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Items: 1 to 50 of 404

1.

Association of crumbs homolog-2 with mTORC1 in developing podocyte.

Hamano S, Nishibori Y, Hada I, Mikami N, Ito-Nitta N, Fukuhara D, Kudo A, Xiao Z, Nukui M, Patrakka J, Tryggvason K, Yan K.

PLoS One. 2018 Aug 20;13(8):e0202400. doi: 10.1371/journal.pone.0202400. eCollection 2018.

PMID:
30125302
2.

Culturing functional pancreatic islets on α5-laminins and curative transplantation to diabetic mice.

Sigmundsson K, Ojala JRM, Öhman MK, Österholm AM, Moreno-Moral A, Domogatskaya A, Chong LY, Sun Y, Chai X, Steele JAM, George B, Patarroyo M, Nilsson AS, Rodin S, Ghosh S, Stevens MM, Petretto E, Tryggvason K.

Matrix Biol. 2018 Sep;70:5-19. doi: 10.1016/j.matbio.2018.03.018. Epub 2018 Mar 27.

3.

A systematic approach to the development of a safe live attenuated Zika vaccine.

Kwek SS, Watanabe S, Chan KR, Ong EZ, Tan HC, Ng WC, Nguyen MTX, Gan ES, Zhang SL, Chan KWK, Tan JH, Sessions OM, Manuel M, Pompon J, Chua C, Hazirah S, Tryggvason K, Vasudevan SG, Ooi EE.

Nat Commun. 2018 Mar 12;9(1):1031. doi: 10.1038/s41467-018-03337-2.

4.

Laminin-521 Protein Therapy for Glomerular Basement Membrane and Podocyte Abnormalities in a Model of Pierson Syndrome.

Lin MH, Miller JB, Kikkawa Y, Suleiman HY, Tryggvason K, Hodges BL, Miner JH.

J Am Soc Nephrol. 2018 May;29(5):1426-1436. doi: 10.1681/ASN.2017060690. Epub 2018 Feb 22.

PMID:
29472414
5.

Preventing tissue fibrosis by local biomaterials interfacing of specific cryptic extracellular matrix information.

Horejs CM, St-Pierre JP, Ojala JRM, Steele JAM, da Silva PB, Rynne-Vidal A, Maynard SA, Hansel CS, Rodríguez-Fernández C, Mazo MM, You AYF, Wang AJ, von Erlach T, Tryggvason K, López-Cabrera M, Stevens MM.

Nat Commun. 2017 Jun 8;8:15509. doi: 10.1038/ncomms15509.

6.

Quality Assurance in Stem Cell Banking: Emphasis on Embryonic and Induced Pluripotent Stem Cell Banking.

Kallur T, Blomberg P, Stenfelt S, Tryggvason K, Hovatta O.

Methods Mol Biol. 2017;1590:11-16. doi: 10.1007/978-1-4939-6921-0_2. Review.

PMID:
28353259
7.

Ab initio solution of macromolecular crystal structures without direct methods.

McCoy AJ, Oeffner RD, Wrobel AG, Ojala JR, Tryggvason K, Lohkamp B, Read RJ.

Proc Natl Acad Sci U S A. 2017 Apr 4;114(14):3637-3641. doi: 10.1073/pnas.1701640114. Epub 2017 Mar 21.

8.

Wolf-Hirschhorn syndrome candidate 1-like 1 epigenetically regulates nephrin gene expression.

Ito Y, Katayama K, Nishibori Y, Akimoto Y, Kudo A, Kurayama R, Hada I, Takahashi S, Kimura T, Fukutomi T, Katada T, Suehiro J, Beltcheva O, Tryggvason K, Yan K.

Am J Physiol Renal Physiol. 2017 Jun 1;312(6):F1184-F1199. doi: 10.1152/ajprenal.00305.2016. Epub 2017 Feb 22.

9.

Differentiation of Human Embryonic Stem Cells to Endothelial Progenitor Cells on Laminins in Defined and Xeno-free Systems.

Nguyen MTX, Okina E, Chai X, Tan KH, Hovatta O, Ghosh S, Tryggvason K.

