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Items: 1 to 50 of 59

1.

DNA Damage Repair in Huntington's Disease and Other Neurodegenerative Diseases.

Maiuri T, Suart CE, Hung CLK, Graham KJ, Barba Bazan CA, Truant R.

Neurotherapeutics. 2019 Jul 30. doi: 10.1007/s13311-019-00768-7. [Epub ahead of print] Review.

PMID:
31364066
2.

High-mobility group box 1 links sensing of reactive oxygen species by huntingtin to its nuclear entry.

Son S, Bowie LE, Maiuri T, Hung CLK, Desmond CR, Xia J, Truant R.

J Biol Chem. 2019 Feb 8;294(6):1915-1923. doi: 10.1074/jbc.RA117.001440. Epub 2018 Dec 11.

PMID:
30538129
3.

DNA Repair Signaling of Huntingtin: The Next Link Between Late-Onset Neurodegenerative Disease and Oxidative DNA Damage.

Maiuri T, Bowie LE, Truant R.

DNA Cell Biol. 2019 Jan;38(1):1-6. doi: 10.1089/dna.2018.4476. Epub 2018 Nov 27.

PMID:
30481056
4.

A patient-derived cellular model for Huntington's disease reveals phenotypes at clinically relevant CAG lengths.

Hung CL, Maiuri T, Bowie LE, Gotesman R, Son S, Falcone M, Giordano JV, Gillis T, Mattis V, Lau T, Kwan V, Wheeler V, Schertzer J, Singh K, Truant R.

Mol Biol Cell. 2018 Nov 15;29(23):2809-2820. doi: 10.1091/mbc.E18-09-0590. Epub 2018 Sep 26.

5.

N6-Furfuryladenine is protective in Huntington's disease models by signaling huntingtin phosphorylation.

Bowie LE, Maiuri T, Alpaugh M, Gabriel M, Arbez N, Galleguillos D, Hung CLK, Patel S, Xia J, Hertz NT, Ross CA, Litchfield DW, Sipione S, Truant R.

Proc Natl Acad Sci U S A. 2018 Jul 24;115(30):E7081-E7090. doi: 10.1073/pnas.1801772115. Epub 2018 Jul 9.

6.

Atraumatic versus conventional lumbar puncture needles: a systematic review and meta-analysis.

Nath S, Koziarz A, Badhiwala JH, Alhazzani W, Jaeschke R, Sharma S, Banfield L, Shoamanesh A, Singh S, Nassiri F, Oczkowski W, Belley-Côté E, Truant R, Reddy K, Meade MO, Farrokhyar F, Bala MM, Alshamsi F, Krag M, Etxeandia-Ikobaltzeta I, Kunz R, Nishida O, Matouk C, Selim M, Rhodes A, Hawryluk G, Almenawer SA.

Lancet. 2018 Mar 24;391(10126):1197-1204. doi: 10.1016/S0140-6736(17)32451-0. Epub 2017 Dec 7. Review.

PMID:
29223694
7.

Bacteria Getting into Shape: Genetic Determinants of E. coli Morphology.

French S, Côté JP, Stokes JM, Truant R, Brown ED.

MBio. 2017 Mar 7;8(2). pii: e01977-16. doi: 10.1128/mBio.01977-16.

8.

Huntingtin is a scaffolding protein in the ATM oxidative DNA damage response complex.

Maiuri T, Mocle AJ, Hung CL, Xia J, van Roon-Mom WM, Truant R.

Hum Mol Genet. 2017 Jan 15;26(2):395-406. doi: 10.1093/hmg/ddw395.

PMID:
28017939
9.

DNA repair: A unifying mechanism in neurodegeneration.

Ross CA, Truant R.

Nature. 2017 Jan 5;541(7635):34-35. doi: 10.1038/nature21107. Epub 2016 Dec 21. No abstract available.

PMID:
28002410
10.

