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Items: 1 to 50 of 139

1.

Design of anti-parasitic and anti-fungal hydroxy-naphthoquinones that are less susceptible to drug resistance.

Hughes LM, Lanteri CA, O'Neil MT, Johnson JD, Gribble GW, Trumpower BL.

Mol Biochem Parasitol. 2011 May;177(1):12-9. doi: 10.1016/j.molbiopara.2011.01.002. Epub 2011 Jan 18.

2.

Bcs1p can rescue a large and productive cytochrome bc(1) complex assembly intermediate in the inner membrane of yeast mitochondria.

Conte L, Trumpower BL, Zara V.

Biochim Biophys Acta. 2011 Jan;1813(1):91-101. doi: 10.1016/j.bbamcr.2010.08.004. Epub 2010 Aug 18.

3.
4.

Probing binding determinants in center P of the cytochrome bc(1) complex using novel hydroxy-naphthoquinones.

Hughes LM, Covian R, Gribble GW, Trumpower BL.

Biochim Biophys Acta. 2010 Jan;1797(1):38-43. doi: 10.1016/j.bbabio.2009.07.010. Epub 2009 Aug 4.

5.

Membrane potential greatly enhances superoxide generation by the cytochrome bc1 complex reconstituted into phospholipid vesicles.

Rottenberg H, Covian R, Trumpower BL.

J Biol Chem. 2009 Jul 17;284(29):19203-10. doi: 10.1074/jbc.M109.017376. Epub 2009 May 28.

6.

Chapter 27 An improved method for introducing point mutations into the mitochondrial cytochrome B gene to facilitate studying the role of cytochrome B in the formation of reactive oxygen species.

Ding MG, Butler CA, Saracco SA, Fox TD, Godard F, di Rago JP, Trumpower BL.

Methods Enzymol. 2009;456:491-506. doi: 10.1016/S0076-6879(08)04427-3.

PMID:
19348906
8.

Evidence that the assembly of the yeast cytochrome bc1 complex involves the formation of a large core structure in the inner mitochondrial membrane.

Zara V, Conte L, Trumpower BL.

FEBS J. 2009 Apr;276(7):1900-14. doi: 10.1111/j.1742-4658.2009.06916.x. Epub 2009 Feb 19.

9.

Combining Inhibitor Resistance-conferring Mutations in Cytochrome b Creates Conditional Synthetic Lethality in Saccharomyces cerevisiae.

Ding MG, di Rago JP, Trumpower BL.

J Biol Chem. 2009 Mar 27;284(13):8478-85. doi: 10.1074/jbc.M809278200. Epub 2009 Jan 29.

10.

Ilicicolin Inhibition and Binding at Center N of the Dimeric Cytochrome bc1 Complex Reveal Electron Transfer and Regulatory Interactions between Monomers.

Covian R, Trumpower BL.

J Biol Chem. 2009 Mar 27;284(13):8614-20. doi: 10.1074/jbc.M808914200. Epub 2009 Jan 27.

11.

Biogenesis of the yeast cytochrome bc1 complex.

Zara V, Conte L, Trumpower BL.

Biochim Biophys Acta. 2009 Jan;1793(1):89-96. doi: 10.1016/j.bbamcr.2008.04.011. Epub 2008 May 3. Review.

12.

Introduction of cytochrome b mutations in Saccharomyces cerevisiae by a method that allows selection for both functional and non-functional cytochrome b proteins.

Ding MG, Butler CA, Saracco SA, Fox TD, Godard F, di Rago JP, Trumpower BL.

Biochim Biophys Acta. 2008 Sep;1777(9):1147-56. doi: 10.1016/j.bbabio.2008.04.029. Epub 2008 Apr 27.

13.

Regulatory interactions in the dimeric cytochrome bc(1) complex: the advantages of being a twin.

Covian R, Trumpower BL.

Biochim Biophys Acta. 2008 Sep;1777(9):1079-91. doi: 10.1016/j.bbabio.2008.04.022. Epub 2008 Apr 22. Review.

14.

The dimeric structure of the cytochrome bc(1) complex prevents center P inhibition by reverse reactions at center N.

Covian R, Trumpower BL.

Biochim Biophys Acta. 2008 Jul-Aug;1777(7-8):1044-52. doi: 10.1016/j.bbabio.2008.04.008. Epub 2008 Apr 11.

15.

Mutations in cytochrome b that affect kinetics of the electron transfer reactions at center N in the yeast cytochrome bc1 complex.

Rotsaert FA, Covian R, Trumpower BL.

Biochim Biophys Acta. 2008 Mar;1777(3):239-49. doi: 10.1016/j.bbabio.2007.08.005. Epub 2007 Sep 6.

16.
17.

Modeling the molecular basis of atovaquone resistance in parasites and pathogenic fungi.

Kessl JJ, Meshnick SR, Trumpower BL.

Trends Parasitol. 2007 Oct;23(10):494-501. Epub 2007 Sep 7. Review.

PMID:
17826334
19.
21.

Parameters determining the relative efficacy of hydroxy-naphthoquinone inhibitors of the cytochrome bc1 complex.

Kessl JJ, Moskalev NV, Gribble GW, Nasr M, Meshnick SR, Trumpower BL.

Biochim Biophys Acta. 2007 Apr;1767(4):319-26. Epub 2007 Feb 27.

22.

A comparison of stigmatellin conformations, free and bound to the photosynthetic reaction center and the cytochrome bc1 complex.

Lancaster CR, Hunte C, Kelley J 3rd, Trumpower BL, Ditchfield R.

J Mol Biol. 2007 Apr 20;368(1):197-208. Epub 2007 Feb 11.

PMID:
17337272
23.

