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Tissue-regenerative potential of the secretome of γ-irradiated peripheral blood mononuclear cells is mediated via TNFRSF1B-induced necroptosis.

Simader E, Beer L, Laggner M, Vorstandlechner V, Gugerell A, Erb M, Kalinina P, Copic D, Moser D, Spittler A, Tschachler E, Jan Ankersmit H, Mildner M.

Cell Death Dis. 2019 Sep 30;10(10):729. doi: 10.1038/s41419-019-1974-6.


Autophagic Control of Skin Aging.

Eckhart L, Tschachler E, Gruber F.

Front Cell Dev Biol. 2019 Jul 30;7:143. doi: 10.3389/fcell.2019.00143. eCollection 2019. Review.


Comparative genomics suggests loss of keratin K24 in three evolutionary lineages of mammals.

Ehrlich F, Laggner M, Langbein L, Burger P, Pollreisz A, Tschachler E, Eckhart L.

Sci Rep. 2019 Jul 29;9(1):10924. doi: 10.1038/s41598-019-47422-y.


A Stress Response Program at the Origin of Evolutionary Innovation in the Skin.

Eckhart L, Ehrlich F, Tschachler E.

Evol Bioinform Online. 2019 Jul 3;15:1176934319862246. doi: 10.1177/1176934319862246. eCollection 2019.


Extracellular Vesicles in Human Skin: Cross-Talk from Senescent Fibroblasts to Keratinocytes by miRNAs.

Terlecki-Zaniewicz L, Pils V, Bobbili MR, Lämmermann I, Perrotta I, Grillenberger T, Schwestka J, Weiß K, Pum D, Arcalis E, Schwingenschuh S, Birngruber T, Brandstetter M, Heuser T, Schosserer M, Morizot F, Mildner M, Stöger E, Tschachler E, Weinmüllner R, Gruber F, Grillari J.

J Invest Dermatol. 2019 Jun 18. pii: S0022-202X(19)31754-3. doi: 10.1016/j.jid.2019.05.015. [Epub ahead of print]


The Differentiation-Associated Keratinocyte Protein Cornifelin Contributes to Cell-Cell Adhesion of Epidermal and Mucosal Keratinocytes.

Wagner T, Beer L, Gschwandtner M, Eckhart L, Kalinina P, Laggner M, Ellinger A, Gruber R, Kuchler U, Golabi B, Tschachler E, Mildner M.

J Invest Dermatol. 2019 May 24. pii: S0022-202X(19)31569-6. doi: 10.1016/j.jid.2019.04.019. [Epub ahead of print]


Immunolocalization and phylogenetic profiling of the feather protein with the highest cysteine content.

Lachner J, Ehrlich F, Mlitz V, Hermann M, Alibardi L, Tschachler E, Eckhart L.

Protoplasma. 2019 Sep;256(5):1257-1265. doi: 10.1007/s00709-019-01381-3. Epub 2019 Apr 29.


European S2k Guideline on Chronic Pruritus.

Weisshaar E, Szepietowski JC, Dalgard FJ, Garcovich S, Gieler U, Giménez-Arnau AM, Lambert J, Leslie T, Mettang T, Misery L, Şavk E, Streit M, Tschachler E, Wallengren J, Ständer S.

Acta Derm Venereol. 2019 Apr 1;99(5):469-506. doi: 10.2340/00015555-3164.


Different pro-angiogenic potential of γ-irradiated PBMC-derived secretome and its subfractions.

Wagner T, Traxler D, Simader E, Beer L, Narzt MS, Gruber F, Madlener S, Laggner M, Erb M, Vorstandlechner V, Gugerell A, Radtke C, Gnecchi M, Peterbauer A, Gschwandtner M, Tschachler E, Keibl C, Slezak P, Ankersmit HJ, Mildner M.

Sci Rep. 2018 Dec 20;8(1):18016. doi: 10.1038/s41598-018-36928-6.


Cornification of nail keratinocytes requires autophagy for bulk degradation of intracellular proteins while sparing components of the cytoskeleton.

Jaeger K, Sukseree S, Zhong S, Phinney BS, Mlitz V, Buchberger M, Narzt MS, Gruber F, Tschachler E, Rice RH, Eckhart L.

