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Bacillus cereus non-haemolytic enterotoxin activates the NLRP3 inflammasome.

Fox D, Mathur A, Xue Y, Liu Y, Tan WH, Feng S, Pandey A, Ngo C, Hayward JA, Atmosukarto II, Price JD, Johnson MD, Jessberger N, Robertson AAB, Burgio G, Tscharke DC, Fox EM, Leyton DL, Kaakoush NO, Märtlbauer E, Leppla SH, Man SM.

Nat Commun. 2020 Feb 6;11(1):760. doi: 10.1038/s41467-020-14534-3.


Herpes Simplex Virus Latency Is Noisier the Closer We Look.

Singh N, Tscharke DC.

J Virol. 2020 Jan 31;94(4). pii: e01701-19. doi: 10.1128/JVI.01701-19. Print 2020 Jan 31. Review.


CRISPR/Cas9-Based Genome Editing of HSV.

Velusamy T, Gowripalan A, Tscharke DC.

Methods Mol Biol. 2020;2060:169-183. doi: 10.1007/978-1-4939-9814-2_9.


Modified Vaccinia Virus Ankara Can Induce Optimal CD8+ T Cell Responses to Directly Primed Antigens Depending on Vaccine Design.

Wong YC, Croft S, Smith SA, Lin LCW, Cukalac T, La Gruta NL, Drexler I, Tscharke DC.

J Virol. 2019 Oct 15;93(21). pii: e01154-19. doi: 10.1128/JVI.01154-19. Print 2019 Nov 1.


Quantification of epitope abundance reveals the effect of direct and cross-presentation on influenza CTL responses.

Wu T, Guan J, Handel A, Tscharke DC, Sidney J, Sette A, Wakim LM, Sng XYX, Thomas PG, Croft NP, Purcell AW, La Gruta NL.

Nat Commun. 2019 Jun 28;10(1):2846. doi: 10.1038/s41467-019-10661-8.


Functional paralysis of human natural killer cells by alphaherpesviruses.

Campbell TM, McSharry BP, Steain M, Russell TA, Tscharke DC, Kennedy JJ, Slobedman B, Abendroth A.

PLoS Pathog. 2019 Jun 13;15(6):e1007784. doi: 10.1371/journal.ppat.1007784. eCollection 2019 Jun.


Influenza A Virus Infection Induces Viral and Cellular Defective Ribosomal Products Encoded by Alternative Reading Frames.

Zanker DJ, Oveissi S, Tscharke DC, Duan M, Wan S, Zhang X, Xiao K, Mifsud NA, Gibbs J, Izzard L, Dlugolenski D, Faou P, Laurie KL, Vigneron N, Barr IG, Stambas J, Van den Eynde BJ, Bennink JR, Yewdell JW, Chen W.

J Immunol. 2019 Jun 15;202(12):3370-3380. doi: 10.4049/jimmunol.1900070. Epub 2019 May 15.


Most viral peptides displayed by class I MHC on infected cells are immunogenic.

Croft NP, Smith SA, Pickering J, Sidney J, Peters B, Faridi P, Witney MJ, Sebastian P, Flesch IEA, Heading SL, Sette A, La Gruta NL, Purcell AW, Tscharke DC.

Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):3112-3117. doi: 10.1073/pnas.1815239116. Epub 2019 Feb 4.


Tissue-resident memory T cells in tissue homeostasis, persistent infection, and cancer surveillance.

Gebhardt T, Palendira U, Tscharke DC, Bedoui S.

Immunol Rev. 2018 May;283(1):54-76. doi: 10.1111/imr.12650. Review.


Increasing antigen presentation on HSV-1-infected cells increases lesion size but does not alter neural infection or latency.

Russell TA, Velusamy T, Tseng YY, Tscharke DC.

J Gen Virol. 2018 May;99(5):682-692. doi: 10.1099/jgv.0.001059. Epub 2018 Apr 5.


