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Items: 45

1.

Pediatric Antibacterial and Antifungal Trials From 2007 to 2017.

Thaden JT, Chiswell K, Jaffe I, Bergin SP, Yang WE, Romaine A, Roberts J, Nambiar S, Farley J, Benjamin DK Jr, Smith PB, Tsalik EL.

Pediatrics. 2018 Sep;142(3). pii: e20171849. doi: 10.1542/peds.2017-1849.

PMID:
30158197
2.

The host response as a tool for infectious disease diagnosis and management.

Lydon EC, Ko ER, Tsalik EL.

Expert Rev Mol Diagn. 2018 Aug;18(8):723-738. doi: 10.1080/14737159.2018.1493378. Epub 2018 Jul 2.

PMID:
29939801
3.

Future Research Directions in Pneumonia. NHLBI Working Group Report.

Dela Cruz CS, Wunderink RG, Christiani DC, Cormier SA, Crothers K, Doerschuk CM, Evans SE, Goldstein DR, Khatri P, Kobzik L, Kolls JK, Levy BD, Metersky ML, Niederman MS, Nusrat R, Orihuela CJ, Peyrani P, Prince AS, Ramírez JA, Ridge KM, Sethi S, Suratt BT, Sznajder JI, Tsalik EL, Walkey AJ, Yende S, Aggarwal NR, Caler EV, Mizgerd JP.

Am J Respir Crit Care Med. 2018 Jul 15;198(2):256-263. doi: 10.1164/rccm.201801-0139WS.

PMID:
29546996
4.

Unsupervised Analysis of Transcriptomics in Bacterial Sepsis Across Multiple Datasets Reveals Three Robust Clusters.

Sweeney TE, Azad TD, Donato M, Haynes WA, Perumal TM, Henao R, Bermejo-Martin JF, Almansa R, Tamayo E, Howrylak JA, Choi A, Parnell GP, Tang B, Nichols M, Woods CW, Ginsburg GS, Kingsmore SF, Omberg L, Mangravite LM, Wong HR, Tsalik EL, Langley RJ, Khatri P.

Crit Care Med. 2018 Jun;46(6):915-925. doi: 10.1097/CCM.0000000000003084.

PMID:
29537985
5.

A community approach to mortality prediction in sepsis via gene expression analysis.

Sweeney TE, Perumal TM, Henao R, Nichols M, Howrylak JA, Choi AM, Bermejo-Martin JF, Almansa R, Tamayo E, Davenport EE, Burnham KL, Hinds CJ, Knight JC, Woods CW, Kingsmore SF, Ginsburg GS, Wong HR, Parnell GP, Tang B, Moldawer LL, Moore FE, Omberg L, Khatri P, Tsalik EL, Mangravite LM, Langley RJ.

Nat Commun. 2018 Feb 15;9(1):694. doi: 10.1038/s41467-018-03078-2.

6.

New Molecular Diagnostic Approaches to Bacterial Infections and Antibacterial Resistance.

Tsalik EL, Bonomo RA, Fowler VG Jr.

Annu Rev Med. 2018 Jan 29;69:379-394. doi: 10.1146/annurev-med-052716-030320.

PMID:
29414265
7.

Candidate genes on murine chromosome 8 are associated with susceptibility to Staphylococcus aureus infection in mice and are involved with Staphylococcus aureus septicemia in humans.

Yan Q, Ahn SH, Medie FM, Sharma-Kuinkel BK, Park LP, Scott WK, Deshmukh H, Tsalik EL, Cyr DD, Woods CW, Yu CA, Adams C, Qi R, Hansen B, Fowler VG Jr.

PLoS One. 2017 Jun 8;12(6):e0179033. doi: 10.1371/journal.pone.0179033. eCollection 2017.

8.

Procalcitonin: The Right Answer but to Which Question?

Bergin SP, Tsalik EL.

Clin Infect Dis. 2017 Jul 15;65(2):191-193. doi: 10.1093/cid/cix323. No abstract available.

PMID:
28407096
9.

Advancing Diagnostics to Address Antibacterial Resistance: The Diagnostics and Devices Committee of the Antibacterial Resistance Leadership Group.

