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Structural basis for chain release from the enacyloxin polyketide synthase.

Kosol S, Gallo A, Griffiths D, Valentic TR, Masschelein J, Jenner M, de Los Santos ELC, Manzi L, Sydor PK, Rea D, Zhou S, Fülöp V, Oldham NJ, Tsai SC, Challis GL, Lewandowski JR.

Nat Chem. 2019 Oct;11(10):913-923. doi: 10.1038/s41557-019-0335-5. Epub 2019 Sep 23.


Functional roles of ST8SIA3-mediated sialylation of striatal dopamine D2 and adenosine A2A receptors.

Lin CY, Lai HL, Chen HM, Siew JJ, Hsiao CT, Chang HC, Liao KS, Tsai SC, Wu CY, Kitajima K, Sato C, Khoo KH, Chern Y.

Transl Psychiatry. 2019 Aug 27;9(1):209. doi: 10.1038/s41398-019-0529-z.


Association between mild anemia and physical fitness in a military male cohort: The CHIEF study.

Tsai KZ, Lai SW, Hsieh CJ, Lin CS, Lin YP, Tsai SC, Chung PS, Lin YK, Lin TC, Ho CL, Han CL, Kwon Y, Hsieh CB, Lin GM.

Sci Rep. 2019 Aug 1;9(1):11165. doi: 10.1038/s41598-019-47625-3.


Molecular basis for interactions between an acyl carrier protein and a ketosynthase.

Milligan JC, Lee DJ, Jackson DR, Schaub AJ, Beld J, Barajas JF, Hale JJ, Luo R, Burkart MD, Tsai SC.

Nat Chem Biol. 2019 Jul;15(7):669-671. doi: 10.1038/s41589-019-0301-y. Epub 2019 Jun 17.


Co-Delivery of Natural Compounds with a Dual-Targeted Nanoparticle Delivery System for Improving Synergistic Therapy in an Orthotopic Tumor Model.

Chu PY, Tsai SC, Ko HY, Wu CC, Lin YH.

ACS Appl Mater Interfaces. 2019 Jul 10;11(27):23880-23892. doi: 10.1021/acsami.9b06155. Epub 2019 Jun 25.


Computational structural enzymology methodologies for the study and engineering of fatty acid synthases, polyketide synthases and nonribosomal peptide synthetases.

Schaub AJ, Moreno GO, Zhao S, Truong HV, Luo R, Tsai SC.

Methods Enzymol. 2019;622:375-409. doi: 10.1016/bs.mie.2019.03.001. Epub 2019 Apr 22.


An EXAFS study for characterizing the time-dependent adsorption of cesium on bentonite.

Liu WT, Tsai SC, Tsai TL, Lee CP, Lee CH.

Environ Sci Process Impacts. 2019 Jun 19;21(6):930-937. doi: 10.1039/c9em00124g.


Association of Genetic Variants of RANK, RANKL, and OPG with Ankylosing Spondylitis Clinical Features in Taiwanese.

Wang CM, Tsai SC, Lin JC, Wu YJ, Wu J, Chen JY.

Mediators Inflamm. 2019 Mar 20;2019:8029863. doi: 10.1155/2019/8029863. eCollection 2019.


Automatic EPAP intelligent volume-assured pressure support is effective in patients with chronic respiratory failure: A randomized trial.

Orr JE, Coleman J, Criner GJ, Sundar KM, Tsai SC, Benjafield AV, Crocker ME, Willes L, Malhotra A, Owens RL, Wolfe LF.

Respirology. 2019 Apr 22. doi: 10.1111/resp.13546. [Epub ahead of print]


Effects of periodic carbohydrate ingestion on endurance and cognitive performances during a 40-km cycling time-trial under normobaric hypoxia in well-trained triathletes.

Liao YH, Mündel T, Yang YT, Wei CC, Tsai SC.