Stem Cell Reports. 2016 Oct 11;7(4):802-816. doi: 10.1016/j.stemcr.2016.08.017. Epub 2016 Sep 29.

10.

COL4A6 is dispensable for autosomal recessive Alport syndrome.

Murata T, Katayama K, Oohashi T, Jahnukainen T, Yonezawa T, Sado Y, Ishikawa E, Nomura S, Tryggvason K, Ito M.

Sci Rep. 2016 Jul 5;6:29450. doi: 10.1038/srep29450.

11.

A novel podocyte gene, semaphorin 3G, protects glomerular podocyte from lipopolysaccharide-induced inflammation.

Ishibashi R, Takemoto M, Akimoto Y, Ishikawa T, He P, Maezawa Y, Sakamoto K, Tsurutani Y, Ide S, Ide K, Kawamura H, Kobayashi K, Tokuyama H, Tryggvason K, Betsholtz C, Yokote K.

Sci Rep. 2016 May 16;6:25955. doi: 10.1038/srep25955.

12.

Wnt/β-Catenin Stimulation and Laminins Support Cardiovascular Cell Progenitor Expansion from Human Fetal Cardiac Mesenchymal Stromal Cells.

Månsson-Broberg A, Rodin S, Bulatovic I, Ibarra C, Löfling M, Genead R, Wärdell E, Felldin U, Granath C, Alici E, Le Blanc K, Smith CIE, Salašová A, Westgren M, Sundström E, Uhlén P, Arenas E, Sylvén C, Tryggvason K, Corbascio M, Simonson OE, Österholm C, Grinnemo KH.

Stem Cell Reports. 2016 Apr 12;6(4):607-617. doi: 10.1016/j.stemcr.2016.02.014. Epub 2016 Mar 24.

13.

Human embryonic stem cells.

Damdimopoulou P, Rodin S, Stenfelt S, Antonsson L, Tryggvason K, Hovatta O.

Best Pract Res Clin Obstet Gynaecol. 2016 Feb;31:2-12. doi: 10.1016/j.bpobgyn.2015.08.010. Epub 2015 Sep 11. Review.

PMID:
26602389
14.

Knockdown of Tmem234 in zebrafish results in proteinuria.

Rodriguez PQ, Oddsson A, Ebarasi L, He B, Hultenby K, Wernerson A, Betsholtz C, Tryggvason K, Patrakka J.

Am J Physiol Renal Physiol. 2015 Dec 1;309(11):F955-66. doi: 10.1152/ajprenal.00525.2014. Epub 2015 Sep 16.

15.

Dendrin ablation prolongs life span by delaying kidney failure.

Weins A, Wong JS, Basgen JM, Gupta R, Daehn I, Casagrande L, Lessman D, Schwartzman M, Meliambro K, Patrakka J, Shaw A, Tryggvason K, He JC, Nicholas SB, Mundel P, Campbell KN.

Am J Pathol. 2015 Aug;185(8):2143-57. doi: 10.1016/j.ajpath.2015.04.011. Epub 2015 Jun 12.

16.

Correction: Schip1 Is a Novel Podocyte Foot Process Protein that Mediates Actin Cytoskeleton Rearrangements and Forms a Complex with Nherf2 and Ezrin.

Perisic L, Rodriguez PQ, Hultenby K, Sun Y, Lal M, Betsholtz C, Uhlén M, Wernerson A, Hedin U, Pikkarainen T, Tryggvason K, Patrakka J.

PLoS One. 2015 May 12;10(5):e0126079. doi: 10.1371/journal.pone.0126079. eCollection 2015. No abstract available.

17.

Schip1 is a novel podocyte foot process protein that mediates actin cytoskeleton rearrangements and forms a complex with Nherf2 and ezrin.

Perisic L, Rodriguez PQ, Hultenby K, Sun Y, Lal M, Betsholtz C, Uhlén M, Wernerson A, Hedin U, Pikkarainen T, Tryggvason K, Patrakka J.

PLoS One. 2015 Mar 25;10(3):e0122067. doi: 10.1371/journal.pone.0122067. eCollection 2015. Erratum in: PLoS One. 2015;10(5):e0126079.

