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Items: 18

1.

Application of Mechanistic Ocular Absorption Modeling and Simulation to Understand the Impact of Formulation Properties on Ophthalmic Bioavailability in Rabbits: a Case Study Using Dexamethasone Suspension.

Le Merdy M, Fan J, Bolger MB, Lukacova V, Spires J, Tsakalozou E, Patel V, Xu L, Stewart S, Chockalingam A, Narayanasamy S, Rouse R, Matta M, Babiskin A, Kozak D, Choi S, Zhang L, Lionberger R, Zhao L.

AAPS J. 2019 May 20;21(4):65. doi: 10.1208/s12248-019-0334-x.

PMID:
31111305
2.

Population pharmacokinetic analysis of AR-67, a lactone stable camptothecin analogue, in cancer patients with solid tumors.

Tang F, Tsakalozou E, Arnold SM, Ng CM, Leggas M.

Invest New Drugs. 2019 Feb 28. doi: 10.1007/s10637-019-00744-0. [Epub ahead of print]

PMID:
30820810
3.

Dissolution and Translational Modeling Strategies Toward Establishing an In Vitro-In Vivo Link-a Workshop Summary Report.

Heimbach T, Suarez-Sharp S, Kakhi M, Holmstock N, Olivares-Morales A, Pepin X, Sjögren E, Tsakalozou E, Seo P, Li M, Zhang X, Lin HP, Montague T, Mitra A, Morris D, Patel N, Kesisoglou F.

AAPS J. 2019 Feb 11;21(2):29. doi: 10.1208/s12248-019-0298-x.

PMID:
30746576
4.

Impact of Pharmaceutical Excipients on Oral Drug Absorption: A Focus on Intestinal Drug Transporters.

Zou L, Ni Z, Tsakalozou E, Giacomini KM.

Clin Pharmacol Ther. 2019 Feb;105(2):323-325. doi: 10.1002/cpt.1292. Epub 2019 Jan 20. No abstract available.

PMID:
30663035
5.

Protocol for evaluation of topical ophthalmic drug products in different compartments of fresh eye tissues in a rabbit model.

Chockalingam A, Xu L, Stewart S, LeMerdy M, Tsakalozou E, Fan J, Patel V, Rouse R.

J Pharmacol Toxicol Methods. 2019 Mar - Apr;96:9-14. doi: 10.1016/j.vascn.2018.12.002. Epub 2018 Dec 13.

PMID:
30552958
6.

Mechanistic Oral Absorption Modeling and Simulation for Formulation Development and Bioequivalence Evaluation: Report of an FDA Public Workshop.

Zhang X, Duan J, Kesisoglou F, Novakovic J, Amidon GL, Jamei M, Lukacova V, Eissing T, Tsakalozou E, Zhao L, Lionberger R.

CPT Pharmacometrics Syst Pharmacol. 2017 Aug;6(8):492-495. doi: 10.1002/psp4.12204. Epub 2017 Jul 11.

7.

Physiologically Based Pharmacokinetic and Absorption Modeling for Osmotic Pump Products.

Ni Z, Talattof A, Fan J, Tsakalozou E, Sharan S, Sun D, Wen H, Zhao L, Zhang X.

AAPS J. 2017 Jul;19(4):1045-1053. doi: 10.1208/s12248-017-0075-7. Epub 2017 Mar 29.

PMID:
28357656
8.

Using Physiologically Based Pharmacokinetic (PBPK) Modeling to Evaluate the Impact of Pharmaceutical Excipients on Oral Drug Absorption: Sensitivity Analyses.

Chow EC, Talattof A, Tsakalozou E, Fan J, Zhao L, Zhang X.

AAPS J. 2016 Nov;18(6):1500-1511. Epub 2016 Aug 12.

PMID:
27520379
9.

Altered morphine glucuronide and bile acid disposition in patients with nonalcoholic steatohepatitis.

Ferslew BC, Johnston CK, Tsakalozou E, Bridges AS, Paine MF, Jia W, Stewart PW, Barritt AS 4th, Brouwer KL.

Clin Pharmacol Ther. 2015 Apr;97(4):419-27. doi: 10.1002/cpt.66. Epub 2015 Mar 15.

10.
11.

Protracted dosing of the lipophilic camptothecin analogue AR-67 in non-small cell lung cancer xenografts and humans.

Tsakalozou E, Adane ED, Liang Y, Arnold SM, Leggas M.

Cancer Chemother Pharmacol. 2014 Jul;74(1):45-54. doi: 10.1007/s00280-014-2472-2. Epub 2014 May 8.

PMID:
24807458
12.
13.

Combination effects of docetaxel and Doxorubicin in hormone-refractory prostate cancer cells.

Tsakalozou E, Eckman AM, Bae Y.

Biochem Res Int. 2012;2012:832059. doi: 10.1155/2012/832059. Epub 2012 Jul 1.

14.

Drug release patterns and cytotoxicity of PEG-poly(aspartate) block copolymer micelles in cancer cells.

Eckman AM, Tsakalozou E, Kang NY, Ponta A, Bae Y.

Pharm Res. 2012 Jul;29(7):1755-67. doi: 10.1007/s11095-012-0697-5. Epub 2012 Feb 10.

PMID:
22322898
15.

An HPLC assay for the lipophilic camptothecin analog AR-67 carboxylate and lactone in human whole blood.

Tsakalozou E, Horn J, Leggas M.

Biomed Chromatogr. 2010 Oct;24(10):1045-51. doi: 10.1002/bmc.1404.

16.

A phase I study of 7-t-butyldimethylsilyl-10-hydroxycamptothecin in adult patients with refractory or metastatic solid malignancies.

Arnold SM, Rinehart JJ, Tsakalozou E, Eckardt JR, Fields SZ, Shelton BJ, DeSimone PA, Kee BK, Moscow JA, Leggas M.

Clin Cancer Res. 2010 Jan 15;16(2):673-80. doi: 10.1158/1078-0432.CCR-09-2429. Epub 2010 Jan 12.

17.

Melatonin pharmacokinetics in premenopausal and postmenopausal healthy female volunteers.

Markantonis SL, Tsakalozou E, Paraskeva A, Staikou C, Fassoulaki A.

J Clin Pharmacol. 2008 Feb;48(2):240-5. Epub 2007 Dec 10. No abstract available.

PMID:
18071190
18.

Acupressure on the extra 1 acupoint: the effect on bispectral index, serum melatonin, plasma beta-endorphin, and stress.

Fassoulaki A, Paraskeva A, Kostopanagiotou G, Tsakalozou E, Markantonis S.

Anesth Analg. 2007 Feb;104(2):312-7.

PMID:
17242086

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