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Items: 1 to 50 of 158

1.

Single-cell characterization of haematopoietic progenitors and their trajectories in homeostasis and perturbed haematopoiesis.

Giladi A, Paul F, Herzog Y, Lubling Y, Weiner A, Yofe I, Jaitin D, Cabezas-Wallscheid N, Dress R, Ginhoux F, Trumpp A, Tanay A, Amit I.

Nat Cell Biol. 2018 Jul;20(7):836-846. doi: 10.1038/s41556-018-0121-4. Epub 2018 Jun 18.

PMID:
29915358
2.

Cardiovascular assessment by imaging photoplethysmography - a review.

Zaunseder S, Trumpp A, Wedekind D, Malberg H.

Biomed Tech (Berl). 2018 Jun 13. pii: /j/bmte.ahead-of-print/bmt-2017-0119/bmt-2017-0119.xml. doi: 10.1515/bmt-2017-0119. [Epub ahead of print]

PMID:
29897880
3.

Developmental vascular regression is regulated by a Wnt/β-catenin, MYC and CDKN1A pathway that controls cell proliferation and cell death.

Nayak G, Odaka Y, Prasad V, Solano AF, Yeo EJ, Vemaraju S, Molkentin JD, Trumpp A, Williams B, Rao S, Lang RA.

Development. 2018 Jun 14;145(12). pii: dev154898. doi: 10.1242/dev.154898.

PMID:
29777010
4.

Author Correction: A Myc enhancer cluster regulates normal and leukaemic haematopoietic stem cell hierarchies.

Bahr C, von Paleske L, Uslu VV, Remeseiro S, Takayama N, Ng SW, Murison A, Langenfeld K, Petretich M, Scognamiglio R, Zeisberger P, Benk AS, Amit I, Zandstra PW, Lupien M, Dick JE, Trumpp A, Spitz F.

Nature. 2018 Jun;558(7711):E4. doi: 10.1038/s41586-018-0113-3.

PMID:
29769714
5.

Causes and Consequences of Hematopoietic Stem Cell Heterogeneity.

Haas S, Trumpp A, Milsom MD.

Cell Stem Cell. 2018 May 3;22(5):627-638. doi: 10.1016/j.stem.2018.04.003. Review.

PMID:
29727678
6.

Camera-based photoplethysmography in an intraoperative setting.

Trumpp A, Lohr J, Wedekind D, Schmidt M, Burghardt M, Heller AR, Malberg H, Zaunseder S.

Biomed Eng Online. 2018 Mar 14;17(1):33. doi: 10.1186/s12938-018-0467-7.

7.

Single cell polarity in liquid phase facilitates tumour metastasis.

Lorentzen A, Becker PF, Kosla J, Saini M, Weidele K, Ronchi P, Klein C, Wolf MJ, Geist F, Seubert B, Ringelhan M, Mihic-Probst D, Esser K, Roblek M, Kuehne F, Bianco G, O'Connor T, Müller Q, Schuck K, Lange S, Hartmann D, Spaich S, Groß O, Utikal J, Haferkamp S, Sprick MR, Damle-Vartak A, Hapfelmeier A, Hüser N, Protzer U, Trumpp A, Saur D, Vartak N, Klein CA, Polzer B, Borsig L, Heikenwalder M.

Nat Commun. 2018 Feb 28;9(1):887. doi: 10.1038/s41467-018-03139-6.

8.

AMPK promotes survival of c-Myc-positive melanoma cells by suppressing oxidative stress.

Kfoury A, Armaro M, Collodet C, Sordet-Dessimoz J, Giner MP, Christen S, Moco S, Leleu M, de Leval L, Koch U, Trumpp A, Sakamoto K, Beermann F, Radtke F.

EMBO J. 2018 Mar 1;37(5). pii: e97673. doi: 10.15252/embj.201797673. Epub 2018 Feb 12.

PMID:
29440228
9.

An Intrinsic Interferon Program Protects Stem Cells from Viral Infection.

Haas S, Trumpp A.

Dev Cell. 2018 Feb 5;44(3):279-280. doi: 10.1016/j.devcel.2018.01.013. Epub 2018 Feb 5.