Apoptosis. 2019 Feb;24(1-2):62-73. doi: 10.1007/s10495-018-1505-4.


Differential Evolution of the Epidermal Keratin Cytoskeleton in Terrestrial and Aquatic Mammals.

Ehrlich F, Fischer H, Langbein L, Praetzel-Wunder S, Ebner B, Figlak K, Weissenbacher A, Sipos W, Tschachler E, Eckhart L.

Mol Biol Evol. 2019 Feb 1;36(2):328-340. doi: 10.1093/molbev/msy214.


A novel role for NUPR1 in the keratinocyte stress response to UV oxidized phospholipids.

Narzt MS, Nagelreiter IM, Oskolkova O, Bochkov VN, Latreille J, Fedorova M, Ni Z, Sialana FJ, Lubec G, Filzwieser M, Laggner M, Bilban M, Mildner M, Tschachler E, Grillari J, Gruber F.

Redox Biol. 2019 Jan;20:467-482. doi: 10.1016/j.redox.2018.11.006. Epub 2018 Nov 13.


Establishment of keratinocyte cell lines from human hair follicles.

Wagner T, Gschwandtner M, Strajeriu A, Elbe-Bürger A, Grillari J, Grillari-Voglauer R, Greiner G, Golabi B, Tschachler E, Mildner M.

Sci Rep. 2018 Sep 7;8(1):13434. doi: 10.1038/s41598-018-31829-0.


Inactivation of autophagy leads to changes in sebaceous gland morphology and function.

Rossiter H, Stübiger G, Gröger M, König U, Gruber F, Sukseree S, Mlitz V, Buchberger M, Oskolkova O, Bochkov V, Eckhart L, Tschachler E.

Exp Dermatol. 2018 Oct;27(10):1142-1151. doi: 10.1111/exd.13752. Epub 2018 Aug 20.


Control of cell death-associated danger signals during cornification prevents autoinflammation of the skin.

Eckhart L, Tschachler E.

Exp Dermatol. 2018 Aug;27(8):884-891. doi: 10.1111/exd.13700.


Blocking negative effects of senescence in human skin fibroblasts with a plant extract.

Lämmermann I, Terlecki-Zaniewicz L, Weinmüllner R, Schosserer M, Dellago H, de Matos Branco AD, Autheried D, Sevcnikar B, Kleissl L, Berlin I, Morizot F, Lejeune F, Fuzzati N, Forestier S, Toribio A, Tromeur A, Weinberg L, Higareda Almaraz JC, Scheideler M, Rietveld M, El Ghalbzouri A, Tschachler E, Gruber F, Grillari J.

NPJ Aging Mech Dis. 2018 Apr 11;4:4. doi: 10.1038/s41514-018-0023-5. eCollection 2018.


A genome wide association study identifies new genes potentially associated with eyelid sagging.

Laville V, Le Clerc S, Ezzedine K, Jdid R, Taing L, Labib T, Coulonges C, Ulveling D, Galan P, Guinot C, Fezeu L, Morizot F, Latreille J, Malvy D, Tschachler E, Zagury JF.

Exp Dermatol. 2019 Aug;28(8):892-898. doi: 10.1111/exd.13559. Epub 2018 Jun 28.


Suppression of Epithelial Autophagy Compromises the Homeostasis of Sweat Glands during Aging.

Sukseree S, Bergmann S, Pajdzik K, Sipos W, Gruber F, Tschachler E, Eckhart L.

J Invest Dermatol. 2018 Sep;138(9):2061-2063. doi: 10.1016/j.jid.2018.03.1502. Epub 2018 Mar 20. No abstract available.


Filamentous Aggregation of Sequestosome-1/p62 in Brain Neurons and Neuroepithelial Cells upon Tyr-Cre-Mediated Deletion of the Autophagy Gene Atg7.

Sukseree S, László L, Gruber F, Bergmann S, Narzt MS, Nagelreiter IM, Höftberger R, Molnár K, Rauter G, Birngruber T, Larue L, Kovacs GG, Tschachler E, Eckhart L.

Mol Neurobiol. 2018 Nov;55(11):8425-8437. doi: 10.1007/s12035-018-0996-x. Epub 2018 Mar 17.


