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Mirc11 Disrupts Inflammatory but Not Cytotoxic Responses of NK Cells.

Nanbakhsh A, Srinivasamani A, Holzhauer S, Riese MJ, Zheng Y, Wang D, Burns R, Reimer MH, Rao S, Lemke A, Tsaih SW, Flister MJ, Lao S, Dahl R, Thakar MS, Malarkannan S.

Cancer Immunol Res. 2019 Sep 12. doi: 10.1158/2326-6066.CIR-18-0934. [Epub ahead of print]


The p52 isoform of SHC1 is a key driver of breast cancer initiation.

Wright KD, Miller BS, El-Meanawy S, Tsaih SW, Banerjee A, Geurts AM, Sheinin Y, Sun Y, Kalyanaraman B, Rui H, Flister MJ, Sorokin A.

Breast Cancer Res. 2019 Jun 15;21(1):74. doi: 10.1186/s13058-019-1155-7.


Neuronatin is a modifier of estrogen receptor-positive breast cancer incidence and outcome.

Plasterer C, Tsaih SW, Peck AR, Chervoneva I, O'Meara C, Sun Y, Lemke A, Murphy D, Smith J, Ran S, Kovatich AJ, Hooke JA, Shriver CD, Hu H, Mitchell EP, Bergom C, Joshi A, Auer P, Prokop J, Rui H, Flister MJ.

Breast Cancer Res Treat. 2019 Aug;177(1):77-91. doi: 10.1007/s10549-019-05307-8. Epub 2019 Jun 4.


Mitochondrial Oxidative Phosphorylation defect in the Heart of Subjects with Coronary Artery Disease.

Ait-Aissa K, Blaszak SC, Beutner G, Tsaih SW, Morgan G, Santos JH, Flister MJ, Joyce DL, Camara AKS, Gutterman DD, Donato AJ, Porter GA Jr, Beyer AM.

Sci Rep. 2019 May 20;9(1):7623. doi: 10.1038/s41598-019-43761-y.


Identification of a Rat Mammary Tumor Risk Locus That Is Syntenic with the Commonly Amplified 8q12.1 and 8q22.1 Regions in Human Breast Cancer Patients.

Plasterer C, Tsaih SW, Lemke A, Schilling R, Dwinell M, Rau A, Auer P, Rui H, Flister MJ.

G3 (Bethesda). 2019 May 7;9(5):1739-1743. doi: 10.1534/g3.118.200873.


Mapping genetic modifiers of radiation-induced cardiotoxicity to rat chromosome 3.

Schlaak RA, Frei A, Schottstaedt AM, Tsaih SW, Fish BL, Harmann L, Liu Q, Gasperetti T, Medhora M, North PE, Strande JL, Sun Y, Rui H, Flister MJ, Bergom C.

Am J Physiol Heart Circ Physiol. 2019 Jun 1;316(6):H1267-H1280. doi: 10.1152/ajpheart.00482.2018. Epub 2019 Mar 8.


Genetic variations in human papillomavirus and cervical cancer outcomes.

Rader JS, Tsaih SW, Fullin D, Murray MW, Iden M, Zimmermann MT, Flister MJ.

Int J Cancer. 2019 May 1;144(9):2206-2214. doi: 10.1002/ijc.32038. Epub 2019 Jan 4.


Mitochondria-Targeted Honokiol Confers a Striking Inhibitory Effect on Lung Cancer via Inhibiting Complex I Activity.

Pan J, Lee Y, Cheng G, Zielonka J, Zhang Q, Bajzikova M, Xiong D, Tsaih SW, Hardy M, Flister M, Olsen CM, Wang Y, Vang O, Neuzil J, Myers CR, Kalyanaraman B, You M.

iScience. 2018 May 25;3:192-207. doi: 10.1016/j.isci.2018.04.013. Epub 2018 Apr 22.


IL-13 promotes in vivo neonatal cardiomyocyte cell cycle activity and heart regeneration.

Wodsedalek DJ, Paddock SJ, Wan TC, Auchampach JA, Kenarsary A, Tsaih SW, Flister MJ, O'Meara CC.

Am J Physiol Heart Circ Physiol. 2019 Jan 1;316(1):H24-H34. doi: 10.1152/ajpheart.00521.2018. Epub 2018 Oct 19.


mTORC1 and mTORC2 differentially promote natural killer cell development.