DIXDC1 Phosphorylation and Control of Dendritic Morphology Are Impaired by Rare Genetic Variants.

Kwan V, Meka DP, White SH, Hung CL, Holzapfel NT, Walker S, Murtaza N, Unda BK, Schwanke B, Yuen RKC, Habing K, Milsom C, Hope KJ, Truant R, Scherer SW, Calderon de Anda F, Singh KK.

Cell Rep. 2016 Nov 8;17(7):1892-1904. doi: 10.1016/j.celrep.2016.10.047.

11.

Huntingtin N17 domain is a reactive oxygen species sensor regulating huntingtin phosphorylation and localization.

DiGiovanni LF, Mocle AJ, Xia J, Truant R.

Hum Mol Genet. 2016 Sep 15;25(18):3937-3945. doi: 10.1093/hmg/ddw234. Epub 2016 Jul 27.

12.

A huntingtin-mediated fast stress response halting endosomal trafficking is defective in Huntington's disease.

Nath S, Munsie LN, Truant R.

Hum Mol Genet. 2015 Jan 15;24(2):450-62. doi: 10.1093/hmg/ddu460. Epub 2014 Sep 8.

13.

Getting to usable EMR data.

Keshavjee K, Williamson T, Martin K, Truant R, Aliarzadeh B, Ghany A, Greiver M.

Can Fam Physician. 2014 Apr;60(4):392. No abstract available.

14.

Live cell imaging and biophotonic methods reveal two types of mutant huntingtin inclusions.

Caron NS, Hung CL, Atwal RS, Truant R.

Hum Mol Genet. 2014 May 1;23(9):2324-38. doi: 10.1093/hmg/ddt625. Epub 2013 Dec 11.

PMID:
24334607
15.

Polyglutamine domain flexibility mediates the proximity between flanking sequences in huntingtin.

Caron NS, Desmond CR, Xia J, Truant R.

Proc Natl Acad Sci U S A. 2013 Sep 3;110(36):14610-5. doi: 10.1073/pnas.1301342110. Epub 2013 Jul 29.

16.

A multifunctional, multi-pathway intracellular localization signal in Huntingtin.

Desmond CR, Maiuri T, Truant R.

Commun Integr Biol. 2013 Mar 1;6(2):e23318. doi: 10.4161/cib.23318.

17.

The huntingtin N17 domain is a multifunctional CRM1 and Ran-dependent nuclear and cilial export signal.

Maiuri T, Woloshansky T, Xia J, Truant R.

Hum Mol Genet. 2013 Apr 1;22(7):1383-94. doi: 10.1093/hmg/dds554. Epub 2013 Jan 7.

18.

The role of the cofilin-actin rod stress response in neurodegenerative diseases uncovers potential new drug targets.

Munsie LN, Truant R.

Bioarchitecture. 2012 Nov-Dec;2(6):204-8. doi: 10.4161/bioa.22549.

19.

Identification of a karyopherin β1/β2 proline-tyrosine nuclear localization signal in huntingtin protein.

Desmond CR, Atwal RS, Xia J, Truant R.

J Biol Chem. 2012 Nov 16;287(47):39626-33. doi: 10.1074/jbc.M112.412379. Epub 2012 Sep 25.

20.

Using FLIM-FRET to measure conformational changes of transglutaminase type 2 in live cells.

Caron NS, Munsie LN, Keillor JW, Truant R.

PLoS One. 2012;7(8):e44159. doi: 10.1371/journal.pone.0044159. Epub 2012 Aug 31.

21.

Cofilin nuclear-cytoplasmic shuttling affects cofilin-actin rod formation during stress.

Munsie LN, Desmond CR, Truant R.

J Cell Sci. 2012 Sep 1;125(Pt 17):3977-88. doi: 10.1242/jcs.097667. Epub 2012 May 23.

22.

Ganglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease mice.