Comparative Analysis of Epidermal Differentiation Genes of Crocodilians Suggests New Models for the Evolutionary Origin of Avian Feather Proteins.

Holthaus KB, Strasser B, Lachner J, Sukseree S, Sipos W, Weissenbacher A, Tschachler E, Alibardi L, Eckhart L.

Genome Biol Evol. 2018 Feb 1;10(2):694-704. doi: 10.1093/gbe/evy035.


Suppression of autophagy perturbs turnover of sequestosome-1/p62 in Merkel cells but not in keratinocytes.

Sukseree S, Bergmann S, Pajdzik K, Tschachler E, Eckhart L.

J Dermatol Sci. 2018 May;90(2):209-211. doi: 10.1016/j.jdermsci.2018.01.008. Epub 2018 Jan 31. No abstract available.


The Reticulum-Associated Protein RTN1A Specifically Identifies Human Dendritic Cells.

Gschwandtner M, Kienzl P, Tajpara P, Schuster C, Stipek G, Buchberger M, Mildner M, Mairhofer M, Eppel W, Vierhapper M, Pammer J, Koller R, Elbe-Bürger A, Tschachler E.

J Invest Dermatol. 2018 Jun;138(6):1318-1327. doi: 10.1016/j.jid.2018.01.002. Epub 2018 Jan 31.


Mice over-expressing placenta growth factor in the skin exhibit increased vascularization and vessel permeability independently of VEGF-A.

Failla CM, De Luca N, Zaccaria ML, De Domenico E, Avitabile S, Tatangelo L, Rossiter H, Tschachler E, Odorisio T.

J Dermatol Sci. 2018 Apr;90(1):93-96. doi: 10.1016/j.jdermsci.2017.12.015. Epub 2017 Dec 30. No abstract available.


Epidermal cornification is preceded by the expression of a keratinocyte-specific set of pyroptosis-related genes.

Lachner J, Mlitz V, Tschachler E, Eckhart L.

Sci Rep. 2017 Dec 12;7(1):17446. doi: 10.1038/s41598-017-17782-4.


OLR1 scavenger receptor knockdown affects mitotic gene expression but is dispensable for oxidized phospholipid- mediated stress signaling in SZ 95 sebocytes.

Nagelreiter IM, Parvardeh M, Narzt MS, Beer L, Kremslehner C, Muresan XM, Grillari J, Zouboulis CC, Tschachler E, Gruber F.

Mech Ageing Dev. 2018 Jun;172:35-44. doi: 10.1016/j.mad.2017.11.002. Epub 2017 Nov 21.


Validation of digital photographic reference scales for evaluating facial aging signs.

Jdid R, Latreille J, Soppelsa F, Tschachler E, Morizot F.

Skin Res Technol. 2018 May;24(2):196-202. doi: 10.1111/srt.12413. Epub 2017 Oct 22.


Double deficiency of Trex2 and DNase1L2 nucleases leads to accumulation of DNA in lingual cornifying keratinocytes without activating inflammatory responses.

Manils J, Fischer H, Climent J, Casas E, García-Martínez C, Bas J, Sukseree S, Vavouri T, Ciruela F, de Anta JM, Tschachler E, Eckhart L, Soler C.

Sci Rep. 2017 Sep 19;7(1):11902. doi: 10.1038/s41598-017-12308-4.


Long-term exposure of immortalized keratinocytes to arsenic induces EMT, impairs differentiation in organotypic skin models and mimics aspects of human skin derangements.

Weinmuellner R, Kryeziu K, Zbiral B, Tav K, Schoenhacker-Alte B, Groza D, Wimmer L, Schosserer M, Nagelreiter F, Rösinger S, Mildner M, Tschachler E, Grusch M, Grillari J, Heffeter P.

Arch Toxicol. 2018 Jan;92(1):181-194. doi: 10.1007/s00204-017-2034-6. Epub 2017 Aug 3.


Inactivation of DNase1L2 and DNase2 in keratinocytes suppresses DNA degradation during epidermal cornification and results in constitutive parakeratosis.

Fischer H, Buchberger M, Napirei M, Tschachler E, Eckhart L.

Sci Rep. 2017 Jul 25;7(1):6433. doi: 10.1038/s41598-017-06652-8.