PMID:
29408233
10.

Saa3 is a key mediator of the protumorigenic properties of cancer-associated fibroblasts in pancreatic tumors.

Djurec M, Graña O, Lee A, Troulé K, Espinet E, Cabras L, Navas C, Blasco MT, Martín-Díaz L, Burdiel M, Li J, Liu Z, Vallespinós M, Sanchez-Bueno F, Sprick MR, Trumpp A, Sainz B Jr, Al-Shahrour F, Rabadan R, Guerra C, Barbacid M.

Proc Natl Acad Sci U S A. 2018 Feb 6;115(6):E1147-E1156. doi: 10.1073/pnas.1717802115. Epub 2018 Jan 19.

PMID:
29351990
11.

A Myc enhancer cluster regulates normal and leukaemic haematopoietic stem cell hierarchies.

Bahr C, von Paleske L, Uslu VV, Remeseiro S, Takayama N, Ng SW, Murison A, Langenfeld K, Petretich M, Scognamiglio R, Zeisberger P, Benk AS, Amit I, Zandstra PW, Lupien M, Dick JE, Trumpp A, Spitz F.

Nature. 2018 Jan 25;553(7689):515-520. doi: 10.1038/nature25193. Epub 2018 Jan 17. Erratum in: Nature. 2018 May 16;:.

PMID:
29342133
12.

Circulating free DNA integrity and concentration as independent prognostic markers in metastatic breast cancer.

Cheng J, Holland-Letz T, Wallwiener M, Surowy H, Cuk K, Schott S, Trumpp A, Pantel K, Sohn C, Schneeweiss A, Burwinkel B.

Breast Cancer Res Treat. 2018 May;169(1):69-82. doi: 10.1007/s10549-018-4666-5. Epub 2018 Jan 16.

PMID:
29340881
13.

The molecular signature of AML with increased ALDH activity suggests a stem cell origin.

Blume R, Rempel E, Manta L, Saeed BR, Wang W, Raffel S, Ermakova O, Eckstein V, Benes V, Trumpp A, Ho AD, Lutz C.

Leuk Lymphoma. 2018 Jan 16:1-10. doi: 10.1080/10428194.2017.1422862. [Epub ahead of print]

PMID:
29334844
14.

Senescence-associated reprogramming promotes cancer stemness.

Milanovic M, Fan DNY, Belenki D, Däbritz JHM, Zhao Z, Yu Y, Dörr JR, Dimitrova L, Lenze D, Monteiro Barbosa IA, Mendoza-Parra MA, Kanashova T, Metzner M, Pardon K, Reimann M, Trumpp A, Dörken B, Zuber J, Gronemeyer H, Hummel M, Dittmar G, Lee S, Schmitt CA.

Nature. 2018 Jan 4;553(7686):96-100. doi: 10.1038/nature25167. Epub 2017 Dec 20.

PMID:
29258294
15.

Screening drug effects in patient-derived cancer cells links organoid responses to genome alterations.

Jabs J, Zickgraf FM, Park J, Wagner S, Jiang X, Jechow K, Kleinheinz K, Toprak UH, Schneider MA, Meister M, Spaich S, Sütterlin M, Schlesner M, Trumpp A, Sprick M, Eils R, Conrad C.

Mol Syst Biol. 2017 Nov 27;13(11):955. doi: 10.15252/msb.20177697.

16.

BCAT1 restricts αKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation.

Raffel S, Falcone M, Kneisel N, Hansson J, Wang W, Lutz C, Bullinger L, Poschet G, Nonnenmacher Y, Barnert A, Bahr C, Zeisberger P, Przybylla A, Sohn M, Tönjes M, Erez A, Adler L, Jensen P, Scholl C, Fröhling S, Cocciardi S, Wuchter P, Thiede C, Flörcken A, Westermann J, Ehninger G, Lichter P, Hiller K, Hell R, Herrmann C, Ho AD, Krijgsveld J, Radlwimmer B, Trumpp A.

Nature. 2017 Nov 16;551(7680):384-388. doi: 10.1038/nature24294. Epub 2017 Nov 8.

PMID:
29144447
17.

