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Antioxidant-inspired drug discovery: antitumor metabolite is formed in situ from a hydroxycinnamic acid derivative upon free radical scavenging.
Fási L, Di Meo F, Kuo CY, Stojkovic Buric S, Martins A, Kúsz N, Béni Z, Dékány M, Balogh GT, Pesic M, Wang HC, Trouillas P, Hunyadi A.
J Med Chem. 2019 Jan 7. doi: 10.1021/acs.jmedchem.8b01994. [Epub ahead of print]
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Lipid bilayer position and orientation of novel carprofens, modulators of γ-secretase in Alzheimer's disease.
Salnikov E, Drung B, Fabre G, Itkin A, Otyepka M, Dencher NA, Schmidt B, Hauß T, Trouillas P, Bechinger B.
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Binding Modes and Selectivity of Ruthenium Complexes to Human Telomeric DNA G-Quadruplexes.
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Chemistry. 2018 Oct 17;24(58):15577-15588. doi: 10.1002/chem.201802147. Epub 2018 Sep 14.
Combining (Non)linear Optical and Fluorescence Analysis of DiD To Enhance Lipid Phase Recognition.
Osella S, Di Meo F, Murugan NA, Fabre G, Ameloot M, Trouillas P, Knippenberg S.
J Chem Theory Comput. 2018 Oct 9;14(10):5350-5359. doi: 10.1021/acs.jctc.8b00553. Epub 2018 Sep 26.
Local low dose curcumin treatment improves functional recovery and remyelination in a rat model of sciatic nerve crush through inhibition of oxidative stress.
Caillaud M, Chantemargue B, Richard L, Vignaud L, Favreau F, Faye PA, Vignoles P, Sturtz F, Trouillas P, Vallat JM, Desmoulière A, Billet F.
Neuropharmacology. 2018 Sep 1;139:98-116. doi: 10.1016/j.neuropharm.2018.07.001. Epub 2018 Jul 3.
Atomistic Picture of Fluorescent Probes with Hydrocarbon Tails in Lipid Bilayer Membranes: An Investigation of Selective Affinities and Fluorescent Anisotropies in Different Environmental Phases.
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Langmuir. 2018 Jul 31;34(30):9072-9084. doi: 10.1021/acs.langmuir.8b01164. Epub 2018 Jul 19.
Structural patterns of the human ABCC4/MRP4 exporter in lipid bilayers rationalize clinically observed polymorphisms.
Chantemargue B, Di Meo F, Berka K, Picard N, Arnion H, Essig M, Marquet P, Otyepka M, Trouillas P.
Pharmacol Res. 2018 Jul;133:318-327. doi: 10.1016/j.phrs.2018.02.029. Epub 2018 Mar 10.
Chemoenzymatic Preparation and Biophysical Properties of Sulfated Quercetin Metabolites.
Valentová K, Káňová K, Di Meo F, Pelantová H, Chambers CS, Rydlová L, Petrásková L, Křenková A, Cvačka J, Trouillas P, Křen V.
Int J Mol Sci. 2017 Oct 25;18(11). pii: E2231. doi: 10.3390/ijms18112231.
Single nucleotide polymorphisms of ABCC2 modulate renal secretion of endogenous organic anions.
Muhrez K, Largeau B, Emond P, Montigny F, Halimi JM, Trouillas P, Barin-Le Guellec C.
Biochem Pharmacol. 2017 Sep 15;140:124-138. doi: 10.1016/j.bcp.2017.05.012. Epub 2017 May 19.
Impact of lipid composition and photosensitizer hydrophobicity on the efficiency of light-triggered liposomal release.
Massiot J, Makky A, Di Meo F, Chapron D, Trouillas P, Rosilio V.
Phys Chem Chem Phys. 2017 May 10;19(18):11460-11473. doi: 10.1039/c7cp00983f.
Novel flavonolignan hybrid antioxidants: From enzymatic preparation to molecular rationalization.
Vavříková E, Křen V, Jezova-Kalachova L, Biler M, Chantemargue B, Pyszková M, Riva S, Kuzma M, Valentová K, Ulrichová J, Vrba J, Trouillas P, Vacek J.
Eur J Med Chem. 2017 Feb 15;127:263-274. doi: 10.1016/j.ejmech.2016.12.051. Epub 2016 Dec 26.
p-Hydroxyphenyl-pyranoanthocyanins: An Experimental and Theoretical Investigation of Their Acid-Base Properties and Molecular Interactions.