J Sports Sci. 2019 Aug;37(16):1805-1815. doi: 10.1080/02640414.2019.1595338. Epub 2019 Mar 21.


Soymilk ingestion immediately after therapeutic exercise enhances rehabilitation outcomes in chronic stroke patients: A randomized controlled trial.

Liao YH, Chen CN, Hu CY, Tsai SC, Kuo YC.

NeuroRehabilitation. 2019;44(2):217-229. doi: 10.3233/NRE-182574.


The association between human papillomavirus infection and head and neck cancer: A population-based cohort study.

Tsai SC, Huang JY, Lin C, Liaw YP, Lin FC.

Medicine (Baltimore). 2019 Feb;98(7):e14436. doi: 10.1097/MD.0000000000014436.


Diffusiophoresis of a Highly Charged Porous Particle Induced by Diffusion Potential.

Tsai SC, Lee E.

Langmuir. 2019 Feb 26;35(8):3143-3155. doi: 10.1021/acs.langmuir.8b04146. Epub 2019 Feb 13.


Polysomnographic characteristics of adolescents with asthma and low risk for sleep-disordered breathing.

Khassawneh B, Tsai SC, Meltzer LJ.

Sleep Breath. 2019 Sep;23(3):943-951. doi: 10.1007/s11325-018-01774-3. Epub 2019 Jan 28.


Caspase‑dependent apoptotic death by gadolinium chloride (GdCl3) via reactive oxygen species production and MAPK signaling in rat C6 glioma cells.

Tsai YF, Chen YF, Hsiao CY, Huang CW, Lu CC, Tsai SC, Yang JS.

Oncol Rep. 2019 Feb;41(2):1324-1332. doi: 10.3892/or.2018.6913. Epub 2018 Dec 7.


Novel method for analyzing transport parameters in through-diffusion tests.

Wang BT, Lee CP, Wu MC, Tsai TL, Tsai SC, Hsu KC.

J Environ Radioact. 2019 Jan;196:125-132. doi: 10.1016/j.jenvrad.2018.11.004. Epub 2018 Nov 16.


Exploiting Honokiol-induced ER stress CHOP activation inhibits the growth and metastasis of melanoma by suppressing the MITF and β-catenin pathways.

Chiu CS, Tsai CH, Hsieh MS, Tsai SC, Jan YJ, Lin WY, Lai DW, Wu SM, Hsing HY, Arbiser JL, Sheu ML.

Cancer Lett. 2019 Feb 1;442:113-125. doi: 10.1016/j.canlet.2018.10.026. Epub 2018 Nov 1.


Benzyl isothiocyanate (BITC) triggers mitochondria-mediated apoptotic machinery in human cisplatin-resistant oral cancer CAR cells.

Lee CF, Chiang NN, Lu YH, Huang YS, Yang JS, Tsai SC, Lu CC, Chen FA.

Biomedicine (Taipei). 2018 Sep;8(3):15. doi: 10.1051/bmdcn/2018080315. Epub 2018 Aug 24.


Neurocognitive performance in insomnia disorder: The impact of hyperarousal and short sleep duration.

Khassawneh BY, Bathgate CJ, Tsai SC, Edinger JD.

J Sleep Res. 2018 Dec;27(6):e12747. doi: 10.1111/jsr.12747. Epub 2018 Aug 1.


Computed tomography-guided localization with laser angle guide for thoracic procedures.

Lin FC, Tsai SC, Tu HT, Lai YL, Wu TC.

J Thorac Dis. 2018 Jun;10(6):3824-3828. doi: 10.21037/jtd.2018.05.162.


Ursolic acid elicits intrinsic apoptotic machinery by downregulating the phosphorylation of AKT/BAD signaling in human cisplatin‑resistant oral cancer CAR cells.

Chen CF, Yang JS, Chen WK, Lu CC, Chiang JH, Chiu HY, Tsai SC, Juan YN, Huang HJ, Way TD.