Tsalik EL, Petzold E, Kreiswirth BN, Bonomo RA, Banerjee R, Lautenbach E, Evans SR, Hanson KE, Klausner JD, Patel R; and the Diagnostics and Devices Committee; of the Antibacterial Resistance Leadership Group.

Clin Infect Dis. 2017 Mar 15;64(suppl_1):S41-S47. doi: 10.1093/cid/ciw831. Review.

10.

Human genetic and metabolite variation reveals that methylthioadenosine is a prognostic biomarker and an inflammatory regulator in sepsis.

Wang L, Ko ER, Gilchrist JJ, Pittman KJ, Rautanen A, Pirinen M, Thompson JW, Dubois LG, Langley RJ, Jaslow SL, Salinas RE, Rouse DC, Moseley MA, Mwarumba S, Njuguna P, Mturi N; Wellcome Trust Case Control Consortium 2; Kenyan Bacteraemia Study Group, Williams TN, Scott JA, Hill AV, Woods CW, Ginsburg GS, Tsalik EL, Ko DC.

Sci Adv. 2017 Mar 8;3(3):e1602096. doi: 10.1126/sciadv.1602096. eCollection 2017 Mar.

11.

Nasopharyngeal Protein Biomarkers of Acute Respiratory Virus Infection.

Burke TW, Henao R, Soderblom E, Tsalik EL, Thompson JW, McClain MT, Nichols M, Nicholson BP, Veldman T, Lucas JE, Moseley MA, Turner RB, Lambkin-Williams R, Hero AO 3rd, Woods CW, Ginsburg GS.

EBioMedicine. 2017 Mar;17:172-181. doi: 10.1016/j.ebiom.2017.02.015. Epub 2017 Feb 21.

12.

MASTERMIND: Bringing Microbial Diagnostics to the Clinic.

Patel R, Tsalik EL, Petzold E, Fowler VG Jr, Klausner JD, Evans S; Antibacterial Resistance Leadership Group (ARLG).

Clin Infect Dis. 2017 Feb 1;64(3):355-360. doi: 10.1093/cid/ciw788. Epub 2016 Dec 7.

13.

Host-Based Peripheral Blood Gene Expression Analysis for Diagnosis of Infectious Diseases.

Holcomb ZE, Tsalik EL, Woods CW, McClain MT.

J Clin Microbiol. 2017 Feb;55(2):360-368. doi: 10.1128/JCM.01057-16. Epub 2016 Oct 19. Review.

14.

Systematic Molecular Phenotyping: A Path Toward Precision Emergency Medicine?

Limkakeng AT Jr, Monte AA, Kabrhel C, Puskarich M, Heitsch L, Tsalik EL, Shapiro NI.

Acad Emerg Med. 2016 Oct;23(10):1097-1106. doi: 10.1111/acem.13027. Epub 2016 Oct 3. Review.

15.

A Genomic Signature of Influenza Infection Shows Potential for Presymptomatic Detection, Guiding Early Therapy, and Monitoring Clinical Responses.

McClain MT, Nicholson BP, Park LP, Liu TY, Hero AO 3rd, Tsalik EL, Zaas AK, Veldman T, Hudson LL, Lambkin-Williams R, Gilbert A, Burke T, Nichols M, Ginsburg GS, Woods CW.

Open Forum Infect Dis. 2016 Jan 19;3(1):ofw007. doi: 10.1093/ofid/ofw007. eCollection 2016 Jan.

16.

Host gene expression classifiers diagnose acute respiratory illness etiology.

Tsalik EL, Henao R, Nichols M, Burke T, Ko ER, McClain MT, Hudson LL, Mazur A, Freeman DH, Veldman T, Langley RJ, Quackenbush EB, Glickman SW, Cairns CB, Jaehne AK, Rivers EP, Otero RM, Zaas AK, Kingsmore SF, Lucas J, Fowler VG Jr, Carin L, Ginsburg GS, Woods CW.

Sci Transl Med. 2016 Jan 20;8(322):322ra11. doi: 10.1126/scitranslmed.aad6873.

17.

Transcriptomic Analysis of the Host Response and Innate Resilience to Enterotoxigenic Escherichia coli Infection in Humans.

