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The Hepatokine TSK does not affect brown fat thermogenic capacity, body weight gain, and glucose homeostasis.

Mouchiroud M, Camiré É, Aldow M, Caron A, Jubinville É, Turcotte L, Kaci I, Beaulieu MJ, Roy C, Labbé SM, Varin TV, Gélinas Y, Lamothe J, Trottier J, Mitchell PL, Guénard F, Festuccia WT, Joubert P, Rose CF, Karvellas CJ, Barbier O, Morissette MC, Marette A, Laplante M.

Mol Metab. 2019 Dec;30:184-191. doi: 10.1016/j.molmet.2019.09.014. Epub 2019 Oct 4.


The hepatokine Tsukushi is released in response to NAFLD and impacts cholesterol homeostasis.

Mouchiroud M, Camiré É, Aldow M, Caron A, Jubinville É, Turcotte L, Kaci I, Beaulieu MJ, Roy C, Labbé SM, Varin TV, Gélinas Y, Lamothe J, Trottier J, Mitchell PL, Guénard F, Festuccia WT, Joubert P, Rose CF, Karvellas CJ, Barbier O, Morissette MC, Marette A, Laplante M.

JCI Insight. 2019 Aug 8;4(15). pii: 129492. doi: 10.1172/jci.insight.129492. eCollection 2019 Aug 8.


Organisation des services dans une urgence rurale éloignée : réflexions autour du cas de Fermont, Québec.

Fleet R, Turgeon-Pelchat C, Tounkara FK, Trottier JG, Ouellet J, Lapointe L, Renaud MP, Fortin JP.

Can J Rural Med. 2018 Fall;23(4):106-112.


Treatment with camu camu (Myrciaria dubia) prevents obesity by altering the gut microbiota and increasing energy expenditure in diet-induced obese mice.

Anhê FF, Nachbar RT, Varin TV, Trottier J, Dudonné S, Le Barz M, Feutry P, Pilon G, Barbier O, Desjardins Y, Roy D, Marette A.

Gut. 2018 Jul 31. pii: gutjnl-2017-315565. doi: 10.1136/gutjnl-2017-315565. [Epub ahead of print]


Urinary Elimination of Bile Acid Glucuronides under Severe Cholestatic Situations: Contribution of Hepatic and Renal Glucuronidation Reactions.

Perreault M, Wunsch E, Białek A, Trottier J, Verreault M, Caron P, Poirier GG, Milkiewicz P, Barbier O.

Can J Gastroenterol Hepatol. 2018 Apr 11;2018:8096314. doi: 10.1155/2018/8096314. eCollection 2018.


N-3 Polyunsaturated Fatty Acids Stimulate Bile Acid Detoxification in Human Cell Models.

Cieślak A, Trottier J, Verreault M, Milkiewicz P, Vohl MC, Barbier O.

Can J Gastroenterol Hepatol. 2018 Apr 5;2018:6031074. doi: 10.1155/2018/6031074. eCollection 2018.


Membrane permeabilizing amphiphilic peptide delivers recombinant transcription factor and CRISPR-Cas9/Cpf1 ribonucleoproteins in hard-to-modify cells.

Del'Guidice T, Lepetit-Stoffaes JP, Bordeleau LJ, Roberge J, Théberge V, Lauvaux C, Barbeau X, Trottier J, Dave V, Roy DC, Gaillet B, Garnier A, Guay D.

PLoS One. 2018 Apr 4;13(4):e0195558. doi: 10.1371/journal.pone.0195558. eCollection 2018.


Arctic berry extracts target the gut-liver axis to alleviate metabolic endotoxaemia, insulin resistance and hepatic steatosis in diet-induced obese mice.

Anhê FF, Varin TV, Le Barz M, Pilon G, Dudonné S, Trottier J, St-Pierre P, Harris CS, Lucas M, Lemire M, Dewailly É, Barbier O, Desjardins Y, Roy D, Marette A.

Diabetologia. 2018 Apr;61(4):919-931. doi: 10.1007/s00125-017-4520-z. Epub 2017 Dec 21.


Crypt Organoid Culture as an in Vitro Model in Drug Metabolism and Cytotoxicity Studies.

Lu W, Rettenmeier E, Paszek M, Yueh MF, Tukey RH, Trottier J, Barbier O, Chen S.

Drug Metab Dispos. 2017 Jul;45(7):748-754. doi: 10.1124/dmd.117.075945. Epub 2017 May 3.


H19 promotes cholestatic liver fibrosis by preventing ZEB1-mediated inhibition of epithelial cell adhesion molecule.