Mutational analysis of cytochrome b at the ubiquinol oxidation site of yeast complex III.

Wenz T, Covian R, Hellwig P, Macmillan F, Meunier B, Trumpower BL, Hunte C.

J Biol Chem. 2007 Feb 9;282(6):3977-88. Epub 2006 Dec 4.

24.

Similar transition states mediate the Q-cycle and superoxide production by the cytochrome bc1 complex.

Forquer I, Covian R, Bowman MK, Trumpower BL, Kramer DM.

J Biol Chem. 2006 Dec 15;281(50):38459-65. Epub 2006 Sep 28.

25.
26.
27.

Molecular basis of Toxoplasma gondii atovaquone resistance modeled in Saccharomyces cerevisiae.

Kessl JJ, Ha KH, Merritt AK, Meshnick SR, Trumpower BL.

Mol Biochem Parasitol. 2006 Apr;146(2):255-8. Epub 2005 Dec 27. No abstract available.

PMID:
16412524
28.

Rapid electron transfer between monomers when the cytochrome bc1 complex dimer is reduced through center N.

Covian R, Trumpower BL.

J Biol Chem. 2005 Jun 17;280(24):22732-40. Epub 2005 Apr 15.

29.

Cytochrome b mutations that modify the ubiquinol-binding pocket of the cytochrome bc1 complex and confer anti-malarial drug resistance in Saccharomyces cerevisiae.

Kessl JJ, Ha KH, Merritt AK, Lange BB, Hill P, Meunier B, Meshnick SR, Trumpower BL.

J Biol Chem. 2005 Apr 29;280(17):17142-8. Epub 2005 Feb 17.

30.

DB75, a novel trypanocidal agent, disrupts mitochondrial function in Saccharomyces cerevisiae.

Lanteri CA, Trumpower BL, Tidwell RR, Meshnick SR.

Antimicrob Agents Chemother. 2004 Oct;48(10):3968-74.

32.

Anti-cooperative oxidation of ubiquinol by the yeast cytochrome bc1 complex.

Covian R, Gutierrez-Cirlos EB, Trumpower BL.

J Biol Chem. 2004 Apr 9;279(15):15040-9. Epub 2004 Feb 3.

33.

Inhibition of the yeast cytochrome bc1 complex by ilicicolin H, a novel inhibitor that acts at the Qn site of the bc1 complex.

Gutierrez-Cirlos EB, Merbitz-Zahradnik T, Trumpower BL.

J Biol Chem. 2004 Mar 5;279(10):8708-14. Epub 2003 Dec 10.

35.

Disulfide bond formation involves a quinhydrone-type charge-transfer complex.

Regeimbal J, Gleiter S, Trumpower BL, Yu CA, Diwakar M, Ballou DP, Bardwell JC.

Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):13779-84. Epub 2003 Nov 11.

36.

Superoxide anion generation by the cytochrome bc1 complex.

Sun J, Trumpower BL.

Arch Biochem Biophys. 2003 Nov 15;419(2):198-206.

PMID:
14592463
37.

Molecular basis for atovaquone resistance in Pneumocystis jirovecii modeled in the cytochrome bc(1) complex of Saccharomyces cerevisiae.

Kessl JJ, Hill P, Lange BB, Meshnick SR, Meunier B, Trumpower BL.

J Biol Chem. 2004 Jan 23;279(4):2817-24. Epub 2003 Oct 23.

38.

Recapitulation in Saccharomyces cerevisiae of cytochrome b mutations conferring resistance to atovaquone in Pneumocystis jiroveci.

Hill P, Kessl J, Fisher N, Meshnick S, Trumpower BL, Meunier B.

Antimicrob Agents Chemother. 2003 Sep;47(9):2725-31.

39.

Molecular basis for atovaquone binding to the cytochrome bc1 complex.

Kessl JJ, Lange BB, Merbitz-Zahradnik T, Zwicker K, Hill P, Meunier B, Pálsdóttir H, Hunte C, Meshnick S, Trumpower BL.

J Biol Chem. 2003 Aug 15;278(33):31312-8. Epub 2003 Jun 5.

40.

Protonmotive pathways and mechanisms in the cytochrome bc1 complex.

Hunte C, Palsdottir H, Trumpower BL.

FEBS Lett. 2003 Jun 12;545(1):39-46. Review.

41.

Structure of the yeast cytochrome bc1 complex with a hydroxyquinone anion Qo site inhibitor bound.

Palsdottir H, Lojero CG, Trumpower BL, Hunte C.

J Biol Chem. 2003 Aug 15;278(33):31303-11. Epub 2003 Jun 2.

42.

Failure to insert the iron-sulfur cluster into the Rieske iron-sulfur protein impairs both center N and center P of the cytochrome bc1 complex.

Gutierrez-Cirlos EB, Merbitz-Zahradnik T, Trumpower BL.

J Biol Chem. 2002 Dec 27;277(52):50703-9. Epub 2002 Oct 10.

43.
45.

Specific roles of protein-phospholipid interactions in the yeast cytochrome bc1 complex structure.

Lange C, Nett JH, Trumpower BL, Hunte C.

EMBO J. 2001 Dec 3;20(23):6591-600.

49.

Evidence for a concerted mechanism of ubiquinol oxidation by the cytochrome bc1 complex.

Snyder CH, Gutierrez-Cirlos EB, Trumpower BL.

J Biol Chem. 2000 May 5;275(18):13535-41.

50.

Role of the Rieske iron-sulfur protein midpoint potential in the protonmotive Q-cycle mechanism of the cytochrome bc1 complex.

Snyder CH, Merbitz-Zahradnik T, Link TA, Trumpower BL.

J Bioenerg Biomembr. 1999 Jun;31(3):235-42. Review.

PMID:
10591529

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