Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 49

1.

Caspase-2 and tau-a toxic partnership?

Troy CM, Shelanski ML.

Nat Med. 2016 Nov 8;22(11):1207-1208. doi: 10.1038/nm.4227. No abstract available.

PMID:
27824824
2.

Mutations in CRADD Result in Reduced Caspase-2-Mediated Neuronal Apoptosis and Cause Megalencephaly with a Rare Lissencephaly Variant.

Di Donato N, Jean YY, Maga AM, Krewson BD, Shupp AB, Avrutsky MI, Roy A, Collins S, Olds C, Willert RA, Czaja AM, Johnson R, Stover JA, Gottlieb S, Bartholdi D, Rauch A, Goldstein A, Boyd-Kyle V, Aldinger KA, Mirzaa GM, Nissen A, Brigatti KW, Puffenberger EG, Millen KJ, Strauss KA, Dobyns WB, Troy CM, Jinks RN.

Am J Hum Genet. 2016 Nov 3;99(5):1117-1129. doi: 10.1016/j.ajhg.2016.09.010. Epub 2016 Oct 20.

3.

Stereotaxic Infusion of Oligomeric Amyloid-beta into the Mouse Hippocampus.

Jean YY, Baleriola J, Fà M, Hengst U, Troy CM.

J Vis Exp. 2015 Jun 17;(100):e52805. doi: 10.3791/52805.

4.

Caspases: therapeutic targets in neurologic disease.

Troy CM, Jean YY.

Neurotherapeutics. 2015 Jan;12(1):42-8. doi: 10.1007/s13311-014-0307-9. Review.

5.

Caspase-9 mediates photoreceptor death after blunt ocular trauma.

Blanch RJ, Ahmed Z, Thompson AR, Akpan N, Snead DR, Berry M, Troy CM, Scott RA, Logan A.

Invest Ophthalmol Vis Sci. 2014 Sep 4;55(10):6350-7. doi: 10.1167/iovs.13-13708.

6.

Axonally synthesized ATF4 transmits a neurodegenerative signal across brain regions.

Baleriola J, Walker CA, Jean YY, Crary JF, Troy CM, Nagy PL, Hengst U.

Cell. 2014 Aug 28;158(5):1159-1172. doi: 10.1016/j.cell.2014.07.001.

7.

Combined suppression of CASP2 and CASP6 protects retinal ganglion cells from apoptosis and promotes axon regeneration through CNTF-mediated JAK/STAT signalling.

Vigneswara V, Akpan N, Berry M, Logan A, Troy CM, Ahmed Z.

Brain. 2014 Jun;137(Pt 6):1656-75. doi: 10.1093/brain/awu037. Epub 2014 Apr 10.

8.

Caspase-2 is essential for c-Jun transcriptional activation and Bim induction in neuron death.

Jean YY, Ribe EM, Pero ME, Moskalenko M, Iqbal Z, Marks LJ, Greene LA, Troy CM.

Biochem J. 2013 Oct 1;455(1):15-25. doi: 10.1042/BJ20130556.

9.

Caspase-2 is required for dendritic spine and behavioural alterations in J20 APP transgenic mice.

Pozueta J, Lefort R, Ribe EM, Troy CM, Arancio O, Shelanski M.

Nat Commun. 2013;4:1939. doi: 10.1038/ncomms2927.

10.

Caspase-9 mediates synaptic plasticity and memory deficits of Danish dementia knock-in mice: caspase-9 inhibition provides therapeutic protection.

Tamayev R, Akpan N, Arancio O, Troy CM, D'Adamio L.

Mol Neurodegener. 2012 Dec 10;7:60. doi: 10.1186/1750-1326-7-60.

11.

Caspase inhibitors: prospective therapies for stroke.

Akpan N, Troy CM.

Neuroscientist. 2013 Apr;19(2):129-36. doi: 10.1177/1073858412447875. Epub 2012 May 29. Review.

PMID:
22645109
12.

Neuronal caspase 2 activity and function requires RAIDD, but not PIDD.

Ribe EM, Jean YY, Goldstein RL, Manzl C, Stefanis L, Villunger A, Troy CM.

Biochem J. 2012 Jun 15;444(3):591-9. doi: 10.1042/BJ20111588.

13.

Intranasal delivery of caspase-9 inhibitor reduces caspase-6-dependent axon/neuron loss and improves neurological function after stroke.

