbach PB, Haeger CM, Coronata AMF, Choi KM, Varelas X, Tschumperlin DJ, Fredenburgh LE.

Am J Physiol Lung Cell Mol Physiol. 2017 Sep 1;313(3):L628-L647. doi: 10.1152/ajplung.00173.2017. Epub 2017 Jun 22.

20.

Measured pulmonary arterial tissue stiffness is highly sensitive to AFM indenter dimensions.

Sicard D, Fredenburgh LE, Tschumperlin DJ.

J Mech Behav Biomed Mater. 2017 Oct;74:118-127. doi: 10.1016/j.jmbbm.2017.05.039. Epub 2017 May 31.

21.

Phenylpyrrolidine structural mimics of pirfenidone lacking antifibrotic activity: A new tool for mechanism of action studies.

Haak AJ, Girtman MA, Ali MF, Carmona EM, Limper AH, Tschumperlin DJ.

Eur J Pharmacol. 2017 Sep 15;811:87-92. doi: 10.1016/j.ejphar.2017.05.050. Epub 2017 May 30.

22.

Zinc deficiency primes the lung for ventilator-induced injury.

Boudreault F, Pinilla-Vera M, Englert JA, Kho AT, Isabelle C, Arciniegas AJ, Barragan-Bradford D, Quintana C, Amador-Munoz D, Guan J, Choi KM; MICU Registry, Sholl L, Hurwitz S, Tschumperlin DJ, Baron RM.

JCI Insight. 2017 Jun 2;2(11). pii: 86507. doi: 10.1172/jci.insight.86507. eCollection 2017 Jun 2.

23.

Cellular senescence mediates fibrotic pulmonary disease.

Schafer MJ, White TA, Iijima K, Haak AJ, Ligresti G, Atkinson EJ, Oberg AL, Birch J, Salmonowicz H, Zhu Y, Mazula DL, Brooks RW, Fuhrmann-Stroissnigg H, Pirtskhalava T, Prakash YS, Tchkonia T, Robbins PD, Aubry MC, Passos JF, Kirkland JL, Tschumperlin DJ, Kita H, LeBrasseur NK.

Nat Commun. 2017 Feb 23;8:14532. doi: 10.1038/ncomms14532.

24.

TAZ activation drives fibroblast spheroid growth, expression of profibrotic paracrine signals, and context-dependent ECM gene expression.

Jorgenson AJ, Choi KM, Sicard D, Smith KM, Hiemer SE, Varelas X, Tschumperlin DJ.

Am J Physiol Cell Physiol. 2017 Mar 1;312(3):C277-C285. doi: 10.1152/ajpcell.00205.2016. Epub 2016 Nov 23.

25.

Human airway organoid engineering as a step toward lung regeneration and disease modeling.

Tan Q, Choi KM, Sicard D, Tschumperlin DJ.

Biomaterials. 2017 Jan;113:118-132. doi: 10.1016/j.biomaterials.2016.10.046. Epub 2016 Oct 28.

26.

Distal vessel stiffening is an early and pivotal mechanobiological regulator of vascular remodeling and pulmonary hypertension.

Liu F, Haeger CM, Dieffenbach PB, Sicard D, Chrobak I, Coronata AM, Suárez Velandia MM, Vitali S, Colas RA, Norris PC, Marinković A, Liu X, Ma J, Rose CD, Lee SJ, Comhair SA, Erzurum SC, McDonald JD, Serhan CN, Walsh SR, Tschumperlin DJ, Fredenburgh LE.

JCI Insight. 2016 Jun 2;1(8). pii: e86987.

27.

Nondestructive measurement of esophageal biaxial mechanical properties utilizing sonometry.

Aho JM, Qiang B, Wigle DA, Tschumperlin DJ, Urban MW.

Phys Med Biol. 2016 Jul 7;61(13):4781-95. doi: 10.1088/0031-9155/61/13/4781. Epub 2016 Jun 8.

28.

Matrix-driven Myosin II Mediates the Pro-fibrotic Fibroblast Phenotype.

Southern BD, Grove LM, Rahaman SO, Abraham S, Scheraga RG, Niese KA, Sun H, Herzog EL, Liu F, Tschumperlin DJ, Egelhoff TT, Rosenfeld SS, Olman MA.

