Sort by
Items per page

Send to

Choose Destination

Search results

Items: 47


Molecular and structural insights into an asymmetric proteolytic complex (ClpP1P2) from Mycobacterium smegmatis.

Nagpal J, Paxman JJ, Zammit JE, Alhuwaider A, Truscott KN, Heras B, Dougan DA.

Sci Rep. 2019 Dec 2;9(1):18019. doi: 10.1038/s41598-019-53736-8.


Perrault syndrome type 3 caused by diverse molecular defects in CLPP.

Brodie EJ, Zhan H, Saiyed T, Truscott KN, Dougan DA.

Sci Rep. 2018 Aug 27;8(1):12862. doi: 10.1038/s41598-018-30311-1.


Crystal structure of bacterial succinate:quinone oxidoreductase flavoprotein SdhA in complex with its assembly factor SdhE.

Maher MJ, Herath AS, Udagedara SR, Dougan DA, Truscott KN.

Proc Natl Acad Sci U S A. 2018 Mar 20;115(12):2982-2987. doi: 10.1073/pnas.1800195115. Epub 2018 Mar 7.


Pupylation of PafA or Pup inhibits components of the Pup-Proteasome System.

Alhuwaider AAH, Truscott KN, Dougan DA.

FEBS Lett. 2018 Jan;592(1):15-23. doi: 10.1002/1873-3468.12930. Epub 2017 Dec 17.


The N-end rule adaptor protein ClpS from Plasmodium falciparum exhibits broad substrate specificity.

Tan JL, Ward L, Truscott KN, Dougan DA.

FEBS Lett. 2016 Oct;590(19):3397-3406. doi: 10.1002/1873-3468.12382. Epub 2016 Sep 23.


LON is the master protease that protects against protein aggregation in human mitochondria through direct degradation of misfolded proteins.

Bezawork-Geleta A, Brodie EJ, Dougan DA, Truscott KN.

Sci Rep. 2015 Dec 2;5:17397. doi: 10.1038/srep17397.


Anti-adaptors use distinct modes of binding to inhibit the RssB-dependent turnover of RpoS (σ(S)) by ClpXP.

Micevski D, Zammit JE, Truscott KN, Dougan DA.

Front Mol Biosci. 2015 Apr 23;2:15. doi: 10.3389/fmolb.2015.00015. eCollection 2015.


Mitochondrial matrix proteostasis is linked to hereditary paraganglioma: LON-mediated turnover of the human flavinylation factor SDH5 is regulated by its interaction with SDHA.

Bezawork-Geleta A, Saiyed T, Dougan DA, Truscott KN.

FASEB J. 2014 Apr;28(4):1794-804. doi: 10.1096/fj.13-242420. Epub 2014 Jan 10.


Control of protein function through regulated protein degradation: biotechnological and biomedical applications.

Nagpal J, Tan JL, Truscott KN, Heras B, Dougan DA.

J Mol Microbiol Biotechnol. 2013;23(4-5):335-44. doi: 10.1159/000352043. Epub 2013 Aug 5. Review.


The role of AAA+ proteases in mitochondrial protein biogenesis, homeostasis and activity control.

Voos W, Ward LA, Truscott KN.

Subcell Biochem. 2013;66:223-63. doi: 10.1007/978-94-007-5940-4_9. Review.


In vivo evidence for cooperation of Mia40 and Erv1 in the oxidation of mitochondrial proteins.

Böttinger L, Gornicka A, Czerwik T, Bragoszewski P, Loniewska-Lwowska A, Schulze-Specking A, Truscott KN, Guiard B, Milenkovic D, Chacinska A.

Mol Biol Cell. 2012 Oct;23(20):3957-69. doi: 10.1091/mbc.E12-05-0358. Epub 2012 Aug 23.


Substrate recognition and processing by a Walker B mutant of the human mitochondrial AAA+ protein CLPX.

Lowth BR, Kirstein-Miles J, Saiyed T, Brötz-Oesterhelt H, Morimoto RI, Truscott KN, Dougan DA.

J Struct Biol. 2012 Aug;179(2):193-201. doi: 10.1016/j.jsb.2012.06.001. Epub 2012 Jun 16.


Dual function of Sdh3 in the respiratory chain and TIM22 protein translocase of the mitochondrial inner membrane.

Gebert N, Gebert M, Oeljeklaus S, von der Malsburg K, Stroud DA, Kulawiak B, Wirth C, Zahedi RP, Dolezal P, Wiese S, Simon O, Schulze-Specking A, Truscott KN, Sickmann A, Rehling P, Guiard B, Hunte C, Warscheid B, van der Laan M, Pfanner N, Wiedemann N.

Mol Cell. 2011 Dec 9;44(5):811-8. doi: 10.1016/j.molcel.2011.09.025.