Yang WE, Suchindran S, Nicholson BP, McClain MT, Burke T, Ginsburg GS, Harro CD, Chakraborty S, Sack DA, Woods CW, Tsalik EL.

J Infect Dis. 2016 May 1;213(9):1495-504. doi: 10.1093/infdis/jiv593. Epub 2016 Jan 18.

18.

Potential Cost-effectiveness of Early Identification of Hospital-acquired Infection in Critically Ill Patients.

Tsalik EL, Li Y, Hudson LL, Chu VH, Himmel T, Limkakeng AT, Katz JN, Glickman SW, McClain MT, Welty-Wolf KE, Fowler VG, Ginsburg GS, Woods CW, Reed SD.

Ann Am Thorac Soc. 2016 Mar;13(3):401-13. doi: 10.1513/AnnalsATS.201504-205OC.

PMID:
26700878
19.

Differential evolution of peripheral cytokine levels in symptomatic and asymptomatic responses to experimental influenza virus challenge.

McClain MT, Henao R, Williams J, Nicholson B, Veldman T, Hudson L, Tsalik EL, Lambkin-Williams R, Gilbert A, Mann A, Ginsburg GS, Woods CW.

Clin Exp Immunol. 2016 Mar;183(3):441-51. doi: 10.1111/cei.12736. Epub 2015 Dec 16.

20.

Respiratory Tract Infection Clinical Trials from 2007 to 2012. A Systematic Review of ClinicalTrials.gov.

Ruopp M, Chiswell K, Thaden JT, Merchant K, Tsalik EL.

Ann Am Thorac Soc. 2015 Dec;12(12):1852-63. doi: 10.1513/AnnalsATS.201505-291OC. Review.

PMID:
26360527
21.

What was old is new again: using the host response to diagnose infectious disease.

Ko ER, Yang WE, McClain MT, Woods CW, Ginsburg GS, Tsalik EL.

Expert Rev Mol Diagn. 2015;15(9):1143-58. doi: 10.1586/14737159.2015.1059278. Epub 2015 Jul 4. Review.

PMID:
26145249
22.

Renal systems biology of patients with systemic inflammatory response syndrome.

Tsalik EL, Willig LK, Rice BJ, van Velkinburgh JC, Mohney RP, McDunn JE, Dinwiddie DL, Miller NA, Mayer ES, Glickman SW, Jaehne AK, Glew RH, Sopori ML, Otero RM, Harrod KS, Cairns CB, Fowler VG, Rivers EP, Woods CW, Kingsmore SF, Langley RJ.

Kidney Int. 2015 Oct;88(4):804-14. doi: 10.1038/ki.2015.150. Epub 2015 May 20.

23.

Moving toward prime time: host signatures for diagnosis of respiratory infections.

Tsalik EL, McClain M, Zaas AK.

J Infect Dis. 2015 Jul 15;212(2):173-5. doi: 10.1093/infdis/jiv032. Epub 2015 Jan 29. No abstract available.

PMID:
25637349
24.

An integrated transcriptome and expressed variant analysis of sepsis survival and death.

Tsalik EL, Langley RJ, Dinwiddie DL, Miller NA, Yoo B, van Velkinburgh JC, Smith LD, Thiffault I, Jaehne AK, Valente AM, Henao R, Yuan X, Glickman SW, Rice BJ, McClain MT, Carin L, Corey GR, Ginsburg GS, Cairns CB, Otero RM, Fowler VG Jr, Rivers EP, Woods CW, Kingsmore SF.

Genome Med. 2014 Nov 26;6(11):111. doi: 10.1186/s13073-014-0111-5. eCollection 2014.

25.

The current epidemiology and clinical decisions surrounding acute respiratory infections.

Zaas AK, Garner BH, Tsalik EL, Burke T, Woods CW, Ginsburg GS.

Trends Mol Med. 2014 Oct;20(10):579-88. doi: 10.1016/j.molmed.2014.08.001. Epub 2014 Sep 5. Review.

PMID:
25201713
26.

Integrative "omic" analysis of experimental bacteremia identifies a metabolic signature that distinguishes human sepsis from systemic inflammatory response syndromes.