An ultrastructural investigation of tumors undergoing regression mediated by immunotherapy.

Westwood JA, Ellis S, Danne J, Johnson C, Oorschot V, Ramm G, Tscharke DC, Davenport AJ, Whisstock JC, Darcy PK, Kershaw MH, Slaney CY.

Oncotarget. 2017 Dec 14;8(70):115215-115229. doi: 10.18632/oncotarget.23215. eCollection 2017 Dec 29.


Local proliferation maintains a stable pool of tissue-resident memory T cells after antiviral recall responses.

Park SL, Zaid A, Hor JL, Christo SN, Prier JE, Davies B, Alexandre YO, Gregory JL, Russell TA, Gebhardt T, Carbone FR, Tscharke DC, Heath WR, Mueller SN, Mackay LK.

Nat Immunol. 2018 Feb;19(2):183-191. doi: 10.1038/s41590-017-0027-5. Epub 2018 Jan 8.


Effective Priming of Herpes Simplex Virus-Specific CD8+ T Cells In Vivo Does Not Require Infected Dendritic Cells.

Whitney PG, Makhlouf C, MacLeod B, Ma JZ, Gressier E, Greyer M, Hochheiser K, Bachem A, Zaid A, Voehringer D, Heath WR, Wagle MV, Parish I, Russell TA, Smith SA, Tscharke DC, Gebhardt T, Bedoui S.

J Virol. 2018 Jan 17;92(3). pii: e01508-17. doi: 10.1128/JVI.01508-17. Print 2018 Feb 1.


Systems-guided forward genetic screen reveals a critical role of the replication stress response protein ETAA1 in T cell clonal expansion.

Miosge LA, Sontani Y, Chuah A, Horikawa K, Russell TA, Mei Y, Wagle MV, Howard DR, Enders A, Tscharke DC, Goodnow CC, Parish IA.

Proc Natl Acad Sci U S A. 2017 Jun 27;114(26):E5216-E5225. doi: 10.1073/pnas.1705795114. Epub 2017 Jun 12.


Dual-specific Chimeric Antigen Receptor T Cells and an Indirect Vaccine Eradicate a Variety of Large Solid Tumors in an Immunocompetent, Self-antigen Setting.

Slaney CY, von Scheidt B, Davenport AJ, Beavis PA, Westwood JA, Mardiana S, Tscharke DC, Ellis S, Prince HM, Trapani JA, Johnstone RW, Smyth MJ, Teng MW, Ali A, Yu Z, Rosenberg SA, Restifo NP, Neeson P, Darcy PK, Kershaw MH.

Clin Cancer Res. 2017 May 15;23(10):2478-2490. doi: 10.1158/1078-0432.CCR-16-1860. Epub 2016 Dec 13.


Ectromelia virus N1L is essential for virulence but not dissemination in a classical model of mousepox.

Melo-Silva CR, Tscharke DC, Lobigs M, Koskinen A, Müllbacher A, Regner M.

Virus Res. 2017 Jan 15;228:61-65. doi: 10.1016/j.virusres.2016.11.017. Epub 2016 Nov 16.


Lytic Promoters Express Protein during Herpes Simplex Virus Latency.

Russell TA, Tscharke DC.

PLoS Pathog. 2016 Jun 27;12(6):e1005729. doi: 10.1371/journal.ppat.1005729. eCollection 2016 Jun.


The Epstein-Barr Virus Glycoprotein gp150 Forms an Immune-Evasive Glycan Shield at the Surface of Infected Cells.

Gram AM, Oosenbrug T, Lindenbergh MF, Büll C, Comvalius A, Dickson KJ, Wiegant J, Vrolijk H, Lebbink RJ, Wolterbeek R, Adema GJ, Griffioen M, Heemskerk MH, Tscharke DC, Hutt-Fletcher LM, Wiertz EJ, Hoeben RC, Ressing ME.