Unfolded protein responses in bacteria and mitochondria: a central role for the ClpXP machine.

Truscott KN, Bezawork-Geleta A, Dougan DA.

IUBMB Life. 2011 Nov;63(11):955-63. doi: 10.1002/iub.526. Review.


The N-end rule pathway: from recognition by N-recognins, to destruction by AAA+proteases.

Dougan DA, Micevski D, Truscott KN.

Biochim Biophys Acta. 2012 Jan;1823(1):83-91. doi: 10.1016/j.bbamcr.2011.07.002. Epub 2011 Jul 12. Review.


The bacterial N-end rule pathway: expect the unexpected.

Dougan DA, Truscott KN, Zeth K.

Mol Microbiol. 2010 May;76(3):545-58. doi: 10.1111/j.1365-2958.2010.07120.x. Epub 2010 Mar 30. Review.


Diverse functions of mitochondrial AAA+ proteins: protein activation, disaggregation, and degradation.

Truscott KN, Lowth BR, Strack PR, Dougan DA.

Biochem Cell Biol. 2010 Feb;88(1):97-108. doi: 10.1139/o09-167. Review.


Distinct forms of mitochondrial TOM-TIM supercomplexes define signal-dependent states of preprotein sorting.

Chacinska A, van der Laan M, Mehnert CS, Guiard B, Mick DU, Hutu DP, Truscott KN, Wiedemann N, Meisinger C, Pfanner N, Rehling P.

Mol Cell Biol. 2010 Jan;30(1):307-18. doi: 10.1128/MCB.00749-09.


Modification of PATase by L/F-transferase generates a ClpS-dependent N-end rule substrate in Escherichia coli.

Ninnis RL, Spall SK, Talbo GH, Truscott KN, Dougan DA.

EMBO J. 2009 Jun 17;28(12):1732-44. doi: 10.1038/emboj.2009.134. Epub 2009 May 14.


Structural basis of N-end rule substrate recognition in Escherichia coli by the ClpAP adaptor protein ClpS.

Schuenemann VJ, Kralik SM, Albrecht R, Spall SK, Truscott KN, Dougan DA, Zeth K.

EMBO Rep. 2009 May;10(5):508-14. doi: 10.1038/embor.2009.62. Epub 2009 Apr 17. Erratum in: EMBO Rep. 2009 Jun;10(6):662.


The assembly pathway of the mitochondrial carrier translocase involves four preprotein translocases.

Wagner K, Gebert N, Guiard B, Brandner K, Truscott KN, Wiedemann N, Pfanner N, Rehling P.

Mol Cell Biol. 2008 Jul;28(13):4251-60. doi: 10.1128/MCB.02216-07. Epub 2008 May 5.


Conserved residues in the N-domain of the AAA+ chaperone ClpA regulate substrate recognition and unfolding.

Erbse AH, Wagner JN, Truscott KN, Spall SK, Kirstein J, Zeth K, Turgay K, Mogk A, Bukau B, Dougan DA.

FEBS J. 2008 Apr;275(7):1400-10. doi: 10.1111/j.1742-4658.2008.06304.x. Epub 2008 Feb 14.


Tim50 maintains the permeability barrier of the mitochondrial inner membrane.

Meinecke M, Wagner R, Kovermann P, Guiard B, Mick DU, Hutu DP, Voos W, Truscott KN, Chacinska A, Pfanner N, Rehling P.

Science. 2006 Jun 9;312(5779):1523-6.


Preprotein translocase of the outer mitochondrial membrane: reconstituted Tom40 forms a characteristic TOM pore.

Becker L, Bannwarth M, Meisinger C, Hill K, Model K, Krimmer T, Casadio R, Truscott KN, Schulz GE, Pfanner N, Wagner R.

J Mol Biol. 2005 Nov 11;353(5):1011-20. Epub 2005 Sep 26.


Isolation of yeast mitochondria.

Meisinger C, Pfanner N, Truscott KN.

Methods Mol Biol. 2006;313:33-9.


Mitochondrial presequence translocase: switching between TOM tethering and motor recruitment involves Tim21 and Tim17.

Chacinska A, Lind M, Frazier AE, Dudek J, Meisinger C, Geissler A, Sickmann A, Meyer HE, Truscott KN, Guiard B, Pfanner N, Rehling P.

Cell. 2005 Mar 25;120(6):817-29.


Essential role of Mia40 in import and assembly of mitochondrial intermembrane space proteins.

Chacinska A, Pfannschmidt S, Wiedemann N, Kozjak V, Sanjuán Szklarz LK, Schulze-Specking A, Truscott KN, Guiard B, Meisinger C, Pfanner N.

EMBO J. 2004 Oct 1;23(19):3735-46. Epub 2004 Sep 9.


Pam16 has an essential role in the mitochondrial protein import motor.