Oncol Rep. 2018 Sep;40(3):1752-1760. doi: 10.3892/or.2018.6530. Epub 2018 Jun 27.


The Structural Enzymology of Iterative Aromatic Polyketide Synthases: A Critical Comparison with Fatty Acid Synthases.

Tsai SC.

Annu Rev Biochem. 2018 Jun 20;87:503-531. doi: 10.1146/annurev-biochem-063011-164509. Review.


High exposure compared with standard exposure to metoclopramide associated with a higher risk of parkinsonism: a nationwide population-based cohort study.

Tsai SC, Sheu SY, Chien LN, Lee HC, Yuan EJ, Yuan RY.

Br J Clin Pharmacol. 2018 Sep;84(9):2000-2009. doi: 10.1111/bcp.13630. Epub 2018 Jun 19.


An Oxetane-Based Polyketide Surrogate To Probe Substrate Binding in a Polyketide Synthase.

Ellis BD, Milligan JC, White AR, Duong V, Altman PX, Mohammed LY, Crump MP, Crosby J, Luo R, Vanderwal CD, Tsai SC.

J Am Chem Soc. 2018 Apr 18;140(15):4961-4964. doi: 10.1021/jacs.7b11793. Epub 2018 Apr 10.


The molecular mechanism of contrast-induced nephropathy (CIN) and its link to in vitro studies on iodinated contrast media (CM).

Yang JS, Peng YR, Tsai SC, Tyan YS, Lu CC, Chiu HY, Chiu YJ, Kuo SC, Tsai YF, Lin PC, Tsai FJ.

Biomedicine (Taipei). 2018 Mar;8(1):1. doi: 10.1051/bmdcn/2018080101. Epub 2018 Feb 26.


An Amino Acids Mixture Attenuates Glycemic Impairment but not Affects Adiposity Development in Rats Fed with AGEs-containing Diet.

Liao YH, Chen CY, Chen CN, Wu CY, Tsai SC.

Int J Med Sci. 2018 Jan 1;15(2):176-187. doi: 10.7150/ijms.22008. eCollection 2018.


Relaxant and vasoprotective effects of ginger extracts on porcine coronary arteries.

Wu HC, Horng CT, Tsai SC, Lee YL, Hsu SC, Tsai YJ, Tsai FJ, Chiang JH, Kuo DH, Yang JS.

Int J Mol Med. 2018 Apr;41(4):2420-2428. doi: 10.3892/ijmm.2018.3380. Epub 2018 Jan 11.


Faraday Waves-Based Integrated Ultrasonic Micro-Droplet Generator and Applications.

Tsai CS, Mao RW, Tsai SC, Shahverdi K, Zhu Y, Lin SK, Hsu YH, Boss G, Brenner M, Mahon S, Smaldone GC.

Micromachines (Basel). 2017;8(2). pii: 56. doi: 10.3390/mi8020056. Epub 2017 Feb 14.


IsoPlot: a database for comparison of mRNA isoforms in fruit fly and mosquitoes.

Ng IM, Huang JH, Tsai SC, Tsai HK.

Database (Oxford). 2017 Jan 1;2017. doi: 10.1093/database/bax069.


Effectiveness of Oral Rinsing Solutions on Mucus, Odor, and Plaque in the Hospitalized Elderly in Taiwan.

Chen SC, Weng LC, Tsai SC, Wang SM, Han HM.

Clin Nurs Res. 2019 Jul;28(6):762-776. doi: 10.1177/1054773817744151. Epub 2017 Nov 22.


Structural and Functional Studies of the Daunorubicin Priming Ketosynthase DpsC.

Jackson DR, Shakya G, Patel AB, Mohammed LY, Vasilakis K, Wattana-Amorn P, Valentic TR, Milligan JC, Crump MP, Crosby J, Tsai SC.

ACS Chem Biol. 2018 Jan 19;13(1):141-151. doi: 10.1021/acschembio.7b00551. Epub 2017 Dec 11.