Pancreatic Ductal Adenocarcinoma Subtyping Using the Biomarkers Hepatocyte Nuclear Factor-1A and Cytokeratin-81 Correlates with Outcome and Treatment Response.

Muckenhuber A, Berger AK, Schlitter AM, Steiger K, Konukiewitz B, Trumpp A, Eils R, Werner J, Friess H, Esposito I, Klöppel G, Ceyhan GO, Jesinghaus M, Denkert C, Bahra M, Stenzinger A, Sprick MR, Jäger D, Springfeld C, Weichert W.

Clin Cancer Res. 2018 Jan 15;24(2):351-359. doi: 10.1158/1078-0432.CCR-17-2180. Epub 2017 Nov 3.

PMID:
29101303
18.

Survival of pancreatic cancer cells lacking KRAS function.

Muzumdar MD, Chen PY, Dorans KJ, Chung KM, Bhutkar A, Hong E, Noll EM, Sprick MR, Trumpp A, Jacks T.

Nat Commun. 2017 Oct 23;8(1):1090. doi: 10.1038/s41467-017-00942-5.

19.

Stem cells make leukemia grow again.

Bahr C, Correia NC, Trumpp A.

EMBO J. 2017 Sep 15;36(18):2667-2669. doi: 10.15252/embj.201797773. Epub 2017 Aug 21. No abstract available.

PMID:
28827287
20.

The value of polarization in camera-based photoplethysmography.

Trumpp A, Bauer PL, Rasche S, Malberg H, Zaunseder S.

Biomed Opt Express. 2017 May 1;8(6):2822-2834. doi: 10.1364/BOE.8.002822. eCollection 2017 Jun 1.

21.

Systemic Virus Infections Differentially Modulate Cell Cycle State and Functionality of Long-Term Hematopoietic Stem Cells In Vivo.

Hirche C, Frenz T, Haas SF, Döring M, Borst K, Tegtmeyer PK, Brizic I, Jordan S, Keyser K, Chhatbar C, Pronk E, Lin S, Messerle M, Jonjic S, Falk CS, Trumpp A, Essers MAG, Kalinke U.

Cell Rep. 2017 Jun 13;19(11):2345-2356. doi: 10.1016/j.celrep.2017.05.063.

22.

Reduced hematopoietic stem cell frequency predicts outcome in acute myeloid leukemia.

Wang W, Stiehl T, Raffel S, Hoang VT, Hoffmann I, Poisa-Beiro L, Saeed BR, Blume R, Manta L, Eckstein V, Bochtler T, Wuchter P, Essers M, Jauch A, Trumpp A, Marciniak-Czochra A, Ho AD, Lutz C.

Haematologica. 2017 Sep;102(9):1567-1577. doi: 10.3324/haematol.2016.163584. Epub 2017 May 26.

23.

Corrigendum: Acquired CYP19A1 amplification is an early specific mechanism of aromatase inhibitor resistance in ERα metastatic breast cancer.

Magnani L, Frigè G, Gadaleta RM, Corleone G, Fabris S, Kempe MH, Vershure PJ, Barozzi I, Vircillo V, Hong SP, Perone Y, Saini M, Trumpp A, Viale G, Neri A, Ali S, Colleoni MA, Pruneri G, Minucci S.

Nat Genet. 2017 May 26;49(6):970. doi: 10.1038/ng0617-970b. No abstract available.

PMID:
28546573
24.

Vitamin A-Retinoic Acid Signaling Regulates Hematopoietic Stem Cell Dormancy.

Cabezas-Wallscheid N, Buettner F, Sommerkamp P, Klimmeck D, Ladel L, Thalheimer FB, Pastor-Flores D, Roma LP, Renders S, Zeisberger P, Przybylla A, Schönberger K, Scognamiglio R, Altamura S, Florian CM, Fawaz M, Vonficht D, Tesio M, Collier P, Pavlinic D, Geiger H, Schroeder T, Benes V, Dick TP, Rieger MA, Stegle O, Trumpp A.

Cell. 2017 May 18;169(5):807-823.e19. doi: 10.1016/j.cell.2017.04.018. Epub 2017 May 4.

25.

