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Acute exposure to triphenyl phosphate inhibits the proliferation and cardiac differentiation of mouse embryonic stem cells and zebrafish embryos.

Qi Z, Chen M, Song Y, Wang X, Li B, Chen ZF, Tsang SY, Cai Z.

J Cell Physiol. 2019 Apr 29. doi: 10.1002/jcp.28729. [Epub ahead of print]


TRPC3 Regulates the Proliferation and Apoptosis Resistance of Triple Negative Breast Cancer Cells through the TRPC3/RASA4/MAPK Pathway.

Wang Y, Qi YX, Qi Z, Tsang SY.

Cancers (Basel). 2019 Apr 18;11(4). pii: E558. doi: 10.3390/cancers11040558.


Flow Cytometric Detection of Newly-formed Breast Cancer Stem Cell-like Cells After Apoptosis Reversal.

Xu Y, So C, Lam HM, Fung MC, Tsang SY.

J Vis Exp. 2019 Jan 26;(143). doi: 10.3791/58642.


Stem/Progenitor Cells in Cardiopulmonary Health, Disease, and Treatment.

Sharifpanah F, Ghofrani HA, Tsang SY, Sauer H.

Stem Cells Int. 2019 Jan 6;2019:9861403. doi: 10.1155/2019/9861403. eCollection 2019. No abstract available.


The Milk Thistle (Silybum marianum) Compound Silibinin Inhibits Cardiomyogenesis of Embryonic Stem Cells by Interfering with Angiotensin II Signaling.

Ali EH, Sharifpanah F, Taha A, Tsang SY, Wartenberg M, Sauer H.

Stem Cells Int. 2018 Dec 13;2018:9215792. doi: 10.1155/2018/9215792. eCollection 2018.


Forward and reverse mutations in stages of cancer development.

Hu T, Kumar Y, Shazia I, Duan SJ, Li Y, Chen L, Chen JF, Yin R, Kwong A, Leung GK, Mat WK, Wu Z, Long X, Chan CH, Chen S, Lee P, Ng SK, Ho TYC, Yang J, Ding X, Tsang SY, Zhou X, Zhang DH; International Cancer Genome Consortium, Zhou EX, Xu L, Poon WS, Wang HY, Xue H.

Hum Genomics. 2018 Aug 22;12(1):40. doi: 10.1186/s40246-018-0170-6.


Gabrb2-knockout mice displayed schizophrenia-like and comorbid phenotypes with interneuron-astrocyte-microglia dysregulation.

Yeung RK, Xiang ZH, Tsang SY, Li R, Ho TYC, Li Q, Hui CK, Sham PC, Qiao MQ, Xue H.

Transl Psychiatry. 2018 Jul 17;8(1):128. doi: 10.1038/s41398-018-0176-9.


Apoptosis Reversal Promotes Cancer Stem Cell-Like Cell Formation.

Xu Y, So C, Lam HM, Fung MC, Tsang SY.

Neoplasia. 2018 Mar;20(3):295-303. doi: 10.1016/j.neo.2018.01.005. Epub 2018 Feb 22.


MicroRNA-27a-3p affects estradiol and androgen imbalance by targeting Creb1 in the granulosa cells in mouse polycytic ovary syndrome model.

Wang M, Liu M, Sun J, Jia L, Ma S, Gao J, Xu Y, Zhang H, Tsang SY, Li X.

Reprod Biol. 2017 Dec;17(4):295-304. doi: 10.1016/j.repbio.2017.09.005. Epub 2017 Oct 28.


Functional Characterization of MicroRNA-27a-3p Expression in Human Polycystic Ovary Syndrome.

Wang M, Sun J, Xu B, Chrusciel M, Gao J, Bazert M, Stelmaszewska J, Xu Y, Zhang H, Pawelczyk L, Sun F, Tsang SY, Rahman N, Wolczynski S, Li X.

Endocrinology. 2018 Jan 1;159(1):297-309. doi: 10.1210/en.2017-00219. Erratum in: Endocrinology. 2018 Feb 1;159(2):1187.