Frazier AE, Dudek J, Guiard B, Voos W, Li Y, Lind M, Meisinger C, Geissler A, Sickmann A, Meyer HE, Bilanchone V, Cumsky MG, Truscott KN, Pfanner N, Rehling P.

Nat Struct Mol Biol. 2004 Mar;11(3):226-33. Epub 2004 Feb 15.


Biogenesis of the protein import channel Tom40 of the mitochondrial outer membrane: intermembrane space components are involved in an early stage of the assembly pathway.

Wiedemann N, Truscott KN, Pfannschmidt S, Guiard B, Meisinger C, Pfanner N.

J Biol Chem. 2004 Apr 30;279(18):18188-94. Epub 2004 Feb 20.


A J-protein is an essential subunit of the presequence translocase-associated protein import motor of mitochondria.

Truscott KN, Voos W, Frazier AE, Lind M, Li Y, Geissler A, Dudek J, Müller H, Sickmann A, Meyer HE, Meisinger C, Guiard B, Rehling P, Pfanner N.

J Cell Biol. 2003 Nov 24;163(4):707-13.


Mitochondria use different mechanisms for transport of multispanning membrane proteins through the intermembrane space.

Frazier AE, Chacinska A, Truscott KN, Guiard B, Pfanner N, Rehling P.

Mol Cell Biol. 2003 Nov;23(21):7818-28.


Mechanisms of protein import into mitochondria.

Truscott KN, Brandner K, Pfanner N.

Curr Biol. 2003 Apr 15;13(8):R326-37. Review.


Protein insertion into the mitochondrial inner membrane by a twin-pore translocase.

Rehling P, Model K, Brandner K, Kovermann P, Sickmann A, Meyer HE, Kühlbrandt W, Wagner R, Truscott KN, Pfanner N.

Science. 2003 Mar 14;299(5613):1747-51.


Biogenesis of yeast mitochondrial cytochrome c: a unique relationship to the TOM machinery.

Wiedemann N, Kozjak V, Prinz T, Ryan MT, Meisinger C, Pfanner N, Truscott KN.

J Mol Biol. 2003 Mar 21;327(2):465-74.


The mitochondrial presequence translocase: an essential role of Tim50 in directing preproteins to the import channel.

Geissler A, Chacinska A, Truscott KN, Wiedemann N, Brandner K, Sickmann A, Meyer HE, Meisinger C, Pfanner N, Rehling P.

Cell. 2002 Nov 15;111(4):507-18.


Mitochondrial import of the ADP/ATP carrier: the essential TIM complex of the intermembrane space is required for precursor release from the TOM complex.

Truscott KN, Wiedemann N, Rehling P, Müller H, Meisinger C, Pfanner N, Guiard B.

Mol Cell Biol. 2002 Nov;22(22):7780-9.


Insertion and assembly of human tom7 into the preprotein translocase complex of the outer mitochondrial membrane.

Johnston AJ, Hoogenraad J, Dougan DA, Truscott KN, Yano M, Mori M, Hoogenraad NJ, Ryan MT.

J Biol Chem. 2002 Nov 1;277(44):42197-204. Epub 2002 Aug 26.


Powering mitochondrial protein import.

Pfanner N, Truscott KN.

Nat Struct Biol. 2002 Apr;9(4):234-6. No abstract available.


Tim22, the essential core of the mitochondrial protein insertion complex, forms a voltage-activated and signal-gated channel.

Kovermann P, Truscott KN, Guiard B, Rehling P, Sepuri NB, Müller H, Jensen RE, Wagner R, Pfanner N.

Mol Cell. 2002 Feb;9(2):363-73.


A presequence- and voltage-sensitive channel of the mitochondrial preprotein translocase formed by Tim23.

Truscott KN, Kovermann P, Geissler A, Merlin A, Meijer M, Driessen AJ, Rassow J, Pfanner N, Wagner R.

Nat Struct Biol. 2001 Dec;8(12):1074-82.


The mitochondrial import machinery for preproteins.

Rehling P, Wiedemann N, Pfanner N, Truscott KN.

Crit Rev Biochem Mol Biol. 2001;36(3):291-336. Review.


Transport of proteins into mitochondria.

Truscott KN, Pfanner N, Voos W.

Rev Physiol Biochem Pharmacol. 2001;143:81-136. Review.


Multistep assembly of the protein import channel of the mitochondrial outer membrane.

Model K, Meisinger C, Prinz T, Wiedemann N, Truscott KN, Pfanner N, Ryan MT.

Nat Struct Biol. 2001 Apr;8(4):361-70.


Import of carrier proteins into mitochondria.

Truscott KN, Pfanner N.

Biol Chem. 1999 Oct;380(10):1151-6. Review.


Supplemental Content

Loading ...
Support Center