Di Pardo A, Maglione V, Alpaugh M, Horkey M, Atwal RS, Sassone J, Ciammola A, Steffan JS, Fouad K, Truant R, Sipione S.

Proc Natl Acad Sci U S A. 2012 Feb 28;109(9):3528-33. doi: 10.1073/pnas.1114502109. Epub 2012 Feb 13.

23.

Kinase inhibitors modulate huntingtin cell localization and toxicity.

Atwal RS, Desmond CR, Caron N, Maiuri T, Xia J, Sipione S, Truant R.

Nat Chem Biol. 2011 May 29;7(7):453-60. doi: 10.1038/nchembio.582.

PMID:
21623356
24.

Mutant huntingtin causes defective actin remodeling during stress: defining a new role for transglutaminase 2 in neurodegenerative disease.

Munsie L, Caron N, Atwal RS, Marsden I, Wild EJ, Bamburg JR, Tabrizi SJ, Truant R.

Hum Mol Genet. 2011 May 15;20(10):1937-51. doi: 10.1093/hmg/ddr075. Epub 2011 Feb 25.

25.

In vivo formation of protein based aqueous microcompartments.

Ge X, Conley AJ, Brandle JE, Truant R, Filipe CD.

J Am Chem Soc. 2009 Jul 1;131(25):9094-9. doi: 10.1021/ja902890r.

PMID:
19496598
26.

Lifeact cannot visualize some forms of stress-induced twisted F-actin.

Munsie LN, Caron N, Desmond CR, Truant R.

Nat Methods. 2009 May;6(5):317. doi: 10.1038/nmeth0509-317. No abstract available.

PMID:
19404250
27.

Determination of the topology of the hydrophobic segment of mammalian diacylglycerol kinase epsilon in a cell membrane and its relationship to predictions from modeling.

Decaffmeyer M, Shulga YV, Dicu AO, Thomas A, Truant R, Topham MK, Brasseur R, Epand RM.

J Mol Biol. 2008 Nov 21;383(4):797-809. doi: 10.1016/j.jmb.2008.08.076. Epub 2008 Sep 6.

PMID:
18801368
28.

Huntington's disease: revisiting the aggregation hypothesis in polyglutamine neurodegenerative diseases.

Truant R, Atwal RS, Desmond C, Munsie L, Tran T.

FEBS J. 2008 Sep;275(17):4252-62. doi: 10.1111/j.1742-4658.2008.06561.x. Epub 2008 Jul 15. Review.

29.

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes.