Vallverdú-Queralt A, Biler M, Meudec E, Guernevé CL, Vernhet A, Mazauric JP, Legras JL, Loonis M, Trouillas P, Cheynier V, Dangles O.
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Unravelling the immunopathological mechanisms of heavy chain deposition disease with implications for clinical management.
Bridoux F, Javaugue V, Bender S, Leroy F, Aucouturier P, Debiais-Delpech C, Goujon JM, Quellard N, Bonaud A, Clavel M, Trouillas P, Di Meo F, Gombert JM, Fermand JP, Jaccard A, Cogné M, Touchard G, Sirac C.
Kidney Int. 2017 Feb;91(2):423-434. doi: 10.1016/j.kint.2016.09.004. Epub 2016 Oct 20.
Dimerization of quercetin, Diels-Alder vs. radical-coupling approach: a joint thermodynamics, kinetics, and topological study.
Fourré I, Di Meo F, Podloucká P, Otyepka M, Trouillas P.
J Mol Model. 2016 Aug;22(8):190. doi: 10.1007/s00894-016-3051-8. Epub 2016 Jul 24.
Multidrug resistance-associated protein 4 (MRP4) controls ganciclovir intracellular accumulation and contributes to ganciclovir-induced neutropenia in renal transplant patients.
Billat PA, Ossman T, Saint-Marcoux F, Essig M, Rerolle JP, Kamar N, Rostaing L, Kaminski H, Fabre G, Otyepka M, Woillard JB, Marquet P, Trouillas P, Picard N.
Pharmacol Res. 2016 Sep;111:501-508. doi: 10.1016/j.phrs.2016.07.012. Epub 2016 Jul 9. Review.
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Pharmacol Res. 2016 Sep;111:471-486. doi: 10.1016/j.phrs.2016.06.030. Epub 2016 Jul 1. Review.
Flavonolignans As a Novel Class of Sodium Pump Inhibitors.
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Front Physiol. 2016 Mar 30;7:115. doi: 10.3389/fphys.2016.00115. eCollection 2016.
A Blue-Light-Emitting BODIPY Probe for Lipid Membranes.
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Langmuir. 2016 Apr 12;32(14):3495-505. doi: 10.1021/acs.langmuir.6b00478. Epub 2016 Mar 29.
Stabilizing and Modulating Color by Copigmentation: Insights from Theory and Experiment.
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Chem Rev. 2016 May 11;116(9):4937-82. doi: 10.1021/acs.chemrev.5b00507. Epub 2016 Mar 9. Review.
Flavonolignan 2,3-dehydroderivatives: Preparation, antiradical and cytoprotective activity.
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Free Radic Biol Med. 2016 Jan;90:114-25. doi: 10.1016/j.freeradbiomed.2015.11.014. Epub 2015 Nov 12.
Unraveling the performance of dispersion-corrected functionals for the accurate description of weakly bound natural polyphenols.
Di Meo F, Bayach I, Trouillas P, Sancho-García JC.
J Mol Model. 2015 Nov;21(11):291. doi: 10.1007/s00894-015-2838-3. Epub 2015 Oct 26.
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Sun X, Berthiller J, Trouillas P, Derex L, Diallo L, Hanss M.
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Oligostilbenoids from the heartwood of N. Heimii: role of non-covalent association in their biogenesis.
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Chem Asian J. 2015 Jan;10(1):198-211. doi: 10.1002/asia.201402673. Epub 2014 Sep 18.
Quercetin-imprinted chromatographic sorbents revisited: optimization of synthesis and rebinding protocols for application to natural resources.
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cis-trans Isomerization of silybins A and B.
Novotná M, Gažák R, Biedermann D, Di Meo F, Marhol P, Kuzma M, Bednárová L, Fuksová K, Trouillas P, Křen V.
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Elucidation of antioxidant properties of wood bark derived saturated diarylheptanoids: a comprehensive (DFT-supported) understanding.
Ponomarenko J, Trouillas P, Martin N, Dizhbite T, Krasilnikova J, Telysheva G.
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Anouar el H, Raweh S, Bayach I, Taha M, Baharudin MS, Di Meo F, Hasan MH, Adam A, Ismail NH, Weber JF, Trouillas P.
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Di Meo F, Trouillas P, Adamo C, Sancho-García JC.
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Gupta G, Garci A, Murray BS, Dyson PJ, Fabre G, Trouillas P, Giannini F, Furrer J, Süss-Fink G, Therrien B.
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Tuning color variation in grape anthocyanins at the molecular scale.
Rustioni L, Di Meo F, Guillaume M, Failla O, Trouillas P.