Yang C, Tsaih SW, Lemke A, Flister MJ, Thakar MS, Malarkannan S.

Elife. 2018 May 29;7. pii: e35619. doi: 10.7554/eLife.35619.


A High-Resolution Genetic Map for the Laboratory Rat.

Littrell J, Tsaih SW, Baud A, Rastas P, Solberg-Woods L, Flister MJ.

G3 (Bethesda). 2018 Jul 2;8(7):2241-2248. doi: 10.1534/g3.118.200187.


Genetic Fine-Mapping and Identification of Candidate Genes and Variants for Adiposity Traits in Outbred Rats.

Keele GR, Prokop JW, He H, Holl K, Littrell J, Deal A, Francic S, Cui L, Gatti DM, Broman KW, Tschannen M, Tsaih SW, Zagloul M, Kim Y, Baur B, Fox J, Robinson M, Levy S, Flister MJ, Mott R, Valdar W, Solberg Woods LC.

Obesity (Silver Spring). 2018 Jan;26(1):213-222. doi: 10.1002/oby.22075. Epub 2017 Nov 28.


SmgGDS is a transient nucleolar protein that protects cells from nucleolar stress and promotes the cell cycle by regulating DREAM complex gene expression.

Gonyo P, Bergom C, Brandt AC, Tsaih SW, Sun Y, Bigley TM, Lorimer EL, Terhune SS, Rui H, Flister MJ, Long RM, Williams CL.

Oncogene. 2017 Dec 14;36(50):6873-6883. doi: 10.1038/onc.2017.280. Epub 2017 Aug 14.


Host genetic modifiers of nonproductive angiogenesis inhibit breast cancer.

Flister MJ, Tsaih SW, Stoddard A, Plasterer C, Jagtap J, Parchur AK, Sharma G, Prisco AR, Lemke A, Murphy D, Al-Gizawiy M, Straza M, Ran S, Geurts AM, Dwinell MR, Greene AS, Bergom C, LaViolette PS, Joshi A.

Breast Cancer Res Treat. 2017 Aug;165(1):53-64. doi: 10.1007/s10549-017-4311-8. Epub 2017 May 31.


The phenotypic impact of the male-specific region of chromosome-Y in inbred mating: the role of genetic variants and gene duplications in multiple inbred rat strains.

Prokop JW, Tsaih SW, Faber AB, Boehme S, Underwood AC, Troyer S, Playl L, Milsted A, Turner ME, Ely D, Martins AS, Tutaj M, Lazar J, Dwinell MR, Jacob HJ.

Biol Sex Differ. 2016 Feb 3;7:10. doi: 10.1186/s13293-016-0064-z. eCollection 2016.


A locus on mouse chromosome 13 inversely regulates CD1d expression and the development of invariant natural killer T-cells.

Tsaih SW, Presa M, Khaja S, Ciecko AE, Serreze DV, Chen YG.

Genes Immun. 2015 Apr-May;16(3):221-30. doi: 10.1038/gene.2014.81. Epub 2015 Feb 5.


SH2B3 Is a Genetic Determinant of Cardiac Inflammation and Fibrosis.

Flister MJ, Hoffman MJ, Lemke A, Prisco SZ, Rudemiller N, O'Meara CC, Tsaih SW, Moreno C, Geurts AM, Lazar J, Adhikari N, Hall JL, Jacob HJ.

Circ Cardiovasc Genet. 2015 Apr;8(2):294-304. doi: 10.1161/CIRCGENETICS.114.000527. Epub 2015 Jan 27.


Identification of a novel gene for diabetic traits in rats, mice, and humans.

Tsaih SW, Holl K, Jia S, Kaldunski M, Tschannen M, He H, Andrae JW, Li SH, Stoddard A, Wiederhold A, Parrington J, Ruas da Silva M, Galione A, Meigs J; Meta-Analyses of Glucose and Insulin-Related Traits Consortium (MAGIC) Investigators, Hoffmann RG, Simpson P, Jacob H, Hessner M, Solberg Woods LC.

Genetics. 2014 Sep;198(1):17-29. doi: 10.1534/genetics.114.162982.


CXM: a new tool for mapping breast cancer risk in the tumor microenvironment.