PLoS Pathog. 2016 Apr 14;12(4):e1005550. doi: 10.1371/journal.ppat.1005550. eCollection 2016 Apr.


Immunology by numbers: quantitation of antigen presentation completes the quantitative milieu of systems immunology!

Purcell AW, Croft NP, Tscharke DC.

Curr Opin Immunol. 2016 Jun;40:88-95. doi: 10.1016/j.coi.2016.03.007. Epub 2016 Apr 6. Review.


Sizing up the key determinants of the CD8(+) T cell response.

Tscharke DC, Croft NP, Doherty PC, La Gruta NL.

Nat Rev Immunol. 2015 Nov;15(11):705-16. doi: 10.1038/nri3905. Epub 2015 Oct 9. Review.


Redundancy complicates the definition of essential genes for vaccinia virus.

Dobson BM, Tscharke DC.

J Gen Virol. 2015 Nov;96(11):3326-37.


Extent of Systemic Spread Determines CD8+ T Cell Immunodominance for Laboratory Strains, Smallpox Vaccines, and Zoonotic Isolates of Vaccinia Virus.

Flesch IE, Hollett NA, Wong YC, Quinan BR, Howard D, da Fonseca FG, Tscharke DC.

J Immunol. 2015 Sep 1;195(5):2263-72. doi: 10.4049/jimmunol.1402508. Epub 2015 Jul 20.


Quantifying epitope presentation using mass spectrometry.

Croft NP, Purcell AW, Tscharke DC.

Mol Immunol. 2015 Dec;68(2 Pt A):77-80. doi: 10.1016/j.molimm.2015.06.010. Epub 2015 Jun 25. Review.


Delayed control of herpes simplex virus infection and impaired CD4(+) T-cell migration to the skin in mouse models of DOCK8 deficiency.

Flesch IE, Randall KL, Hollett NA, Di Law H, Miosge LA, Sontani Y, Goodnow CC, Tscharke DC.

Immunol Cell Biol. 2015 Jul;93(6):517-21. doi: 10.1038/icb.2015.32. Epub 2015 Mar 17.


Simultaneous Quantification of Viral Antigen Expression Kinetics Using Data-Independent (DIA) Mass Spectrometry.

Croft NP, de Verteuil DA, Smith SA, Wong YC, Schittenhelm RB, Tscharke DC, Purcell AW.

Mol Cell Proteomics. 2015 May;14(5):1361-72. doi: 10.1074/mcp.M114.047373. Epub 2015 Mar 9.


Engineering herpes simplex viruses by infection-transfection methods including recombination site targeting by CRISPR/Cas9 nucleases.

Russell TA, Stefanovic T, Tscharke DC.

J Virol Methods. 2015 Mar;213:18-25. doi: 10.1016/j.jviromet.2014.11.009. Epub 2014 Dec 3.


The cellular redox environment alters antigen presentation.

Trujillo JA, Croft NP, Dudek NL, Channappanavar R, Theodossis A, Webb AI, Dunstone MA, Illing PT, Butler NS, Fett C, Tscharke DC, Rossjohn J, Perlman S, Purcell AW.

J Biol Chem. 2014 Oct 3;289(40):27979-91. doi: 10.1074/jbc.M114.573402. Epub 2014 Aug 18.


Distinct APC subtypes drive spatially segregated CD4+ and CD8+ T-cell effector activity during skin infection with HSV-1.

Macleod BL, Bedoui S, Hor JL, Mueller SN, Russell TA, Hollett NA, Heath WR, Tscharke DC, Brooks AG, Gebhardt T.

PLoS Pathog. 2014 Aug 14;10(8):e1004303. doi: 10.1371/journal.ppat.1004303. eCollection 2014 Aug.


Lytic gene expression is frequent in HSV-1 latent infection and correlates with the engagement of a cell-intrinsic transcriptional response.

Ma JZ, Russell TA, Spelman T, Carbone FR, Tscharke DC.