18.

Neph1 is reduced in primary focal segmental glomerulosclerosis, minimal change nephrotic syndrome, and corresponding experimental animal models of adriamycin-induced nephropathy and puromycin aminonucleoside nephrosis.

Hulkko J, Patrakka J, Lal M, Tryggvason K, Hultenby K, Wernerson A.

Nephron Extra. 2014 Sep 19;4(3):146-54. doi: 10.1159/000365091. eCollection 2014 Sep.

19.

Searching for a treatment for Alport syndrome using mouse models.

Katayama K, Nomura S, Tryggvason K, Ito M.

World J Nephrol. 2014 Nov 6;3(4):230-6. doi: 10.5527/wjn.v3.i4.230. Review.

20.

Laminin α4 deficient mice exhibit decreased capacity for adipose tissue expansion and weight gain.

Vaicik MK, Thyboll Kortesmaa J, Movérare-Skrtic S, Kortesmaa J, Soininen R, Bergström G, Ohlsson C, Chong LY, Rozell B, Emont M, Cohen RN, Brey EM, Tryggvason K.

PLoS One. 2014 Oct 13;9(10):e109854. doi: 10.1371/journal.pone.0109854. eCollection 2014.

21.

Concise review: animal substance-free human embryonic stem cells aiming at clinical applications.

Hovatta O, Rodin S, Antonsson L, Tryggvason K.

Stem Cells Transl Med. 2014 Nov;3(11):1269-74. doi: 10.5966/sctm.2014-0129. Epub 2014 Oct 8. Review.

22.

Perlecan heparan sulfate proteoglycan is a critical determinant of angiogenesis in response to mouse hind-limb ischemia.

Qiang B, Lim SY, Lekas M, Kuliszewski MA, Wolff R, Osherov AB, Rudenko D, Leong-Poi H, Noyan H, Husain M, Tran K, Tryggvason K, Hedin U, Tran-Lundmark K, Strauss BH.

Can J Cardiol. 2014 Nov;30(11):1444-51. doi: 10.1016/j.cjca.2014.06.003. Epub 2014 Jun 12.

PMID:
25249499
23.

Monolayer culturing and cloning of human pluripotent stem cells on laminin-521-based matrices under xeno-free and chemically defined conditions.

Rodin S, Antonsson L, Hovatta O, Tryggvason K.

Nat Protoc. 2014 Oct;9(10):2354-68. doi: 10.1038/nprot.2014.159. Epub 2014 Sep 11.

PMID:
25211513
24.

Rhophilin-1 is a key regulator of the podocyte cytoskeleton and is essential for glomerular filtration.

Lal MA, Andersson AC, Katayama K, Xiao Z, Nukui M, Hultenby K, Wernerson A, Tryggvason K.

J Am Soc Nephrol. 2015 Mar;26(3):647-62. doi: 10.1681/ASN.2013111195. Epub 2014 Jul 28.

25.

Repeatable, Inducible Micro-RNA-Based Technology Tightly Controls Liver Transgene Expression.

Oprea II, Viola JR, Moreno PM, Simonson OE, Rodin S, Teller N, Tryggvason K, Lundin KE, Girnita L, Smith CI.

Mol Ther Nucleic Acids. 2014 Jul 1;3:e172. doi: 10.1038/mtna.2014.25.

26.

Novel genetic susceptibility loci for diabetic end-stage renal disease identified through robust naive Bayes classification.

Sambo F, Malovini A, Sandholm N, Stavarachi M, Forsblom C, Mäkinen VP, Harjutsalo V, Lithovius R, Gordin D, Parkkonen M, Saraheimo M, Thorn LM, Tolonen N, Wadén J, He B, Osterholm AM, Tuomilehto J, Lajer M, Salem RM, McKnight AJ; GENIE Consortium, Tarnow L, Panduru NM, Barbarini N, Di Camillo B, Toffolo GM, Tryggvason K, Bellazzi R, Cobelli C; FinnDiane Study Group, Groop PH.

Diabetologia. 2014 Aug;57(8):1611-22. doi: 10.1007/s00125-014-3256-2. Epub 2014 May 29.