High prevalence of incidental and symptomatic venous thromboembolic events in patients with advanced pancreatic cancer under palliative chemotherapy: A retrospective cohort study.

Berger AK, Singh HM, Werft W, Muckenhuber A, Sprick MR, Trumpp A, Weichert W, Jäger D, Springfeld C.

Pancreatology. 2017 Jul - Aug;17(4):629-634. doi: 10.1016/j.pan.2017.04.012. Epub 2017 Apr 22.

PMID:
28462862
26.

Human haematopoietic stem cell lineage commitment is a continuous process.

Velten L, Haas SF, Raffel S, Blaszkiewicz S, Islam S, Hennig BP, Hirche C, Lutz C, Buss EC, Nowak D, Boch T, Hofmann WK, Ho AD, Huber W, Trumpp A, Essers MA, Steinmetz LM.

Nat Cell Biol. 2017 Apr;19(4):271-281. doi: 10.1038/ncb3493. Epub 2017 Mar 20.

27.

Assessment of blind source separation techniques for video-based cardiac pulse extraction.

Wedekind D, Trumpp A, Gaetjen F, Rasche S, Matschke K, Malberg H, Zaunseder S.

J Biomed Opt. 2017 Mar 1;22(3):35002. doi: 10.1117/1.JBO.22.3.035002.

PMID:
28257535
28.

Endothelial Notch1 Activity Facilitates Metastasis.

Wieland E, Rodriguez-Vita J, Liebler SS, Mogler C, Moll I, Herberich SE, Espinet E, Herpel E, Menuchin A, Chang-Claude J, Hoffmeister M, Gebhardt C, Brenner H, Trumpp A, Siebel CW, Hecker M, Utikal J, Sprinzak D, Fischer A.

Cancer Cell. 2017 Mar 13;31(3):355-367. doi: 10.1016/j.ccell.2017.01.007. Epub 2017 Feb 23.

29.

MALDI versus ESI: The Impact of the Ion Source on Peptide Identification.

Nadler WM, Waidelich D, Kerner A, Hanke S, Berg R, Trumpp A, Rösli C.

J Proteome Res. 2017 Mar 3;16(3):1207-1215. doi: 10.1021/acs.jproteome.6b00805. Epub 2017 Feb 15.

PMID:
28176526
30.

Identification of a tumor-reactive T-cell repertoire in the immune infiltrate of patients with resectable pancreatic ductal adenocarcinoma.

Poschke I, Faryna M, Bergmann F, Flossdorf M, Lauenstein C, Hermes J, Hinz U, Hank T, Ehrenberg R, Volkmar M, Loewer M, Glimm H, Hackert T, Sprick MR, Höfer T, Trumpp A, Halama N, Hassel JC, Strobel O, Büchler M, Sahin U, Offringa R.

Oncoimmunology. 2016 Oct 7;5(12):e1240859. doi: 10.1080/2162402X.2016.1240859. eCollection 2016.

31.

Acquired CYP19A1 amplification is an early specific mechanism of aromatase inhibitor resistance in ERα metastatic breast cancer.

Magnani L, Frige G, Gadaleta RM, Corleone G, Fabris S, Kempe MH, Vershure PJ, Barozzi I, Vircillo V, Hong SP, Perone Y, Saini M, Trumpp A, Viale G, Neri A, Ali S, Colleoni MA, Pruneri G, Minucci S.

Nat Genet. 2017 Mar;49(3):444-450. doi: 10.1038/ng.3773. Epub 2017 Jan 23. Erratum in: Nat Genet. 2017 May 26;49(6):970.

32.

Myc/Mycn-mediated glycolysis enhances mouse spermatogonial stem cell self-renewal.

Kanatsu-Shinohara M, Tanaka T, Ogonuki N, Ogura A, Morimoto H, Cheng PF, Eisenman RN, Trumpp A, Shinohara T.

Genes Dev. 2016 Dec 1;30(23):2637-2648. doi: 10.1101/gad.287045.116.

33.

Metabolic cues for hematopoietic stem cells.

Sommerkamp P, Trumpp A.

Science. 2016 Dec 2;354(6316):1103-1104. No abstract available.

PMID:
27934722
34.