PLoS Pathog. 2014 Jul 24;10(7):e1004237. doi: 10.1371/journal.ppat.1004237. eCollection 2014 Jul. Erratum in: PLoS Pathog. 2014 Aug;10(8):e1004361.


Vaccinia virus F5 is required for normal plaque morphology in multiple cell lines but not replication in culture or virulence in mice.

Dobson BM, Procter DJ, Hollett NA, Flesch IE, Newsome TP, Tscharke DC.

Virology. 2014 May;456-457:145-56. doi: 10.1016/j.virol.2014.03.020. Epub 2014 Apr 5.


An intact signal peptide on dengue virus E protein enhances immunogenicity for CD8(+) T cells and antibody when expressed from modified vaccinia Ankara.

Quinan BR, Flesch IE, Pinho TM, Coelho FM, Tscharke DC, da Fonseca FG.

Vaccine. 2014 May 23;32(25):2972-9. doi: 10.1016/j.vaccine.2014.03.093. Epub 2014 Apr 14.


Strikingly poor CD8+ T-cell immunogenicity of vaccinia virus strain MVA in BALB/c mice.

Russell TA, Tscharke DC.

Immunol Cell Biol. 2014 May-Jun;92(5):466-9. doi: 10.1038/icb.2014.10. Epub 2014 Feb 25.


The developmental pathway for CD103(+)CD8+ tissue-resident memory T cells of skin.

Mackay LK, Rahimpour A, Ma JZ, Collins N, Stock AT, Hafon ML, Vega-Ramos J, Lauzurica P, Mueller SN, Stefanovic T, Tscharke DC, Heath WR, Inouye M, Carbone FR, Gebhardt T.

Nat Immunol. 2013 Dec;14(12):1294-301. doi: 10.1038/ni.2744. Epub 2013 Oct 27.


Truncation of gene F5L partially masks rescue of vaccinia virus strain MVA growth on mammalian cells by restricting plaque size.

Dobson BM, Tscharke DC.

J Gen Virol. 2014 Feb;95(Pt 2):466-71. doi: 10.1099/vir.0.058495-0. Epub 2013 Oct 21.


Genome scale evolution of myxoma virus reveals host-pathogen adaptation and rapid geographic spread.

Kerr PJ, Rogers MB, Fitch A, Depasse JV, Cattadori IM, Twaddle AC, Hudson PJ, Tscharke DC, Read AF, Holmes EC, Ghedin E.

J Virol. 2013 Dec;87(23):12900-15. doi: 10.1128/JVI.02060-13. Epub 2013 Sep 25.


Comparative analysis of the complete genome sequence of the California MSW strain of myxoma virus reveals potential host adaptations.

Kerr PJ, Rogers MB, Fitch A, Depasse JV, Cattadori IM, Hudson PJ, Tscharke DC, Holmes EC, Ghedin E.

J Virol. 2013 Nov;87(22):12080-9. doi: 10.1128/JVI.01923-13. Epub 2013 Aug 28.


Systemic toll-like receptor ligation and selective killing of dendritic cell subsets fail to dissect priming pathways for anti-vaccinia virus CD8⁺ T cells.

Wong YC, Smith SA, Tscharke DC.

J Virol. 2013 Nov;87(22):11978-86. doi: 10.1128/JVI.01835-13. Epub 2013 Aug 28.


IL-4 and IL-13 mediated down-regulation of CD8 expression levels can dampen anti-viral CD8⁺ T cell avidity following HIV-1 recombinant pox viral vaccination.

Wijesundara DK, Jackson RJ, Tscharke DC, Ranasinghe C.

Vaccine. 2013 Sep 23;31(41):4548-55. doi: 10.1016/j.vaccine.2013.07.062. Epub 2013 Aug 6.


Immunodomination during peripheral vaccinia virus infection.

Lin LC, Flesch IE, Tscharke DC.