PMID:
24871321
27.

Heparan sulfate side chains have a critical role in the inhibitory effects of perlecan on vascular smooth muscle cell response to arterial injury.

Gotha L, Lim SY, Osherov AB, Wolff R, Qiang B, Erlich I, Nili N, Pillarisetti S, Chang YT, Tran PK, Tryggvason K, Hedin U, Tran-Lundmark K, Advani SL, Gilbert RE, Strauss BH.

Am J Physiol Heart Circ Physiol. 2014 Aug 1;307(3):H337-45. doi: 10.1152/ajpheart.00654.2013. Epub 2014 May 23.

28.

Lmx1b and FoxC combinatorially regulate podocin expression in podocytes.

He B, Ebarasi L, Zhao Z, Guo J, Ojala JR, Hultenby K, De Val S, Betsholtz C, Tryggvason K.

J Am Soc Nephrol. 2014 Dec;25(12):2764-77. doi: 10.1681/ASN.2012080823. Epub 2014 May 22.

29.

Genome-wide association study of urinary albumin excretion rate in patients with type 1 diabetes.

Sandholm N, Forsblom C, Mäkinen VP, McKnight AJ, Osterholm AM, He B, Harjutsalo V, Lithovius R, Gordin D, Parkkonen M, Saraheimo M, Thorn LM, Tolonen N, Wadén J, Tuomilehto J, Lajer M, Ahlqvist E, Möllsten A, Marcovecchio ML, Cooper J, Dunger D, Paterson AD, Zerbini G, Groop L; SUMMIT Consortium, Tarnow L, Maxwell AP, Tryggvason K, Groop PH; FinnDiane Study Group.

Diabetologia. 2014 Jun;57(6):1143-53. doi: 10.1007/s00125-014-3202-3. Epub 2014 Mar 5.

PMID:
24595857
30.

Clonal culturing of human embryonic stem cells on laminin-521/E-cadherin matrix in defined and xeno-free environment.

Rodin S, Antonsson L, Niaudet C, Simonson OE, Salmela E, Hansson EM, Domogatskaya A, Xiao Z, Damdimopoulou P, Sheikhi M, Inzunza J, Nilsson AS, Baker D, Kuiper R, Sun Y, Blennow E, Nordenskjöld M, Grinnemo KH, Kere J, Betsholtz C, Hovatta O, Tryggvason K.

Nat Commun. 2014;5:3195. doi: 10.1038/ncomms4195.

PMID:
24463987
31.

Wtip- and gadd45a-interacting protein dendrin is not crucial for the development or maintenance of the glomerular filtration barrier.

Xiao Z, Rodriguez PQ, He L, Betsholtz C, Tryggvason K, Patrakka J.

PLoS One. 2013 Dec 20;8(12):e83133. doi: 10.1371/journal.pone.0083133. eCollection 2013.

32.

Chromosome 2q31.1 associates with ESRD in women with type 1 diabetes.

Sandholm N, McKnight AJ, Salem RM, Brennan EP, Forsblom C, Harjutsalo V, Mäkinen VP, McKay GJ, Sadlier DM, Williams WW, Martin F, Panduru NM, Tarnow L, Tuomilehto J, Tryggvason K, Zerbini G, Comeau ME, Langefeld CD; FIND Consortium, Godson C, Hirschhorn JN, Maxwell AP, Florez JC, Groop PH; FinnDiane Study Group and the GENIE Consortium.

J Am Soc Nephrol. 2013 Oct;24(10):1537-43. doi: 10.1681/ASN.2012111122. Epub 2013 Sep 12.

33.

Myo1e impairment results in actin reorganization, podocyte dysfunction, and proteinuria in zebrafish and cultured podocytes.

Mao J, Wang D, Mataleena P, He B, Niu D, Katayama K, Xu X, Ojala JR, Wang W, Shu Q, Du L, Liu A, Pikkarainen T, Patrakka J, Tryggvason K.

PLoS One. 2013 Aug 19;8(8):e72750. doi: 10.1371/journal.pone.0072750. eCollection 2013.

34.

A meta-analysis of expression signatures in glomerular disease.