Identification and Validation of Novel Subtype-Specific Protein Biomarkers in Pancreatic Ductal Adenocarcinoma.

Kuhlmann L, Nadler WM, Kerner A, Hanke SA, Noll EM, Eisen C, Espinet E, Vogel V, Trumpp A, Sprick MR, Roesli CP.

Pancreas. 2017 Mar;46(3):311-322. doi: 10.1097/MPA.0000000000000743.

PMID:
27846146
35.

Leukocyte-platelet aggregates-a phenotypic characterization of different stages of peripheral arterial disease.

Dopheide JF, Rubrech J, Trumpp A, Geissler P, Zeller GC, Bock K, Dünschede F, Trinh TT, Dorweiler B, Münzel T, Radsak MP, Espinola-Klein C.

Platelets. 2016 Nov;27(7):658-667. Epub 2016 Apr 11.

PMID:
27352829
36.

Impact of apoptotic circulating tumor cells (aCTC) in metastatic breast cancer.

Deutsch TM, Riethdorf S, Nees J, Hartkopf AD, Schönfisch B, Domschke C, Sprick MR, Schütz F, Brucker SY, Stefanovic S, Sohn C, Pantel K, Trumpp A, Schneeweiss A, Wallwiener M.

Breast Cancer Res Treat. 2016 Nov;160(2):277-290. Epub 2016 Oct 1.

PMID:
27696083
37.

Supervised exercise training in peripheral arterial disease increases vascular shear stress and profunda femoral artery diameter.

Dopheide JF, Rubrech J, Trumpp A, Geissler P, Zeller GC, Schnorbus B, Schmidt F, Gori T, Münzel T, Espinola-Klein C.

Eur J Prev Cardiol. 2017 Jan;24(2):178-191. doi: 10.1177/2047487316665231. Epub 2016 Sep 27.

PMID:
27550906
38.

Desymmetrizing Electron-Deficient Diboranes(4): Diverse Products and Their Reactivity.

Arnold N, Braunschweig H, Dewhurst RD, Hupp F, Radacki K, Trumpp A.

Chemistry. 2016 Sep 19;22(39):13927-13934. doi: 10.1002/chem.201602805. Epub 2016 Aug 12.

PMID:
27514500
39.

Controlling Regiochemistry in the Syntheses of Boraindanes from Diborane(4) Starting Materials.

Arnold N, Braunschweig H, Ewing WC, Kupfer T, Radacki K, Thiess T, Trumpp A.

Chemistry. 2016 Aug 1;22(32):11441-9. doi: 10.1002/chem.201601522. Epub 2016 Jul 7.

PMID:
27385314
40.

Mutational hierarchies in myelodysplastic syndromes dynamically adapt and evolve upon therapy response and failure.

Mossner M, Jann JC, Wittig J, Nolte F, Fey S, Nowak V, Obländer J, Pressler J, Palme I, Xanthopoulos C, Boch T, Metzgeroth G, Röhl H, Witt SH, Dukal H, Klein C, Schmitt S, Gelß P, Platzbecker U, Balaian E, Fabarius A, Blum H, Schulze TJ, Meggendorfer M, Haferlach C, Trumpp A, Hofmann WK, Medyouf H, Nowak D.

Blood. 2016 Sep 1;128(9):1246-59. doi: 10.1182/blood-2015-11-679167. Epub 2016 Jun 6.

41.

Plasma S100P level as a novel prognostic marker of metastatic breast cancer.

Peng C, Chen H, Wallwiener M, Modugno C, Cuk K, Madhavan D, Trumpp A, Heil J, Marmé F, Nees J, Riethdorf S, Schott S, Sohn C, Pantel K, Schneeweiss A, Yang R, Burwinkel B.

Breast Cancer Res Treat. 2016 Jun;157(2):329-338. doi: 10.1007/s10549-016-3776-1. Epub 2016 May 4.

PMID:
27146585
42.

The pivotal role of reactivity in the design of novel biotinylation reagents for the chemical-proteomics-based identification of vascular accessible biomarkers.

Hanke SA, Kerner A, Nadler WM, Trumpp A, Zhang Y, Rösli CP.

