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Items: 20

1.

Context-specific tumor suppression by PHF6.

Trowbridge JJ.

Blood. 2019 Apr 18;133(16):1698-1700. doi: 10.1182/blood-2019-03-900829. No abstract available.

PMID:
31000514
2.

Sequentially inducible mouse models reveal that Npm1 mutation causes malignant transformation of Dnmt3a-mutant clonal hematopoiesis.

Loberg MA, Bell RK, Goodwin LO, Eudy E, Miles LA, SanMiguel JM, Young K, Bergstrom DE, Levine RL, Schneider RK, Trowbridge JJ.

Leukemia. 2019 Jul;33(7):1635-1649. doi: 10.1038/s41375-018-0368-6. Epub 2019 Jan 28.

3.

Open chromatin profiling as a novel strategy for identifying cancer cell of origin.

Young K, Trowbridge JJ.

Mol Cell Oncol. 2016 Sep 30;3(6):e1236770. doi: 10.1080/23723556.2016.1236770. eCollection 2016.

4.

The Mediator of Hematopoietic Stem Cell Homeostasis.

Borikar S, Trowbridge JJ.

Cell Stem Cell. 2016 Dec 1;19(6):677-678. doi: 10.1016/j.stem.2016.11.012.

5.

Progressive alterations in multipotent hematopoietic progenitors underlie lymphoid cell loss in aging.

Young K, Borikar S, Bell R, Kuffler L, Philip V, Trowbridge JJ.

J Exp Med. 2016 Oct 17;213(11):2259-2267. Epub 2016 Oct 10.

6.

Loss-of-function mutations in the C9ORF72 mouse ortholog cause fatal autoimmune disease.

Burberry A, Suzuki N, Wang JY, Moccia R, Mordes DA, Stewart MH, Suzuki-Uematsu S, Ghosh S, Singh A, Merkle FT, Koszka K, Li QZ, Zon L, Rossi DJ, Trowbridge JJ, Notarangelo LD, Eggan K.

Sci Transl Med. 2016 Jul 13;8(347):347ra93. doi: 10.1126/scitranslmed.aaf6038.

7.

Leukaemia cell of origin identified by chromatin landscape of bulk tumour cells.

George J, Uyar A, Young K, Kuffler L, Waldron-Francis K, Marquez E, Ucar D, Trowbridge JJ.

Nat Commun. 2016 Jul 11;7:12166. doi: 10.1038/ncomms12166.

8.

Corepressor-dependent silencing of fetal hemoglobin expression by BCL11A.

Xu J, Bauer DE, Kerenyi MA, Vo TD, Hou S, Hsu YJ, Yao H, Trowbridge JJ, Mandel G, Orkin SH.

Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6518-23. doi: 10.1073/pnas.1303976110. Epub 2013 Apr 1.

9.

TiF1-gamma plays an essential role in murine hematopoiesis and regulates transcriptional elongation of erythroid genes.

Bai X, Trowbridge JJ, Riley E, Lee JA, DiBiase A, Kaartinen VM, Orkin SH, Zon LI.

Dev Biol. 2013 Jan 15;373(2):422-30. doi: 10.1016/j.ydbio.2012.10.008. Epub 2012 Nov 16.

10.

Haploinsufficiency of Dnmt1 impairs leukemia stem cell function through derepression of bivalent chromatin domains.

Trowbridge JJ, Sinha AU, Zhu N, Li M, Armstrong SA, Orkin SH.

Genes Dev. 2012 Feb 15;26(4):344-9. doi: 10.1101/gad.184341.111.

11.

Dnmt3a silences hematopoietic stem cell self-renewal.

Trowbridge JJ, Orkin SH.

Nat Genet. 2011 Dec 27;44(1):13-4. doi: 10.1038/ng.1043.

PMID:
22200773
12.

Context-dependent function of "GATA switch" sites in vivo.

Snow JW, Trowbridge JJ, Johnson KD, Fujiwara T, Emambokus NE, Grass JA, Orkin SH, Bresnick EH.

Blood. 2011 May 5;117(18):4769-72. doi: 10.1182/blood-2010-10-313031. Epub 2011 Mar 11.

13.

A single cis element maintains repression of the key developmental regulator Gata2.

Snow JW, Trowbridge JJ, Fujiwara T, Emambokus NE, Grass JA, Orkin SH, Bresnick EH.

PLoS Genet. 2010 Sep 9;6(9):e1001103. doi: 10.1371/journal.pgen.1001103.

14.

Proteomic studies of stem cells.

Wang J, Trowbridge JJ, Rao S, Orkin SH.

StemBook [Internet]. Cambridge (MA): Harvard Stem Cell Institute; 2008-.
2008 Jul 14.

15.

Wnt3a activates dormant c-Kit(-) bone marrow-derived cells with short-term multilineage hematopoietic reconstitution capacity.

Trowbridge JJ, Guezguez B, Moon RT, Bhatia M.

Stem Cells. 2010 Aug;28(8):1379-89. doi: 10.1002/stem.457.

16.

DNA methylation in adult stem cells: new insights into self-renewal.

Trowbridge JJ, Orkin SH.

Epigenetics. 2010 Apr;5(3):189-93. Epub 2010 Apr 1.

PMID:
20364115
17.

DNA methyltransferase 1 is essential for and uniquely regulates hematopoietic stem and progenitor cells.

Trowbridge JJ, Snow JW, Kim J, Orkin SH.

Cell Stem Cell. 2009 Oct 2;5(4):442-9. doi: 10.1016/j.stem.2009.08.016.

18.

Hematopoietic stem cell biology: too much of a Wnt thing.

Trowbridge JJ, Moon RT, Bhatia M.

Nat Immunol. 2006 Oct;7(10):1021-3. No abstract available.

PMID:
16985497
19.

Hedgehog modulates cell cycle regulators in stem cells to control hematopoietic regeneration.

Trowbridge JJ, Scott MP, Bhatia M.

Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):14134-9. Epub 2006 Sep 12.

20.

Glycogen synthase kinase-3 is an in vivo regulator of hematopoietic stem cell repopulation.

Trowbridge JJ, Xenocostas A, Moon RT, Bhatia M.

Nat Med. 2006 Jan;12(1):89-98. Epub 2005 Dec 11.

PMID:
16341242

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