Histone Deacetylase Inhibitors Relax Mouse Aorta Partly through Their Inhibitory Action on L-Type Ca2+ Channels.

Zheng C, Zhong M, Qi Z, Shen F, Zhao Q, Wu L, Huang Y, Tsang SY, Yao X.

J Pharmacol Exp Ther. 2017 Nov;363(2):211-220. doi: 10.1124/jpet.117.242685. Epub 2017 Aug 31.


Role of inducible nitric oxide synthase in endothelium-independent relaxation to raloxifene in rat aorta.

Wong CM, Au CL, Tsang SY, Lau CW, Yao X, Cai Z, Chung AC.

Br J Pharmacol. 2017 Apr;174(8):718-733. doi: 10.1111/bph.13733. Epub 2017 Feb 27.


Versatile Roles of Intracellularly Located TRPV1 Channel.

Zhao R, Tsang SY.

J Cell Physiol. 2017 Aug;232(8):1957-1965. doi: 10.1002/jcp.25704. Epub 2017 Feb 28. Review.


Validation of the virtual-reality prospective memory test (Hong Kong Chinese version) for individuals with first-episode schizophrenia.

Man DWK, Ganesan B, Yip CCK, Lee COP, Tsang SYL, Yu PWP, Young JGE, Shum DHK.

Neuropsychol Rehabil. 2018 Oct;28(7):1197-1210. doi: 10.1080/09602011.2016.1251949. Epub 2016 Nov 13.


Variation of global DNA methylation levels with age and in autistic children.

Tsang SY, Ahmad T, Mat FW, Zhao C, Xiao S, Xia K, Xue H.

Hum Genomics. 2016 Sep 23;10(1):31.


Cyanidin-3-o-glucoside directly binds to ERα36 and inhibits EGFR-positive triple-negative breast cancer.

Wang L, Li H, Yang S, Ma W, Liu M, Guo S, Zhan J, Zhang H, Tsang SY, Zhang Z, Wang Z, Li X, Guo YD, Li X.

Oncotarget. 2016 Oct 18;7(42):68864-68882. doi: 10.18632/oncotarget.12025.


Cancer-Associated Fibroblasts Regulate Tumor-Initiating Cell Plasticity in Hepatocellular Carcinoma through c-Met/FRA1/HEY1 Signaling.

Lau EY, Lo J, Cheng BY, Ma MK, Lee JM, Ng JK, Chai S, Lin CH, Tsang SY, Ma S, Ng IO, Lee TK.

Cell Rep. 2016 May 10;15(6):1175-89. doi: 10.1016/j.celrep.2016.04.019. Epub 2016 Apr 28.


Feature co-localization landscape of the human genome.

Ng SK, Hu T, Long X, Chan CH, Tsang SY, Xue H.

Sci Rep. 2016 Feb 8;6:20650. doi: 10.1038/srep20650.


GABRB2 Haplotype Association with Heroin Dependence in Chinese Population.

Kim YS, Yang M, Mat WK, Tsang SY, Su Z, Jiang X, Ng SK, Liu S, Hu T, Pun F, Liao Y, Tang J, Chen X, Hao W, Xue H.

PLoS One. 2015 Nov 12;10(11):e0142049. doi: 10.1371/journal.pone.0142049. eCollection 2015.


TRPC3 regulates the automaticity of embryonic stem cell-derived cardiomyocytes.

Qi Z, Wong CK, Suen CH, Wang J, Long C, Sauer H, Yao X, Tsang SY.

Int J Cardiol. 2016 Jan 15;203:169-81. doi: 10.1016/j.ijcard.2015.10.018. Epub 2015 Oct 9.


SAMSVM: A tool for misalignment filtration of SAM-format sequences with support vector machine.

Yang J, Ding X, Sun X, Tsang SY, Xue H.

J Bioinform Comput Biol. 2015 Dec;13(6):1550025. doi: 10.1142/S0219720015500250. Epub 2015 Aug 24.