Klionsky DJ, Abeliovich H, Agostinis P, Agrawal DK, Aliev G, Askew DS, Baba M, Baehrecke EH, Bahr BA, Ballabio A, Bamber BA, Bassham DC, Bergamini E, Bi X, Biard-Piechaczyk M, Blum JS, Bredesen DE, Brodsky JL, Brumell JH, Brunk UT, Bursch W, Camougrand N, Cebollero E, Cecconi F, Chen Y, Chin LS, Choi A, Chu CT, Chung J, Clarke PG, Clark RS, Clarke SG, Clavé C, Cleveland JL, Codogno P, Colombo MI, Coto-Montes A, Cregg JM, Cuervo AM, Debnath J, Demarchi F, Dennis PB, Dennis PA, Deretic V, Devenish RJ, Di Sano F, Dice JF, Difiglia M, Dinesh-Kumar S, Distelhorst CW, Djavaheri-Mergny M, Dorsey FC, Dröge W, Dron M, Dunn WA Jr, Duszenko M, Eissa NT, Elazar Z, Esclatine A, Eskelinen EL, Fésüs L, Finley KD, Fuentes JM, Fueyo J, Fujisaki K, Galliot B, Gao FB, Gewirtz DA, Gibson SB, Gohla A, Goldberg AL, Gonzalez R, González-Estévez C, Gorski S, Gottlieb RA, Häussinger D, He YW, Heidenreich K, Hill JA, Høyer-Hansen M, Hu X, Huang WP, Iwasaki A, Jäättelä M, Jackson WT, Jiang X, Jin S, Johansen T, Jung JU, Kadowaki M, Kang C, Kelekar A, Kessel DH, Kiel JA, Kim HP, Kimchi A, Kinsella TJ, Kiselyov K, Kitamoto K, Knecht E, Komatsu M, Kominami E, Kondo S, Kovács AL, Kroemer G, Kuan CY, Kumar R, Kundu M, Landry J, Laporte M, Le W, Lei HY, Lenardo MJ, Levine B, Lieberman A, Lim KL, Lin FC, Liou W, Liu LF, Lopez-Berestein G, López-Otín C, Lu B, Macleod KF, Malorni W, Martinet W, Matsuoka K, Mautner J, Meijer AJ, Meléndez A, Michels P, Miotto G, Mistiaen WP, Mizushima N, Mograbi B, Monastyrska I, Moore MN, Moreira PI, Moriyasu Y, Motyl T, Münz C, Murphy LO, Naqvi NI, Neufeld TP, Nishino I, Nixon RA, Noda T, Nürnberg B, Ogawa M, Oleinick NL, Olsen LJ, Ozpolat B, Paglin S, Palmer GE, Papassideri I, Parkes M, Perlmutter DH, Perry G, Piacentini M, Pinkas-Kramarski R, Prescott M, Proikas-Cezanne T, Raben N, Rami A, Reggiori F, Rohrer B, Rubinsztein DC, Ryan KM, Sadoshima J, Sakagami H, Sakai Y, Sandri M, Sasakawa C, Sass M, Schneider C, Seglen PO, Seleverstov O, Settleman J, Shacka JJ, Shapiro IM, Sibirny A, Silva-Zacarin EC, Simon HU, Simone C, Simonsen A, Smith MA, Spanel-Borowski K, Srinivas V, Steeves M, Stenmark H, Stromhaug PE, Subauste CS, Sugimoto S, Sulzer D, Suzuki T, Swanson MS, Tabas I, Takeshita F, Talbot NJ, Tallóczy Z, Tanaka K, Tanaka K, Tanida I, Taylor GS, Taylor JP, Terman A, Tettamanti G, Thompson CB, Thumm M, Tolkovsky AM, Tooze SA, Truant R, Tumanovska LV, Uchiyama Y, Ueno T, Uzcátegui NL, van der Klei I, Vaquero EC, Vellai T, Vogel MW, Wang HG, Webster P, Wiley JW, Xi Z, Xiao G, Yahalom J, Yang JM, Yap G, Yin XM, Yoshimori T, Yu L, Yue Z, Yuzaki M, Zabirnyk O, Zheng X, Zhu X, Deter RL.

Autophagy. 2008 Feb;4(2):151-75. Epub 2007 Nov 21. Review.

30.
31.

The inhibition of endocytosis affects HDL-lipid uptake mediated by the human scavenger receptor class B type I.

Zhang Y, Ahmed AM, Tran TL, Lin J, McFarlane N, Boreham DR, Igdoura SA, Truant R, Trigatti BL.

Mol Membr Biol. 2007 Sep-Dec;24(5-6):442-54.

PMID:
17710648
32.

Huntingtin has a membrane association signal that can modulate huntingtin aggregation, nuclear entry and toxicity.

Atwal RS, Xia J, Pinchev D, Taylor J, Epand RM, Truant R.

Hum Mol Genet. 2007 Nov 1;16(21):2600-15. Epub 2007 Aug 18.

PMID:
17704510
33.

Proteolytic cleavage of ataxin-7 by caspase-7 modulates cellular toxicity and transcriptional dysregulation.

Young JE, Gouw L, Propp S, Sopher BL, Taylor J, Lin A, Hermel E, Logvinova A, Chen SF, Chen S, Bredesen DE, Truant R, Ptacek LJ, La Spada AR, Ellerby LM.