Flister MJ, Endres BT, Rudemiller N, Sarkis AB, Santarriaga S, Roy I, Lemke A, Geurts AM, Moreno C, Ran S, Tsaih SW, De Pons J, Carlson DF, Tan W, Fahrenkrug SC, Lazarova Z, Lazar J, North PE, LaViolette PS, Dwinell MB, Shull JD, Jacob HJ.

Cancer Res. 2014 Nov 15;74(22):6419-29. doi: 10.1158/0008-5472.CAN-13-3212. Epub 2014 Aug 29.


Identifying multiple causative genes at a single GWAS locus.

Flister MJ, Tsaih SW, O'Meara CC, Endres B, Hoffman MJ, Geurts AM, Dwinell MR, Lazar J, Jacob HJ, Moreno C.

Genome Res. 2013 Dec;23(12):1996-2002. doi: 10.1101/gr.160283.113. Epub 2013 Sep 4.


Genomics in clinical practice: lessons from the front lines.

Jacob HJ, Abrams K, Bick DP, Brodie K, Dimmock DP, Farrell M, Geurts J, Harris J, Helbling D, Joers BJ, Kliegman R, Kowalski G, Lazar J, Margolis DA, North P, Northup J, Roquemore-Goins A, Scharer G, Shimoyama M, Strong K, Taylor B, Tsaih SW, Tschannen MR, Veith RL, Wendt-Andrae J, Wilk B, Worthey EA.

Sci Transl Med. 2013 Jul 17;5(194):194cm5. doi: 10.1126/scitranslmed.3006468.


Genetic control of murine invariant natural killer T cells maps to multiple type 1 diabetes regions.

Tsaih SW, Khaja S, Ciecko AE, MacKinney E, Chen YG.

Genes Immun. 2013 Sep;14(6):380-6. doi: 10.1038/gene.2013.32. Epub 2013 May 30.


Increased proliferative cells in the medullary thick ascending limb of the loop of Henle in the Dahl salt-sensitive rat.

Yang C, Stingo FC, Ahn KW, Liu P, Vannucci M, Laud PW, Skelton M, O'Connor P, Kurth T, Ryan RP, Moreno C, Tsaih SW, Patone G, Hummel O, Jacob HJ, Liang M, Cowley AW Jr.

Hypertension. 2013 Jan;61(1):208-15. doi: 10.1161/HYPERTENSIONAHA.112.199380. Epub 2012 Nov 26.


Fine-mapping diabetes-related traits, including insulin resistance, in heterogeneous stock rats.

Solberg Woods LC, Holl KL, Oreper D, Xie Y, Tsaih SW, Valdar W.

Physiol Genomics. 2012 Nov 1;44(21):1013-26. doi: 10.1152/physiolgenomics.00040.2012. Epub 2012 Sep 4.


Genetic analysis of albuminuria in collaborative cross and multiple mouse intercross populations.

Thaisz J, Tsaih SW, Feng M, Philip VM, Zhang Y, Yanas L, Sheehan S, Xu L, Miller DR, Paigen B, Chesler EJ, Churchill GA, Dipetrillo K.

Am J Physiol Renal Physiol. 2012 Oct;303(7):F972-81. doi: 10.1152/ajprenal.00690.2011. Epub 2012 Aug 1.


Subcongenic analyses reveal complex interactions between distal chromosome 4 genes controlling diabetogenic B cells and CD4 T cells in nonobese diabetic mice.

Stolp J, Chen YG, Cox SL, Henck V, Zhang W, Tsaih SW, Chapman H, Stearns T, Serreze DV, Silveira PA.

J Immunol. 2012 Aug 1;189(3):1406-17. doi: 10.4049/jimmunol.1200120. Epub 2012 Jun 25.


Role of genetic modifiers in an orthologous rat model of ARPKD.

O'Meara CC, Hoffman M, Sweeney WE Jr, Tsaih SW, Xiao B, Jacob HJ, Avner ED, Moreno C.

Physiol Genomics. 2012 Aug 1;44(15):741-53. doi: 10.1152/physiolgenomics.00187.2011. Epub 2012 Jun 5.


Genetic coregulation of age of female sexual maturation and lifespan through circulating IGF1 among inbred mouse strains.