J Proteomics. 2016 Jun 1;141:57-66. doi: 10.1016/j.jprot.2016.04.014. Epub 2016 Apr 23.

PMID:
27113135
43.

New outcomes of Lewis base addition to diboranes(4): electronic effects override strong steric disincentives.

Arnold N, Braunschweig H, Damme A, Dewhurst RD, Pentecost L, Radacki K, Stellwag-Konertz S, Thiess T, Trumpp A, Vargas A.

Chem Commun (Camb). 2016 Apr 7;52(27):4898-901. doi: 10.1039/c6cc01493c. Epub 2016 Mar 14.

PMID:
26974684
44.

Camera-based photoplethysmography in critical care patients.

Rasche S, Trumpp A, Waldow T, Gaetjen F, Plötze K, Wedekind D, Schmidt M, Malberg H, Matschke K, Zaunseder S.

Clin Hemorheol Microcirc. 2016 Nov 4;64(1):77-90.

PMID:
26890242
45.

Myc Depletion Induces a Pluripotent Dormant State Mimicking Diapause.

Scognamiglio R, Cabezas-Wallscheid N, Thier MC, Altamura S, Reyes A, Prendergast ÁM, Baumgärtner D, Carnevalli LS, Atzberger A, Haas S, von Paleske L, Boroviak T, Wörsdörfer P, Essers MA, Kloz U, Eisenman RN, Edenhofer F, Bertone P, Huber W, van der Hoeven F, Smith A, Trumpp A.

Cell. 2016 Feb 11;164(4):668-80. doi: 10.1016/j.cell.2015.12.033.

46.

miR-126 Drives Quiescence and Self-Renewal in Leukemic Stem Cells.

Raffel S, Trumpp A.

Cancer Cell. 2016 Feb 8;29(2):133-5. doi: 10.1016/j.ccell.2016.01.007.

47.

CYP3A5 mediates basal and acquired therapy resistance in different subtypes of pancreatic ductal adenocarcinoma.

Noll EM, Eisen C, Stenzinger A, Espinet E, Muckenhuber A, Klein C, Vogel V, Klaus B, Nadler W, Rösli C, Lutz C, Kulke M, Engelhardt J, Zickgraf FM, Espinosa O, Schlesner M, Jiang X, Kopp-Schneider A, Neuhaus P, Bahra M, Sinn BV, Eils R, Giese NA, Hackert T, Strobel O, Werner J, Büchler MW, Weichert W, Trumpp A, Sprick MR.

Nat Med. 2016 Mar;22(3):278-87. doi: 10.1038/nm.4038. Epub 2016 Feb 8.

48.

Influence of exercise training on proangiogenic TIE-2 monocytes and circulating angiogenic cells in patients with peripheral arterial disease.

Dopheide JF, Geissler P, Rubrech J, Trumpp A, Zeller GC, Daiber A, Münzel T, Radsak MP, Espinola-Klein C.

Clin Res Cardiol. 2016 Aug;105(8):666-76. doi: 10.1007/s00392-016-0966-0. Epub 2016 Jan 30.

PMID:
26830098
49.

Circulating miRNAs with prognostic value in metastatic breast cancer and for early detection of metastasis.

Madhavan D, Peng C, Wallwiener M, Zucknick M, Nees J, Schott S, Rudolph A, Riethdorf S, Trumpp A, Pantel K, Sohn C, Chang-Claude J, Schneeweiss A, Burwinkel B.

Carcinogenesis. 2016 May;37(5):461-70. doi: 10.1093/carcin/bgw008. Epub 2016 Jan 19.

PMID:
26785733
50.

Transcriptional Heterogeneity and Lineage Commitment in Myeloid Progenitors.

Paul F, Arkin Y, Giladi A, Jaitin DA, Kenigsberg E, Keren-Shaul H, Winter D, Lara-Astiaso D, Gury M, Weiner A, David E, Cohen N, Lauridsen FKB, Haas S, Schlitzer A, Mildner A, Ginhoux F, Jung S, Trumpp A, Porse BT, Tanay A, Amit I.

Cell. 2016 Jan 14;164(1-2):325. doi: 10.1016/j.cell.2015.12.046. Epub 2016 Jan 14. No abstract available.

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