Tryggvason SH, Guo J, Nukui M, Norlin J, Haraldsson B, Jörnvall H, Tryggvason K, He L.

Kidney Int. 2013 Sep;84(3):591-9. doi: 10.1038/ki.2013.169. Epub 2013 Jun 19.

35.

Progressive reactive lymphoid connective tissue disease and development of autoantibodies in scavenger receptor A5-deficient mice.

Ojala JR, Pikkarainen T, Elmberger G, Tryggvason K.

Am J Pathol. 2013 May;182(5):1681-95. doi: 10.1016/j.ajpath.2013.01.042. Epub 2013 Mar 15.

PMID:
23499552
36.

A remote cis-acting variant at 3q links glomerular NCK1 to diabetic nephropathy.

He B, Österholm AM, Ojala JR, Andersson AC, Tryggvason K.

PLoS One. 2013;8(2):e56414. doi: 10.1371/journal.pone.0056414. Epub 2013 Feb 18.

37.

Resveratrol rescues SIRT1-dependent adult stem cell decline and alleviates progeroid features in laminopathy-based progeria.

Liu B, Ghosh S, Yang X, Zheng H, Liu X, Wang Z, Jin G, Zheng B, Kennedy BK, Suh Y, Kaeberlein M, Tryggvason K, Zhou Z.

Cell Metab. 2012 Dec 5;16(6):738-50. doi: 10.1016/j.cmet.2012.11.007.

38.

Functional diversity of laminins.

Domogatskaya A, Rodin S, Tryggvason K.

Annu Rev Cell Dev Biol. 2012;28:523-53. doi: 10.1146/annurev-cellbio-101011-155750. Review.

PMID:
23057746
39.
40.

New susceptibility loci associated with kidney disease in type 1 diabetes.

Sandholm N, Salem RM, McKnight AJ, Brennan EP, Forsblom C, Isakova T, McKay GJ, Williams WW, Sadlier DM, Mäkinen VP, Swan EJ, Palmer C, Boright AP, Ahlqvist E, Deshmukh HA, Keller BJ, Huang H, Ahola AJ, Fagerholm E, Gordin D, Harjutsalo V, He B, Heikkilä O, Hietala K, Kytö J, Lahermo P, Lehto M, Lithovius R, Osterholm AM, Parkkonen M, Pitkäniemi J, Rosengård-Bärlund M, Saraheimo M, Sarti C, Söderlund J, Soro-Paavonen A, Syreeni A, Thorn LM, Tikkanen H, Tolonen N, Tryggvason K, Tuomilehto J, Wadén J, Gill GV, Prior S, Guiducci C, Mirel DB, Taylor A, Hosseini SM; DCCT/EDIC Research Group, Parving HH, Rossing P, Tarnow L, Ladenvall C, Alhenc-Gelas F, Lefebvre P, Rigalleau V, Roussel R, Tregouet DA, Maestroni A, Maestroni S, Falhammar H, Gu T, Möllsten A, Cimponeriu D, Ioana M, Mota M, Mota E, Serafinceanu C, Stavarachi M, Hanson RL, Nelson RG, Kretzler M, Colhoun HM, Panduru NM, Gu HF, Brismar K, Zerbini G, Hadjadj S, Marre M, Groop L, Lajer M, Bull SB, Waggott D, Paterson AD, Savage DA, Bain SC, Martin F, Hirschhorn JN, Godson C, Florez JC, Groop PH, Maxwell AP.

PLoS Genet. 2012 Sep;8(9):e1002921. doi: 10.1371/journal.pgen.1002921. Epub 2012 Sep 20.

41.

Novel INF2 mutation p. L77P in a family with glomerulopathy and Charcot-Marie-Tooth neuropathy.

Rodriguez PQ, Lohkamp B, Celsi G, Mache CJ, Auer-Grumbach M, Wernerson A, Hamajima N, Tryggvason K, Patrakka J.

Pediatr Nephrol. 2013 Feb;28(2):339-43. doi: 10.1007/s00467-012-2299-1. Epub 2012 Sep 11.

PMID:
22961558
42.

Neuronal proteins are novel components of podocyte major processes and their expression in glomerular crescents supports their role in crescent formation.