Akpan N, Serrano-Saiz E, Zacharia BE, Otten ML, Ducruet AF, Snipas SJ, Liu W, Velloza J, Cohen G, Sosunov SA, Frey WH 2nd, Salvesen GS, Connolly ES Jr, Troy CM.

J Neurosci. 2011 Jun 15;31(24):8894-904. doi: 10.1523/JNEUROSCI.0698-11.2011.

14.

Endogenous amyloid-β is necessary for hippocampal synaptic plasticity and memory.

Puzzo D, Privitera L, Fa' M, Staniszewski A, Hashimoto G, Aziz F, Sakurai M, Ribe EM, Troy CM, Mercken M, Jung SS, Palmeri A, Arancio O.

Ann Neurol. 2011 May;69(5):819-30. doi: 10.1002/ana.22313. Epub 2011 Apr 6.

15.

Regulation of caspases in the nervous system implications for functions in health and disease.

Troy CM, Akpan N, Jean YY.

Prog Mol Biol Transl Sci. 2011;99:265-305. doi: 10.1016/B978-0-12-385504-6.00007-5. Review.

PMID:
21238939
16.

Cystatin C protects neuronal cells from amyloid-beta-induced toxicity.

Tizon B, Ribe EM, Mi W, Troy CM, Levy E.

J Alzheimers Dis. 2010;19(3):885-94. doi: 10.3233/JAD-2010-1291.

17.

Selective inhibition of hypoxia-inducible factor (HIF) prolyl-hydroxylase 1 mediates neuroprotection against normoxic oxidative death via HIF- and CREB-independent pathways.

Siddiq A, Aminova LR, Troy CM, Suh K, Messer Z, Semenza GL, Ratan RR.

J Neurosci. 2009 Jul 8;29(27):8828-38. doi: 10.1523/JNEUROSCI.1779-09.2009.

18.
19.

Caspase-2: vestigial remnant or master regulator?

Troy CM, Ribe EM.

Sci Signal. 2008 Sep 23;1(38):pe42. doi: 10.1126/scisignal.138pe42.

PMID:
18812565
20.

Mechanisms of neuronal death in disease: defining the models and the players.

Ribe EM, Serrano-Saiz E, Akpan N, Troy CM.

Biochem J. 2008 Oct 15;415(2):165-82. doi: 10.1042/BJ20081118. Review.

PMID:
18800967
21.

Bim is elevated in Alzheimer's disease neurons and is required for beta-amyloid-induced neuronal apoptosis.

Biswas SC, Shi Y, Vonsattel JP, Leung CL, Troy CM, Greene LA.

J Neurosci. 2007 Jan 24;27(4):893-900.

22.

Cell cycle molecules define a pathway required for neuron death in development and disease.

Greene LA, Liu DX, Troy CM, Biswas SC.

Biochim Biophys Acta. 2007 Apr;1772(4):392-401. Epub 2006 Dec 13. Review.

23.

RAIDD is required for apoptosis of PC12 cells and sympathetic neurons induced by trophic factor withdrawal.

Wang Q, Maniati M, Jabado O, Pavlaki M, Troy CM, Greene LA, Stefanis L.

Cell Death Differ. 2006 Jan;13(1):75-83.

24.

Caspase function in neuronal death: delineation of the role of caspases in ischemia.

Prunell GF, Arboleda VA, Troy CM.

Curr Drug Targets CNS Neurol Disord. 2005 Feb;4(1):51-61. Review.

PMID:
15723613
25.

Highly efficient small interfering RNA delivery to primary mammalian neurons induces MicroRNA-like effects before mRNA degradation.

Davidson TJ, Harel S, Arboleda VA, Prunell GF, Shelanski ML, Greene LA, Troy CM.

J Neurosci. 2004 Nov 10;24(45):10040-6. Erratum in: J Neurosci. 2005 Feb 2;25(5):1311.

26.

Balancing neuronal death.

Prunell GF, Troy CM.

J Neurosci Res. 2004 Oct 1;78(1):1-6. Review.

PMID:
15372573
27.

Divergence of the apoptotic pathways induced by 4-hydroxynonenal and amyloid beta-protein.

Rabacchi SA, Friedman WJ, Shelanski ML, Troy CM.

Neurobiol Aging. 2004 Sep;25(8):1057-66.

PMID:
15212831
28.

RAIDD aggregation facilitates apoptotic death of PC12 cells and sympathetic neurons.

Jabado O, Wang Q, Rideout HJ, Yeasmin M, Guo KX, Vekrellis K, Papantonis S, Angelastro JM, Troy CM, Stefanis L.

