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Items: 34

1.

Transforming growth factor-beta2 is a molecular determinant for site-specific melanoma metastasis in the brain.

Zhang C, Zhang F, Tsan R, Fidler IJ.

Cancer Res. 2009 Feb 1;69(3):828-35. doi: 10.1158/0008-5472.CAN-08-2588. Epub 2009 Jan 13.

2.

Modification of the primary tumor microenvironment by transforming growth factor alpha-epidermal growth factor receptor signaling promotes metastasis in an orthotopic colon cancer model.

Sasaki T, Nakamura T, Rebhun RB, Cheng H, Hale KS, Tsan RZ, Fidler IJ, Langley RR.

Am J Pathol. 2008 Jul;173(1):205-16. doi: 10.2353/ajpath.2008.071147.

3.

Survival of cancer cells is maintained by EGFR independent of its kinase activity.

Weihua Z, Tsan R, Huang WC, Wu Q, Chiu CH, Fidler IJ, Hung MC.

Cancer Cell. 2008 May;13(5):385-93. doi: 10.1016/j.ccr.2008.03.015.

4.
5.

Expression of epidermal growth factor (EGF)/transforming growth factor-alpha by human lung cancer cells determines their response to EGF receptor tyrosine kinase inhibition in the lungs of mice.

Wu W, O'Reilly MS, Langley RR, Tsan RZ, Baker CH, Bekele N, Tang XM, Onn A, Fidler IJ, Herbst RS.

Mol Cancer Ther. 2007 Oct;6(10):2652-63. Epub 2007 Oct 3.

6.
7.

Apoptotic cells initiate endothelial cell sprouting via electrostatic signaling.

Weihua Z, Tsan R, Schroit AJ, Fidler IJ.

Cancer Res. 2005 Dec 15;65(24):11529-35.

8.

Construction of a novel constitutively active chimeric EGFR to identify new targets for therapy.

Cheng H, Langley RR, Wu Q, Wu W, Feng J, Tsan R, Fan D, Fidler IJ.

Neoplasia. 2005 Dec;7(12):1065-72.

9.

Antivascular therapy for orthotopic human ovarian carcinoma through blockade of the vascular endothelial growth factor and epidermal growth factor receptors.

Thaker PH, Yazici S, Nilsson MB, Yokoi K, Tsan RZ, He J, Kim SJ, Fidler IJ, Sood AK.

Clin Cancer Res. 2005 Jul 1;11(13):4923-33.

10.
12.

Activation of the platelet-derived growth factor-receptor enhances survival of murine bone endothelial cells.

Langley RR, Fan D, Tsan RZ, Rebhun R, He J, Kim SJ, Fidler IJ.

Cancer Res. 2004 Jun 1;64(11):3727-30.

13.

IGF-1 receptor contributes to the malignant phenotype in human and canine osteosarcoma.

MacEwen EG, Pastor J, Kutzke J, Tsan R, Kurzman ID, Thamm DH, Wilson M, Radinsky R.

J Cell Biochem. 2004 May 1;92(1):77-91.

PMID:
15095405
14.
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16.

c-Met tyrosine kinase receptor expression and function in human and canine osteosarcoma cells.

MacEwen EG, Kutzke J, Carew J, Pastor J, Schmidt JA, Tsan R, Thamm DH, Radinsky R.

Clin Exp Metastasis. 2003;20(5):421-30.

PMID:
14524531
17.

Activation of c-Met in colorectal carcinoma cells leads to constitutive association of tyrosine-phosphorylated beta-catenin.

Herynk MH, Tsan R, Radinsky R, Gallick GE.

Clin Exp Metastasis. 2003;20(4):291-300.

PMID:
12856716
18.

Tissue-specific microvascular endothelial cell lines from H-2K(b)-tsA58 mice for studies of angiogenesis and metastasis.

Langley RR, Ramirez KM, Tsan RZ, Van Arsdall M, Nilsson MB, Fidler IJ.

Cancer Res. 2003 Jun 1;63(11):2971-6.

19.

Effects of blocking platelet-derived growth factor-receptor signaling in a mouse model of experimental prostate cancer bone metastases.

Uehara H, Kim SJ, Karashima T, Shepherd DL, Fan D, Tsan R, Killion JJ, Logothetis C, Mathew P, Fidler IJ.