Song Y, Liu C, Liu X, Trottier J, Beaudoin M, Zhang L, Pope C, Peng G, Barbier O, Zhong X, Li L, Wang L.

Hepatology. 2017 Oct;66(4):1183-1196. doi: 10.1002/hep.29209. Epub 2017 Aug 26.


Selective and sensitive quantification of the cytochrome P450 3A4 protein in human liver homogenates through multiple reaction monitoring mass spectrometry.

Cieślak A, Kelly I, Trottier J, Verreault M, Wunsch E, Milkiewicz P, Poirier G, Droit A, Barbier O.

Proteomics. 2016 Nov;16(21):2827-2837. doi: 10.1002/pmic.201500386. Epub 2016 Oct 10.


Treatment with a novel agent combining docosahexaenoate and metformin increases protectin DX and IL-6 production in skeletal muscle and reduces insulin resistance in obese diabetic db/db mice.

Mitchell PL, Nachbar R, Lachance D, St-Pierre P, Trottier J, Barbier O, Marette A.

Diabetes Obes Metab. 2017 Mar;19(3):313-319. doi: 10.1111/dom.12818. Epub 2016 Dec 9.


Heterozygous Inactivation of the Nuclear Receptor PXR/NR1I2 in a Patient With Anabolic Steroid-Induced Intrahepatic Cholestasis.

Liebe R, Krawczyk M, Raszeja-Wyszomirska J, Kruk B, Preis R, Trottier J, Barbier O, Milkiewicz P, Lammert F.

Hepat Mon. 2016 Jul 23;16(8):e35953. eCollection 2016 Aug.


Long noncoding RNA MEG3 induces cholestatic liver injury by interaction with PTBP1 to facilitate shp mRNA decay.

Zhang L, Yang Z, Trottier J, Barbier O, Wang L.

Hepatology. 2017 Feb;65(2):604-615. doi: 10.1002/hep.28882. Epub 2016 Dec 24.


Serum Autotaxin is a Marker of the Severity of Liver Injury and Overall Survival in Patients with Cholestatic Liver Diseases.

Wunsch E, Krawczyk M, Milkiewicz M, Trottier J, Barbier O, Neurath MF, Lammert F, Kremer AE, Milkiewicz P.

Sci Rep. 2016 Aug 10;6:30847. doi: 10.1038/srep30847.


Portrait of trauma care in Quebec's rural emergency departments and identification of priority intervention needs to improve the quality of care: a study protocol.

Fleet R, Tounkara FK, Ouimet M, Dupuis G, Poitras J, Tanguay A, Fortin JP, Trottier JG, Ouellet J, Lortie G, Plant J, Morris J, Chauny JM, Lauzier F, Légaré F.

BMJ Open. 2016 Apr 20;6(4):e010900. doi: 10.1136/bmjopen-2015-010900.


Expression of hepatic Fibroblast Growth Factor 19 is enhanced in Primary Biliary Cirrhosis and correlates with severity of the disease.

Wunsch E, Milkiewicz M, Wasik U, Trottier J, Kempińska-Podhorodecka A, Elias E, Barbier O, Milkiewicz P.

Sci Rep. 2015 Aug 21;5:13462. doi: 10.1038/srep13462.


Transgenic ω-3 PUFA enrichment alters morphology and gene expression profile in adipose tissue of obese mice: Potential role for protectins.

White PJ, Mitchell PL, Schwab M, Trottier J, Kang JX, Barbier O, Marette A.

Metabolism. 2015 Jun;64(6):666-76. doi: 10.1016/j.metabol.2015.01.017. Epub 2015 Feb 3. Erratum in: Metabolism. 2015 Sep;64(9):e7-8.


Process of implementing collaborative care and its impacts on the provision of care and rehabilitation services to patients with a moderate or severe traumatic brain injury.

Talbot LR, Lévesque A, Trottier J.

J Multidiscip Healthc. 2014 Jul 28;7:313-20. doi: 10.2147/JMDH.S64897. eCollection 2014.


Prospective evaluation of ursodeoxycholic acid withdrawal in patients with primary sclerosing cholangitis.

Wunsch E, Trottier J, Milkiewicz M, Raszeja-Wyszomirska J, Hirschfield GM, Barbier O, Milkiewicz P.

Hepatology. 2014 Sep;60(3):931-40. doi: 10.1002/hep.27074. Epub 2014 Jul 30.


Role of glucuronidation for hepatic detoxification and urinary elimination of toxic bile acids during biliary obstruction.

Perreault M, Białek A, Trottier J, Verreault M, Caron P, Milkiewicz P, Barbier O.