Langley RJ, Tipper JL, Bruse S, Baron RM, Tsalik EL, Huntley J, Rogers AJ, Jaramillo RJ, O'Donnell D, Mega WM, Keaton M, Kensicki E, Gazourian L, Fredenburgh LE, Massaro AF, Otero RM, Fowler VG Jr, Rivers EP, Woods CW, Kingsmore SF, Sopori ML, Perrella MA, Choi AM, Harrod KS.

Am J Respir Crit Care Med. 2014 Aug 15;190(4):445-55. doi: 10.1164/rccm.201404-0624OC.

27.

Dusp3 and Psme3 are associated with murine susceptibility to Staphylococcus aureus infection and human sepsis.

Yan Q, Sharma-Kuinkel BK, Deshmukh H, Tsalik EL, Cyr DD, Lucas J, Woods CW, Scott WK, Sempowski GD, Thaden JT, Rude TH, Ahn SH, Fowler VG Jr.

PLoS Pathog. 2014 Jun 5;10(6):e1004149. doi: 10.1371/journal.ppat.1004149. eCollection 2014 Jun. Erratum in: PLoS Pathog. 2014 Jun;10(6):e1004259. Thaden, Joshua [corrected to Thaden, Joshua T].

28.

A cross-sectional analysis of HIV and hepatitis C clinical trials 2007 to 2010: the relationship between industry sponsorship and randomized study design.

Goswami ND, Tsalik EL, Naggie S, Miller WC, Horton JR, Pfeiffer CD, Hicks CB.

Trials. 2014 Jan 22;15:31. doi: 10.1186/1745-6215-15-31.

29.

The state of infectious diseases clinical trials: a systematic review of ClinicalTrials.gov.

Goswami ND, Pfeiffer CD, Horton JR, Chiswell K, Tasneem A, Tsalik EL.

PLoS One. 2013 Oct 16;8(10):e77086. doi: 10.1371/journal.pone.0077086. eCollection 2013. Review.

30.

A host-based RT-PCR gene expression signature to identify acute respiratory viral infection.

Zaas AK, Burke T, Chen M, McClain M, Nicholson B, Veldman T, Tsalik EL, Fowler V, Rivers EP, Otero R, Kingsmore SF, Voora D, Lucas J, Hero AO, Carin L, Woods CW, Ginsburg GS.

Sci Transl Med. 2013 Sep 18;5(203):203ra126. doi: 10.1126/scitranslmed.3006280.

31.

Plasma microRNA signature as a noninvasive biomarker for acute graft-versus-host disease.

Xiao B, Wang Y, Li W, Baker M, Guo J, Corbet K, Tsalik EL, Li QJ, Palmer SM, Woods CW, Li Z, Chao NJ, He YW.

Blood. 2013 Nov 7;122(19):3365-75. doi: 10.1182/blood-2013-06-510586. Epub 2013 Sep 16.

32.

An integrated clinico-metabolomic model improves prediction of death in sepsis.

Langley RJ, Tsalik EL, van Velkinburgh JC, Glickman SW, Rice BJ, Wang C, Chen B, Carin L, Suarez A, Mohney RP, Freeman DH, Wang M, You J, Wulff J, Thompson JW, Moseley MA, Reisinger S, Edmonds BT, Grinnell B, Nelson DR, Dinwiddie DL, Miller NA, Saunders CJ, Soden SS, Rogers AJ, Gazourian L, Fredenburgh LE, Massaro AF, Baron RM, Choi AM, Corey GR, Ginsburg GS, Cairns CB, Otero RM, Fowler VG Jr, Rivers EP, Woods CW, Kingsmore SF.

Sci Transl Med. 2013 Jul 24;5(195):195ra95. doi: 10.1126/scitranslmed.3005893.

33.

Gene expression-based classifiers identify Staphylococcus aureus infection in mice and humans.

Ahn SH, Tsalik EL, Cyr DD, Zhang Y, van Velkinburgh JC, Langley RJ, Glickman SW, Cairns CB, Zaas AK, Rivers EP, Otero RM, Veldman T, Kingsmore SF, Lucas J, Woods CW, Ginsburg GS, Fowler VG Jr.