Safety and tolerability of topically administered autologous, apoptotic PBMC secretome (APOSEC) in dermal wounds: a randomized Phase 1 trial (MARSYAS I).

Simader E, Traxler D, Kasiri MM, Hofbauer H, Wolzt M, Glogner C, Storka A, Mildner M, Gouya G, Geusau A, Fuchs C, Eder C, Graf A, Schaden M, Golabi B, Aretin MB, Suessner S, Gabriel C, Klepetko W, Tschachler E, Ankersmit HJ.

Sci Rep. 2017 Jul 24;7(1):6216. doi: 10.1038/s41598-017-06223-x.


Autophagy - how to control your intracellular diet.

Tschachler E, Eckhart L.

Br J Dermatol. 2017 Jun;176(6):1417-1419. doi: 10.1111/bjd.15566. No abstract available.


The caspase-1 inhibitor CARD18 is specifically expressed during late differentiation of keratinocytes and its expression is lost in lichen planus.

Qin H, Jin J, Fischer H, Mildner M, Gschwandtner M, Mlitz V, Eckhart L, Tschachler E.

J Dermatol Sci. 2017 Aug;87(2):176-182. doi: 10.1016/j.jdermsci.2017.04.015. Epub 2017 May 1.


Identification and comparative analysis of the epidermal differentiation complex in snakes.

Holthaus KB, Mlitz V, Strasser B, Tschachler E, Alibardi L, Eckhart L.

Sci Rep. 2017 Mar 27;7:45338. doi: 10.1038/srep45338.


Filaggrin has evolved from an "S100 fused-type protein" (SFTP) gene present in a common ancestor of amphibians and mammals.

Mlitz V, Hussain T, Tschachler E, Eckhart L.

Exp Dermatol. 2017 Oct;26(10):955-957. doi: 10.1111/exd.13317. Epub 2017 May 2.


Autophagy deficient keratinocytes display increased DNA damage, senescence and aberrant lipid composition after oxidative stress in vitro and in vivo.

Song X, Narzt MS, Nagelreiter IM, Hohensinner P, Terlecki-Zaniewicz L, Tschachler E, Grillari J, Gruber F.

Redox Biol. 2017 Apr;11:219-230. doi: 10.1016/j.redox.2016.12.015. Epub 2016 Dec 18.


Phylogenetic profiling and gene expression studies implicate a primary role of PSORS1C2 in terminal differentiation of keratinocytes.

Abbas Zadeh S, Mlitz V, Lachner J, Golabi B, Mildner M, Pammer J, Tschachler E, Eckhart L.

Exp Dermatol. 2017 Apr;26(4):352-358. doi: 10.1111/exd.13272. Epub 2017 Feb 16.


Immunolocalization of a Histidine-Rich Epidermal Differentiation Protein in the Chicken Supports the Hypothesis of an Evolutionary Developmental Link between the Embryonic Subperiderm and Feather Barbs and Barbules.

Alibardi L, Holthaus KB, Sukseree S, Hermann M, Tschachler E, Eckhart L.

PLoS One. 2016 Dec 9;11(12):e0167789. doi: 10.1371/journal.pone.0167789. eCollection 2016.


The Expression of the Endogenous mTORC1 Inhibitor Sestrin 2 Is Induced by UVB and Balanced with the Expression Level of Sestrin 1.

Mlitz V, Gendronneau G, Berlin I, Buchberger M, Eckhart L, Tschachler E.

PLoS One. 2016 Nov 18;11(11):e0166832. doi: 10.1371/journal.pone.0166832. eCollection 2016.


Holocrine Secretion of Sebum Is a Unique DNase2-Dependent Mode of Programmed Cell Death.

Fischer H, Fumicz J, Rossiter H, Napirei M, Buchberger M, Tschachler E, Eckhart L.

J Invest Dermatol. 2017 Mar;137(3):587-594. doi: 10.1016/j.jid.2016.10.017. Epub 2016 Oct 19.


Autophagy deficient melanocytes display a senescence associated secretory phenotype that includes oxidized lipid mediators.

Ni C, Narzt MS, Nagelreiter IM, Zhang CF, Larue L, Rossiter H, Grillari J, Tschachler E, Gruber F.

Int J Biochem Cell Biol. 2016 Dec;81(Pt B):375-382. doi: 10.1016/j.biocel.2016.10.006. Epub 2016 Oct 11.