PLoS One. 2013 Nov 14;8(11):e80994. doi: 10.1371/journal.pone.0080994. eCollection 2013. Erratum in: PLoS One. 2014;9(1). doi:10.1371/annotation/ef13ed51-6848-419d-94d8-1bb62e7bcf52.


Profiling serum bile acid glucuronides in humans: gender divergences, genetic determinants, and response to fenofibrate.

Trottier J, Perreault M, Rudkowska I, Levy C, Dallaire-Theroux A, Verreault M, Caron P, Staels B, Vohl MC, Straka RJ, Barbier O.

Clin Pharmacol Ther. 2013 Oct;94(4):533-43. doi: 10.1038/clpt.2013.122. Epub 2013 Jun 12.


The Human UDP-glucuronosyltransferase UGT2A1 and UGT2A2 enzymes are highly active in bile acid glucuronidation.

Perreault M, Gauthier-Landry L, Trottier J, Verreault M, Caron P, Finel M, Barbier O.

Drug Metab Dispos. 2013 Sep;41(9):1616-20. doi: 10.1124/dmd.113.052613. Epub 2013 Jun 11.


Enantiomer selective glucuronidation of the non-steroidal pure anti-androgen bicalutamide by human liver and kidney: role of the human UDP-glucuronosyltransferase (UGT)1A9 enzyme.

Grosse L, Campeau AS, Caron S, Morin FA, Meunier K, Trottier J, Caron P, Verreault M, Barbier O.

Basic Clin Pharmacol Toxicol. 2013 Aug;113(2):92-102. doi: 10.1111/bcpt.12071. Epub 2013 May 20.


Design, methodological issues and participation in a multiple sclerosis case-control study.

Williamson DM, Marrie RA, Ashley-Koch A, Schiffer R, Trottier J, Wagner L.

Acta Neurol Scand. 2012 Sep;126(3):197-204. doi: 10.1111/j.1600-0404.2011.01629.x. Epub 2011 Dec 16.


Metabolomic profiling of 17 bile acids in serum from patients with primary biliary cirrhosis and primary sclerosing cholangitis: a pilot study.

Trottier J, Białek A, Caron P, Straka RJ, Heathcote J, Milkiewicz P, Barbier O.

Dig Liver Dis. 2012 Apr;44(4):303-10. doi: 10.1016/j.dld.2011.10.025. Epub 2011 Dec 9.


Profiling circulating and urinary bile acids in patients with biliary obstruction before and after biliary stenting.

Trottier J, Białek A, Caron P, Straka RJ, Milkiewicz P, Barbier O.

PLoS One. 2011;6(7):e22094. doi: 10.1371/journal.pone.0022094. Epub 2011 Jul 8.


Profile of serum bile acids in noncholestatic volunteers: gender-related differences in response to fenofibrate.

Trottier J, Caron P, Straka RJ, Barbier O.

Clin Pharmacol Ther. 2011 Aug;90(2):279-86. doi: 10.1038/clpt.2011.124. Epub 2011 Jun 29.


Letter to the editor.

Trottier J.

Dimens Crit Care Nurs. 2010 Nov-Dec;29(6):275. doi: 10.1097/0.1.DCC.000035162.20335.e9. No abstract available.


The prevalence of multiple sclerosis in 3 US communities.

Noonan CW, Williamson DM, Henry JP, Indian R, Lynch SG, Neuberger JS, Schiffer R, Trottier J, Wagner L, Marrie RA.

Prev Chronic Dis. 2010 Jan;7(1):A12. Epub 2009 Dec 15.


The human UGT1A3 enzyme conjugates norursodeoxycholic acid into a C23-ester glucuronide in the liver.

Trottier J, El Husseini D, Perreault M, Pâquet S, Caron P, Bourassa S, Verreault M, Inaba TT, Poirier GG, Bélanger A, Guillemette C, Trauner M, Barbier O.

J Biol Chem. 2010 Jan 8;285(2):1113-21. doi: 10.1074/jbc.M109.073908. Epub 2009 Nov 4.


Regulation of endobiotics glucuronidation by ligand-activated transcription factors: physiological function and therapeutic potential.

Verreault M, Kaeding J, Caron P, Trottier J, Grosse L, Houssin E, Pâquet S, Perreault M, Barbier O.

Drug Metab Rev. 2010 Feb;42(1):110-22. doi: 10.3109/03602530903219220. Review.


Lipid-activated transcription factors control bile acid glucuronidation.

Barbier O, Trottier J, Kaeding J, Caron P, Verreault M.

Mol Cell Biochem. 2009 Jun;326(1-2):3-8. doi: 10.1007/s11010-008-0001-5. Epub 2009 Jan 7. Review.