PLoS Pathog. 2013;9(4):e1003329. doi: 10.1371/journal.ppat.1003329. Epub 2013 Apr 25.


Reduced interleukin-4 receptor α expression on CD8+ T cells correlates with higher quality anti-viral immunity.

Wijesundara DK, Tscharke DC, Jackson RJ, Ranasinghe C.

PLoS One. 2013;8(1):e55788. doi: 10.1371/journal.pone.0055788. Epub 2013 Jan 31.


Kinetics of antigen expression and epitope presentation during virus infection.

Croft NP, Smith SA, Wong YC, Tan CT, Dudek NL, Flesch IE, Lin LC, Tscharke DC, Purcell AW.

PLoS Pathog. 2013 Jan;9(1):e1003129. doi: 10.1371/journal.ppat.1003129. Epub 2013 Jan 31.


Evolutionary history and attenuation of myxoma virus on two continents.

Kerr PJ, Ghedin E, DePasse JV, Fitch A, Cattadori IM, Hudson PJ, Tscharke DC, Read AF, Holmes EC.

PLoS Pathog. 2012;8(10):e1002950. doi: 10.1371/journal.ppat.1002950. Epub 2012 Oct 4.


Linear fidelity in quantification of anti-viral CD8+ T cells.

Flesch IE, Hollett NA, Wong YC, Tscharke DC.

PLoS One. 2012;7(6):e39533. doi: 10.1371/journal.pone.0039533. Epub 2012 Jun 20.


Analyzing CD8 T cells in mouse models of poxvirus infection.

Flesch IE, Wong YC, Tscharke DC.

Methods Mol Biol. 2012;890:199-218. doi: 10.1007/978-1-61779-876-4_12.


An intradermal model for vaccinia virus pathogenesis in mice.

Lin LC, Smith SA, Tscharke DC.

Methods Mol Biol. 2012;890:147-59. doi: 10.1007/978-1-61779-876-4_9.


The ectromelia virus SPI-2 protein causes lethal mousepox by preventing NK cell responses.

Melo-Silva CR, Tscharke DC, Lobigs M, Koskinen A, Wong YC, Buller RM, Müllbacher A, Regner M.

J Virol. 2011 Nov;85(21):11170-82. doi: 10.1128/JVI.00256-11. Epub 2011 Aug 17.


Engineering recombinant poxviruses using a compact GFP-blasticidin resistance fusion gene for selection.

Wong YC, Lin LC, Melo-Silva CR, Smith SA, Tscharke DC.

J Virol Methods. 2011 Jan;171(1):295-8. doi: 10.1016/j.jviromet.2010.11.003. Epub 2010 Nov 10.


Analysis of A47, an immunoprevalent protein of vaccinia virus, leads to a reevaluation of the total antiviral CD8+ T cell response.

Yuen TJ, Flesch IE, Hollett NA, Dobson BM, Russell TA, Fahrer AM, Tscharke DC.

J Virol. 2010 Oct;84(19):10220-9. doi: 10.1128/JVI.01281-10. Epub 2010 Jul 28.


Uncovering the interplay between CD8, CD4 and antibody responses to complex pathogens.

Moutaftsi M, Tscharke DC, Vaughan K, Koelle DM, Stern L, Calvo-Calle M, Ennis F, Terajima M, Sutter G, Crotty S, Drexler I, Franchini G, Yewdell JW, Head SR, Blum J, Peters B, Sette A.

Future Microbiol. 2010 Feb;5(2):221-39. doi: 10.2217/fmb.09.110. Review.


Altered CD8(+) T cell immunodominance after vaccinia virus infection and the naive repertoire in inbred and F(1) mice.

Flesch IE, Woo WP, Wang Y, Panchanathan V, Wong YC, La Gruta NL, Cukalac T, Tscharke DC.

J Immunol. 2010 Jan 1;184(1):45-55. doi: 10.4049/jimmunol.0900999. Epub 2009 Nov 30.

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