J Natl Cancer Inst. 2003 Mar 19;95(6):458-70.

PMID:
12644539
20.

Blockade of epidermal growth factor receptor signaling on tumor cells and tumor-associated endothelial cells for therapy of human carcinomas.

Baker CH, Kedar D, McCarty MF, Tsan R, Weber KL, Bucana CD, Fidler IJ.

Am J Pathol. 2002 Sep;161(3):929-38.

21.

Optimization for the blockade of epidermal growth factor receptor signaling for therapy of human pancreatic carcinoma.

Solorzano CC, Baker CH, Tsan R, Traxler P, Cohen P, Buchdunger E, Killion JJ, Fidler IJ.

Clin Cancer Res. 2001 Aug;7(8):2563-72.

22.

Targeting the insulin-like growth factor axis in the therapy of colorectal carcinoma liver metastasis.

Portera CA Jr, Shinohara H, Mima T, Miller A, Tsan R, Mascarenhas D, Radinsky R.

Growth Horm IGF Res. 2000 Apr;10 Suppl A:S47-8. No abstract available.

PMID:
10984292
23.

Blockade of the epidermal growth factor receptor signaling by a novel tyrosine kinase inhibitor leads to apoptosis of endothelial cells and therapy of human pancreatic carcinoma.

Bruns CJ, Solorzano CC, Harbison MT, Ozawa S, Tsan R, Fan D, Abbruzzese J, Traxler P, Buchdunger E, Radinsky R, Fidler IJ.

Cancer Res. 2000 Jun 1;60(11):2926-35.

24.

Epidermal growth factor receptor blockade with C225 plus gemcitabine results in regression of human pancreatic carcinoma growing orthotopically in nude mice by antiangiogenic mechanisms.

Bruns CJ, Harbison MT, Davis DW, Portera CA, Tsan R, McConkey DJ, Evans DB, Abbruzzese JL, Hicklin DJ, Radinsky R.

Clin Cancer Res. 2000 May;6(5):1936-48.

25.

Preferential activation of the epidermal growth factor receptor in human colon carcinoma liver metastases in nude mice.

Parker C, Roseman BJ, Bucana CD, Tsan R, Radinsky R.

J Histochem Cytochem. 1998 May;46(5):595-602.

PMID:
9562568
26.
27.

Regulation of genes associated with angiogenesis, growth, and metastasis by specific p53 point mutations in a murine melanoma cell line.

Koura A, Vangolen K, Tsan R, Radinsky R, Price J, Ellis L.

Oncol Rep. 1997 May-Jun;4(3):475-9.

PMID:
21590080
28.
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30.

Transcriptional induction of the melanocyte-stimulating hormone receptor in brain metastases of murine K-1735 melanoma.

Radinsky R, Beltran PJ, Tsan R, Zhang R, Cone RD, Fidler IJ.

Cancer Res. 1995 Jan 1;55(1):141-8.

31.

Human recombinant interferons-beta and -gamma decrease gelatinase production and invasion by human KG-2 renal-carcinoma cells.

Gohji K, Fidler IJ, Tsan R, Radinsky R, von Eschenbach AC, Tsuruo T, Nakajima M.

Int J Cancer. 1994 Aug 1;58(3):380-4.

PMID:
8050821
32.

Terminal differentiation and apoptosis in experimental lung metastases of human osteogenic sarcoma cells by wild type p53.

Radinsky R, Fidler IJ, Price JE, Esumi N, Tsan R, Petty CM, Bucana CD, Bar-Eli M.

Oncogene. 1994 Jul;9(7):1877-83.

PMID:
8208533
33.

Organ-specific modulation of steady-state mdr gene expression and drug resistance in murine colon cancer cells.

Dong Z, Radinsky R, Fan D, Tsan R, Bucana CD, Wilmanns C, Fidler IJ.

J Natl Cancer Inst. 1994 Jun 15;86(12):913-20.

PMID:
7910854
34.

Modulation of Doxorubicin sensitivity and level of p-glycoprotein expression in human colon-carcinoma cells by ectopic and orthotopic environments in nude-mice.

Wilmanns C, Fan D, Obrian C, Radinsky R, Bucana C, Tsan R, Fidler I.

Int J Oncol. 1993 Sep;3(3):413-22.

PMID:
21573380

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