Expression of the human UGT1 locus in transgenic mice by 4-chloro-6-(2,3-xylidino)-2-pyrimidinylthioacetic acid (WY-14643) and implications on drug metabolism through peroxisome proliferator-activated receptor alpha activation.

Senekeo-Effenberger K, Chen S, Brace-Sinnokrak E, Bonzo JA, Yueh MF, Argikar U, Kaeding J, Trottier J, Remmel RP, Ritter JK, Barbier O, Tukey RH.

Drug Metab Dispos. 2007 Mar;35(3):419-27. Epub 2006 Dec 6.


Microcontact printing-based fabrication of digital microfluidic devices.

Watson MW, Abdelgawad M, Ye G, Yonson N, Trottier J, Wheeler AR.

Anal Chem. 2006 Nov 15;78(22):7877-85.


Human UDP-glucuronosyltransferase (UGT)1A3 enzyme conjugates chenodeoxycholic acid in the liver.

Trottier J, Verreault M, Grepper S, Monté D, Bélanger J, Kaeding J, Caron P, Inaba TT, Barbier O.

Hepatology. 2006 Nov;44(5):1158-70.


The liver X-receptor alpha controls hepatic expression of the human bile acid-glucuronidating UGT1A3 enzyme in human cells and transgenic mice.

Verreault M, Senekeo-Effenberger K, Trottier J, Bonzo JA, Bélanger J, Kaeding J, Staels B, Caron P, Tukey RH, Barbier O.

Hepatology. 2006 Aug;44(2):368-78.


Enzymatic production of bile Acid glucuronides used as analytical standards for liquid chromatography-mass spectrometry analyses.

Caron P, Trottier J, Verreault M, Bélanger J, Kaeding J, Barbier O.

Mol Pharm. 2006 May-Jun;3(3):293-302.


Coordinate regulation of hepatic bile acid oxidation and conjugation by nuclear receptors.

Trottier J, Milkiewicz P, Kaeding J, Verreault M, Barbier O.

Mol Pharm. 2006 May-Jun;3(3):212-22. Review.


Tissue-specific, inducible, and hormonal control of the human UDP-glucuronosyltransferase-1 (UGT1) locus.

Chen S, Beaton D, Nguyen N, Senekeo-Effenberger K, Brace-Sinnokrak E, Argikar U, Remmel RP, Trottier J, Barbier O, Ritter JK, Tukey RH.

J Biol Chem. 2005 Nov 11;280(45):37547-57. Epub 2005 Sep 9.


Analysis of alpha-linolenic acid biohydrogenation intermediates in milk fat with emphasis on conjugated linolenic acids.

Destaillats F, Trottier JP, Galvez JM, Angers P.

J Dairy Sci. 2005 Sep;88(9):3231-9.


An outbreak of Escherichia coli O157 infection following exposure to a contaminated building.

Varma JK, Greene KD, Reller ME, DeLong SM, Trottier J, Nowicki SF, DiOrio M, Koch EM, Bannerman TL, York ST, Lambert-Fair MA, Wells JG, Mead PS.

JAMA. 2003 Nov 26;290(20):2709-12.


Assessment of human exposure and human health effects after indoor application of methyl parathion in Lorain County, Ohio, 1995-1996.

Rubin C, Esteban E, Kieszak S, Hill RH Jr, Dunlop B, Yacovac R, Trottier J, Boylan K, Tomasewski T, Pearce K.

Environ Health Perspect. 2002 Dec;110 Suppl 6:1047-51.


A randomized controlled trial to prevent patient lift and transfer injuries of health care workers.

Yassi A, Cooper JE, Tate RB, Gerlach S, Muir M, Trottier J, Massey K.

Spine (Phila Pa 1976). 2001 Aug 15;26(16):1739-46.


Role of endogenous opioid system in the regulation of the stress response.

Drolet G, Dumont EC, Gosselin I, Kinkead R, Laforest S, Trottier JF.

Prog Neuropsychopharmacol Biol Psychiatry. 2001 May;25(4):729-41. Review.


Overexpression of human apolipoprotein A-II in mice induces hypertriglyceridemia due to defective very low density lipoprotein hydrolysis.

Boisfer E, Lambert G, Atger V, Tran NQ, Pastier D, Benetollo C, Trottier JF, Beaucamps I, Antonucci M, Laplaud M, Griglio S, Chambaz J, Kalopissis AD.

J Biol Chem. 1999 Apr 23;274(17):11564-72.


Causes of staff abuse in health care facilities. Implications for prevention.

Yassi A, Tate R, Cooper J, Jenkins J, Trottier J.

AAOHN J. 1998 Oct;46(10):484-91.


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