Massive interstitial copy-neutral loss-of-heterozygosity as evidence for cancer being a disease of the DNA-damage response.

Kumar Y, Yang J, Hu T, Chen L, Xu Z, Xu L, Hu XX, Tang G, Wang JM, Li Y, Poon WS, Wan W, Zhang L, Mat WK, Pun FW, Lee P, Cheong TH, Ding X, Ng SK, Tsang SY, Chen JF, Zhang P, Li S, Wang HY, Xue H.

BMC Med Genomics. 2015 Jul 25;8:42. doi: 10.1186/s12920-015-0104-2.


Role of TRPV1 in the Differentiation of Mouse Embryonic Stem Cells into Cardiomyocytes.

Qi Y, Qi Z, Li Z, Wong CK, So C, Lo IC, Huang Y, Yao X, Tsang SY.

PLoS One. 2015 Jul 24;10(7):e0133211. doi: 10.1371/journal.pone.0133211. eCollection 2015.


Glioma Association and Balancing Selection of ZFPM2.

Tsang SY, Mei L, Wan W, Li J, Li Y, Zhao C, Ding X, Pun FW, Hu X, Wang J, Zhang J, Luo R, Cheung ST, Leung GK, Poon WS, Ng HK, Zhang L, Xue H.

PLoS One. 2015 Jul 24;10(7):e0133003. doi: 10.1371/journal.pone.0133003. eCollection 2015.


TRPV3 Channel Negatively Regulates Cell Cycle Progression and Safeguards the Pluripotency of Embryonic Stem Cells.

Lo IC, Chan HC, Qi Z, Ng KL, So C, Tsang SY.

J Cell Physiol. 2016 Feb;231(2):403-13. doi: 10.1002/jcp.25086.


Stimulation of cardiomyogenesis from mouse embryonic stem cells by nuclear translocation of cardiotrophin-1.

Mascheck L, Sharifpanah F, Tsang SY, Wartenberg M, Sauer H.

Int J Cardiol. 2015 Aug 15;193:23-33. doi: 10.1016/j.ijcard.2015.05.019. Epub 2015 May 8.


MiR-25 suppresses 3T3-L1 adipogenesis by directly targeting KLF4 and C/EBPα.

Liang WC, Wang Y, Liang PP, Pan XQ, Fu WM, Yeung VS, Lu YF, Wan DC, Tsui SK, Tsang SY, Ma WB, Zhang JF, Waye MM.

J Cell Biochem. 2015 Nov;116(11):2658-66. doi: 10.1002/jcb.25214.


Copy number variation analysis based on AluScan sequences.

Yang JF, Ding XF, Chen L, Mat WK, Xu MZ, Chen JF, Wang JM, Xu L, Poon WS, Kwong A, Leung GK, Tan TC, Yu CH, Ke YB, Xu XY, Ke XY, Ma RC, Chan JC, Wan WQ, Zhang LW, Kumar Y, Tsang SY, Li S, Wang HY, Xue H.

J Clin Bioinforma. 2014 Dec 5;4(1):15. doi: 10.1186/s13336-014-0015-z. eCollection 2014.


A novel missense mutation in CCDC88C activates the JNK pathway and causes a dominant form of spinocerebellar ataxia.

Tsoi H, Yu AC, Chen ZS, Ng NK, Chan AY, Yuen LY, Abrigo JM, Tsang SY, Tsui SK, Tong TM, Lo IF, Lam ST, Mok VC, Wong LK, Ngo JC, Lau KF, Chan TF, Chan HY.

J Med Genet. 2014 Sep;51(9):590-5. doi: 10.1136/jmedgenet-2014-102333. Epub 2014 Jul 25.


Application of Machine Learning to Development of Copy Number Variation-based Prediction of Cancer Risk.

Ding X, Tsang SY, Ng SK, Xue H.

Genomics Insights. 2014 Jun 26;7:1-11. doi: 10.4137/GEI.S15002. eCollection 2014.