Yuan R, Meng Q, Nautiyal J, Flurkey K, Tsaih SW, Krier R, Parker MG, Harrison DE, Paigen B.

Proc Natl Acad Sci U S A. 2012 May 22;109(21):8224-9. doi: 10.1073/pnas.1121113109. Epub 2012 May 7.


Using bioinformatics and systems genetics to dissect HDL-cholesterol genetics in an MRL/MpJ x SM/J intercross.

Leduc MS, Blair RH, Verdugo RA, Tsaih SW, Walsh K, Churchill GA, Paigen B.

J Lipid Res. 2012 Jun;53(6):1163-75. doi: 10.1194/jlr.M025833. Epub 2012 Apr 11.


Genetic variation in TRPS1 may regulate hip geometry as well as bone mineral density.

Ackert-Bicknell CL, Demissie S, Tsaih SW, Beamer WG, Cupples LA, Paigen BJ, Hsu YH, Kiel DP, Karasik D.

Bone. 2012 May;50(5):1188-95. doi: 10.1016/j.bone.2012.01.011. Epub 2012 Jan 28.


Genetic control of murine invariant natural killer T-cell development dynamically differs dependent on the examined tissue type.

Chen YG, Tsaih SW, Serreze DV.

Genes Immun. 2012 Feb;13(2):164-74. doi: 10.1038/gene.2011.68. Epub 2011 Sep 22.


Integration of QTL and bioinformatic tools to identify candidate genes for triglycerides in mice.

Leduc MS, Hageman RS, Verdugo RA, Tsaih SW, Walsh K, Churchill GA, Paigen B.

J Lipid Res. 2011 Sep;52(9):1672-82. doi: 10.1194/jlr.M011130. Epub 2011 May 26.


Genetic analysis of mouse strains with variable serum sodium concentrations identifies the Nalcn sodium channel as a novel player in osmoregulation.

Sinke AP, Caputo C, Tsaih SW, Yuan R, Ren D, Deen PM, Korstanje R.

Physiol Genomics. 2011 Mar 16;43(5):265-70. doi: 10.1152/physiolgenomics.00188.2010. Epub 2010 Dec 21.


Uncovering genes and regulatory pathways related to urinary albumin excretion.

Hageman RS, Leduc MS, Caputo CR, Tsaih SW, Churchill GA, Korstanje R.

J Am Soc Nephrol. 2011 Jan;22(1):73-81. doi: 10.1681/ASN.2010050561. Epub 2010 Oct 28.


Sequence variation at multiple loci influences red cell hemoglobin concentration.

Peters LL, Shavit JA, Lambert AJ, Tsaih SW, Li Q, Su Z, Leduc MS, Paigen B, Churchill GA, Ginsburg D, Brugnara C.

Blood. 2010 Dec 16;116(25):e139-49. doi: 10.1182/blood-2010-05-283879. Epub 2010 Sep 10.


Comparison of unrestrained plethysmography and forced oscillation for identifying genetic variability of airway responsiveness in inbred mice.

Berndt A, Leme AS, Williams LK, Von Smith R, Savage HS, Stearns TM, Tsaih SW, Shapiro SD, Peters LL, Paigen B, Svenson KL.

Physiol Genomics. 2011 Jan 7;43(1):1-11. doi: 10.1152/physiolgenomics.00108.2010. Epub 2010 Sep 7.


Identification of genetic determinants of IGF-1 levels and longevity among mouse inbred strains.

Leduc MS, Hageman RS, Meng Q, Verdugo RA, Tsaih SW, Churchill GA, Paigen B, Yuan R.

Aging Cell. 2010 Oct;9(5):823-36. doi: 10.1111/j.1474-9726.2010.00612.x.


Mouse BMD quantitative trait loci show improved concordance with human genome-wide association loci when recalculated on a new, common mouse genetic map.

Ackert-Bicknell CL, Karasik D, Li Q, Smith RV, Hsu YH, Churchill GA, Paigen BJ, Tsaih SW.

J Bone Miner Res. 2010 Aug;25(8):1808-20. doi: 10.1002/jbmr.72.


A survey of airway responsiveness in 36 inbred mouse strains facilitates gene mapping studies and identification of quantitative trait loci.