PLoS One. 2013;8(1):e48979. doi: 10.1371/journal.pone.0048979. Epub 2013 Jan 9.

34.

Discriminative value of inflammatory biomarkers for suspected sepsis.

Tsalik EL, Jaggers LB, Glickman SW, Langley RJ, van Velkinburgh JC, Park LP, Fowler VG, Cairns CB, Kingsmore SF, Woods CW.

J Emerg Med. 2012 Jul;43(1):97-106. doi: 10.1016/j.jemermed.2011.05.072. Epub 2011 Nov 6.

35.

An Infection Control Program for a 2009 influenza A H1N1 outbreak in a university-based summer camp.

Tsalik EL, Cunningham CK, Cunningham HM, Lopez-Marti MG, Sangvai DG, Purdy WK, Anderson DJ, Thompson JR, Brown M, Woods CW, Jaggers LB, Hendershot EF.

J Am Coll Health. 2011;59(5):419-26. doi: 10.1080/07448481.2010.534215.

PMID:
21500062
36.

Life-threatening asymptomatic incidentaloma: a case report of idiopathic CD4 lymphocytopenia and opportunistic infections.

Tsalik EL, Jaggers LB.

Am J Med Sci. 2010 Aug;340(2):158-9. doi: 10.1097/MAJ.0b013e3181e5f118.

PMID:
20581653
37.

Disease progression in hemodynamically stable patients presenting to the emergency department with sepsis.

Glickman SW, Cairns CB, Otero RM, Woods CW, Tsalik EL, Langley RJ, van Velkinburgh JC, Park LP, Glickman LT, Fowler VG Jr, Kingsmore SF, Rivers EP.

Acad Emerg Med. 2010 Apr;17(4):383-90. doi: 10.1111/j.1553-2712.2010.00664.x.

38.

Clinical presentation and response to treatment of novel influenza A H1N1 in a university-based summer camp population.

Tsalik EL, Hendershot EF, Sangvai DG, Cunningham HM, Cunningham CK, Lopez-Marti MG, Purdy WK, Woods CW, Caram LB.

J Clin Virol. 2010 Mar;47(3):286-8. doi: 10.1016/j.jcv.2009.12.012. Epub 2010 Jan 12.

PMID:
20064740
39.

Sepsis redefined: the search for surrogate markers.

Tsalik EL, Woods CW.

Int J Antimicrob Agents. 2009;34 Suppl 4:S16-20. doi: 10.1016/S0924-8579(09)70560-6.

PMID:
19931810
40.

Multiplex PCR to diagnose bloodstream infections in patients admitted from the emergency department with sepsis.

Tsalik EL, Jones D, Nicholson B, Waring L, Liesenfeld O, Park LP, Glickman SW, Caram LB, Langley RJ, van Velkinburgh JC, Cairns CB, Rivers EP, Otero RM, Kingsmore SF, Lalani T, Fowler VG, Woods CW.

J Clin Microbiol. 2010 Jan;48(1):26-33. doi: 10.1128/JCM.01447-09. Epub 2009 Oct 21.

41.

DNA-based immunotherapy to treat atopic disease.

Tsalik EL.

Ann Allergy Asthma Immunol. 2005 Nov;95(5):403-10; quiz 410-1, 451. Review.

PMID:
16312161
42.

LIM homeobox gene-dependent expression of biogenic amine receptors in restricted regions of the C. elegans nervous system.

Tsalik EL, Niacaris T, Wenick AS, Pau K, Avery L, Hobert O.

Dev Biol. 2003 Nov 1;263(1):81-102.

43.
44.

A regulatory cascade of three homeobox genes, ceh-10, ttx-3 and ceh-23, controls cell fate specification of a defined interneuron class in C. elegans.

Altun-Gultekin Z, Andachi Y, Tsalik EL, Pilgrim D, Kohara Y, Hobert O.

Development. 2001 Jun;128(11):1951-69.

45.

Curing Saccharomyces cerevisiae of the 2 micron plasmid by targeted DNA damage.

Tsalik EL, Gartenberg MR.

Yeast. 1998 Jun 30;14(9):847-52.

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