Tyrosinase-Cre-Mediated Deletion of the Autophagy Gene Atg7 Leads to Accumulation of the RPE65 Variant M450 in the Retinal Pigment Epithelium of C57BL/6 Mice.

Sukseree S, Chen YT, Laggner M, Gruber F, Petit V, Nagelreiter IM, Mlitz V, Rossiter H, Pollreisz A, Schmidt-Erfurth U, Larue L, Tschachler E, Eckhart L.

PLoS One. 2016 Aug 18;11(8):e0161640. doi: 10.1371/journal.pone.0161640. eCollection 2016.


A genome-wide association study in Caucasian women suggests the involvement of HLA genes in the severity of facial solar lentigines.

Laville V, Clerc SL, Ezzedine K, Jdid R, Taing L, Labib T, Coulonges C, Ulveling D, Carpentier W, Galan P, Hercberg S, Morizot F, Latreille J, Malvy D, Tschachler E, Zagury JF.

Pigment Cell Melanoma Res. 2016 Sep;29(5):550-8. doi: 10.1111/pcmr.12502. Epub 2016 Aug 8.


Urocanic Acid: An Endogenous Regulator of Langerhans Cells.

Bruhs A, Eckhart L, Tschachler E, Schwarz T, Schwarz A.

J Invest Dermatol. 2016 Aug;136(8):1735-1737. doi: 10.1016/j.jid.2016.04.016. Epub 2016 May 14. No abstract available.


Paracrine Factors from Irradiated Peripheral Blood Mononuclear Cells Improve Skin Regeneration and Angiogenesis in a Porcine Burn Model.

Hacker S, Mittermayr R, Nickl S, Haider T, Lebherz-Eichinger D, Beer L, Mitterbauer A, Leiss H, Zimmermann M, Schweiger T, Keibl C, Hofbauer H, Gabriel C, Pavone-Gyöngyösi M, Redl H, Tschachler E, Mildner M, Ankersmit HJ.

Sci Rep. 2016 Apr 29;6:25168. doi: 10.1038/srep25168.


Proteome analysis identifies L1CAM/CD171 and DPP4/CD26 as novel markers of human skin mast cells.

Gschwandtner M, Paulitschke V, Mildner M, Brunner PM, Hacker S, Eisenwort G, Sperr WR, Valent P, Gerner C, Tschachler E.

Allergy. 2017 Jan;72(1):85-97. doi: 10.1111/all.12919. Epub 2016 May 25.


SNEV(Prp19/PSO4) deficiency increases PUVA-induced senescence in mouse skin.

Monteforte R, Beilhack GF, Grausenburger R, Mayerhofer B, Bittner R, Grillari-Voglauer R, Sibilia M, Dellago H, Tschachler E, Gruber F, Grillari J.

Exp Dermatol. 2016 Mar;25(3):212-7. doi: 10.1111/exd.12910.


Keratins K2 and K10 are essential for the epidermal integrity of plantar skin.

Fischer H, Langbein L, Reichelt J, Buchberger M, Tschachler E, Eckhart L.

J Dermatol Sci. 2016 Jan;81(1):10-6. doi: 10.1016/j.jdermsci.2015.10.008. Epub 2015 Oct 22.


Comparative Genomics Identifies Epidermal Proteins Associated with the Evolution of the Turtle Shell.

Holthaus KB, Strasser B, Sipos W, Schmidt HA, Mlitz V, Sukseree S, Weissenbacher A, Tschachler E, Alibardi L, Eckhart L.

Mol Biol Evol. 2016 Mar;33(3):726-37. doi: 10.1093/molbev/msv265. Epub 2015 Nov 24.


Matriptase-1 expression is lost in psoriatic skin lesions and is downregulated by TNFα in vitro.

Mildner M, Bauer R, Mlitz V, Ballaun C, Tschachler E.

J Dtsch Dermatol Ges. 2015 Nov;13(11):1165-74. doi: 10.1111/ddg.12812.


The Influence of MC1R Variants on Facial Aging Rate.

Tschachler E.

J Investig Dermatol Symp Proc. 2015 Jul;17(1):17. doi: 10.1038/jidsymp.2015.13. No abstract available.

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