J Biol Chem. 2016 Mar 18;291(12):6083-95. doi: 10.1074/jbc.M115.712380. Epub 2016 Jan 13.

29.

Use of Shear Wave Ultrasound Vibrometry for Detection of Simulated Esophageal Malignancy in Ex Vivo Porcine Esophagi.

Aho JM, Nenadic IZ, Aristizabal S, Wigle DA, Tschumperlin DJ, Urban MW.

Biomed Phys Eng Express. 2016;2(6). pii: 065002. doi: 10.1088/2057-1976/2/6/065002. Epub 2016 Nov 23.

30.

Coming to terms with tissue engineering and regenerative medicine in the lung.

Prakash YS, Tschumperlin DJ, Stenmark KR.

Am J Physiol Lung Cell Mol Physiol. 2015 Oct 1;309(7):L625-38. doi: 10.1152/ajplung.00204.2015. Epub 2015 Aug 7. Review.

31.

Unjamming and cell shape in the asthmatic airway epithelium.

Park JA, Kim JH, Bi D, Mitchel JA, Qazvini NT, Tantisira K, Park CY, McGill M, Kim SH, Gweon B, Notbohm J, Steward R Jr, Burger S, Randell SH, Kho AT, Tambe DT, Hardin C, Shore SA, Israel E, Weitz DA, Tschumperlin DJ, Henske EP, Weiss ST, Manning ML, Butler JP, Drazen JM, Fredberg JJ.

Nat Mater. 2015 Oct;14(10):1040-8. doi: 10.1038/nmat4357. Epub 2015 Aug 3.

32.

High-throughput screening for modulators of cellular contractile force.

Park CY, Zhou EH, Tambe D, Chen B, Lavoie T, Dowell M, Simeonov A, Maloney DJ, Marinkovic A, Tschumperlin DJ, Burger S, Frykenberg M, Butler JP, Stamer WD, Johnson M, Solway J, Fredberg JJ, Krishnan R.

Integr Biol (Camb). 2015 Oct;7(10):1318-24. doi: 10.1039/c5ib00054h. Epub 2015 May 8.

33.

Matrix, mesenchyme, and mechanotransduction.

Tschumperlin DJ.

Ann Am Thorac Soc. 2015 Mar;12 Suppl 1:S24-9. doi: 10.1513/AnnalsATS.201407-320MG. Review.

34.

Matrix stiffness-modulated proliferation and secretory function of the airway smooth muscle cells.

Shkumatov A, Thompson M, Choi KM, Sicard D, Baek K, Kim DH, Tschumperlin DJ, Prakash YS, Kong H.

Am J Physiol Lung Cell Mol Physiol. 2015 Jun 1;308(11):L1125-35. doi: 10.1152/ajplung.00154.2014. Epub 2015 Feb 27.

35.

Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis.

Liu F, Lagares D, Choi KM, Stopfer L, Marinković A, Vrbanac V, Probst CK, Hiemer SE, Sisson TH, Horowitz JC, Rosas IO, Fredenburgh LE, Feghali-Bostwick C, Varelas X, Tager AM, Tschumperlin DJ.

Am J Physiol Lung Cell Mol Physiol. 2015 Feb 15;308(4):L344-57. doi: 10.1152/ajplung.00300.2014. Epub 2014 Dec 12.

36.

TRPV4 mediates myofibroblast differentiation and pulmonary fibrosis in mice.

Rahaman SO, Grove LM, Paruchuri S, Southern BD, Abraham S, Niese KA, Scheraga RG, Ghosh S, Thodeti CK, Zhang DX, Moran MM, Schilling WP, Tschumperlin DJ, Olman MA.

J Clin Invest. 2014 Dec;124(12):5225-38. doi: 10.1172/JCI75331. Epub 2014 Nov 3.

37.

Matrix biology of idiopathic pulmonary fibrosis: a workshop report of the national heart, lung, and blood institute.

Thannickal VJ, Henke CA, Horowitz JC, Noble PW, Roman J, Sime PJ, Zhou Y, Wells RG, White ES, Tschumperlin DJ.

Am J Pathol. 2014 Jun;184(6):1643-51. doi: 10.1016/j.ajpath.2014.02.003. Epub 2014 Apr 13. Review.

38.

Soft matrix is a natural stimulator for cellular invasiveness.