ITR‑284 modulates cell differentiation in human chronic myelogenous leukemia K562 cells.

Yang JS, Lee CY, Cho HC, Lu CC, Kuo SC, Wen YF, Tsai FJ, Lee MR, Tsai SC.

Oncol Rep. 2018 Jan;39(1):383-391. doi: 10.3892/or.2017.6090. Epub 2017 Nov 9.


The differential regulation of microRNAs is associated with oral cancer.

Tsai SC, Huang SF, Chiang JH, Chen YF, Huang CC, Tsai MH, Tsai FJ, Kao MC, Yang JS.

Oncol Rep. 2017 Sep;38(3):1613-1620. doi: 10.3892/or.2017.5811. Epub 2017 Jul 12.


An integrated microfluidic system for the isolation and detection of ovarian circulating tumor cells using cell selection and enrichment methods.

Tsai SC, Hung LY, Lee GB.

Biomicrofluidics. 2017 Jun 30;11(3):034122. doi: 10.1063/1.4991476. eCollection 2017 May.


Erratum to: Impact of metabolic syndrome and its components on heart rate variability during hemodialysis: a cross-sectional study.

Chang YM, Shiao CC, Huang YT, Chen IL, Yang CL, Leu SC, Su HL, Kao JL, Tsai SC, Jhen RN, Uen CC; SMCKD (Saint Mary’s hospital Chronic Kidney Disease) study group.

Cardiovasc Diabetol. 2017 Jul 14;16(1):90. doi: 10.1186/s12933-017-0562-2. No abstract available.


Correction: Heart rate variability during hemodialysis is an indicator for long-term vascular access survival in uremic patients.

Huang YT, Chang YM, Chen IL, Yang CL, Leu SC, Su HL, Kao JL, Tsai SC, Jhen RN, Tang WR, Shiao CC; SMHRG (Saint Mary’s Hospital Research Group on Geriatrics).

PLoS One. 2017 Jul 7;12(7):e0181283. doi: 10.1371/journal.pone.0181283. eCollection 2017.


A Direct Synthesis of Highly Substituted π-Rich Aromatic Heterocycles from Oxetanes.

White AR, Kozlowski RA, Tsai SC, Vanderwal CD.

Angew Chem Int Ed Engl. 2017 Aug 21;56(35):10525-10529. doi: 10.1002/anie.201704119. Epub 2017 Jul 21.


Autophagy and its link to type II diabetes mellitus.

Yang JS, Lu CC, Kuo SC, Hsu YM, Tsai SC, Chen SY, Chen YT, Lin YJ, Huang YC, Chen CJ, Lin WD, Liao WL, Lin WY, Liu YH, Sheu JC, Tsai FJ.

Biomedicine (Taipei). 2017 Jun;7(2):8. doi: 10.1051/bmdcn/2017070201. Epub 2017 Jun 14.


Polyketide mimetics yield structural and mechanistic insights into product template domain function in nonreducing polyketide synthases.

Barajas JF, Shakya G, Moreno G, Rivera H Jr, Jackson DR, Topper CL, Vagstad AL, La Clair JJ, Townsend CA, Burkart MD, Tsai SC.

Proc Natl Acad Sci U S A. 2017 May 23;114(21):E4142-E4148. doi: 10.1073/pnas.1609001114. Epub 2017 May 8.


Stimulatory Effect of Food Restriction on the Steroidogenesis of Aldosterone in Ovariectomized Rats.

Kau MM, Yu CH, Tsai SC, Wang JR, Wang PS.

Chin J Physiol. 2017 Apr 30;60(2):97-105. doi: 10.4077/CJP.2017.BAF500.


Initial systemic inflammatory state perturbs exercise training adaptations in elite Taekwondo athletes.

Chen CY, Liao YH, Chou CC, Sung YC, Tsai SC.

PLoS One. 2017 Apr 19;12(4):e0176140. doi: 10.1371/journal.pone.0176140. eCollection 2017.