Sistani L, Rodriguez PQ, Hultenby K, Uhlen M, Betsholtz C, Jalanko H, Tryggvason K, Wernerson A, Patrakka J.

Kidney Int. 2013 Jan;83(1):63-71. doi: 10.1038/ki.2012.321. Epub 2012 Aug 22.

43.

Plekhh2, a novel podocyte protein downregulated in human focal segmental glomerulosclerosis, is involved in matrix adhesion and actin dynamics.

Perisic L, Lal M, Hulkko J, Hultenby K, Önfelt B, Sun Y, Dunér F, Patrakka J, Betsholtz C, Uhlen M, Brismar H, Tryggvason K, Wernerson A, Pikkarainen T.

Kidney Int. 2012 Nov;82(10):1071-83. doi: 10.1038/ki.2012.252. Epub 2012 Jul 25.

44.

Association testing of previously reported variants in a large case-control meta-analysis of diabetic nephropathy.

Williams WW, Salem RM, McKnight AJ, Sandholm N, Forsblom C, Taylor A, Guiducci C, McAteer JB, McKay GJ, Isakova T, Brennan EP, Sadlier DM, Palmer C, Söderlund J, Fagerholm E, Harjutsalo V, Lithovius R, Gordin D, Hietala K, Kytö J, Parkkonen M, Rosengård-Bärlund M, Thorn L, Syreeni A, Tolonen N, Saraheimo M, Wadén J, Pitkäniemi J, Sarti C, Tuomilehto J, Tryggvason K, Österholm AM, He B, Bain S, Martin F, Godson C, Hirschhorn JN, Maxwell AP, Groop PH, Florez JC; GENIE Consortium.

Diabetes. 2012 Aug;61(8):2187-94. Epub 2012 Jun 20.

45.

Knocking out podocyte rho GTPases: and the winner is...

Lal MA, Tryggvason K.

J Am Soc Nephrol. 2012 Jul;23(7):1128-9. doi: 10.1681/ASN.2012050494. Epub 2012 Jun 7. No abstract available.

46.

MT1-MMP inactivates ADAM9 to regulate FGFR2 signaling and calvarial osteogenesis.

Chan KM, Wong HL, Jin G, Liu B, Cao R, Cao Y, Lehti K, Tryggvason K, Zhou Z.

Dev Cell. 2012 Jun 12;22(6):1176-90. doi: 10.1016/j.devcel.2012.04.014. Epub 2012 May 24.

47.

Towards understanding the inherited susceptibility for nephropathy in diabetes.

Thomas MC, Groop PH, Tryggvason K.

Curr Opin Nephrol Hypertens. 2012 Mar;21(2):195-202. doi: 10.1097/MNH.0b013e328350313e. Review.

PMID:
22314557
48.

Targeted knock-down of a structurally atypical zebrafish 12S-lipoxygenase leads to severe impairment of embryonic development.

Haas U, Raschperger E, Hamberg M, Samuelsson B, Tryggvason K, Haeggström JZ.

Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20479-84. doi: 10.1073/pnas.1117094108. Epub 2011 Dec 5.

49.

Deficiency in Crumbs homolog 2 (Crb2) affects gastrulation and results in embryonic lethality in mice.

Xiao Z, Patrakka J, Nukui M, Chi L, Niu D, Betsholtz C, Pikkarainen T, Vainio S, Tryggvason K.

Dev Dyn. 2011 Dec;240(12):2646-56. doi: 10.1002/dvdy.22778. Erratum in: Dev Dyn. 2012 Feb;241(2):431. Pikkarainan, Timo [corrected to Pikkarainen, Timo].

50.

Endothelial basement membrane limits tip cell formation by inducing Dll4/Notch signalling in vivo.

Stenzel D, Franco CA, Estrach S, Mettouchi A, Sauvaget D, Rosewell I, Schertel A, Armer H, Domogatskaya A, Rodin S, Tryggvason K, Collinson L, Sorokin L, Gerhardt H.

EMBO Rep. 2011 Oct 28;12(11):1135-43. doi: 10.1038/embor.2011.194.

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