Gu Z, Liu F, Tonkova EA, Lee SY, Tschumperlin DJ, Brenner MB.

Mol Biol Cell. 2014 Feb;25(4):457-69. doi: 10.1091/mbc.E13-05-0260. Epub 2013 Dec 11.

39.

Fibroblasts and the ground they walk on.

Tschumperlin DJ.

Physiology (Bethesda). 2013 Nov;28(6):380-90. doi: 10.1152/physiol.00024.2013. Review.

40.

Human neutrophil elastase-mediated goblet cell metaplasia is attenuated in TACE-deficient mice.

Park JA, Sharif AS, Shiomi T, Kobzik L, Kasahara DI, Tschumperlin DJ, Voynow J, Drazen JM.

Am J Physiol Lung Cell Mol Physiol. 2013 May 15;304(10):L701-7. doi: 10.1152/ajplung.00259.2012. Epub 2013 Apr 5.

41.

Matrix stiffness corresponding to strictured bowel induces a fibrogenic response in human colonic fibroblasts.

Johnson LA, Rodansky ES, Sauder KL, Horowitz JC, Mih JD, Tschumperlin DJ, Higgins PD.

Inflamm Bowel Dis. 2013 Apr;19(5):891-903. doi: 10.1097/MIB.0b013e3182813297.

42.

Matrices of physiologic stiffness potently inactivate idiopathic pulmonary fibrosis fibroblasts.

Marinković A, Liu F, Tschumperlin DJ.

Am J Respir Cell Mol Biol. 2013 Apr;48(4):422-30. doi: 10.1165/rcmb.2012-0335OC.

43.

The fibrotic matrix in control: does the extracellular matrix drive progression of idiopathic pulmonary fibrosis?

Tschumperlin DJ, Jones JC, Senior RM.

Am J Respir Crit Care Med. 2012 Nov 1;186(9):814-6. doi: 10.1164/rccm.201208-1561ED. No abstract available.

PMID:
23118079
44.

Biomechanical regulation of mesenchymal cell function.

Tschumperlin DJ, Liu F, Tager AM.

Curr Opin Rheumatol. 2013 Jan;25(1):92-100. doi: 10.1097/BOR.0b013e32835b13cd. Review.

45.

Matrix stiffness reverses the effect of actomyosin tension on cell proliferation.

Mih JD, Marinkovic A, Liu F, Sharif AS, Tschumperlin DJ.

J Cell Sci. 2012 Dec 15;125(Pt 24):5974-83. doi: 10.1242/jcs.108886. Epub 2012 Oct 24.

46.

Tissue factor-bearing exosome secretion from human mechanically stimulated bronchial epithelial cells in vitro and in vivo.

Park JA, Sharif AS, Tschumperlin DJ, Lau L, Limbrey R, Howarth P, Drazen JM.

J Allergy Clin Immunol. 2012 Dec;130(6):1375-83. doi: 10.1016/j.jaci.2012.05.031. Epub 2012 Jul 22.

47.

Improved throughput traction microscopy reveals pivotal role for matrix stiffness in fibroblast contractility and TGF-β responsiveness.

Marinković A, Mih JD, Park JA, Liu F, Tschumperlin DJ.

Am J Physiol Lung Cell Mol Physiol. 2012 Aug 1;303(3):L169-80. doi: 10.1152/ajplung.00108.2012. Epub 2012 Jun 1.

48.

Matrix rigidity regulates cancer cell growth by modulating cellular metabolism and protein synthesis.

Tilghman RW, Blais EM, Cowan CR, Sherman NE, Grigera PR, Jeffery ED, Fox JW, Blackman BR, Tschumperlin DJ, Papin JA, Parsons JT.

PLoS One. 2012;7(5):e37231. doi: 10.1371/journal.pone.0037231. Epub 2012 May 18.

49.

Micro-mechanical characterization of lung tissue using atomic force microscopy.

Liu F, Tschumperlin DJ.

J Vis Exp. 2011 Aug 28;(54). pii: 2911. doi: 10.3791/2911.

50.

A multiwell platform for studying stiffness-dependent cell biology.

Mih JD, Sharif AS, Liu F, Marinkovic A, Symer MM, Tschumperlin DJ.

PLoS One. 2011;6(5):e19929. doi: 10.1371/journal.pone.0019929. Epub 2011 May 27.

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