Regulation of multiple transcription factors by reactive oxygen species and effects of pro-inflammatory cytokines released during myocardial infarction on cardiac differentiation of embryonic stem cells.

Law SK, Leung CS, Yau KL, Tse CL, Wong CK, Leung FP, Mascheck L, Huang Y, Sauer H, Tsang SY.

Int J Cardiol. 2013 Oct 9;168(4):3458-72. doi: 10.1016/j.ijcard.2013.04.178. Epub 2013 May 23.


Social cognitive role of schizophrenia candidate gene GABRB2.

Tsang SY, Zhong S, Mei L, Chen J, Ng SK, Pun FW, Zhao C, Jing B, Chark R, Guo J, Tan Y, Li L, Wang C, Chew SH, Xue H.

PLoS One. 2013 Apr 24;8(4):e62322. doi: 10.1371/journal.pone.0062322. Print 2013.


β-Sitosterol oxidation products attenuate vasorelaxation by increasing reactive oxygen species and cyclooxygenase-2.

Yang C, Chen ZY, Wong SL, Liu J, Liang YT, Lau CW, Lee HK, Huang Y, Tsang SY.

Cardiovasc Res. 2013 Mar 1;97(3):520-32. doi: 10.1093/cvr/cvs370. Epub 2012 Dec 17.


Differential effects of estrogen/androgen on the prevention of nonalcoholic fatty liver disease in the male rat.

Zhang H, Liu Y, Wang L, Li Z, Zhang H, Wu J, Rahman N, Guo Y, Li D, Li N, Huhtaniemi I, Tsang SY, Gao GF, Li X.

J Lipid Res. 2013 Feb;54(2):345-57. doi: 10.1194/jlr.M028969. Epub 2012 Nov 21.


CAG expansion induces nucleolar stress in polyglutamine diseases.

Tsoi H, Lau TC, Tsang SY, Lau KF, Chan HY.

Proc Natl Acad Sci U S A. 2012 Aug 14;109(33):13428-33. doi: 10.1073/pnas.1204089109. Epub 2012 Jul 30.


From skeleton to cytoskeleton: osteocalcin transforms vascular fibroblasts to myofibroblasts via angiotensin II and Toll-like receptor 4.

Yuen CY, Wong SL, Lau CW, Tsang SY, Xu A, Zhu Z, Ng CF, Yao X, Kong SK, Lee HK, Huang Y.

Circ Res. 2012 Jul 20;111(3):e55-66. doi: 10.1161/CIRCRESAHA.112.271361. Epub 2012 Jun 7.


Prostacyclin receptor-dependent inhibition of human erythroleukemia cell differentiation is STAT3-dependent.

Lau AH, Lai HK, Yeung BH, Leung SL, Tsang SY, Wong YH, Wise H.

Prostaglandins Leukot Essent Fatty Acids. 2012 Mar;86(3):119-26. doi: 10.1016/j.plefa.2011.12.002. Epub 2012 Feb 13.


Epigenetic regulation on GABRB2 isoforms expression: developmental variations and disruptions in psychotic disorders.

Zhao C, Wang F, Pun FW, Mei L, Ren L, Yu Z, Ng SK, Chen J, Tsang SY, Xue H.

Schizophr Res. 2012 Feb;134(2-3):260-6. doi: 10.1016/j.schres.2011.11.029. Epub 2011 Dec 27.


NaHS relaxes rat cerebral artery in vitro via inhibition of l-type voltage-sensitive Ca2+ channel.

Tian XY, Wong WT, Sayed N, Luo J, Tsang SY, Bian ZX, Lu Y, Cheang WS, Yao X, Chen ZY, Huang Y.

Pharmacol Res. 2012 Feb;65(2):239-46. doi: 10.1016/j.phrs.2011.11.006. Epub 2011 Nov 25.


AluScan: a method for genome-wide scanning of sequence and structure variations in the human genome.