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Antioxidant, metal-binding and DNA-damaging properties of flavonolignans: a joint experimental and computational highlight based on 7-O-galloylsilybin.
Vacek J, Zatloukalová M, Desmier T, Nezhodová V, Hrbáč J, Kubala M, Křen V, Ulrichová J, Trouillas P.
Chem Biol Interact. 2013 Oct 5;205(3):173-80. doi: 10.1016/j.cbi.2013.07.006. Epub 2013 Jul 18.
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Trouillas P, Marchetti C, Bonnefont-Rousselot D, Lazzaroni R, Jore D, Gardès-Albert M, Collin F.
Phys Chem Chem Phys. 2013 Jun 28;15(24):9871-8. doi: 10.1039/c3cp50602a.
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Denisiuk A, Schubert V, Wolter FE, Irran E, Trouillas P, Süssmuth RD.
Bioorg Med Chem. 2013 Jun 15;21(12):3582-9. doi: 10.1016/j.bmc.2013.02.051. Epub 2013 Mar 16.
Regio- and stereocontrolled synthesis of oligostilbenoids: theoretical highlights at the supramolecular level.
Velu SS, Di Meo F, Trouillas P, Sancho-Garcia JC, Weber JF.
J Nat Prod. 2013 Apr 26;76(4):538-46. doi: 10.1021/np300705p. Epub 2013 Feb 26.
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Di Meo F, Steel M, Nicolas P, Marquet P, Duroux JL, Trouillas P.
J Mol Model. 2013 Jun;19(6):2423-32. doi: 10.1007/s00894-013-1790-3. Epub 2013 Feb 19.
Free radical scavenging by natural polyphenols: atom versus electron transfer.
Di Meo F, Lemaur V, Cornil J, Lazzaroni R, Duroux JL, Olivier Y, Trouillas P.
J Phys Chem A. 2013 Mar 14;117(10):2082-92. doi: 10.1021/jp3116319. Epub 2013 Mar 5.
From anti-GAD to ataxia with ocular motor apraxia type 2: through the looking glass.
Mariani LL, Degos B, Honnorat J, Trouillas P, Rabin M, Koenig M, Anheim M.
J Neurol. 2013 Apr;260(4):1158-9. doi: 10.1007/s00415-013-6840-3. Epub 2013 Jan 31. No abstract available.
Synthesis, characterisation and in vitro anticancer activity of hexanuclear thiolato-bridged arene ruthenium metalla-prisms.
Furrer MA, Garci A, Denoyelle-Di-Muro E, Trouillas P, Giannini F, Furrer J, Clavel CM, Dyson PJ, Süss-Fink G, Therrien B.
Chemistry. 2013 Feb 25;19(9):3198-203. doi: 10.1002/chem.201203712. Epub 2013 Jan 23.
Influence of a flavan-3-ol substituent on the affinity of anthocyanins (pigments) toward vinylcatechin dimers and proanthocyanidins (copigments).
Nave F, Brás NF, Cruz L, Teixeira N, Mateus N, Ramos MJ, Di Meo F, Trouillas P, Dangles O, De Freitas V.
J Phys Chem B. 2012 Dec 6;116(48):14089-99. doi: 10.1021/jp307782y. Epub 2012 Nov 27.
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Di Meo F, Sancho Garcia JC, Dangles O, Trouillas P.
J Chem Theory Comput. 2012 Jun 12;8(6):2034-43. doi: 10.1021/ct300276p. Epub 2012 May 21.
Photoprotective capacities of lichen metabolites: a joint theoretical and experimental study.
Millot M, Di Meo F, Tomasi S, Boustie J, Trouillas P.
J Photochem Photobiol B. 2012 Jun 4;111:17-26. doi: 10.1016/j.jphotobiol.2012.03.005. Epub 2012 Mar 24.
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Mechtouff L, Canoui-Poitrine F, Schott AM, Nighoghossian N, Trouillas P, Termoz A, Porthault-Chatard S, David JS, Chasles V, Derex L.
Int J Stroke. 2012 Dec;7(8):669-74. doi: 10.1111/j.1747-4949.2011.00737.x. Epub 2012 Feb 7.
Positioning of antioxidant quercetin and its metabolites in lipid bilayer membranes: implication for their lipid-peroxidation inhibition.
Košinová P, Berka K, Wykes M, Otyepka M, Trouillas P.
J Phys Chem B. 2012 Feb 2;116(4):1309-18. doi: 10.1021/jp208731g. Epub 2012 Jan 19.
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