Leme AS, Berndt A, Williams LK, Tsaih SW, Szatkiewicz JP, Verdugo R, Paigen B, Shapiro SD.

Mol Genet Genomics. 2010 Apr;283(4):317-26. doi: 10.1007/s00438-010-0515-x. Epub 2010 Feb 9.


An experimental assessment of in silico haplotype association mapping in laboratory mice.

Burgess-Herbert SL, Tsaih SW, Stylianou IM, Walsh K, Cox AJ, Paigen B.

BMC Genet. 2009 Dec 9;10:81. doi: 10.1186/1471-2156-10-81.


Genetic analysis of albuminuria in aging mice and concordance with loci for human diabetic nephropathy found in a genome-wide association scan.

Tsaih SW, Pezzolesi MG, Yuan R, Warram JH, Krolewski AS, Korstanje R.

Kidney Int. 2010 Feb;77(3):201-10. doi: 10.1038/ki.2009.434. Epub 2009 Nov 18.


Haplotype association mapping in mice.

Tsaih SW, Korstanje R.

Methods Mol Biol. 2009;573:213-22. doi: 10.1007/978-1-60761-247-6_12. Review.


Genetic analysis of blood pressure in 8 mouse intercross populations.

Feng M, Deerhake ME, Keating R, Thaisz J, Xu L, Tsaih SW, Smith R, Ishige T, Sugiyama F, Churchill GA, DiPetrillo K.

Hypertension. 2009 Oct;54(4):802-9. doi: 10.1161/HYPERTENSIONAHA.109.134569. Epub 2009 Aug 3.


Aging in inbred strains of mice: study design and interim report on median lifespans and circulating IGF1 levels.

Yuan R, Tsaih SW, Petkova SB, Marin de Evsikova C, Xing S, Marion MA, Bogue MA, Mills KD, Peters LL, Bult CJ, Rosen CJ, Sundberg JP, Harrison DE, Churchill GA, Paigen B.

Aging Cell. 2009 Jun;8(3):277-87. doi: 10.1111/j.1474-9726.2009.00478.x. Epub 2009 Apr 9.


A new standard genetic map for the laboratory mouse.

Cox A, Ackert-Bicknell CL, Dumont BL, Ding Y, Bell JT, Brockmann GA, Wergedal JE, Bult C, Paigen B, Flint J, Tsaih SW, Churchill GA, Broman KW.

Genetics. 2009 Aug;182(4):1335-44. doi: 10.1534/genetics.109.105486. Epub 2009 Jun 17.


Genetic influence on electrocardiogram time intervals and heart rate in aging mice.

Xing S, Tsaih SW, Yuan R, Svenson KL, Jorgenson LM, So M, Paigen BJ, Korstanje R.

Am J Physiol Heart Circ Physiol. 2009 Jun;296(6):H1907-13. doi: 10.1152/ajpheart.00681.2008. Epub 2009 Apr 24.


Genetic factors contributing to obesity and body weight can act through mechanisms affecting muscle weight, fat weight, or both.

Brockmann GA, Tsaih SW, Neuschl C, Churchill GA, Li R.

Physiol Genomics. 2009 Jan 8;36(2):114-26. doi: 10.1152/physiolgenomics.90277.2008. Epub 2008 Nov 4.


Practical applications of the bioinformatics toolbox for narrowing quantitative trait loci.

Burgess-Herbert SL, Cox A, Tsaih SW, Paigen B.

Genetics. 2008 Dec;180(4):2227-35. doi: 10.1534/genetics.108.090175. Epub 2008 Oct 9.


Idd9/11 genetic locus regulates diabetogenic activity of CD4 T-cells in nonobese diabetic (NOD) mice.

Chen YG, Scheuplein F, Osborne MA, Tsaih SW, Chapman HD, Serreze DV.

Diabetes. 2008 Dec;57(12):3273-80. doi: 10.2337/db08-0767. Epub 2008 Sep 5.


Genetic basis of HDL variation in 129/SvImJ and C57BL/6J mice: importance of testing candidate genes in targeted mutant mice.

Su Z, Wang X, Tsaih SW, Zhang A, Cox A, Sheehan S, Paigen B.

J Lipid Res. 2009 Jan;50(1):116-25. doi: 10.1194/jlr.M800411-JLR200. Epub 2008 Sep 4.

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