Cell Death Differ. 2004 Jun;11(6):618-30.

29.

Caspase-2 redux.

Troy CM, Shelanski ML.

Cell Death Differ. 2003 Jan;10(1):101-7. Review.

30.

Caspases on the brain.

Troy CM, Salvesen GS.

J Neurosci Res. 2002 Jul 15;69(2):145-50. Review.

PMID:
12111795
31.

Mechanisms of p75-mediated death of hippocampal neurons. Role of caspases.

Troy CM, Friedman JE, Friedman WJ.

J Biol Chem. 2002 Sep 13;277(37):34295-302. Epub 2002 Jul 3.

32.

Death in the balance: alternative participation of the caspase-2 and -9 pathways in neuronal death induced by nerve growth factor deprivation.

Troy CM, Rabacchi SA, Hohl JB, Angelastro JM, Greene LA, Shelanski ML.

J Neurosci. 2001 Jul 15;21(14):5007-16. Erratum in: J Neurosci 2001 Aug 15;21(16):1b.

33.

beta-Amyloid-induced neuronal apoptosis requires c-Jun N-terminal kinase activation.

Troy CM, Rabacchi SA, Xu Z, Maroney AC, Connors TJ, Shelanski ML, Greene LA.

J Neurochem. 2001 Apr;77(1):157-64.

34.

Caspase-2 mediates neuronal cell death induced by beta-amyloid.

Troy CM, Rabacchi SA, Friedman WJ, Frappier TF, Brown K, Shelanski ML.

J Neurosci. 2000 Feb 15;20(4):1386-92.

35.

CEP-1347 (KT7515), an inhibitor of JNK activation, rescues sympathetic neurons and neuronally differentiated PC12 cells from death evoked by three distinct insults.

Maroney AC, Finn JP, Bozyczko-Coyne D, O'Kane TM, Neff NT, Tolkovsky AM, Park DS, Yan CY, Troy CM, Greene LA.

J Neurochem. 1999 Nov;73(5):1901-12.

36.
37.

Role of caspases in N-methyl-D-aspartate-induced apoptosis in cerebrocortical neurons.

Tenneti L, D'Emilia DM, Troy CM, Lipton SA.

J Neurochem. 1998 Sep;71(3):946-59.

38.

Multiple pathways of neuronal death induced by DNA-damaging agents, NGF deprivation, and oxidative stress.

Park DS, Morris EJ, Stefanis L, Troy CM, Shelanski ML, Geller HM, Greene LA.

J Neurosci. 1998 Feb 1;18(3):830-40.

41.

Mechanisms of neuronal degeneration: a final common pathway?

Troy CM, Stefanis L, Greene LA, Shelanski ML.

Adv Neurol. 1997;72:103-11. Review. No abstract available.

PMID:
8993689
42.

Induction of CPP32-like activity in PC12 cells by withdrawal of trophic support. Dissociation from apoptosis.

Stefanis L, Park DS, Yan CY, Farinelli SE, Troy CM, Shelanski ML, Greene LA.

J Biol Chem. 1996 Nov 29;271(48):30663-71.

43.
44.

Downregulation of Cu/Zn superoxide dismutase leads to cell death via the nitric oxide-peroxynitrite pathway.

Troy CM, Derossi D, Prochiantz A, Greene LA, Shelanski ML.

J Neurosci. 1996 Jan;16(1):253-61.

45.

Down-regulation of copper/zinc superoxide dismutase causes apoptotic death in PC12 neuronal cells.

Troy CM, Shelanski ML.

Proc Natl Acad Sci U S A. 1994 Jul 5;91(14):6384-7.

46.

Neurite outgrowth in peripherin-depleted PC12 cells.

Troy CM, Greene LA, Shelanski ML.

J Cell Biol. 1992 Jun;117(5):1085-92.

47.

Regulation of peripherin and neurofilament expression in regenerating rat motor neurons.

Troy CM, Muma NA, Greene LA, Price DL, Shelanski ML.

Brain Res. 1990 Oct 8;529(1-2):232-8.

PMID:
2126481
48.

Ontogeny of the neuronal intermediate filament protein, peripherin, in the mouse embryo.

Troy CM, Brown K, Greene LA, Shelanski ML.

Neuroscience. 1990;36(1):217-37.

PMID:
2215919
49.

Processing of enkephalin precursors by chromaffin granule enzymes.

Troy CM, Musacchio JM.

Life Sci. 1982 Oct 18-25;31(16-17):1717-20.

PMID:
7154831

Supplemental Content

Support Center