Mei L, Ding X, Tsang SY, Pun FW, Ng SK, Yang J, Zhao C, Li D, Wan W, Yu CH, Tan TC, Poon WS, Leung GK, Ng HK, Zhang L, Xue H.

BMC Genomics. 2011 Nov 17;12:564. doi: 10.1186/1471-2164-12-564.


Effects of flavone 6-substitutions on GABAA receptors efficacy.

Ren L, Chan WM, Wang F, Xu Z, Zhao C, Mat WK, Chai Y, Wong JT, Tsang SY, Xue H.

Eur J Pharmacol. 2011 Nov 16;670(1):121-9. doi: 10.1016/j.ejphar.2011.08.021. Epub 2011 Sep 2.


Estrogen controls embryonic stem cell proliferation via store-operated calcium entry and the nuclear factor of activated T-cells (NFAT).

Wong CK, So WY, Law SK, Leung FP, Yau KL, Yao X, Huang Y, Li X, Tsang SY.

J Cell Physiol. 2012 Jun;227(6):2519-30. doi: 10.1002/jcp.22990.


Genetically-manipulated adult stem cells as therapeutic agents and gene delivery vehicle for wound repair and regeneration.

Peng LH, Tsang SY, Tabata Y, Gao JQ.

J Control Release. 2012 Feb 10;157(3):321-30. doi: 10.1016/j.jconrel.2011.08.027. Epub 2011 Aug 26. Review.


The Ethanol Extract of Fructus trichosanthis Promotes Fetal Hemoglobin Production via p38 MAPK Activation and ERK Inactivation in K562 Cells.

Li H, Ko CH, Tsang SY, Leung PC, Fung MC, Fung KP.

Evid Based Complement Alternat Med. 2011;2011:657056. doi: 10.1093/ecam/neq022. Epub 2011 Aug 11.


Enhanced excitability and down-regulated voltage-gated potassium channels in colonic drg neurons from neonatal maternal separation rats.

Luo JL, Qin HY, Wong CK, Tsang SY, Huang Y, Bian ZX.

J Pain. 2011 May;12(5):600-9. doi: 10.1016/j.jpain.2010.11.005. Epub 2011 Feb 5.


Effects of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel blockers on the proliferation and cell cycle progression of embryonic stem cells.

Lau YT, Wong CK, Luo J, Leung LH, Tsang PF, Bian ZX, Tsang SY.

Pflugers Arch. 2011 Jan;461(1):191-202. doi: 10.1007/s00424-010-0899-9. Epub 2010 Nov 26.


Differential gene expressions in atrial and ventricular myocytes: insights into the road of applying embryonic stem cell-derived cardiomyocytes for future therapies.

Ng SY, Wong CK, Tsang SY.

Am J Physiol Cell Physiol. 2010 Dec;299(6):C1234-49. doi: 10.1152/ajpcell.00402.2009. Epub 2010 Sep 15. Review.


4-aminopyridine-sensitive K+ channels contributes to NaHS-induced membrane hyperpolarization and relaxation in the rat coronary artery.

Cheang WS, Wong WT, Shen B, Lau CW, Tian XY, Tsang SY, Yao X, Chen ZY, Huang Y.

Vascul Pharmacol. 2010 Sep-Oct;53(3-4):94-8. doi: 10.1016/j.vph.2010.04.004. Epub 2010 Apr 27.


Imprinting in the schizophrenia candidate gene GABRB2 encoding GABA(A) receptor β(2) subunit.

Pun FW, Zhao C, Lo WS, Ng SK, Tsang SY, Nimgaonkar V, Chung WS, Ungvari GS, Xue H.

Mol Psychiatry. 2011 May;16(5):557-68. doi: 10.1038/mp.2010.47. Epub 2010 Apr 20.


Role of voltage-gated potassium channels in the fate determination of embryonic stem cells.

Ng SY, Chin CH, Lau YT, Luo J, Wong CK, Bian ZX, Tsang SY.

J Cell Physiol. 2010 Jul;224(1):165-77. doi: 10.1002/jcp.22113.


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