The miR-200b-ZEB1 circuit regulates diverse stemness of human hepatocellular carcinoma.

Tsai SC, Lin CC, Shih TC, Tseng RJ, Yu MC, Lin YJ, Hsieh SY.

Mol Carcinog. 2017 Sep;56(9):2035-2047. doi: 10.1002/mc.22657. Epub 2017 Apr 18.


PG2 for patients with acute spontaneous intracerebral hemorrhage: a double-blind, randomized, placebo-controlled study.

Chen CC, Chen X, Li TC, Lin HL, Chu YT, Lee HC, Cheng YK, Chen DC, Tsai SC, Cho DY, Hsieh CL.

Sci Rep. 2017 Mar 31;7:45628. doi: 10.1038/srep45628.


Overexpression of exogenous kidney-specific Ngal attenuates progressive cyst development and prolongs lifespan in a murine model of polycystic kidney disease.

Wang E, Chiou YY, Jeng WY, Lin HK, Lin HH, Chin HJ, Leo Wang CK, Yu SS, Tsai SC, Chiang CY, Cheng PH, Lin HJ, Jiang ST, Chiu ST, Hsieh-Li HM.

Kidney Int. 2017 Feb;91(2):412-422. doi: 10.1016/j.kint.2016.09.005. Epub 2016 Oct 27.


Heart rate variability during hemodialysis is an indicator for long-term vascular access survival in uremic patients.

Huang YT, Chang YM, Chen IL, Yang CL, Leu SC, Su HL, Kao JL, Tsai SC, Jhen RN, Tang WR, Shiao CC; SMHRG (Saint Mary’s Hospital Research Group on Geriatrics).

PLoS One. 2017 Mar 1;12(3):e0172212. doi: 10.1371/journal.pone.0172212. eCollection 2017. Erratum in: PLoS One. 2017 Jul 7;12 (7):e0181283.


Erratum to: Effects of lanthanum carbonate and calcium carbonate on fibroblast growth factor 23 and hepcidin levels in chronic hemodialysis patients.

Chang YM, Tsai SC, Shiao CC, Liou HH, Yang CL, Tung NY, Hsu KS, Chen IL, Liu MC, Kao JL, Jhen RN, Huang YT.

Clin Exp Nephrol. 2017 Oct;21(5):917-918. doi: 10.1007/s10157-017-1384-y. No abstract available.


Carboxamide analog ITR-284 evokes apoptosis and inhibits migration ability in human lung adenocarcinoma A549 cells.

Yang JS, Lin CA, Lu CC, Wen YF, Tsai FJ, Tsai SC.

Oncol Rep. 2017 Mar;37(3):1786-1792. doi: 10.3892/or.2017.5374. Epub 2017 Jan 16.


Complicated skin and soft tissue infection with Mycobacterium fortuitum following excision of a sebaceous cyst in Taiwan.

Tsai SC, Chen LH, Liao HH, Chiang CY, Lin WL, Chen SC, Tsao SM, Hung HC, Lee YT.

J Infect Dev Ctries. 2016 Dec 30;10(12):1357-1361. doi: 10.3855/jidc.7356.


Ketorolac Tromethamine Spray Prevents Postendotracheal-Intubation-Induced Sore Throat after General Anesthesia.

Yang HL, Liu FC, Tsai SC, Tsay PK, Lin HT, Liu HE.

Biomed Res Int. 2016;2016:4582439. doi: 10.1155/2016/4582439. Epub 2016 Nov 29.


A crotonyl-CoA reductase-carboxylase independent pathway for assembly of unusual alkylmalonyl-CoA polyketide synthase extender units.

Ray L, Valentic TR, Miyazawa T, Withall DM, Song L, Milligan JC, Osada H, Takahashi S, Tsai SC, Challis GL.

Nat Commun. 2016 Dec 21;7:13609. doi: 10.1038/ncomms13609.

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