J Biol Chem. 2007 Oct 12;282(41):30150-60. Epub 2007 Jul 23.

34.

Nucleocytoplasmic trafficking and transcription effects of huntingtin in Huntington's disease.

Truant R, Atwal RS, Burtnik A.

Prog Neurobiol. 2007 Nov;83(4):211-27. Epub 2007 Jan 22. Review.

PMID:
17240517
35.

Hypothesis: Huntingtin may function in membrane association and vesicular trafficking.

Truant R, Atwal R, Burtnik A.

Biochem Cell Biol. 2006 Dec;84(6):912-7. Review.

PMID:
17215878
36.

Regulation of SR-BI-mediated selective lipid uptake in Chinese hamster ovary-derived cells by protein kinase signaling pathways.

Zhang Y, Ahmed AM, McFarlane N, Capone C, Boreham DR, Truant R, Igdoura SA, Trigatti BL.

J Lipid Res. 2007 Feb;48(2):405-16. Epub 2006 Nov 1.

37.

Canadian Association of Neurosciences Review: polyglutamine expansion neurodegenerative diseases.

Truant R, Raymond LA, Xia J, Pinchev D, Burtnik A, Atwal RS.

Can J Neurol Sci. 2006 Aug;33(3):278-91. Review.

PMID:
17001815
38.

Practical three color live cell imaging by widefield microscopy.

Xia J, Kim SH, Macmillan S, Truant R.

Biol Proced Online. 2006;8:63-8. Epub 2006 Jul 21.

39.

Ataxin-7 can export from the nucleus via a conserved exportin-dependent signal.

Taylor J, Grote SK, Xia J, Vandelft M, Graczyk J, Ellerby LM, La Spada AR, Truant R.

J Biol Chem. 2006 Feb 3;281(5):2730-9. Epub 2005 Nov 28.

41.

Inhibition of metabotropic glutamate receptor signaling by the huntingtin-binding protein optineurin.

Anborgh PH, Godin C, Pampillo M, Dhami GK, Dale LB, Cregan SP, Truant R, Ferguson SS.

J Biol Chem. 2005 Oct 14;280(41):34840-8. Epub 2005 Aug 9.

42.

RNA association and nucleocytoplasmic shuttling by ataxin-1.

Irwin S, Vandelft M, Pinchev D, Howell JL, Graczyk J, Orr HT, Truant R.

J Cell Sci. 2005 Jan 1;118(Pt 1):233-42.

43.
44.

Re-expression of TSLC1 in a non-small-cell lung cancer cell line induces apoptosis and inhibits tumor growth.

Mao X, Seidlitz E, Truant R, Hitt M, Ghosh HP.

Oncogene. 2004 Jul 22;23(33):5632-42.

PMID:
15184878
45.

Huntingtin contains a highly conserved nuclear export signal.

Xia J, Lee DH, Taylor J, Vandelft M, Truant R.

Hum Mol Genet. 2003 Jun 15;12(12):1393-403.

PMID:
12783847
46.
47.

An ancient family of human endogenous retroviruses encodes a functional homolog of the HIV-1 Rev protein.

Yang J, Bogerd HP, Peng S, Wiegand H, Truant R, Cullen BR.

Proc Natl Acad Sci U S A. 1999 Nov 9;96(23):13404-8.

49.

Definition of a consensus transportin-specific nucleocytoplasmic transport signal.

Bogerd HP, Benson RE, Truant R, Herold A, Phingbodhipakkiya M, Cullen BR.

J Biol Chem. 1999 Apr 2;274(14):9771-7.

50.

Nucleocytoplasmic shuttling by protein nuclear import factors.

Truant R, Fridell RA, Benson ER, Herold A, Cullen BR.

Eur J Cell Biol. 1998 Dec;77(4):269-75.

PMID:
9930651

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